key: cord-0048861-g8uwox0k
authors: Capoferri, Gioele; Osthoff, Michael; Egli, Adrian; Stoeckle, Marcel; Bassetti, Stefano
title: Relative bradycardia in patients with coronavirus disease 2019 (COVID-19)
date: 2020-08-18
journal: Clin Microbiol Infect
DOI: 10.1016/j.cmi.2020.08.013
sha: 9dae0673489dfeec744a3293598008f4a6c49025
doc_id: 48861
cord_uid: g8uwox0k

nan

To the Editor, 23 Arrhythmias and other cardiovascular symptoms in patients with COVID-19 are 24 frequently reported and are likely associated with infection-related myocarditis, 25 ischemia, and/or systemic proinflammatory stimulation ("cytokine storm"). In a case 26 series including 138 hospitalized patients, 17% (and 44% of the patients admitted to 27 the intensive care unit) had an (unspecified) arrhythmia [1] . Moreover, medications 28 used in COVID-19 patients may increase arrhythmic risk. We have observed fever 29 plus relative bradycardia, i.e. an inappropriately low heart rate response to increased 30 body temperature [2], in several hospitalized COVID-19 patients. Our primary 31 objective was to assess the prevalence of relative bradycardia in patients with 32 COVID-19. 33 We retrospectively reviewed the electronic medical records of the first 174 patients 

Clinical characteristics of 138 105 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan

The diagnostic significance of relative bradycardia in infectious 108 disease

Relative bradycardia in 110 patients with mild-to-moderate coronavirus disease

Proposed 113 mechanisms of relative bradycardia

Clinical analysis of sinus 115 bradycardia in patients with severe COVID-19 pneumonia