key: cord-0682375-i0urwkcj
authors: Aloysius, Mark M.; Thatti, Ashwin; Gupta, Anjalika; Sharma, Nishant; Bansal, Pardeep; Goyal, Hemant
title: COVID-19 presenting as acute pancreatitis
date: 2020-05-08
journal: Pancreatology
DOI: 10.1016/j.pan.2020.05.003
sha: 1e4c3fd1a1a4876c3a9e351e11ae2b96761f673e
doc_id: 682375
cord_uid: i0urwkcj

Abstract The ongoing pandemic of Coronavirus disease-2019 (COVID-19) has spread over 200 countries worldwide, affecting >2 million people and >120,000 deaths. COVID-19 is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The most common symptoms include cough, shortness of breath, and fever. However, gastrointestinal manifestations of COVID-19 are increasingly being recognized. Herein, we report a case of COVID-19 who presented with acute pancreatitis (AP) without any other risk factors.

COVID-19 pathogenesis is thought to be mediated by angiotensin-converting enzyme-2 (ACE-2) receptor on the host cells, which are highly expressed in the pancreatic islets (4) Although clear pathogenesis is unknown, AP in COVID19 could occur due to the direct cytopathic effect of local SARS-CoV-2 replication or indirectly by harmful immune response induced by the virus.

Nevertheless, our understanding of clinical manifestations of COVID-19 continues to progress, and this case illustrates that SARS-CoV-2 can precipitate AP in the setting of COVID-19.

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