key: cord-0692337-0wkcqakv
authors: nan
title: Erratum: Immunomodulators in COVID-19: Two Sides to Every Coin
date: 2021-03-15
journal: Am J Respir Crit Care Med
DOI: 10.1164/rccm.v203erratum5
sha: f232a056a03d562d767c0812faf071a4f9f4c7cf
doc_id: 692337
cord_uid: 0wkcqakv

nan

Erratum: Immunomodulators in COVID-19: Two Sides to Every Coin

There is an error in the letter by Snow and colleagues (1) , published in the November 15, 2020, issue of the Journal. In Figure 1 , the drug PUL-042 is incorrectly indicated as an inhibitor of Toll-like receptors 2/6/9 (TLR-2/6/9), when in fact it is comprised of agonists of the TLR-2/6 heterodimer and the TLR-9 homodimer. A corrected version of the figure is included here.

The Figure 1 [Revised image]. Summary of biological therapies undergoing randomized controlled trials in coronavirus disease (COVID-19). A3AR = adenosine A3 receptor; CAR = chimeric antigen receptor; CCR = C-C chemokine receptor; CSF-1R = colony-stimulating factor 1 receptor; CTGF = connective tissue growth factor; DAMP = damage-associated molecular patterns; DHODH = dihydroorotate dehydrogenase; GM-CSF = granulocyte-macrophage colony-stimulating factor; IMP = inosine-59-monophosphate; IMPDH = inosine-59-monophosphate dehydrogenase; JAK = Janus kinase; L-MOD = leukocyte modulator hemoperfusion; MAPK = mitogen-activated protein kinase; NF-kB = nuclear factor-kB; NLRP-3 = NOD-, LRR-, and pyrin domain-containing protein 3; NRP-2 = neuropilin 2; PD-1 = programmed cell death protein 1; PI3K = phosphoinositide 3-kinase; SARS-CoV-2 = severe acute respiratory syndrome coronavirus 2; STAT = signal transducer and activator of transcription; TREM-1 = triggering receptor expressed on myeloid cells-1; VEGF = vascular endothelial growth factor.

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