key: cord-0687479-4gzl1bc1
authors: Corley, Douglas A.; Sedki, Mai; Ritzwoller, Debra P.; Greenlee, Robert T.; Neslund-Dudas, Christine; Rendle, Katharine A.; Honda, Stacey A.; Schottinger, Joanne E.; Udaltsova, Natalia; Vachani, Anil; Kobrin, Sarah; Li, Christopher I.; Haas, Jennifer S.
title: Cancer Screening during COVID-19: A Perspective from NCI’s PROSPR consortium
date: 2020-10-21
journal: Gastroenterology
DOI: 10.1053/j.gastro.2020.10.030
sha: b46fa24932bcfb07cc7130cd842ef997c2510b39
doc_id: 687479
cord_uid: 4gzl1bc1

nan

The SARS-CoV-2 virus pandemic and related coronavirus disease (COVID-19) have dramatically altered healthcare delivery, worsened non-virus-related health outcomes, and increased the potential for disparities. As COVID-19 infections increased, public health and professional organizations issued guidance that all nonurgent surgeries and procedures, including cancer screening, should be delayed. 1 Not surprisingly, early data suggest that these restrictions drastically impacted preventive care that requires direct patient-provider contact. Even for conditions requiring urgent intervention, such as myocardial infarctions, 2 there is evidence that patients recently reduced healthcare use. An online evaluation by the EPIC health research network suggested fewer cancer screening encounters during the pandemic; however, these analyses did not directly measure recommended cancer screening tests within age-eligible populations and did not examine disparities over time. 3 Thus, the pandemic's broader impact on commonly performed cancer prevention and control measures remains largely unknown.

Decreases in cancer screening are particularly alarming as routinely screening asymptomatic people reduces morbidity and mortality related to breast, cervical, colorectal, and lung cancers. 4 To address these knowledge gaps and to formulate a roadmap for resuming cancer screening, the National Cancer Institute's Population-based Research to Optimize the Screening Process (PROSPR) consortium compared breast, cervical, colorectal, and lung cancer screening rates before and after the pandemic and developed pragmatic recommendations. The PROSPR consortium is designed to evaluate and improve cancer screening processes and outcomes. Data were available from eight large healthcare systems in seven states, covering more than 11 million individuals (approximately one of every 30 people in the United States). Most sites studied rapidly approached zero screening among target-age populations during the early phase of the pandemic, across diverse types of health care delivery systems ( Figure 1 ).

Breast cancer screening had the largest decline (a 96% decrease), from 5.3% of age-eligible persons screened per month in April -September 2019 to 0.23% in April -May 2020 (p < 0.01). Screening for lung, cervical, and colorectal cancer at most sites had similar declines with 62%, 92%, and 82% decreases, respectively.

Two important findings may inform future actions. First, one large site in the Western United States continued mailing FIT for colorectal screening, which does not require face-to-face interaction, and maintained high screening test returns during April -May 2020 ( Figure; tests are sent steadily over year related to birthday, for members not up to date with screening. Typical FIT return rates are >50% and the net screening up to date proportion for this site, using all modalities, is >80% (this includes people with a prior colonoscopy for FIT positive). This notable exception strongly suggests that remote cancer screening methods can be successful during the pandemic. Although remote sampling methods, such as FIT or HPV testing, allow widespread testing without in-person contacts for initial screening, they still require follow-up in-person evaluations for positive tests. This emphasizes the need for safe in-person J o u r n a l P r e -p r o o f testing environments. Second, screening reductions were uniform across sites, despite marked geographical variation in underlying SARS-CoV-2 infection rates: around May 10, for example, the 7-day average test positivity rates for states with PROSPR centers studied ranged from 0.3% to 16.8%, even though almost all sites approached zero screening. This discordance suggests the potential for closer alignment between local infection risk and concomitant reductions in preventive healthcare delivery, assuming ample SARS-CoV-2 monitoring is available. Positive testing rates for SARS-CoV-2 are difficult to interpret, given variation in testing criteria during the pandemic (e.g. symptomatic vs. asymptomatic). The infection rates for pre-procedure testing of asymptomatic people are likely far lower. 5 The costs of decreasing cancer screening are likely to include delayed cancer detection, more advanced stages of malignancy at diagnosis, and loss of life-years among those with cancer. A modeling study from the National Cancer Institute's Cancer Intervention and Surveillance Modeling Network suggested that even moderately longer times between a positive screening test and follow-up diagnostic testing could significantly reduce the life-years gained from cancer screening. 6 Significantly decreased benefit was suggested with even a few weeks delay for breast cancer and within months for colorectal cancer. 6 The declines in screening across the United States demonstrated by PROSPR data predict substantial increases in cancer morbidity and mortality in the coming years. Although detailed cancer diagnoses, staging, and survival during the pandemic await verification from cancer registries, one PROSPR site with such real-time pathology data demonstrated that monthly average colorectal cancer diagnoses decreased by 31% between April -September 2019 and April -May 2020 (p<0.01).

Still unknown is whether pandemic-related healthcare changes will induce disparities in other health outcomes, including cancers amenable to screening. 7 This uncertainty is despite well-documented racial, ethnic, and socioeconomic disparities for COVID-related diagnoses and deaths. 8, 9 Among persons completing screening within the PROSPR populations studied, screening rates decreased markedly across all PROSPR sites, for all cancer types, independent of race/ethnicity (p>0.10 for all comparisons). Among J o u r n a l P r e -p r o o f persons screened, the demographic proportions completing a test were similar pre vs. during-COVID-19 by race/ethnicity (e.g. non-Hispanic whites 50% v. 46%; Hispanic 22% vs. 29%; Asian 16% vs. 13%; and

African Americans 7% vs. 8%, respectively).

The re-introduction of cancer screening during the pandemic, however, poses a large risk for enhancing or introducing new disparities. Will the COVID-19 related financial stresses on healthcare systems allow equal resumption of robust screening programs across the population? Will shifts to telemedicine generate differences in who will request or be referred for screening, who will receive and complete active outreach, or who will schedule in-person follow-up testing? Will the pandemic's economic ramifications (which impact job and insurance status) exacerbate existing national sociodemographic differences in healthcare access and outcomes? The resumption of routine healthcare practices, including cancer screening, must incorporate intentional strategies to minimize the introduction of health disparities.

We urgently recommend several pragmatic steps to address the opportunities and challenges of resuming cancer screening services during the pandemic. Informed by the data presented, and with the goal of increasing effective, consistent, and universal delivery of safe screening services, the PROSPR consortium has developed and recommends the following urgent interventions:

• Broader implementation of remote testing, to reduce the need for in person visits, such as increased use of established methods (e.g. mailed FIT for colorectal cancer screening) and rapid evaluation of emerging strategies (e.g. self-sampling for human papillomavirus for cervical cancer screening).

• Screening outreach programs that intentionally target patients at highest social risk, including demographic groups who are less likely to spontaneously seek or complete screening.

• Rapid implementation of risk stratification tools to identify those at highest medical risk of cancer by age and other risk factors (including lack of prior screening) and those at lowest risk, who are unlikely to benefit from screening.

• Infection control measures to maximize patients and staff safety, such as pre-procedure testing.

These measures should include effective communication to decrease patient concerns regarding screening. Test performance characteristics (i.e. false positives and negatives) will influence the benefit of pre-procedure testing at very low or moderately high background levels of disease prevalence. 5 • Customized cancer screening practices, coordinated with local SARS-CoV-2 risk, to maximize screening test completion in areas with low viral prevalence.

• Real-time demographic data for early identification of screening service uptake disparities.

The COVID-19 pandemic has created unprecedented decreases in cancer screening services which will likely have long-term deleterious effects on cancer morbidity and mortality. When to resume routine care remains uncertain and delivery patterns may change. Several pragmatic steps are urgently recommended to reduce potential cancer-related outcomes and to avoid exacerbating disparities. These steps can help re-start screening and thereby equitably decrease the non-infectious impacts of the SARS-CoV-2 virus pandemic.

Funding: "This study was conducted as part of the NCI-funded consortium Population-based Research to Optimize the Screening Process (PROSPR) consortium. The overall aim of PROSPR is to conduct multisite, coordinated, transdisciplinary research to evaluate and improve cervical, colorectal, and lung cancer screening processes. The PROSPR Research Centers and their associated sites reflect the diversity of US delivery system organizations. UM1CA222035, UM1CA221939, U24CA221936.

Non-Essential Medical, Surgical, and Dental Procedures During COVID-19 Response | CMS

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AGA Rapid Recommendations for Gastrointestinal Procedures During the COVID-19 Pandemic

Effect of time to diagnostic testing for breast, cervical, and colorectal cancer screening abnormalities on screening efficacy: A modeling study

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Cancer Screening Rates Among Screening Eligible Ages (by Cancer Type

three sites to colorectal cancer data, one to breast cancer data, and one to cervical cancer data. Two colorectal cancer sites provided data for both total colonoscopies performed and FIT completed. Variations in FIT-based screening also relate to site-specific variations in outreach during holiday periods (less outreach) and colon cancer awareness month