key: cord-0691301-cpmues1j
authors: Pruthi, Himanshu; Muthu, Valliappan; Bhujade, Harish; Sharma, Arun; Baloji, Abhiman; Ratnakara, Rao G; Bal, Amanjit; Singh, Harkant; Sandhu, Manavjit Singh; Negi, Sunder; Chakrabarti, Arunaloke; Singhal, Manphool
title: Pulmonary Artery Pseudoaneurysm in COVID-19-Associated Pulmonary Mucormycosis: Case Series and Systematic Review of the Literature
date: 2021-12-22
journal: Mycopathologia
DOI: 10.1007/s11046-021-00610-9
sha: 873df3a1a2b6a13f7387e6133c9bd3e32bdc00cf
doc_id: 691301
cord_uid: cpmues1j

Literature on COVID-19-associated pulmonary mucormycosis (CAPM) is sparse. Pulmonary artery pseudoaneurysm (PAP) is an uncommon complication of pulmonary mucormycosis (PM), and rarely reported in CAPM. Herein, we report five cases of CAPM with PAP managed at our center and perform a systematic review of the literature. We diagnosed PM in those with clinico-radiological suspicion and confirmed it by microbiology or histopathology. We encountered five cases of CAPM with PAP (size ranged from 1 × 0.8 cm to ~ 4.9 × 4.8 cm). All subjects had diabetes and were aged 55–62 years (75% men). In two cases, COVID-19 and mucormycosis were diagnosed simultaneously, while in three others, COVID-19 preceded PM. One subject who underwent surgery survived, while all others died (80% mortality). From our systematic review, we identified one additional case of CAPM with PAP in a transplant recipient. CAPM with PAP is rare with high mortality. Early diagnosis and multimodality management are imperative to improve outcomes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11046-021-00610-9.

Mucormycosis following coronavirus disease has emerged as a serious problem worldwide. [1, 2] Lungs from COVID-19 patients have been shown to have widespread thrombosis and vascular endothelialitis. [3] COVID-19 may thus potentiate the vascular complications associated with pulmonary mucormycosis (PM), an aggressive angioinvasive infection. While COVID-19-associated pulmonary mucormycosis (CAPM) has been described, [4] [5] [6] pulmonary artery pseudoaneurysm (PAP) in CAPM is rare. [7] Herein, we report on five cases of CAPM with PAP. We also systematically review the literature for additional cases and discuss the challenges in the management of CAPM with PAP.

A 59-year-old male was diagnosed with mild COVID-19 when he developed fever, dry cough, and sore throat. His oxygen saturation in room air was 95% and was managed on home isolation and systemic glucocorticoids (methylprednisolone) for two weeks. Three weeks after the COVID-19 illness, he developed a productive cough and mild hemoptysis. He was referred to us when symptoms did not resolve with broad-spectrum antibiotics. At our hospital, chest radiograph and high-resolution computed tomography (HRCT) showed right hydropneumothorax with a thick-walled cavity in the right lower lobe. His sputum did not grow bacteria, and smear for acid-fast bacilli was negative. KOH smear from sputum showed aseptate hyphae (subsequently identified as Mucor spp. by molecular diagnostics), and he was started on liposomal amphotericin B (3 mg/kg). Ten days after hospitalization and treatment with intravenous amphotericin, he developed an episode of massive hemoptysis (200 mL). Computed tomography bronchial angiography (CTBA) (Fig. 1 ) revealed a pseudoaneurysm (* 2.2 9 3.5 cm) from a branch of the right descending pulmonary artery (RDPA). He underwent digital subtraction angiography (DSA) and coil embolization (Fig. 2 ) of the offending branch of RDPA. The hemoptysis was controlled, and he underwent right lower lobectomy (Fig. 3) . He was discharged after 45 days and is currently doing well after two months of follow-up. (Table 1) The summary of the other index cases is provided in Table 1 , and the additional case details are described in the supplemental file. We diagnosed PM in all five subjects based on a clinico-radiologic suspicion and confirmed it by the presence of aseptate hyphae on a fungal smear (KOH mount) or growth of Mucorales in the culture of sputum or bronchoalveolar lavage, or histopathology of the surgical specimen. PM was diagnosed simultaneously or within eight weeks of confirmed SARS-CoV-2 infection in all the included cases. The organism causing CAPM was identified to be Rhizopus arrhizus in two subjects (case 2 and 5) by molecular methods (sequencing of the internal transcribed spacer [ITS] region of rDNA). Culture showed growth of Rhizopus homothallicus and Rhizopus microsporus in case 4. The index patients were aged 55-62 years, and four of the five cases were men. CAPM and COVID-19 were simultaneously diagnosed in two cases (cases 2 and 3). In cases 1, 4, and 5, CAPM was diagnosed three and four weeks after COVID-19, respectively. None of the five cases had hypoxemia during COVID-19 illness (yet three were treated inappropriately with glucocorticoids [cases 1, 4, and 5]). All five subjects had diabetes mellitus (diagnosed during this presentation in case 1). One of the patients also had alcohol-related chronic liver disease (case 2). Case 3 also had rhino-orbital mucormycosis, which was surgically treated.

We managed patients as per the existing guidelines. [2] Briefly, liposomal amphotericin-B (beginning with 3 mg/kg) was used for the medical management of pulmonary mucormycosis. After initial medical therapy (preferably 10-14 days) and glycemic control, patients with resectable disease were offered surgery. Early surgery or digital subtraction angiography and embolization were performed in cases of massive hemoptysis after a multidisciplinary discussion involving pulmonary physicians, radiologists, and thoracic surgeons.

We searched the PubMed and Embase databases using the following terms: (''COVID'' OR ''SARS-CoV'' 

In our case series of five patients with COVID-19associated pulmonary mucormycosis and pulmonary artery pseudoaneurysm, we noted a high case fatality rate (80%). One patient who received multimodality management (DSA embolization followed by surgery) survived. We identified only one additional case of CAPM with PAP. Infection with SARS-CoV-2 can result in a myriad of pulmonary complications. Hemoptysis is unusual in coronavirus disease (COVID-19), [8] and has been observed with pulmonary embolism or invasive pulmonary aspergillosis. [9] [10] [11] Bronchial circulation (contributes to 2% of the blood supply to the lungs) accounts for most cases of hemoptysis. Pulmonary artery as a source of bleeding is uncommon, easily missed, and challenging to manage. [12] [13] [14] [15] [16] We observed that only four of the five cases had presented with hemoptysis (either mild or streaky), and two of them developed severe hemoptysis later. Notably, one of the patients who died due to CAPM (case 4) had no hemoptysis at presentation and later developed massive hemoptysis (despite improving on appropriate treatment). Hence, a high index of suspicion needs to be maintained, and CT angiography should be considered at the earliest.

PM accounts for only about 10-20% of the total mucormycosis (and \ 10% among COVID-19-associated mucormycosis) but carries a high mortality. [17] [18] [19] [20] PM is difficult to diagnose, primarily due to the non-specific imaging findings [21] and lack of awareness. [22, 23] Massive hemoptysis can be seen in as high as one-third of PM [24] and is an independent predictor of survival. [25] However, the proportion of PM with PAP is unknown. Undiagnosed and unsuspected PAP may underlie several of these cases of massive hemoptysis. Further, diagnostic modalities such as bronchoscopy may also result in severe bleeding in patients with PM. [26] Additionally, COVID-19 poses difficulties in diagnosing PM. [5] Early initiation of appropriate antifungal therapy (amphotericin B) and timely surgery are key factors determining the outcome. [2, 17] Endovascular therapy can act as a bridge before more definite surgical therapy is undertaken (case 1). While surgery can improve outcome, several patients with PM may be inoperable due to bilateral disease, hypoxemia, and systemic illness such as chronic liver disease (case 2). In such instances, medical management and interventional endovascular treatment (including direct coil embolization of the feeding vessel) may help. Our study is limited by its retrospective design. Also, the current series is from a single referral center with the required expertise to diagnose and manage mucormycosis, and the results may not be generalizable.

Pulmonary artery pseudoaneurysm is a severe complication of CAPM and can be fatal. Early diagnosis and multimodality management are imperative to improve outcomes. Further research and a systematic evaluation are required to ascertain the various findings of CAPM.

Funding None.

Conflict of interest None of the study authors have any conflicts of interest to declare.

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