key: cord-0041812-0pqnsiid
authors: nan
title: Abstract
date: 2008-04-10
journal: J Small Anim Pract
DOI: 10.1111/j.1748-5827.1991.tb00876.x
sha: e20d45ddd2749c9745ae38232681d5a818272583
doc_id: 41812
cord_uid: 0pqnsiid

nan

FIVE 10-week-old puppies were inoculated oronasally with 10"' TCID50 of ccv-C54, an isolate of canine coronavirus (ccv), and killed three, five, seven, 10 and 14 days later. The dogs had mild diarrhoea from three to 11 days after inoculation, approximately at the same time as the virus was excreted in the faeces. Virus could be isolated from the tonsils on day 3, and then from small and large intestinal tissues up to 14 days after inoculation; it was also isolated from liver and lung tissue. No histological changes were observed in any of the tissues, but antigen to the virus was detected mainly in the epithelium overlying gut-associated lymphoid tissue. Virus neutralising antibody was first detected on day 10. Specific anti-ccv IgM was first detected in plasma three days after inoculation and IgG on days 4 to 7. Small amounts of anti-ccv IgG, IgM and IgA were detected in duodenal secretions, but none in bile.

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The authors wish to thank Karen Wadewell and Denise Wigney for expert technical assistance, and Dr A. D. J. Watson for assistance with the manuscript.