key: cord-0684296-cfwdf0ha authors: Zojer, Niklas title: SARS-CoV-2 vaccination in patients with solid tumors or hematological malignancies: Is the pandemic over for fully vaccinated patients? date: 2021-09-16 journal: Memo DOI: 10.1007/s12254-021-00741-1 sha: f52beeca671b67bd82e2437f1017efac3fbfd835 doc_id: 684296 cord_uid: cfwdf0ha nan pose cancer patients to severe COVID-19, due to therapeutically activated T-cells augmenting the virally induced cytokine storm, but so far these concerns could not be substantiated. As in the general population, mortality of COVID-19 in cancer patients increases substantially with age. Currently, there are insufficient data for estimating COVID-19 risks for cancer survivors, i.e., patients in long-term follow-up without active disease or treatment, but highest risk for severe COVID-19 seems to affect cancer patients with active and/or advanced disease [1] . Clearly, the availability of SARS-CoV-2 vaccines has alleviated the immediate threat of the pandemic for cancer patients. However, several points need to be addressed in vaccination programs for these patients. Most available data in relation to vaccination efficacy in cancer patients relate to mRNA vaccines, either BNT162b2 or mRNA-1273. No safety issues distinct from those evident in the general population have appeared [8] . With regard to efficacy, a single vaccine dose seems unable to induce protective immunity in most cancer patients (immunity in less than 40%), while this can be achieved in 94% of healthy controls [9] . After the second dose, response improves, with 98% of patients with solid tumors achieving seroconversion [10, 11] , approaching seroconversion rates of healthy subjects. On average, however, lower IgG titers are observed in cancer patients even after the full prime-boost scheme as compared to a healthy control group, with substantial heterogeneity [12, 13] . As antibody levels seem to wane over time, this heterogeneity likely has an impact on the duration of protection against infection and protection against developing severe disease. Possibly, earlier second boost vaccinations are necessary in patients with suboptimal antibody response, especially in the context of emergence of SARS-CoV-2 variants of concern, when low IgG levels unfavorably combine with low affinity to a mutated editorial spike protein. While in a small study on healthy subjects protective antibodies persisted 6 months after the second dose of a mRNA vaccine, although at declining levels [14] , in a larger trial on patients recovering from COVID-19, different trajectories of antibody decay were evident, with a significant fraction of patients losing protective titers within 6 months (27%; [15] ). Due to the short incubation period after SARS-CoV-2 infection, it is unclear to what extent immunological memory (e.g., long-lived B-cells) confers some protection despite loss of anti-spike antibodies. Cytotoxic T cells are thought to rather control and clear established infection, rather than to prevent infection [16] and there seems to be a broad consensus with regard to the importance of humoral immunity in vaccine efficacy. However, different methods have been applied for measuring serological response to vaccination (receptor binding domain ELISA, pseudovirus or live virus neutralization assays), without clear indication which of these assays best correlates with clinical protection. While immune responses to SARS-CoV-2 vaccines may be suboptimal in patients with solid tumors, antibody production is even more suppressed in patients with hematological malignancies. Seroconversion rates are around 80% in these patients after the second vaccine dose, lower than the 98% seroconversion rate noted in patients with solid tumors [10, 11] . In a study on 167 patients with chronic lymphocytic leukemia, the antibody response rate was only 39.5% after 2 doses of the BNT162b2 vaccine [17] . Vaccine response was especially poor in patients treated with either Bruton's tyrosine kinase (BTK) inhibitors or venetoclax and/or anti-CD20 antibodies (around 15%). None of the patients exposed to anti-CD20 antibodies < 12 months before vaccination responded. In a study on 320 myeloma patients, 84.2% of patients developed measurable anti-spike antibodies after full vaccination (with either BNT162b2 or mRNA-1273), with titers varying three orders of magnitude [18] . In multivariate analysis, receiving either anti-CD38 or BCMA-targeted treatment were significantly associated with a failure of vaccine response. A large nation-wide cohort study from Lithuania can be highlighted, which included 885 patient with hematological malignancies, vaccinated with BTN162b2 [19] . A comparison was made between 315 of these patients and 67 age-matched healthcare workers, showing lower median anti-spike IgG responses in the group of patients with hematological malignancies. Particularly poor responses were evident in patients under treatment with BTK inhibitors, venetoclax or anti-CD20 therapy. Most notably, 9 SARS-CoV-2 infections and 3 COVID-19related deaths were observed in fully vaccinated patients with hematological malignancies, underlining the clinical significance of the serological findings. In contrast, more adequate immune responses were observed in patients vaccinated after autologous or allo-geneic transplantation (recommendation > 3 months after transplantation) and in patients treated with imatinib, dasatinib, nilotinib, gilteritinib. It was suggested that vulnerable individuals should receive the second vaccine dose in appropriate time, so that protective immunity is achieved as soon as possible. In addition, SARS-CoV-2 antibody levels should be determined in cancer patients to assure that protective levels of neutralizing antibodies have been reached. If that is not the case, a third booster dose might be administered. Eventually, a heterologous prime-boost regimen could be considered in these patients [20] . It seems important to provide a status of herd immunity in healthcare personnel, close family and other care givers. In care homes and hospitals for the elderly, influenza vaccination of care givers was shown to reduce mortality of patients and elderly residents significantly during the seasonal influenza epidemic [21, 22] . Two antibody cocktails are currently approved for treatment of vulnerable patients with early COVID-19 disease, to prevent disease deterioration. Studies in cancer patients are not available as yet, but likely these treatments are also beneficial in vulnerable cancer patients, i.e., those patients who are unable to mount an effective immune response to SARS-CoV-2 vaccination. Application could be considered as post-exposure prophylaxis or in early phases of COVID-19 disease, ideally as soon as a positive result is evident by SARS-CoV-2 PCR. Similar considerations might apply to pre-emptive therapy with convalescent plasma. In a randomized trial of convalescent plasma with high IgG titers, which included elderly patients within 72 h after the onset of mild COVID-19 symptoms [23] , the risk to develop severe disease was reduced from 31% in the control population to 16% in the population receiving convalescent plasma. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. 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Zojer declares that he has no competing interests.