key: cord-0693407-iqdgsnzq authors: Jafari, Ramezan; Cegolon, Luca; Dehghanpoor, Fatemeh; Javanbakht, Mohammad; Tabatabaei, Seyed Mohammad Hossein title: Typical Covid-19 case with primary pneumomediastinum in a 37 year old male date: 2021-05-09 journal: Radiol Case Rep DOI: 10.1016/j.radcr.2021.04.079 sha: 23d6ef3a79f6e68213633953a06d5540894da4ad doc_id: 693407 cord_uid: iqdgsnzq We report a case of 37-year-old man who was admitted to Baqiyatallah hospital in Tehran (Iran) for retrosternal pain, fever, fatigue, dyspnoea and severe non-productive cough. He was subsequently confirmed as positive for COVID-19 at real-time polymerase chain reaction (RT-PCR) test. Chest computed tomography (CT) revealed also the presence of pneumomediastinum. This case highlights the importance of chest CT imaging for COVID-19 pneumonia to detect co-existing conditions as pneumomediastinum. The COVID-19 pandemic has rapidly spread across the globe [1] . Chest computerized tomography (CT) scan is important to detect COIVD-19 penumonia and manage patients affected by severe form of the disease [1, 2] . The most common imagings of COVID-19 penumonia at chest CT scan include lung consolidation, interlobular thickening, and multiple patchy ground glass opacities (GGO) [2] [3] [4] [5] . Pneumomediastinum is a rare condition of unknown etiology, usually presenting in young patients aged 15 to 41 years [6] [7] [8] . The diagnosis of pneumo-mediastinum requires a chest X-ray or a CT scan. A 37-year-old man was admitted to our accident & emergency (A&E) service at Baqiyatallah hospital in Tehran (Iran), complaining retrosternal pain, 2-day history of fever (38.3°C), fatigue, dyspnoea, severe repetitive non-productive cough. At physical examination the patient was febrile, tachycardic, tachypnoeic with O 2 saturation of about 70% and presented diffuse ronchi at chest auscultation. Notable laboratory findings were lymphopenia, increased erythro-sedimentation ratio (ESR) and C-reactive protein (CRP). A chest CT-scan revealed bilateral multi-focal patchy GGO and air density around the esophagus with pneumomediastinum ( Figure 1) . The clinical pattern of the patient and the chest CT scan were highly suggestive of COVID-19 pneumonia, which was subsequently confirmed by Real Time-Polymerase Chain Reaction (RT-PCR). Despite an increase up to 82% in O 2 saturation thanks to ventilation, the patient was transferred to intensive care unit (ICU), because the O 2 saturation was fluctuating and pneumomediastinum can lead to deterioration of the patients' health status. The patient received treatment in compliance with the COVID-19 therapeutic protocol of Iran and was discharged after 12 days of good general health conditions. CT scan maging play a critical role in the diagnosis and management of COVID-19 pneumonia [9, 10, 11] , showing a 97% sensitivity in a study on 1,1014 patients [12] . The most common chest CT scan features in COVID-19 penumonia are multifocal, bilateral and usually ill-defined GGO, with lung consolidations and peripheral as well as basal predominancy [13, 15] . Further radiological imaging can be "crazy-paving" appearance in progressive stage or septal thickening and bronchiectasia in late stage [16, 17] . Lymphadenopathy, pleural effusion, cavitation and pulmonary nodules are not typical features of COVID-19 pneumonia, hence usually suggest other diagnoses [13] [14] [15] . Despite having an unclear etiology, alveolar rupture is a frequent cause of pneumomediastinum [7, 18] , whose most common symptom is retrosternal pain [19] , reported by 60-100% affected patients [19] [20] [21] . 80% patitents with pneumomediastinum can have elevated C-reactive protein and leukocytosis [7, 19] . The above clinical and laboratory features were shared also by our COVID-19 patient. Noetheless, the definite diagnosis of pneumomediastinum requires thoracic CT scan, which was performed upon admission in our patient. Penumomediatium associated with COVID-19 pneumonia and/or other conditions as pneumothorax have been reported in the literautre [22] [23] [24] [25] . However, the peculiarity of the present case report was the presence of para-esophageal emphysema. The most important aspect of this clinical case was pneumomediastinum, an extremely rare manifestation of an early stage COVID-19 pneumonia. Since the latter condition carries intrinsic health risks for the patient and could negatively influence the course and outcome of COVID-19 infection, suspected pneumomediastinum needs to be diagnosed as early as possible by CT scan and closely monitored thereafter in order to avoid potential complications. 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Spontaneous pneumomediastinum, pneumopericardium, pneumothorax, and subcutaneous emphysema in a patient with COVID-19 Spontaneous pneumothorax and pneumomediastinum as a rare complication of COVID-19 pneumonia: Report of 6 cases Spontaneous pneumomediastinum as a complication of a COVID-19 related pneumonia: case report and review of literature Figure 1 (A-D) four axial Ct scan images show bilateral multifocal patchy ground-glass opacities on both lung fields, compatible with COVID-19 pneumonia. Air density around esophagus and pneumomediastinum (white arrows) can be seen , an extremely rare imaging finding in COVID-19 pneumonia The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors obtained written informed consent from the patient for submission of this manuscript for publication.