key: cord-0690945-gcaj3p0f authors: Shah, Pir Tariq; Xing, Li title: Increasing and declining of COVID-19 cases puzzling the health experts in Pakistan date: 2020-10-17 journal: New Microbes New Infect DOI: 10.1016/j.nmni.2020.100791 sha: 857090c707a69b9d300a101313a686a59a14984a doc_id: 690945 cord_uid: gcaj3p0f Although the comprehensive social measures had been engaged, COVID-19 cases remained increasing until mid-July in Pakistan, which was followed by unexplained declining. Therefore, those countermeasures need to be re-examined to find out the loopholes or defects in implementing policies in order to eventually win the war against COVID-19. Bangladesh (1.3%) were observed to be lower than that in other regional countries including China (5.2%), Iran (5.7%), and Afghanistan (3.6%), and major developed countries including the United States of America (USA, 3.1%), the United Kingdom (UK, 13%), France (14.9%), Germany (4.1%), Italy (13.9%) and Spain (8.3%) ( Figure 3A ). The lower case-fatality rate in Pakistan can also be seen in individual regions including Azad Kashmir, Balochistan, Gilgit-Baltistan, Islamabad, Khyber Pakhtunkhwa, Punjab, and Sindh ( Figure 3B ). The reasons for the lower case-fatality rate have yet to be investigated. One of the possible reasons may be the age demographics of Pakistan. Pakistan's population is over 220 million with an estimated 64% under the age of 30 years old (10) . Globally, individuals with older age have proven to be more susceptible to COVID-19 (11). In conclusion, while the comprehensive social measures had been taken even at the early stage of COVID-19 pandemic in Pakistan, the data shown in this letter suggest that the engagement of countermeasures needs to be re-examined to find out the loopholes or defects in implementing policies in order to eventually win the war against COVID-19. The data and information used in this report are available from public sources, including the databases of the World Health Organisation (WHO) (https://www.who.int/emergencies/diseases/novelcoronavirus-2019). PTS and LX conceived the study, analyzed the data, and wrote the manuscript. All authors read and approved the final manuscript. A pneumonia outbreak associated with a new coronavirus of probable bat origin WHO. Coronavirus disease (COVID-2019) situation reports 2020 COVID-19 outbreak: current scenario of Pakistan Is Pakistan prepared to tackle the coronavirus epidemic? Countrywide lockdown stretched till May 9 The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application Unexplained decline in COVID-19 cases' in Pakistan puzzles health experts and policymakers. The News International Early Successes in the Epidemiological Battle Unleashing the potential of a young Pakistan COVID-19 and the elderly: insights into pathogenesis and clinical decision-making The authors thank all the persons who contributed to the production and the collection of the data in WHO database. Authors' contributions