key: cord-0684732-1gu2av4y authors: Marasca, Claudio; Ruggiero, Angelo; Napolitano, Maddalena; Fabbrocini, Gabriella; Megna, Matteo title: May COVID-19 outbreaks lead to a worsening of skin chronic inflammatory conditions? date: 2020-05-19 journal: Med Hypotheses DOI: 10.1016/j.mehy.2020.109853 sha: ee94789a2f9133323a53059a1c117fa4772c7292 doc_id: 684732 cord_uid: 1gu2av4y The emergence of the novel beta Coronavirus has raised serious concerns due to the virus rapid dissemination worldwide. Many areas throughout the world are now experiencing the COVID 19 outbreaks with government and policy authorities taking many aggressive isolation or restriction measures, drastically reducing also patient’s visits and limiting only to the most urgent ones such as oncological visits or emergencies. Several studies have demonstrated a relationship between increased weight, obesity, diabetes, hypertension and inflammatory skin diseases. Furthermore, weight loss interventions have been shown to improve psoriasis, as well as hidradenitis suppurativa, and increase responsiveness to treatment of this conditions. We suppose that due to aggressive isolation or restriction measures, in the next future dermatologist will face with a common worsening of chronic skin inflammatory conditions due to reduced physical activities, increased intake of calories with the derived increase body weight and always more frequent treatment discontinuation. It is time to start potential preventive strategies which could limit the expected negative impact of COVID-19 related quarantine on skin diseases. The emergence of the novel beta Coronavirus has raised serious concerns due to the virus rapid dissemination worldwide. Many areas throughout the world are now experiencing the COVID 19 outbreaks with government and policy authorities taking many aggressive isolation or restriction measures, drastically reducing also patient's visits and limiting only to the most urgent ones such as oncological visits or emergencies. Several studies have demonstrated a relationship between increased weight, obesity, diabetes, hypertension and inflammatory skin diseases. Furthermore, weight loss interventions have been shown to improve psoriasis, as well as hidradenitis suppurativa, and increase responsiveness to treatment of this conditions. We suppose that due to aggressive isolation or restriction measures, in the next future dermatologist will face with a common worsening of chronic skin inflammatory conditions due to reduced physical activities, increased intake of calories with the derived increase body weight and always more frequent treatment discontinuation. It is time to start potential preventive strategies which could limit the expected negative impact of COVID-19 related quarantine on skin diseases. symptoms of COVID-19 should better continue their treatment instead of risking severe flares that could be increased during this quarantine-period. (5) . In Western countries, overweight and obesity prevalence has risen dramatically in recent decades. It is well known that overweight and obesity are associated with a wide range of chronic diseases, especially skin diseases such as psoriasis and hidradenitis suppurativa (HS) (6, 7) . Indeed, several studies have demonstrated a relationship between increased weight, obesity, diabetes, hypertension and inflammatory skin diseases. Furthermore, weight loss interventions have been shown to improve psoriasis, as well as HS, and increase responsiveness to treatment (6, 8) . Overweight and obesity could promote skin inflammation through the increased release of pro-inflammatory cytokines such as interlukin-6 and tumour necrosis factor-α by hypertrophied adipocytes (7, 8) . At the same time, psoriasis and HS can also lead to a reduced participation in social, recreational and physical activity due to the high impact of visible skin lesions on quality of life, thus favouring weight gain (7) . Hence, chronic skin inflammatory diseases and metabolic factors (overweight, obesity, metabolic syndrome) are strictly linked so that a multidisciplinary is mandatory for their treatment with prevention strategies being a key public health issue. The emergence of the novel SARS-CoV-2, has raised serious concerns due to the virus rapid dissemination worldwide (9) . Many areas throughout the world are now experiencing COVID-19 outbreaks with government and policy authorities taking aggressive isolation or restriction measures (limit traveler mobility, quarantines and border restrictions, etc). In particular, Italy is currently one of the most COVID-19 involved country in the world with Italian government imposing quarantine for all citizens, limiting the possibility to perform physical activity (gyms, swimming pools, and other sports related structures will be close up to 3 April 2020). Indubitably, limiting physical activity with most people spending the whole day at home is likely to lead to an increase in body weight as well as in calories intake. Indeed, isolation at home may share some analogue restriction aspects with another forced condition of restriction such as the prison. A recent study investigated prisoners' weight and waist circumference, showing that the obesity prevalence rate increased 50% from baseline (before imprisonment) (16%) to the 6-month follow-up (24%) (10) . Hence, we suppose that the current situation of forced reduced physical activity, higher calories intake linked to home constriction as well as to negative impact of quarantine on mood and psychological aspects may act as a cofactor in worsening natural course of chronic inflammatory skin diseases with a higher impact on psoriasis and HS for all the reasons described above. We believe that this is particularly true for these diseases since moderate-to-severe forms are commonly treated with biologics. In a significant percentage of the cases the treatment will be interrupted for different reasons such as fear of SARS-CoV-2 risk infections consequent to their immunemodulating action, impossibility to seek dermatologists for the previously scheduled visits, delayed biologic scheme administration which could also favour the genesis of anti-drug antibodies limiting biologics efficacy. Thus, in the next future dermatologist will face with a common worsening of chronic skin inflammatory conditions due to reduced physical activities, increased body weight and treatment discontinuation. Therefore, it is time to start potential preventive strategies which could limit the expected negative impact of COVID-19 related quarantine on skin diseases. In this context, interventions and recommendations which are being performed by our Dermatology Clinic are shown in table 1. Coronavirus Disease 2019 (COVID-19) in Italy Covid-19: Italy confirms 11 deaths as cases spread from north Covid-19: WHO declares pandemic because of "alarming levels" of spread, severity, and inaction Megna Face the COVID-19 emergency: measures applied in an Italian Dermatologic Clinic Challenges of Covid-19 Pandemic for Dermatology Overweight, diabetes and disease duration influence clinical severity in hidradenitis suppurativa-acne inversa: evidence from the national Italian registry Psoriasis and sport: a new ally? Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study A doubt of multiple introduction of SARS-CoV-2 in Italy: a preliminary overview Obesity and Weight Change in Two United Kingdom Male Prisons. J Correct Health Care No financial support was used for the development or writing of this manuscript. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.