key: cord-0055598-u7gec83u
authors: nan
title: Contents continued
date: 2021-01-01
journal: Eur J Med Chem
DOI: 10.1016/j.ejmech.2020.113090
sha: fbdb4b645aecf8cd555670eca41e20d6b49d5f50
doc_id: 55598
cord_uid: u7gec83u

nan

Ohmline-pyrene 2 (OP2) is the first fluorescent amphiphilic compound able to modulate SK3 channels. The kinetic of cell internalization indicates a rapid incorporation in the plasma membrane followed, after 2 h, by cell internalization.

Jinyun Dong, Guang Huang, Qing Cui, Qingqing Meng, Shaoshun Li and Jiahua Cui**

Begüm Nurpelin Sağlık, Derya Osmaniye, Serkan Levent, Ulviye Acar Çevik, Betül Kaya Çavuşoğlu, Yusuf Özkay and Zafer Asım Kaplancıklı 

Jingjing Chen, Yalei Li, Jie Zhang, Minmin Zhang, Aihuan Wei, Hongchun Liu, Zhicheng Xie, Wenming Ren, Wenwen Duan, Zhuo Zhang, Aijun Shen** and Youhong Hu A series of pyrrolopyridone derivatives were designed and synthesized for their HDAC1/6 and BRD4(BD1/BD2) inhibitory activity and selectivity. Lead compounds with potent selective HDAC and BRD4 dual inhibitions were achieved based on SARs and the first HDAC6/BRD4(BD2) dual inhibitor was discovered.

Ryad M. Noha, professorMohammed.K. Abdelhameid, M. Mohsen Ismail, Manal.R Mohammed and Elmeligie Salwa A series of pyrrolopyridone derivatives were designed and synthesized for their HDAC1/6 and BRD4(BD1/BD2) inhibitory activity and selectivity. Lead compounds with potent selective HDAC and BRD4 dual inhibitions were achieved based on SARs and the first HDAC6/BRD4(BD2) dual inhibitor was discovered.

Enrica Fabbri, Anna Tamanini, Tiziana Jakova, Jessica Gasparello, Alex Manicardi, Roberto Corradini, Alessia Finotti, Monica Borgatti, Ilaria Lampronti, Silvia Munari, Maria Cristina Dechecchi, Giulio Cabrini and Roberto Gambari 

study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors

Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase

Di-aryl guanidinium derivatives: Towards improved a2-Adrenergic affinity and antagonist activity

From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action