key: cord-0050924-nxu0e3xk authors: Irfan Ul Haq, Mir; Khuroo, Suhail; Raina, Ankush; Khajuria, Sabiyata; Javaid, Mohd; Farhan Ul Haq, Mir; Haleem, Abid title: 3D printing for development of medical equipment amidst coronavirus (COVID-19) pandemic—review and advancements date: 2020-10-01 journal: Res DOI: 10.1007/s42600-020-00098-0 sha: da583319ed3996a5f6efdeddf7f79fe32283c95a doc_id: 50924 cord_uid: nxu0e3xk BACKGROUND AND AIMS: Coronavirus (COVID-19) has surfaced as a global pandemic and has created an unprecedented global demand for medical equipment. The shortage of onsite workforce, need for social distancing and less time available for sourcing have further made it difficult for the governments and the medical professionals to combat the pandemic. This study’s prime objective is to review the advancements in the area of 3D printing to develop medical equipment and explore the potential of 3D printing in addressing the shortage of medical equipment mainly the personal protective equipment (PPE) amidst COVID-19 pandemic. METHODS: 3D printing or additive manufacturing has emerged as a new manufacturing process with tremendous potential to develop complex products in short time with minimal human interventions. The paper summarises 3D printing’s potential to serve the increasing need for medical equipment, mainly personal protective equipment (PPE) and ventilator equipment in the ongoing global COVID-19 pandemic. RESULTS: The minimum human interventions required to carry out production using 3D printing also make the technology an excellent option to deal with the current situation. CONCLUSIONS: The recommendations and opinions presented in the paper shall act as a stimulant to develop components very critical for the pandemic and help save precious lives globally. Introduction 3D printing is an additive manufacturing process by which products are manufactured layer by layer techniques from digital CAD files (Singh and Chhabra, 2017) . This technology is preferred in the medical field due to its capability of customisation. The medical field requires customised parts because of diverse patient data. This technology can adapt to any changes as per the patient requirement (Marro et al., 2016) . Different softwares are available to design medical parts rapidly, which can further be easily 3D printed in lesser time and cost. The 3D printing technology has led to a considerable shortening of the product development cycles (Conner et al., 2014) . Major 3D printing technologies available in the market include stereolithography (SLA), selective laser sintering (SLS), fused deposition modelling (FDM), direct metal laser sintering (DMLS), laminated object manufacturing (LOM), colour jet printing (CJP), sand binder jetting (SBJ), inkjet 3D printing (IJP), electron beam melting (EBM), digital light processing (DLP), polyjet 3D printing (PJP) and drop on demand (DOD) (Negi et al., 2013; Lee et al., 2017) . These technologies have a high capability to print complex-shaped products economically. The modification of the existing products and reverse engineering can be carried out by 3D printing without much cost and labour involvement. An option of multi-material printing is also available in some technologies to meet the customer's functional requirements. Different types of materials are used in 3D printing to manufacture the essential medical parts (Durfee and Iaizzo, 2019) . These printing technologies can manufacture lightweight, transparent, durable, flexible and biocompatible materials to fulfil the required demand. Figure 1 shows the various materials which can be printed by using 3D printing technology. Recently, much research has been focussed towards the development of composites with 3D printing. Further, 3D printing has the ability to develop materials such as functionally graded materials, having potential medical applications in orthopaedics (Cai, 2015) and dentistry (Dawood et al., 2015) . Further, the biocompatible materials such as titanium alloys, which are otherwise difficult to manufacture, are easy to manufacture with 3D printing (Ngo et al., 2018) . The printing of metals by 3D printing technique involves melting of metallic feedstock which can be either in a powder or a wire form. A solid part is obtained via layer by layer transformation of the melted part. Powder bed fusion (PBF) and direct energy deposition (DED) are the two main printing metal methods. PBF technique is used in the manufacturing of many metallic materials such as some aluminium alloys, stainless steel, nickel-based alloys, titanium and its alloys (Dutta and Froes, 2015) . For the fabrication of various polymers and composi t e s , s p e c i f i c 3 D p r i n t i n g t e c h n i q u e s l i k e stereolithography, selective laser sintering (SLS), fused deposition modelling (FDM), 3D bioprinting and inkjet printing are used. Polymer composites and thermoplastics with a low melting point are fabricated mainly by the FDM technique (Chadha et al., 2019; Aziz et al., 2020) . Mechanical properties of various polymer composites can be enhanced by the addition of fibre as reinforcement. Nanomaterials are also incorporated in 3D printing as they are quite effective in lowering the sintering temperature and also enhancing the mechanical and electrical properties of the host matrix. Manufacturing of various advanced ceramics is also accomplished with 3D printing, which finds various applications in tissue engineering and the production of various biomaterials (Ho et al., 2015; Javaid and Haleem, 2018; Haleem and Javaid, 2020) . Given the discussion mentioned above, the main aim of this work is to review the advancements related to 3D printing to develop medical equipment and to highlight the potential of 3D printing in addressing the growing demand for medical equipment mainly the personal protective equipment (PPE) amidst COVID-19 pandemic or during future emergency conditions. Further, we suggest how low-cost FDM 3D printing technologies such as FDM can print customised medical parts in lesser time and cost without any tooling and fixtures. The review is carried out by identifying and studying relevant and recent papers by searching keywords such as "3D printing and COVID-19", "3D printing and Masks", "3D printing and medical equipment" and "3D printing and ventilators", etc. from the relevant knowledge databases. Around 50 relevant papers are identified and included in the review; however, to gain an insight into the allied fields, around 120 articles were studied. Based on the relevance and context of COVID-19, recent articles, wherein the potential of 3D printing for the development of medical equipment critical for COVID-19 was highlighted, were included in this review. Also, articles which do not convey any substantial information concerning 3D printing and COVID-19 were excluded. Moreover, articles containing too much technical jargon were excluded keeping in view the wide and interdisciplinary prospective readership. Coronaviruses are a group of related viruses identified in causing diseases in mammals and birds (Ismail et al., 2003; Cavanagh, 2007) . Coronaviridae are enveloped, single positive-sense stranded RNA (26-32 kb) viruses (Su et al., 2016) that can be divided into four genera: alpha, beta, delta and gamma, of which alpha and beta CoVs are known to infect humans (Tripp and Tompkins, 2018) . Coronaviridae pathogenic to humans or human coronaviruses (HCoVs) is considered inconsequential pathogens, causing common cold in otherwise healthy persons. The two previous notable exceptions in the twenty-first century include the severe acute respiratory syndrome coronavirus (SARS-CoV), a novel betacoronavirus that emerged in Guandong, Southern China (Peiris et al., 2004) and the famous middle east respiratory syndrome coronavirus (MERS-CoV), first detected in Saudi Arabia in 2012 (Zaki et al., 2012) emerging from animal reservoirs leading to global epidemics with startling morbidity and mortality. In December 2019, another pathogenic HCoV, a novel enveloped RNA beta-coronavirus, was recognised in Wuhan, the capital city of Hubei province in China (Huang et al., 2020) , which has led to serious illness and death and been named as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), phylogenetically similar to SARS-CoV (Zhu et al., 2019) . On March 11, 2020, the World Health Organization designated "Coronavirus Disease 2019" (COVID-19) as a global pandemic. As of 5th August 2020, more than 18 million cases of COVID-19 have been reported in over 200 countries and territories, resulting in approximately 700, 000 deaths. Figure 2 shows the percentage of COVID-19 cases and deaths due to COVID-19 in top nine countries of the world (Coronavirus Update (Live) Worldometer., 2020). Scientists reported that SARS-CoV-2 did not escape from a jar. Its RNA sequences very much resemble those of viruses found in bats, and epidemiologic information implicates a bat-origin virus infecting unrevealed animal species sold at live-animal markets in China. As the number of cases in the world continues to grow, global leaders are encouraging physical (or "social") distancing to slow the transmission rate. This practice aims to flatten the curve of a new infection, thereby avoiding a surge of demand on the health care system. With a world population of over 7.8 billion people, a combined effect of altered human behaviours, environmental changes, and an inadequate global public health mechanism can quickly turn obscure animal viruses into a pragmatic human crisis (Allen et al., 2020) . The classic example is coronavirus pandemic causing large-scale loss of life and human suffering (Nicola et al., 2020) . This pandemic has become a cause of third and most significant economic, financial and social shock of the twentyfirst century. The self-imposed or mandatory lockdown observed by various countries has led to a halt in production in affected countries hitting supply chain across the globe. Further, a steep drop in consumption and a collapse in confidence amongst investors and consumers have also been reported (Fernandes, 2020; McKibbin and Fernando, 2020) . Apart from the socio-economic problems, the only concern throughout the world is the shortage of key medical equipment such as ventilators and personal protective equipment (PPE), including respirators, gloves, face shields gowns and hand sanitisers (Preece et al., 2020) . Lack of adequate PPE for frontline healthcare workers renders them vulnerable to the pandemic, thus endangering the entire health care system's functioning. In Italy itself, the lack of adequate access to PPE has led to higher infection rates amongst the health care workers (Balmer and Pollina, 2020) . In this regard, Center for Disease Control and Prevention (CDC) has recommended the use of N95 respirator masks during aerosol-generating procedures. Table 1 Comparison of benefits of medical protection equipment developed with 3D printing over traditional manufacturing technology (Wu et al., 2016; Attaran, 2017; Ventola, 2014) Parameter 3D printing Traditional manufacturing technology Cost • The complex and customised medical protection equipments are manufactured in lesser cost • Traditional manufacturing technologies are popular due to mass production of products, so customised product manufactured by these technologies are very costly Time • During the COVID-19 outbreak, there is a requirement of medical equipments which can be manufactured by using 3D printing in lesser time • These technologies do not fulfil rapid requirements in lesser time. • Quality of the product can be improved with the input of quality raw materials and during the post-processing step. • Easy and fast design iterations possible to improve the quality of the products. • Quality of the equipment is dependent on a variety of parameters and a robust quality control mechanism needed for quality improvement. • Patient-specific medical equipment are manufactured to fulfil the desired requirements which can reduce the risk during the treatment process Apart from PPEs, most of the countries are facing a shortage of ventilators due to the outbreak of COVID-19 pandemic. The demand for ventilators across the globe is ten times more than the availability and is expected to grow further (Hong J, 2020) . The total number of ventilators in the USA as per the data of American Hospital Association is nearly 160,000 (Rubinson et al., 2010) . Out of these, nearly 98,000 can provide basic functions leaving about 62,000 ventilators with advance facilities to cope with the severe complications caused due to COVID-19. As of now, more than 4.9 million cases have been reported in the USA, which stands at number 1, amongst the worst COVID-19-affected countries (Sanger-Katz et al., 2020) . It has been observed that owing to the rapid increase in the COVID-19 cases, and there are chances that the USA is going to face the shortage of ventilators. Further, it is estimated that out of the 320 million US population 20% will be infected under severe conditions due to COVID=-19 and the number of patients requiring intensive healthcare services may account for 3,840,000, whereas under moderate conditions the patient requiring health care services is one-fourth of this data, i.e. 960,000 (Emanuel et al., 2020) . In this regard, the USA has already taken steps to increase the number of ventilators, and there are high chances that USA may enforce Defence Production Act (DPA) to make necessary equipment (M, 2020). More than 248,803 COVID-19 cases have been reported in Italy with more than 35,000 deaths, despite the advanced healthcare facilities. To mention a few Italy has 3.2 hospital beds per 1000 people which is even more in comparison to the USA, which has 2.8 (Rosenbaum, 2020) . The number of infected healthcare workers due to COVID-19 is also high in Italy. It is primarily due to the lack of PPE, which includes the respirators, gloves, face shields, gowns and sanitisers (Ranney et al., 2020) . Thus, it is clear that for developed nations like the USA and Italy, it has become a challenge to combat COVID-19, due to the surge in the number of cases and lack of ventilators and PPE. For the countries that are still in the developing phase, it will be challenging to meet the exponentially increasing demand for the medical equipment. As the world braces for a mounting wave of COVID-19 patients in hospitals and intensive care units (ICUs), it needs to be ensured that our medical establishments are fully equipped with key equipment required to establish care for patients and to keep our health care personnel safe. There is a broad range of estimates of the number of ventilators we will need to care for COVID-19 patients, from several hundred thousand to as many as a million. The estimates would vary depending on the number, speed and severity of infections. Moreover, the traditionally treated patients with non-invasive positive-pressure ventilation (NIPPV) for conditions such as exacerbation of chronic obstructive pulmonary disease may need to be presumptively intubated while awaiting COVID-19 testing results. Thus, in order to fill the gap between the availability and need of the ventilators and PPE in view of the COVID-19 pandemic, the focus must be laid on the following aspects (Ranney et al., 2020) as it has been opined that mechanical ventilation is going to be a difference between the recovery and death(X, 2020). Material and design costs ›Essential material cost is the same. However, less material is consumed due to easy geometry optimisation and very lesser material wastage (Berman, 2012) . ›The design complexity in medical equipment is achieved at a very lesser additional cost by 3D printing technologies (Mobbs et al., 2017) . ›Since design iterations are easy by 3D printing design cost is much lower than conventional processes. ›3D printing carried out automatic manufacturing with CAD model input so there is very lesser involvement of human labour (Gebler et al., 2014) ›These technologies reduce the labour cost because products are manufactured in one go. ›A low-cost 3D printer like FDM capable of printing medical equipment is available in the market (Tan et al., 2016) . Running costs/energy costs ›There are lesser maintenance and energy cost for the smooth running of these technologies particularly FDM (Petrick and Simpson, 2013) ›The energy input to the technologies like FDM is very less and is eco-friendly (Mello et al., 2010) Tooling and die costs ›No tooling cost or cost of jigs and fixtures involved in 3D printing. ›Only 3D printer is required which can print the part in lesser cost and time (Rayna and Striukova, 2016) Post processing costs ›Very little or no post processing required hence very little or no such cost involved (Rengier et al., 2010) . The various technical benefits associated with 3D printing technologies in general and fused deposition modelling (FDM) in particular makes 3D printing a promising solution to manufacture medical equipment for the emerging medical crisis. Table 1 summarises the benefits offered by 3D printing technologies in comparison with conventional manufacturing processes, whereas Table 2 gives an account of costeffectiveness of the 3D printing technologies, particularly FDM technology. The printing is possible through remote access mode with minimal human interventions, ensuring the safety of the personnel involved in mask manufacturing. The following sections present the viability of 3D printing for the production of low-cost equipment faster. The layered structure of the masks makes 3D printing a viable option for mass production of the masks. Moreover, the issue of loose-fitting associated with the conventional cloth-based masks can be dealt with by using polymeric materials for better fitting, which can be designed for a wide range of facial profiles. Table 3 summarises the work reported in this regard for designing and developing medical masks by 3D printing technologies. The materials used for the development of surgical masks such as polypropylene, polystyrene, polycarbonate, polyethylene, polylactic acid (PLA) and polyester are easily 3D printable by extrusion based additive manufacturing methods. Further, the low cost of the FDM based printers also offers tremendous opportunities for the developing economies which are currently under lockdown. The versatility of the process to produce complex shapes and minimal post-processing in minimum time can serve the current global need for masks. Figure 3 presents a proposed schematic on the process to develop 3D-printed masks via extrusion-based 3D printing. Given the kind of risk involved particularly to the medical staff, apart from the masks, much protective gear such as face shields and medical gloves can be printed on a mass scale by 3D printing technology. Figure 4 presents a representative image denoting the various protective gears needed for the medical professionals. Moreover, the types of equipment associated with the testing of COVID-19 patients such as syringes, test tubes, swabs, etc. made of polymeric parts can also be 3D printed and can suffice the hospitals' growing demands. (2020) 2 Effectiveness of N95 respirators vs. surgical masks studied Long et al. (2020) 3 Environmental aspects of convectional surgical masks Huang and Morawska (2019) 4 • Infection susceptibility on the outer surface of masks • Problems associated with prolonged use of conventional masks such as pressure on the face, breathing difficulty, discomfort, trouble communicating, and headache. Chughtai et al. (2019) 5 • Successfully printed 3D-printed masks • PLA as a base material via extrusion-based printing B (2020) properties of the PPEs. As evident from Table 4 , most of the equipment are made of polymer. Therefore, the low-cost FDM can be easily exploited for the production of these parts. Furthermore, the production of customised designs of this equipment is also possible through 3D printing. Face shields are capable of protecting the face from hazards where goggles or eyewear are insufficient. 3D printing has the potential to print face shields as per the face design of the patient. Face shields also allow better hydration to the skin apart from better blood circulation in comparison with conventional masks. 3D printing has an excellent capability to print face shield rapidly. Further, 3D printing can easily print mask adjuster to meet the ongoing demand caused by COVID-19. The mask adjuster improves the comfort and adjustability of the mask. A mechanical ventilator is a machine that aids in patient breathing (ventilate) when surgery is undergoing or is not in a position to breathe normally due to some illness. The patient is connected to the ventilator with a hollow tube (artificial airway) through the trachea's mouth. The schematic of a conventional ventilator is presented in Fig. 5 . Mechanical ventilation ensures effortless breathing by the supply of adequate oxygen to the patient. Designing the ventilator for a safe, continuous and with minimum human intervention needs three basic components (Chatburn and Mireles-Cabodevilla, 2013; Huang et al., 2017) : 1 The energy source to run the device 2 A unit which supplies air at the desired pressure and flows with a regulated timing and size of breaths 3 A unit to monitor the output performance of the device and the condition of the patient While some previous researchers had opined to ramp up the ventilator stock in the hospitals for pandemic situations (Huang et al., 2017) , the current shortage of ventilators particularly in the developing countries amidst the coronavirus pandemic can be solved via 3D printing by manufacturing the various parts of the ventilator such as values, connectors, etc. The development of low-cost locally developed ventilator may act as a lifesaving system. One good strategy is to develop low-cost connectors to divide the existing ventilator facility in order to save lives while ensuring the maintenance of proper air pressure. The ventilator parts, particularly the polymeric parts, can be manufactured in shorter time durations. Figure 6 presents an overall strategy to be followed for the printing of different types of medical equipment. A prerequisite for 3D printing is the 3D CAD model of the product. The modelling requires extra time and cost, due to the involvement of expensive design software and skilled workforce. This poses a challenge in the current context for exploiting 3D printing potential, particularly in developing economies. Further, for a large-scale use of this technology, reverse engineering of existing products or their parts may be needed. Non-availability of the machinery, design software and skill may lead to difficulty in performing reverse engineering of parts. The current lockdown due to COVID-19 and the subsequent disruption of the supply chains, the raw material supplies are also severely affected. Therefore, the non-availability of raw materials at the consumer end is a constraint in taking full advantage of the 3D printing technology. Future studies may focus on cost reduction and planning robust medical supply chains related to 3D printing. Further, dissemination of 3D printing-related knowledge and related skill development amongst the medical professionals may go a long way to deal with such future situations. More research can be undertaken in future, how low cost and rapid production can be carried out in the context of a pandemic like situations. Further, 3D printing technology needs to be augmented with the medical infrastructure to ensure better preparedness for future emergencies. COVID-19 emerged rapidly amongst the whole world and has disrupted the whole supply chain of critical medical parts required for the patients and the safety equipment required for the medical professionals dealing with the situation. There is a vast gap between the demand and the supply of parts such as masks, protective gear and ventilator parts, etc. This gap can be fulfilled by a technology which could economically manufacture parts in less time. 3D printing, because of its intrinsic advantages, offers a solution to the emergent need in the medical field. This technology can be introduced to manufacture the critical items required for the safety of COVID-19. Further, 3D-printed personal protective equipment such as mask, protective gears, ventilator parts, face shield, mask adjuster and other essential equipment can emerge more efficiently in dealing with the pandemic situation, saving human lives globally. The minimum human interventions required to carry out production using 3D printing also makes the technology a good option to deal with the current situation. The paper systematically summarises and reviews the potential of 3D printing in fighting COVID-19. The opinions, recommendations and suggestions put forward in work shall act as a stimulant globally to exploit 3D printing potential in fighting COVID-19. 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Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Acknowledgements The authors are thankful to in charge of Research Lab, School of Mechanical Engineering, SMVD University, Katra. This paper does not contain any study performed by any of the authors with human participants or animals. The authors declare that they have no conflict of interest.