key: cord-0684160-ywd6jj84
authors: Vergnano, Stefania; Alders, Nele; Armstrong, Catherine; Bamber, Andrew R; Bandi, Srini; Evans, Jennifer A; Hajiani, Nadia; Kenny, Julia; Kucera, Filip; Tometzki, Andrew; Uzun, Orhan; Wilkinson, Nick; Ramanan, Athimalaipet V
title: Severe refractory Kawasaki disease in seven infants in the COVID-19 era
date: 2020-07-10
journal: Lancet Rheumatol
DOI: 10.1016/s2665-9913(20)30231-9
sha: b17910b01ee289177dd7b1e28ccb0c03f555a5e4
doc_id: 684160
cord_uid: ywd6jj84

nan

Severe refractory Kawasaki disease in seven infants in the COVID-19 era A cohort of seven infants (aged ≤1 year) with severe Kawasakilike disease were diagnosed and treated at five hospitals in the UK between February and March, 2020 (appendix p 1). All of the infants received prompt intravenous immunoglobulins and steroid treat ment, but none responded and all required the addition of a bio logical agent because of con tinued inflammation, recurring fever, and progressive changes on echo cardio graphy. Six patients (86%) developed coronary artery aneurisms (Z score >2·5) and one infant died as a result of a ruptured aneurysm, despite early aggressive treatment. Five infants (71%) had negative serology for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); therefore, any correlation with the COVID-19 pandemic and paediatric inflam matory multisystemic syndrome temporally associated with SARS-CoV-2 is unclear. 1-3 Nonetheless, we would like to alert paediatricians to this new and very aggressive phenotype in infants. The post-mortem examination of one infant (infant 2) showed markedly abnormal coronary arteries with multiple massive saccular aneurysms (appendix p 4). Histology of the affected vessels showed typical features of Kawasaki disease, with florid vasculitis, vessel wall destruction, and aneurysm formation in the absence of fibrinoid necrosis (appendix p 5). There was no thrombotic occlusion of the coronary arteries or any other myocardial changes (apart from the affected vessels), and no non-cardiac vasculitis. There was no inflammation in the upper or lower airways and no evidence of pneumonitis or myocarditis to suggest ongoing active viral infection. Post-mortem swabs from the naso pharynx and lung of infant 2 were negative for SARS-CoV-2, but respiratory PCR was positive for adenovirus in vivo.

One infant (infant 1) was treated with two doses of infliximab, with the second dose given at day 42 because of new echocardiographic changes and rising C-reactive protein. This infant remains on immunosuppressant therapy 3 months after presentation. Infant 6 did not respond to anakinra and was subsequently treated with infliximab (appendix pp 1-3).

All patients had high C-reactive protein at presentation (80-276 mg/L) and high platelets in the later stages of the disease (468-1419 × 10 9 /L; appendix pp 1-3). The other inflammatory parameters that are typically elevated in paediatric inflammatory multisystemic syndrome temporally associated with SARS-CoV-2, such as ferritin, lactate dehydrogenase, and D-dimers, were only mildly elevated in these patients. Lymphocytopenia was present in one infant. One infant tested positive for SARS-CoV-2 on PCR and one infant tested positive on antibody testing (appendix pp 1-3).

Although it is well known that Kawasaki disease in children aged 1 year and younger has a worse prognosis than in older children (aged >1 year), particularly in boys with coronary artery disease, the severity of disease in this cohort is unusual compared with the literature, in which 10-20% of infants develop aneurysms. 4 We cannot link these cases to the COVID-19 pandemic, as serology and PCR results for SARS-CoV-2 were mostly negative. Nevertheless, we feel that it is important that paediatricians consider early aggressive treatment and close cardiac monitoring of Kawasaki disease in infants, in whom a severe disease course might be occurring.

SV reports non-financial support from Merck and Sanofi Pasteur. AVR reports personal fees from Swedish Orphan Biovitrum, Eli Lilly, Roche, Novartis, Union Chimique Belge, and Pfizer. All other authors declare no competing interests.

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study

Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic

Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19

Kawasaki disease outcomes and response to therapy in a multiethnic community: a 10-year experience