key: cord-0079429-8qobnfhd
authors: Mamkhezri, Jamal; Razzaghi, Somayeh; Khezri, Mohsen; Heshmati, Almas
title: Regional Effects of Maternal Mortality Determinants in Africa and the Middle East: How About Political Risks of Conflicts?
date: 2022-05-16
journal: Front Public Health
DOI: 10.3389/fpubh.2022.865903
sha: 99f20ac2bf9e8c2ef5e315309951366688824365
doc_id: 79429
cord_uid: 8qobnfhd

BACKGROUND: As per the United Nations Women data, the maternal mortality rate in war-affected countries is critical and more than 800 million people live in war-affected countries (ICRC). External and internal conflicts such as foreign pressure, war and cross-border, civil disorder, terrorism, and civil war, are characteristics of Middle Eastern and African countries. Therefore considering the rapid increment of political risks and internal and external conflicts in Africa and the Middle East during the last decade, and considering warfare as a key contributor to maternal mortality; This paper seeks to evaluate the factors that have caused significant rates of maternal mortality in Middle Eastern and African countries by emphasizing the contributions of a number of political risk aspects as Civil Disorder Index, Terrorism Index, Civil War Index, Foreign Pressures Index, Cross-Border Conflict Index, War Index along with other socio-economic factors. METHOD: Data were collected from forty-six countries during 2011–2016 to explore the regional contributions of political risk aspects to the maternal mortality rate through spatial approaches. RESULTS: It was found that GDP per capita, energy intensity, and urbanization strongly impacted maternal mortality. Also, it was observed that natural resource rents and economic growth significantly influenced the reduction of mortality by expanding healthcare services. The urban expansion was found to have elevated maternal mortality. A majority of external and internal conflicts reduced the orientation of production toward healthcare services and thus raised maternal mortality. On the other hand, war and cross-border were found to pose opposite impacts. CONCLUSION: The findings revealed that political risks arising from terrorism, foreign pressure, and war in the adjacent countries would elevate the rate of mortality in the original country. This implies the spillover impacts of regional conflicts on maternal mortality elevation at the regional scale. JEL Classification Codes: C23; I10; I18; N37:

Many factors could affect population health status rather than the national health system, such as socio-economic factors, gender inequality, natural disasters, and political unrest (e.g., warfare). Researchers opine that warfare has deeper and adverse effects on population health status than natural catastrophes (1) . Diseases, malnutrition, and the destruction of health infrastructures are the unpleasant effects of warfare. In addition, studies show that females are more vulnerable than males to war, and women are at a higher risk of death due to the indirect effects of conflicts and poor health conditions in the Post-war period (2, 3) . Bendavid et al. (4) state that Women of reproductive ages living near high-intensity conflicts have three times higher mortality than their counterparts in peaceful settings. Obermeyer et al. (5) demonstrate that women accounted for over 80 percent of reported war fatalities. Internal and external conflicts restrict maternal health and significantly harm the wellbeing of mothers by shrinking the availability of public and private health care services. According to the world health organization (WHO), 75% of countries observing a high maternal mortality rate in the world are war-affected, and in the year 2008, 50% of total women who died in childbirth were originally from only eight countries involving with ongoing or recent armed conflicts (6) . In addition, O'Hare and Southall's (7) research in Africa showed that maternal mortality ratios in war-torn countries were 45% higher than in Non-conflict countries.

Although, warfare is a key contributor to maternal mortality; however, political risks of conflicts have increased rapidly in the last decade, especially in the Middle East and Africa. These countries are mainly suffering from political instability and armed, ethnic, or religious conflicts; thus, they are among the worst countries across the world, with high maternal mortality rates. According to the WHO (8), the Middle East and North African countries record 57 deaths per 100,000 livebirths on average, and United Arab Emirates records 3 deaths per 100,000 livebirths. Moreover, countries that have fragile situations and are conflict-affected, record 568-fold deaths per 100,000 births on average. This implies that women in war-affected countries are nearly 190 times more at risk of death during parturition as compared to UAE mothers. This situation is more serious in South Sudan, with the highest rate of maternal mortality (1,150 deaths per 100,000 livebirths). Chad stood at 1,140 deaths, and Sierra Leone recorded 1,120 deaths per 100,000 livebirths. As these countries are experiencing high maternal mortality rates, they have implemented plans to reduce the maternal mortality rate to below 70 deaths per 100,000 livebirth by 2030; however, the dilemma of high maternal mortality in Africa remains a problem.

Many researchers collectively agreed that maternal mortality is the hidden face of conflicts (9) . Social insecurity, devastated healthcare infrastructures, poor health services, and lower female education are the main consequences of warfare on maternal care (3) . Then the purpose of this study is to investigate the regional effects of political risks of conflicts on maternal mortality in the Middle East and Africa. Also, this study makes two contributions to the literature. First, this study is exhaustive in its coverage of the majority of socioeconomic and conflicts data sets which affect maternal mortality. Second, this study may indeed pioneer the use of a spatial panel data method for exploring the impacts of regional conflicts on maternal mortality in the Middle East and African countries. In this context, many researchers hold that the destructive effects of war permeate to neighboring countries. The existence of a strong economic, political, cultural, religious, and linguistic coherence among these countries leads to the expansion of such adverse events in a single country into a contagious process penetrating the neighboring countries. The transmission mechanism of the 2011 Arab Spring is an obvious example of the spatial effects of events in the region (10) . Therefore, the prominent distinction of the present study is the consideration of the spatial features of the maternal mortality rate in the region.

Warfare has adverse economic, social, political, and environmental consequences, resulting in poor health status in war-torn countries (11) . Conflicts do not have the same effects on maternal mortality in different countries, and the scale of consequence depends on health infrastructures in the Pre-war period and governmental policies and priorities; however, channels through which warfare could affect maternal mortality are common in affected countries.

Political risks of conflicts impose adverse effects on maternal health through different channels, including undernourishment, famines, food shortages, which are the consequences of the eradication of croplands through warfare and put women in danger during pregnancies and after childbirth (12) . The virement of healthcare budget to military expenditures, the destruction of health infrastructures, the shortage of skilled health professionals, and the rebate of medical staff would suspend obstetrical and maternal care in the long run and increase the risk of perilous miscarriage and pregnancy termination. Also, impoverishment, misery, and early marriage are the consequences of warfare, which stimulates maternal mortality (13) . In addition, in most conflicts, the parties of war cut off all resources, block the ways of delivering health care and medical equipment to war-torn regions, and ban the mobility of emergency vehicles; the pregnant mothers could hardly have access to maternity care (14) .

Refugee crises are another channel through which conflicts increase the maternal mortality rate due to the absence of emergency obstetric care, a large risk of infectious diseases spreading among pregnant, and higher malnutrition levels during pregnancies and after birth due to family economic crises in refugee shelters (3) . The hygienic condition is poor in refugee camps, and the refugees struggle with a weak recycling and sanitation system, overcrowding, and a lack of access to clean water and food in camps. Refugee crises in the Middle East and Africa are an important issue. For example, the civil war in Burundi led to 300,000 deaths and a flow of millions of displaced people to the neighboring countries, e.g., Tanzania and the Democratic Republic of Congo. In northern Uganda, two million people have been displaced internally. According to UNHCR (15), Libya witnessed 226,000 internally displaced people, and there were 42,000 refugees. Also, 300,000 Palestinian refugees attempted to reside in Lebanon, and five million Syrians have been sheltered in the neighboring countries (such as Lebanon, Turkey, and Jordan). Refugees impose significant pressure on the host nations in order to meet their essential needs. Toole (16) reports that the maternal mortality rates in refugee camps were 100 times higher than the normal mortality rate. This is more critical to pregnant women who live outside camps and have no access to public health services or international aid. The adverse impacts of war on maternal mortality are not limited to waraffected countries; it has also spill-over effects on maternal health indicators in the neighboring/host countries.

There is a bulk of studies investigating the adverse health effects of war on life expectancy by Woldemicael (17) , and Iqbal and Zorn (18) , prevalence of contagious diseases by Gustafson et al. (19) , disability-adjusted life years by Ghobarah et al. (20) , infant mortality by and Wigley (21) , maternal and child health by and Welander et al. (22) , and gender gap in life expectancy by Neumayer and Plümper (2) . Moreover, few studies in the literature covered the relationship between maternal mortality and conflicts. Mirzazada et al. (23) investigated the impacts of conflicts on maternal mortality in Afghanistan and compared various provinces based on the severity of the conflict through the Delphi process. They demonstrated that maternal health indicators were significantly lower in severe conflict provinces as compared to limited conflict provinces. They also mentioned that unfavorable economic and cultural conditions exacerbated the maternal mortality rate in war-affected provinces. Kotsadam and Ostby (24) employed the sisterhood method to investigate the effect of armed conflicts on the maternal mortality rates in thirty countries within Sub-Saharan Africa from 1989 to 2013. They reported that local conflicts increased the risk of maternal mortality, and this risk was different in rural areas from that in rich and more educated areas. Wagner et al. (25) analyzed the population effects of armed conflicts on Non-combatant vulnerable populations, especially on pregnant women ages 15-49 and orphanhood among children younger than 15 years of age in thirty-five African countries. They found that armed conflicts increased the risk of maternal deaths in Africa. Namasivayam (26) explored the effects of armed conflicts on the utilization of maternal health services in Uganda. They concluded that the utilization of contraception and institutional deliveries among women was significantly lower in northern Uganda as a conflictaffected region than in the rest of the country. Urdal and Che (3) examined the impacts of armed conflicts on fertility and maternal mortality across the world during 1970-2005. They concluded that the relationship between conflicts and the fertility rate was more significant in low-income countries and that the maternal mortality rates were very large in conflict-affected countries. Gopalan et al. (27) showed that maternal health in Asia and the Middle East is very weak and fragile in conflictaffected situations. Asi and Williams (28) showed that warturned and conflict countries are more risky places to pregnant mothers and they argue that applying digital health systems may reduce maternal mortality rate and make progress in achieving sustainable development goals. El-Kak et al. (29) showed Syrian refugees crisis (resulting from war) and the increasing rate of Syrian refugee concentration in Lebanon caused a high maternal mortality rate in Lebanon for the period of 2010-2018. Gopalan et al. (30) showed that acute large conflicts have significant effects on maternal care-seeking and usage in Egypt. Akseer et al. (4) showed that poor access to essential reproductive and maternal health services in conflict countries caused maternal and child mortality rates to remain consistently higher than Non-conflict countries since 1990. Rocanello-Snow (31) showed that incidences of terrorist attacks, conflict, war, and political instability in Afghanistan affected the utilization of maternal healthcare services and the maternal mortality ratio. Alhassan et al. (32) also investigated alternative ways in times of disasters and emergencies in order to control the mortality rate. They recommend telehealth which increases access to healthcare and increases in quality of life which in turn reduces costs and easy access to healthcare services. Chukwuma et al. (33) did not find a significant difference in the impact of violent and Non-violent conflicts on the process quality of care and they showed that in Kenya, deterioration of equipment and infrastructure does not appear to be the main mechanism through which conflict has affected maternal care quality.

The review of the literature indicated that the spatial feature of health problems that arise from the war in neighboring countries have been ignored in previous works. Thus, this paper seeks to fill this gap by applying the spatial econometrics approach.

The present paper proposes an experimental model considering the socio-economic and political explanatory variables of maternal mortality in the Middle East and Africa in line with Wang (34) and Zolala et al. (35) . According to Model 1, the logarithm of the maternal mortality per 100,000 livebirths (lnMATE it ) is a function of some explanatory variables, including the logarithm of GDP per capita (lnGDP), trade openness (lnOPE), natural resources rents (lnRENT), urbanization (lnURB), and conflicts (such as internal and external conflicts (lnCON)). The linear form of Equation (1) is used for experimental estimation:

Where c i is a spatial specific effect, and α t represents a timeperiod specific effect. A few variables, such as urbanization, energy consumption, and trade openness, are generally used as explanatory variables in the literature on maternal mortality rates (34) (35) (36) . Previous works stated that the share of health budget could extend when GDP has risen and economic development has happened in the region; therefore, the country could experience more trained health staff, provide more desirable primary health care, improve pregnant mothers' skills and knowledge to help reduce the maternal mortality rate. Also, urbanization is an important indicator of maternal mortality since it could improve infrastructures such as drinking water delivery, a strong disposal system, further hospitals, and ambulances. It could also improve women's education and training and provide strong maternal care, which could decrease the maternal mortality rate in urban areas (9) . The effect of natural resource rents on the maternal mortality rate is vague. In some cases, natural resource-endowed countries could efficiently allocate resource rents to health expenditure and educate people. This would help decrease maternal mortality; otherwise, the resource rent converts into a curse of resources (37) . The spillover effects of higher internal and external conflicts on maternal mortality can be positive or negative, depending on the impacts of internal and external conflict on the financial resources allocated to health services. Thus, to separate the effects of the economic and Non-economic dimensions of conflicts on maternal mortality rates, the interaction terms of conflicts and GDP per capita are incorporated in a new form as:

where lnGDP it × lnCON it denotes the interaction term, while the coefficient of lnGDP it × lnCON it represents the interaction between the national conflict and GDP per capita. The effect of GDP per capita on maternal mortality is formulated as:

where β 7 is a positive coefficient, suggesting that the uncertainty arising from different types of conflicts leads to lower governmental financial resources allocated to the healthcare system, and vice versa. While coefficient β 6 shows the direct and Non-economic effects of conflicts on the rate of maternal mortality. The present study explores the impacts of maternal mortality factors and emphasizes the indicators of both internal and external conflicts to shed light on the spatial relationships between observations. To this end, several spatial models were incorporated. Anselin et al. (38) argued that a spatial panel model could incorporate a lagged dependent parameter or apply a spatial autoregressive procedure into the error term. Furthermore, the spatial Durbin model was proposed by LeSage and Pace (39) . The spatial Durbin model involves spatially-lagged independent variables. The mathematical formulations of the spatial lag (4), spatial error (5), and spatial Durbin (6) models are represented as:

in which y it denotes a dependent variable for cross-sectional unit

x it represents the 1×K exogenous variable vector, β stands for a K × 1 parameter vector, N j = 1 w ij y jt accounts for the interaction effect of the dependent variable y jt in the neighboring units on the dependent variable, w ij denotes element i, j of the Pre-defined Non-negative N × N matrix of spatial weights, λ stands for the responses of the endogenous interaction effects, υ it represents the error term with independent and identical distribution.

The data of forty-six countries in Africa and the Middle East from 2001 to 2017 were collected to investigate the effects of maternal mortality determinants. A summary of the constructed variables used in the analysis is presented in Table 1 . Also, Table 2 reports the summarized statistics. All variables are presented in the logarithmic form; therefore, the estimated coefficients are elasticity. Figure 1 shows spatial distribution of maternal mortality (per 100,000 livebirths) across countries. It illuminates the spatial interactions between different countries and the regional integration in maternal mortality.

To accurately demonstrate the spatial effects, Moran's I test statistics is provided in Figure 2 . The regional observations and their spatial lag data are the dimensions of Figure 2 . A positive Moran's I represent the spatial accumulation of similar values around the region, while a negative value represents the spatial accumulation of Non-similar values. Most countries exhibit a positive autocorrelation; as can be inferred from the fitting lines, the positive autocorrelation is dominant. Moran's I statistics indicate that the neighboring countries have more similar maternal mortality rates. Therefore, spatial econometric models are employed to investigate determinants of maternal mortality.

To investigate the probability of the time-period fixed effects and spatial fixed effects in the model, two separate likelihood ratio (LR) tests were used. For this purpose, the model with simultaneous spatial and time-period fixed effects is compared to the model of time-period fixed effects and/or the model of spatial fixed effects. If the null hypothesis is rejected, the model with simultaneous spatial and time-period fixed effects is selected. On the other hand, if the null hypothesis is accepted, the subsequent model is selected. LR test statistics for the models are presented in Table 3 . The test results indicate the significance of the LR test statistics and the rejection of the null hypothesis for only the time-period fixed effects in most models. Therefore, the spatial fixed effects are selected as the best model to proceed with estimation. Another test in Table 3 is used to examine whether the inclusion of the spatial lag or spatial error in the model in the absence of spatial interaction effects would lead to a significant improvement in the model or not. Thus, using the residuals of a Non-spatial model, the Lagrange Multiplier (LM) statistics tests are applied to a spatially-lagged dependent variable and spatial error autoregressive (40) . The test statistic has the chi-square distribution. If the null hypothesis of the LM test is rejected, the presence of the spatial lagged model and the spatial error model is confirmed. Since the LR test results confirmed the existence of the spatial fixed effects, this study examines only LM statistics for this model.

The results presented in Table 3 suggest that the test statistic values in all models are significant at the level of one percent. Therefore, spatial lagged and spatial error effects must be considered in the maternal mortality model. Hence, the presence of spatial interaction effects in the model emphasizes the need to consider such effects when investigating the factors affecting maternal mortality in experimental studies. Table 4 presents the Hausman test results to examine the possibility of replacing the fixed-effect model with a randomeffect model. The null hypothesis in this test emphasizes the existence of random effects in the model. The results of the Hausman test reject the assumption of random effects in the spatial lag model for all the models and confirm the existence of fixed effects at a significance level of 1%. Finally, this study evaluates two separate hypotheses H 0 : θ = 0 and H 0 : θ + λβ = 0 in Equation (6). If the first hypothesis is the case, the spatial Durbin model is simplified into the spatial lag model. On the other hand, if the second hypothesis is the case, the spatial Durbin model can be simplified into a spatial error model (41) . The present work uses the LR test or Wald test to explore whether the existence of the spatial lagged independent variable in the model is significant. Each of these two tests has positive and negative characteristics. LR tests are employed to estimate more models, while Wald tests are sensitive to nonlinear constraints.

The test results in Table 4 provide the same outcome for the fixed-and random-effect models. The statistical value of the two tests (i.e., the LR and the Wald test) is significant for all models, and the spatial Durbin model cannot be converted into the spatial error model and spatial lag model in any of the models. Therefore, the existence of the spatial lagged independent variable is also confirmed; finally, the spatial Durbin model is the basis for the analysis of the estimation results.

According to Table 5 , an increase of 1% in the GDP per capita leads to a significant decrease of nearly 0.474% in the maternal mortality rate. However, trade openness does not show a significant effect. Also, the growth of natural resource rents in most models leads to a significant reduction in maternal mortality rates. Urbanization is one of the positive dimensions in the enhancement of maternal mortality rates in the countries under study. Among the conflict indicators, a rise in war and cross-border conflicts index (which shows war and cross border war decrease), raises the maternal mortality rate which is in contrast to theoretical implications. Whereas rise in other indexes (which shows a decrease in foreign pressure, civil war, and civil disorder), yield a lower mortality rate.

Accordingly, Table 6 examines the spillover effects of conflicts and also provides the estimation results of Equation (5) . The incorporation of the spillover effects of internal and external conflicts on GDP per capita yielded the same and significant results for all types of conflicts. The Non-inclusion of the interaction term seems to produce misleading results. Placing the estimated coefficients in Equation (6), the spillover effects are negative for some conflict variables and positive for some others:

The spatial models allow for separating the direct and indirect effects of dependent variables. Direct effects measure the effects of independent variables on the dependent variable of a given country, whereas spillover effects measure the effects of independent variables in the neighboring countries on the dependent variable of a given country. Table 7 reports the direct and indirect effects of all variables for Model 1 and the variables of the internal and external conflicts for Models 2-7. A comparison of Tables 6, 7 suggests that the direct effects are slightly different from the estimates since the indirect effects include feedback effects resulting from the effects of crossing neighboring states and returning to the state of origin. We focus on the spillover effects in Table 7 to examine the effects of the independent variables of the neighboring countries on maternal mortality in the origin country. The coefficient of the logarithmic GDP per capita in the neighboring countries is −0.218, indicating that the economic growth of a neighboring country reduces the maternal mortality rate. Also, the coefficient of trade openness in neighboring countries is insignificant. The effects of urbanization and natural resource rents are significantly negative and positive, respectively. The effects of the conflict indexes, including war, foreign pressures, and terrorism in neighboring countries are negative and significant.

The present study spatially explored the regional determinants of maternal mortality rate with a special emphasis on the contribution of political risks imposed by internal and external conflicts. Data from forty-six African and Middle Eastern countries from 2011 to 2017 were used to examine the regional impacts of internal and external conflicts on maternal mortality rates. Diagnostic tests confirmed the existence of spatial interactions among variables; thus, the spatial Durbin model was used to investigate the effects of independent model variables. (0.000***) (0.066*) (0.000***) (0.000***) (0.000***) (0.000***)

p-value, *** , ** , and * show significance at 1%, 5%, and 10% level, respectively. Authors' estimations.

in line with the results of Nikzadian et al. (37) , this study shows that natural resource rents are a significant variable in reducing mortality rates within the countries under study, in the sense that countries provide the necessary financial resources to cover health expenditures through revenues by the sales of natural resources. The existing realities concerning the countries under study show the weak production structure of these countries; the tax revenues of these countries in the manufacturing sector are very low, and their health expenditures would encounter serious challenges in the absence of natural resource rents. Also, according to the results, the expansion of urbanization has led to an increase in the maternal mortality rate. Although this result is inconsistent with theoretical bases, it is following the results of Akseer et al. (9) and Bornemisza et al. (46) . On one hand, they argue that the intensity and frequency of internal and external conflicts are more in urbanized areas rather than un-urbanized areas and urban areas face more insurgency and political unrests in comparison with later ones. In addition, as population density (and consequently pregnant women crowed) is higher in urban areas, then the large scale of pregnant mothers are encountering in the risk of maternal mortality during war conditions. On the other hand, they argue that urbanization mainly rises inequality and disparities including household income inequalities, and disparities in access to welfare and healthcare facilities, especially at the initial levels of development. Therefore, urbanization couldn't improve maternal health and it seems that the Middle East and African countries are no exceptions to this trend and this result highlights the importance of governmental policies in reducing inequality to control the maternal mortality rate in the mentioned region.

After examining the effects of model control variables, the effects of internal and external conflicts were evaluated in the form of two different models. The results for some variables are inconsistent with theoretical expectations; for example, war and cross-border conflicts were found to reduce maternal mortality rates. The health sector seems to be highly reliant on how internal and external disputes impact the generation and distribution of specialized financial resources. The findings suggest that The data show that war and cross-border conflict exacerbate the beneficial impact of economic expansion on maternal mortality. Therefore, as such conflicts deepen, health financial resource allocations and health services grow, and the economy reorients its output toward health services. The results are quite different for most internal conflict components including civil war, terrorism, and civil disorder, plus foreign pressures, and incidence of these kinds (12) . Indeed, when such disputes become more prevalent in nations, the structure of output changes in a way that harms health care. Overall, most conflict variables increase maternal mortality by reducing health services in the economy. p-value, *** and ** show significance at 1% and 5% level, respectively. Authors' estimations.

According to the results, political risks imposed by war, foreign pressures, and terrorism in neighboring countries have spillover effects on the regional extensions of maternal mortality rates and decrease mortality rates 

The topic of conflict spillover effects on maternal mortality rate has been widely accepted in this study. The results of this research provide fresh insight into the maternal mortality implications of regional violence. The study's practical consequences are as follows: internal conflicts seem to be more detrimental to maternal health than the prospect of foreign war in the Middle East and Africa. As a result, these countries must establish a country-specific framework for resolving internal disputes and political turmoil at the national level. Therefore, these countries must adopt a country-specific mechanism through which they can overcome the occurrence of internal conflicts and national political unrests. In addition, as our results confirm the existence of spatial effects of conflicts and significant spillover effects in the Middle East and African region, then, policymakers in this region are recommended to design effective, region-wide strategies to deal with any kind of internal and external conflicts. Also, it is wise for policymakers to improve political relationships and establish multilateral organizations against external interventions and internal conflicts in the region.

Although the contribution of external conflicts on maternal mortality is insignificant and negligible, however, the effects of internal conflicts on maternal mortality are significantly considerable. Then building the health system resilient and resolving any disruption in maternal care accessibility should be the health policy priorities in mentioned countries. Therefore, paying attention to establishing obstetrics and gynecology clinics in neighborhood/local wide should be preferred to nationwide health programs, because mothers mainly lose access to healthcare delivery systems during internal physical violence inside a country. In addition, as conflicts debilitate economic growth and adversely affect women's wellbeing, then local and Non-governmental organizations (NGOs) in the Middle East and Africa are needed to support pregnant women and supply maternity services as educated and skilled obstetricians and midwives, covering the maternity costs and educate mothers.

Although the most important limitation of this research was the availability of formal data for many countries, however, further researches are necessary to accurately determine which kind of maternal care process including antenatal service, postnatal, or delivery service supply become limited and not accessible for women in the occurrence of internal conflicts, to plan wisely to overcome deficiencies.

Publicly available datasets were analyzed in this study. This data can be found here: https://data.worldbank.org/.

JM, SR, and AH: conceptualization and methodology. MK: software, validation, and formal analysis. JM, MK, SR, and AH: writing-original draft, writing-review and editing, and visualization. All authors contributed to the article and approved the submitted version.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.