key: cord-0684633-7bbu1b1j
authors: Serra, Amanda Munhoz; Ventura, Andréa Maria Cordeiro; Xavier, Lucas Freitas; Simões, Angélica Braz; Duarte-Neto, Amaro Nunes
title: SARS-CoV-2 identification in an acute appendicitis case: Acute abdomen as manifestation of Multisystem Inflammatory Syndrome in a child with COVID-19
date: 2021-11-10
journal: Braz J Infect Dis
DOI: 10.1016/j.bjid.2021.101651
sha: 56f0babe9e4078c3c1600e1c3368912d8a5e0c93
doc_id: 684633
cord_uid: 7bbu1b1j

Coronavirus disease 2019 (COVID-19) pandemic is a global health emergency. The clinical course of COVID-19 in children is mild in most of the cases, but multisystem inflammatory syndrome in children (MIS-C) is recognized as a potential life-threatening complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Acute abdomen as a presentation of COVID-19 is rare, and its correlation to COVID-19 features and prognosis remains undetermined. Herein, we describe a case of appendicitis in a child with confirmed diagnosis of COVID-19 and subsequent SARS-CoV-2 identification in appendix tissue.

Case Report SARS-CoV-2 identification in an acute appendicitis case: Acute abdomen as manifestation of Multisystem Inflammatory Syndrome in a child with COVID-19 Q1 X X Q2 X XD 1 X XAmanda Munhoz Serra D 2 X X a, *, D 3 X XAndr ea Maria Cordeiro Ventura D 4 X X a , D 5 X XLucas Freitas Xavier D 6 X X a , D 7 X XAng elica Braz Simões D 8 X X b , D 9 X XAmaro Nunes Duarte-Neto D 1 0 X X c a Unidade de Terapia Intensiva Pedi atrica, Departamento de Pediatria, Hospital Universit ario da Universidade de São 23 Case presentation 24 A nine-year-old, previously healthy boy presented to the 25 emergency department with a 4-day history of periumbilical 26 abdominal pain and watery diarrhea, vomiting, evolving 27 with a daily fever of up to 38°C and progressive worsening 28 of the pain. The patient was discharged home with analge-29 sics. The next day, he was hospitalized due to worsening of 30 previous symptoms and antibiotics were started. He was 31 transferred to our service for diagnostic procedures and sur-32 gical evaluation due to the hypothesis of appendicitis. Dys-33 uria and oliguria were also described. 

Coronavirus disease 2019, first reported in Wuhan, China, 140 in early December 2019, has now become an international 141 pandemic. The causative agent, SARS-CoV-2, binds to angio

Considering the gastrointestinal symptoms, the inflam-185 matory profile, and the coagulation dysfunction

COVID-19 and appendicitis: a gut reaction to SARS-CoV-2? 285

Clearance and persistence 299 of SARS-CoV-2 RNA in patients with COVID-19

SARS-CoV-2 identification in an acute appendicitis case: Acute abdomen as manifestation of Multisystem Inflammatory Syndrome in a child with COVID-19