key: cord-0048726-pgdmz69j
authors: Brion, Luc P.; Chang, Christina; Adhikari, Emily
title: Comment on Evidence for and against vertical transmission for SARS-CoV-2 (COVID-19)
date: 2020-08-13
journal: Am J Obstet Gynecol
DOI: 10.1016/j.ajog.2020.08.022
sha: 73b8cd66586974aaea52140de0086416c43a3330
doc_id: 48726
cord_uid: pgdmz69j

nan

As consistent with Lamouroux's statement that ACE2 is low in the first trimester, ACE2 37 RNA expression is developmentally regulated with extremely low expression at 6-14 weeks, 38 although there is high expression at 24 weeks of gestation. 3 ACE2 RNA is highly expressed in 39 human villous, extravillous and syncytiotrophoblast as well as in several fetal organ cells (heart, 40 liver, and lung but not kidney) at 24 weeks of gestation. 3 

Evidence for and 65 against vertical transmission for SARS-CoV-2 (COVID-19)

Epub ahead of print

Clinical features of patients infected 69 with 2019 novel coronavirus in Wuhan

The SARS-CoV-2 receptor ACE2 expression of 71 maternal-fetal interface and fetal organs by single-cell transcriptome study

The expression and localization of 74 the human placental prorenin/renin-angiotensin system throughout pregnancy: roles in 75 trophoblast invasion and angiogenesis?

Miscarriage in a Pregnant Woman With SARS-CoV-2 Infection