key: cord-0050128-t87wmcoa
authors: Sudhakar, Murugan; Jindal, Ankur Kumar
title: Pediatric Inflammatory Multisystem Syndrome Temporally Associated With COVID-19
date: 2020-07-15
journal: Indian Pediatr
DOI: 10.1007/s13312-020-1975-7
sha: c80bfcf8648ff247c1a1169b1e6449468e713d35
doc_id: 50128
cord_uid: t87wmcoa

nan

We read with interest the recent systematic review written by Meena, et al. [1] , wherein the authors have highlighted the clinical features and outcome of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children.

The review covers several aspects related to SARS-CoV-2 infection in children. However, recent emergence of a new clinical syndrome in children in association with SARS-CoV-2 infection also needs a special mention. This pediatric inflammatory multisystem syndrome (PIMS) is characterized by an unusual febrile illness with associated features suggestive of Kawasaki disease, toxic shock syndrome, myocardial dysfunction, or multi-organ failure [2] [3] [4] . The diagnostic criteria proposed by the Centre for Disease Control (CDC); World Health Organization (WHO) and Royal College of Paediatrics and Child Health are also not uniform [2] [3] [4] , signifying a possible geographical difference in the spectrum of clinical manifestations.

A large proportion of children with coronavirus disease 2019 (COVID-19) fall in mild disease category [1] . On the contrary, cases of PIMS-TS reported so far have shown a rather severe course of illness with five deaths out of approximately 300 cases that have been reported [5] . Only up to 70% of PIMS individuals reported so far were either RT-PCR and/or serology positive [6] . This signifies that a positive PCR is not mandatory [3] for diagnosis of PIMS as even contact with a confirmed or suspected case of COVID-19 is enough to make the diagnosis [2, 4] .

Clinical features and outcome of SARS-CoV-2 infection in children: A systematic review and meta-analysis

Multisystem Inflammatory Syndrome (MIS-C)

Information for Healthcare Providers about Multisystem Inflammatory Syndrome in Children

Royal College of Paediatrics and Child Health Guidance: Paediatric Multisystem Inflammatory Syndrome Temporally Associated with COVID-19

Multisystem inflammatory syndrome in children and adolescents with COVID-19: Scientific brief

Rapid Risk Assessment: Paediatric inflammatory multisystem syndrome and SARS-CoV-2 infection in children

Multisystem inflammatory syndrome in US children and adolescents

Hyper-inflammatory syndrome in a child with covid-19 treated successfully with intravenous immunoglobulin and tocilizumab