key: cord-0044573-20c7fpji
authors: Hedenstierna, Göran; Chen, Lu; Brochard, Laurent
title: Airway closure, more harmful than atelectasis in intensive care?
date: 2020-06-04
journal: Intensive Care Med
DOI: 10.1007/s00134-020-06144-w
sha: b2d56dd0d29f20467981026f33979c685eae979b
doc_id: 44573
cord_uid: 20c7fpji

nan

was repeated closures of the airway so that gas was trapped within a distance of the airway. This suggests a more complicated background for airway closure, not only trans-airway pressure but also changes in surface tension, liquid distribution within the airway and interdependence between units [7, 8] .

Airway closure increases with increasing age, a consequence of loss of elastic tissue in the lung that may produce a positive pleural pressure in dependent regions [4] . Decrease in resting lung volume, functional residual capacity (FRC), promotes airway closure [4] . Factors that in combination reduce FRC, like anesthesia, age, obesity and head down positions for surgery will all increase likelihood for airway closure. Recently, complete airway closure has been suggested in ARDS [6] . In these patients, lung inflation starts when airway pressure reaches a critical level of opening pressure [9] . This has been mistaken in the past as being a lower inflection point indicating recruitment of a collapsed lung. This phenomenon may be due to collapse of airways at end-expiration. The mechanism and actual location of this collapse is unknown and may not be identical to the classic airway closure that is related to transpulmonary pressure and, thus, is gravitationally oriented [4] . One possible, still speculative, mechanism is that the trachea is compressed by surrounding tissue that may be increased in obesity and/or displaced by body position, and by relaxation of tracheal smooth muscle [10] . Surfactant depletion may add to both central and peripheral airway instability and cause widespread closure and injury, also in distal airways [7, 8] . As a consequence, alveoli remain inflated at endexpiration. A recent study of ARDS found one-third of patients depicting complete airway closure with reopening anywhere between 6 and 20 cm H 2 O [11] . Complete airway closure has also been reported in 22% of obese anesthetized patients with normal lungs [12] . In patients with ARDS, obesity increases the incidence of airway *Correspondence: goran.hedenstierna@medsci.uu.se 1 Hedenstierna Laboratory, Department of Medical Sciences, University Hospital, Uppsala University, Entr 40:2, 75185 Uppsala, Sweden Full author information is available at the end of the article closure (more than 65% of patients with BMI > 39 kg/m 2 ) [13] . Interestingly while auto-PEEP (or intrinsic PEEP) is easily eliminated by prolonging expiratory time, the level of airway opening pressure is not influenced by the duration of expiration and remains at a very reproducible level [11] . The absence of ventilation below this airway opening pressure has been visualized by electric impedance tomography [9] .

There are at least four major consequences of airway closure. Firstly, a continuously closed or briefly open airway will promote atelectasis because of absent or poor ventilation, alveolar gas being sucked up by the capillary A B C Fig. 1 a Study of airway closure in a rabbit whole-lung lavage and injurious ventilation model, using synchrotron radiation technique. The image is an iso-gravitational cut through the lung with the rabbit in an upright position. Note that small airways, 18th of 21 generations, are open when PEEP is 12 cm H 2 O, but begin to close with PEEP 6 and that most small airways are closed at PEEP 3. Alveoli remain open but it may be anticipated that they close after some time, in particular if ventilation is with 100% oxygen [7] . b Low-flow inflation pressure-volume (P-V) curve from a patient without complete airway closure. P-V curve of the patient (blue) and the occluded circuit (red) separate immediately and cardiac oscillations can be seen throughout the whole P-V curve [13] . c Low-flow inflation P-V curve from a patient with complete airway closure. P-V curve of the patient (blue) superimposed to that of the occluded circuit (red) until airway pressure exceeded a critical level-airway opening pressure (black line at blood. Indeed, the atelectasis during anesthesia is almost always caused by airway closure [1] . The use of high inspired oxygen concentration speeds up the atelectasis formation because of rapid absorption of oxygen in the alveoli, whereas nitrogen in the alveoli will prevent or slow down atelectasis formation. Secondly, the impaired ventilation by cyclic airway closure causes a ventilation/perfusion mismatch with impairment of oxygenation of blood. In addition, continuous airway closure promotes alveolar collapse, as said above, that causes a shunt and impairment of arterial oxygenation.

Thirdly, there are animal experiments suggesting that the beginning of an inflammatory reaction in the lung is not in dependent, collapsed/airless regions, nor in the uppermost, possibly over-aerated regions, but in a zone somewhere in the middle of the lung [14] . This zone is mostly poorly aerated, suggesting cyclic airway closure. Such cyclic closure results in a physical stress to the airway wall, opening and closing where surface forces have to be overcome and where the wall may suffer from damage [14] . Importantly, whereas atelectasis results in alveolar injury mostly in aerated regions, the repetitive opening and closing of distal airways occur also in lung regions that are atelectatic [15] .

Fourth, the presence of airway closure makes measurement of alveolar pressure at the airway opening impossible or unreliable. Wrong estimates of driving pressure and compliance happen in case of airway closure because the alveolar pressure is not measured at the airway opening even after an occlusion [13] .

A simple technique to assess complete airway closure is by using the low-flow inflation pressure-volume curve pattern (Fig. 1) . The presence of low inflection point associated with, in the initial part of the curve, the absence of cardiac oscillations and very low compliance, close to the 2.5 mL/cm H 2 O of an occluded breathing circuit, is suggestive of complete airway closure [11] . When pressure exceeds the low inflection point, cardiac oscillations appear and compliance dramatically increases as compared to the initial part of the curve. Even simpler is the use of a pressure-time curve using a low-flow inflation (see a video on rtmaven.com; this can be done on any ICU ventilator). This low inflection point corresponds to the pressure needed to start inflating the lungs and reflects the airway opening pressure. Setting PEEP at the level of this airway opening pressure is recommended to avoid or minimize the repetitive opening and closure of small airways.

In summary, airway closure is a frequent finding in anesthesia and intensive care and is a major cause of lung dysfunction and even inflammation. It is also a major cause of atelectasis. Its detection and prevention are important steps in optimizing ventilator support.

Author details 1 

Open access funding provided by Uppsala University.

The authors declare that they have no conflicts of interest.

The authors declare that there is no ethical concern with the study.

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