key: cord-0694107-5ixopm31
authors: García‐Gil, Miguel Fernando; Monte Serrano, Juan; Lapeña‐Casado, Alejandro; García García, Mar; Matovelle Ochoa, Cristina; Ara‐Martín, Mariano
title: Livedo reticularis and acrocyanosis as late manifestations of COVID‐19 in two cases with familial aggregation. Potential pathogenic role of complement (C4c)
date: 2020-10-11
journal: Int J Dermatol
DOI: 10.1111/ijd.15233
sha: 47a6694e4e39637aba5cc8315bf38e831b9bffbd
doc_id: 694107
cord_uid: 5ixopm31

nan

In the familial cases presented, livedo reticularis was seen as a late manifestation of SARS-CoV-2 infection. In one of the cases, we were unable to find evidence of SARS-CoV-2-specific antibodies. This is despite the patient being in an at-risk environment with family members with a positive serological test for IgG antibodies that confirmed the SARS-CoV-2 past infection and having presented with similar systemic and cutaneous symptoms. This finding is frequent in cutaneous manifestations by COVID-19 in which antibodies are not usually detected. 3 Immunofluorescence studies are frequently found in biopsies from cutaneous lesions caused by COVID-19, showing deposition of IgM, IgA, and C3. 3 The existence of deposition of complements C5b-9, C3d, and C4d has also been found in dermal capillaries of patients with severe COVID-19. 4 

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