key: cord-0684482-acgfwjwi
authors: Luo, Ying; Yuan, Xu; Xue, Ying; Mao, Liyan; Lin, Qun; Tang, Guoxing; Song, Huijuan; Liu, Weiyong; Hou, Hongyan; Wang, Feng; Sun, Ziyong
title: Using the diagnostic model based on routine laboratory tests to distinguish patients infected with SARS-CoV-2 from those infected with influenza virus
date: 2020-05-01
journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
DOI: 10.1016/j.ijid.2020.04.078
sha: 0e4a77da25866e7885c536ec09f7623947f33d92
doc_id: 684482
cord_uid: acgfwjwi

Abstract Background The differential diagnosis between novel coronavirus pneumonia patients (NCPP) and influenza patients (IP) remains a challenge in clinical practice. Methods Between January 2018 and March 2020, 1027 NCPP and 1140 IP were recruited from Tongji hospital. Blood routine examination, biochemical indicators, and coagulation function analysis were performed in all participants simultaneously. Results There was no sex predominance in NCPP. The NCPP were frequently encountered in the sixth and seventh decades of life. The mean age of NCPP (56±16 years) was higher than IP (47±17 years), but without statistical difference. Although most results of routine laboratory tests between NCPP and IP had no significant difference, some laboratory tests showed an obvious change in NCPP. We observed that NCPP had significantly decreased white blood cells, alkaline phosphatase, and d-dimer, compared with IP. However, the results of lactate dehydrogenase, erythrocyte sedimentation rate and fibrinogen were significantly increased in NCPP compared with those in IP. The diagnostic model based on combination of eighteen routine laboratory indicators showed an area under the curve of 0.796 (95% CI, 0.777 to 0.814), with a sensitivity of 46.93% and a specificity of 90.09% when using a cutoff value of 0.598. Conclusions Some routine laboratory results had statistical difference between NCPP and IP. A diagnostic model based on combination of routine laboratory results provides an adjunct approach in the differential diagnosis between NCPP and IP.

There was no sex predominance in NCPP. The NCPP were frequently encountered in 33 the sixth and seventh decades of life. The mean age of NCPP (56±16 years) was 34 higher than IP (47±17 years), but without statistical difference. Although most results 35 of routine laboratory tests between NCPP and IP had no significant difference, some 36 laboratory tests showed an obvious change in NCPP. We observed that NCPP had 37 significantly decreased white blood cells, alkaline phosphatase, and d-dimer, The Lancet, 2020). More than 87,000 individuals have been confirmed infected with 71 the virus in China as of March 1, 2020 and most cases were reported in Wuhan city.

An evaluation version of novaPDF was used to create this PDF file. Purchase a license to generate PDF files without this notice. In total, 1027 NCPP and 1140 IP were recruited from Tongji hospital between January 166 2018 and March 2020. The demographic information was summarized in Table 1 . 167 There was no sex predominance in NCPP. RDW-SD, standard deviation in red cell distribution width; PLT#, platelet count; PDW, platelet distribution width; MPV, mean platelet volume; PLCR, platelet larger cell ratio; THR, thrombocytocrit. *Comparisons were performed between NCPP and IP groups using Mann-Whitney U test. Data were presented as medians (25th-75th percentages).

Variables NCPP (n=1027) IP (n=1140) P*

Genomic characterization of 304 the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical 305 pneumonia after visiting Wuhan

Epidemiological and clinical 307 characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a 308 descriptive study

Return of the Coronavirus: 2019-nCoV

Clinical features of patients 312 infected with 2019 novel coronavirus in Wuhan

An evaluation version of novaPDF was used to create this PDF file. Purchase a license to generate PDF files without this notice