key: cord-0683579-dll2zv8s authors: Tang, Ning; Li, Dengju; Wang, Xiong; Sun, Ziyong title: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia date: 2020-03-13 journal: J Thromb Haemost DOI: 10.1111/jth.14768 sha: 4154fa29573d1400fc91723d12c4e5ea63062fd5 doc_id: 683579 cord_uid: dll2zv8s BACKGROUND: In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern. OBJECTIVES: To describe the coagulation feature of patients with NCP. METHODS: Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed. RESULTS: The overall mortality was 11.5%, the non‐survivors revealed significantly higher D‐dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non‐survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay. CONCLUSIONS: The present study shows that abnormal coagulation results, especially markedly elevated D‐dimer and FDP are common in deaths with NCP. TANG eT Al. thromboplastin time (APTT), antithrombin activity (AT), fibrinogen, fibrin degradation product (FDP), and D-dimer were detected using a STA-R MAX coagulation analyzer and original reagents (Diagnostica Stago, Saint-Denis, France). Between survivors and non-survivors, normally and abnormally distributed quantitative variables were compared using the Student's t test and the Mann-Whitney U test, respectively. Categorical variables were compared using the chi-squared test. The results were given as the mean ± standard deviation, median (interquartile range), or number (percentage), wherever appropriate. A P-value of < .05 was considered statistically significant. Data were analyzed using SPSS 21.0 for Windows (SPSS Inc.). There were 183 patients (85 females and 98 males) with NCP enrolled into the study, and these patients had complete clinical information and the laboratory data required for this study. The mean age at disease onset was 54.1 years (range, 14-94 years). Seventyfive (41.0%) patients had chronic diseases, including cardiovascular and cerebrovascular diseases, respiratory system disease, malignant tumor, chronic liver and kidney disease, and others. All patients received antiviral and supportive therapies after diagnosis. By the end of February 13, 78 (42.6%) patients had been discharged and 21 (11.5%) patients had died, the rest 84 (45.9%) of the patients remain hospitalized in stable condition. The coagulation parameters on admission between survivors and non-survivors were compared (Table 1 ). Based on our detection system, the reportable range of D-dimer and FDP were 0.22-21.00 µg/mL At the late stages of NCP, levels of fibrin-related markers (D-dimer and FDP) moderately or markedly elevated in all deaths, which suggested a common coagulation activation and secondary hyperfibrinolysis condition in these patients. • The role of coagulopathy in severe novel coronavirus pneumonia (NCP) remains to be clarified. • Conventional coagulation parameters of consecutive patients with NCP were retrospectively analyzed. • Abnormal coagulation results, are associated with poor prognosis. • Existence of disseminated intravascular coagulation is common in deaths with NCP. In a previous study, 9 Gralinski We thank all patients involved in the study. N. Tang and X. Wang collected the clinical data and processed statistical data. N. Tang and D. Li drafted and revised the manuscript. Z. Sun designed and guided the study. The authors declare that they have no conflicts of interest. Note: D-dimer cutoff levels were defined according to a previous report derived from more than 1000 samples in intensive care. 7 Abbreviations: DIC, disseminated intravascular coagulation; ISTH, International Society on Thrombosis and Haemostasis; NCP, novel coronavirus pneumonia China novel coronavirus investigating and research team. 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