key: cord-0697455-8vejc27y
authors: Faber, Ingrid; Brandão, Pedro Renato P.; Menegatti, Fiorella; Bispo, Diógenes Diego de Carvalho; Maluf, Fernando Bisinoto; Cardoso, Francisco
title: Covid‐19 and Parkinsonism: A non‐post‐encephalitic case.
date: 2020-08-19
journal: Mov Disord
DOI: 10.1002/mds.28277
sha: 161ffbc43e67d1ede09664fe8d781d47a8aaca7d
doc_id: 697455
cord_uid: 8vejc27y

nan

West-Nile and Japanese encephalitis [6] . In contrast, the COVID-19 clinical and laboratory picture of our patient does not suggest she had encephalitis. In parkinsonism associated with viral infections neuropathology vary from direct acute infection to post-infectious neuroinflammation, both culminating with dopaminergic cell loss. SARS-CoV2 might infect neurons in the CNS through either retrograde axonal transport or hematogenic routes [4] . Our patient probably had direct SARS-CoV2 lesion of the nigro-striatal system [7] .

In conclusion, we report a case of levodopa-responsive parkinsonism probably caused by direct SARS-CoV-2 infection, broadening the disease clinical spectrum. 

This article is protected by copyright. All rights reserved.

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We thank dr. Alaor Barra Sobrinho, Director of Imagens Médicas de Brasilia (IMEB), for kindly giving support for nuclear medicine complementary exams.

This article is protected by copyright. All rights reserved.This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/mds.28277