key: cord-0682963-cpuw9ev4
authors: Nuno‐Gonzalez, A.; Martin‐Carrillo, P.; Magaletsky, K.; Martin Rios, M.D.; Herranz Mañas, C.; Artigas Almazan, J.; García Casasola, G.; Perez Castro, E.; Gallego Arenas, A.; Mayor Ibarguren, A.; Feito Rodríguez, M.; Lozano Masdemont, B.; Beato, M.; Ruiz Bravo, E.; Oliver, P.; Montero Vega, M.D.; Herranz Pinto, P.
title: Prevalence of mucocutaneous manifestations, oral and palmoplantar findings in 666 patients with COVID‐19 in a field hospital in Spain
date: 2020-09-24
journal: Br J Dermatol
DOI: 10.1111/bjd.19564
sha: 1928960586dbedb6cfee0f8ea0807c23ce1b42c8
doc_id: 682963
cord_uid: cpuw9ev4

Coronavirus disease 2019 (Covid‐2019) has been associated with several cutaneous manifestations(1–3). A temporary field hospital was implemented during the pandemic peak in Madrid, Spain, to attend COVID‐19 patients with mild to moderate pneumonia.

glossitis with lateral indentations (6.6%)( Figure 1A ), aphthous stomatitis (6.9%), glossitis with patchy depapillation (3.9%) ( Figure 1B ) and mucositis (3.9%). Burning sensation was reported in 5.3% of patients and taste disturbances (dysgeusia) was commonly associated.

Palmoplantar involvement was observed in 121 patients (39.8%) and included diffuse desquamation in 77 patients (25.3%), often favouring the weight bearing areas and reddish-tobrown acral macules on palms and soles in 46 (15.1%)( Figure 1C and 1D). Mild pruritus was occasionally reported. Fungal cultures of plantar desquamation performed in 9 patients ruled out superficial mycoses. Histological study from the acral macules was performed in 4 patients, showing a mild to moderate lymphocytic infiltrate surrounding the blood vessels and the eccrine Accepted Article sweat glands. 7% of the patients reported burning sensation (erythrodysesthesia) at the beginning of the disease. Urticaria (6.9%), rash (2.9%) and vesicular eruptions (1.6%) were observed in a minority of patients. While urticaria and rash were observed at any stage of the COVID-19 infection, vesicular eruptions typically appeared within the first few days of the symptoms. Both urticaria and vesicular eruptions appeared in younger patients than the rest of the mucocutaneous manifestations with statistical significance (p 0.024) Prior studies have found a significantly lower prevalence of COVID-19 associated dermatoses (20% and 7.8%, respectively)(2,3). The higher prevalence in our study may be due to additional findings non-previously described. Although the oral cavity is frequently involved in viral infections, glossitis or papillitis have not been described in COVID-19 patients(4). However these alterations could also be due to the conditions during hospitalization including ventilation mask, etc. We hypothesize that the contagion risk while examining the oral cavity might have precluded a thorough physical examination in these patients.

Palmoplantar involvement was also a frequent finding. Some patients recalled a burning sensation and redness or swelling of the hands or feet shortly after COVID-19 symptoms began.

Erythrodysesthesia is a common complaint secondary to cancer chemotherapy that is thought to be related to direct drug toxicity and inflammation of the eccrine glands(5). Interestingly, several outbreaks of a poxvirus-related erythromelalgia have been reported in China. The first outbreak occurred in Wuhan in 1987, and all patients had respiratory symptoms as well as redness and swelling of the hands and feet (6) . Also, burning sensation has been described in childblain-like lesions(1) and there is one self-reported case of a physician with COVID-19 complaining of "pin and needles" sensation in palms and soles with subsequent appearance of acral macules.

A diffuse asymptomatic palmoplantar desquamation was another common but previously unreported finding. Although it could be related to other common conditions such as tinea pedis, patients denied its prior existence and fungal infection was excluded in 9 out of 121 patients.

Skin rashes were relatively uncommon, being observed in 11.6% of our patients. Although a variety of rashes have been previously reported(1), both in children and adults (7, 8) the exact prevalence, time of onset and age-specificity remains unknown. Interestingly, pseudo-childblains have been commonly observed in children(1) (some of them with negative RT-PCR or serologies), and were absent in our 666 patients, supporting the age-specificity trend.

This article is protected by copyright. All rights reserved Our study has several limitations. First, we only included patients with mild-to-moderate COVID-19 pneumonia and cannot provide data on skin disease in asymptomatic patients or with more severe forms of COVID-19. Second, all patients were adults and the prevalence of mucocutaneous findings may be different in children. Third, as our work was performed in a two-week period, we may have missed earlier or late cutaneous manifestations of COVID-19.

In summary, almost half of patients with mild to moderate COVID-19 admitted in a field-hospital during a two-week period show mucocutaneous findings. Oral cavity is frequently involved and deserves specific examination under the appropriate circumstances to avoid contagion risk.

Redness and swelling of the hands and feet, fine palmoplantar desquamation and reddish-to-brown macules can help us to diagnose COVID-19 infection and should be routinely checked.

Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases

Cutaneous manifestations in COVID-19: a first perspective

Cutaneous manifestations related to coronavirus disease 2019 (COVID-19): A prospective study from China and Italy

Enanthem in Patients With COVID-19 and Skin Rash

Acral Erythema: A Clinical and Histopathologic Study of 44 Cases. Actas Dermo-Sifiliográficas Engl Ed

Genome Sequence of Erythromelalgia-Related Poxvirus Identifies it as an Ectromelia Virus Strain

Varicella-like exanthem as a specific COVID-19-associated skin manifestation: multicenter case series of 22 patients

Acute urticaria with pyrexia as the first

Acknowledgments: we would like to thank Dr. Angela Hernandez-Martín for her valuable comments during the preparation of this paper.A. Nuno-Gonzalez, 1,2 P. Martin-Carrillo, 3