key: cord-0031972-4owlvjse
authors: Yang, Lixiang; Chen, Yuanyuan; Lou, Fei; Zhao, Xiaoxia; Zhou, Jia
title: Efficacy of Dialectical Comprehensive Treatment of Traditional Chinese Medicine in Patients with Chronic Stable Heart Failure: A Randomized Controlled Trial
date: 2022-05-12
journal: Cardiol Res Pract
DOI: 10.1155/2022/5408063
sha: 247fe3e00fe429fe91b87ca370ad0344af258d49
doc_id: 31972
cord_uid: 4owlvjse

The treatment of chronic stable heart failure (CSHF) with integrated traditional Chinese and Western medicine has been of wide concern. We mainly discuss the clinical efficacy of TCM decoction combined with acupuncture and moxibustion (A&M) in CSHF treatment on the basis of syndrome differentiation and treatment (SDT). The control group was given conventional cardiac rehabilitation (CCR), and the treatment group was given TCM decoction combined with A&M treatment based on SDT on the basis of conventional cardiac rehabilitation. The clinical efficacy and cardiopulmonary exercise testing (CPET) indicators were evaluated. Left ventricular ejection fraction (LVEF), NT-proBNP, myocardial ischemia threshold (MIT), and 6-minute walking distance (6MWD) were measured by ultrasound, ELISA, electrocardiogram, and 6MWD test. After treatment, the clinical efficacy, LVEF, and 6MWD of the treatment group were better than in the control group. The NT-proBNP plasma level and MIT in the treatment group were lower than in the control group. The treatment group had enhanced AT, VO(2) Peak, VO(2) Peak/HR, and Peak power and decreased resting systolic pressure and peak systolic pressure, and the difference was statistically significant. Dialectical comprehensive treatment of TCM could effectively improve cardiac function and clinical treatment effect, which was worthy of clinical application.

Among cardiovascular diseases, heart failure (HF) is a kind of chronic and progressive clinical syndrome in which the cardiac output cannot meet the metabolic needs of the body due to abnormal cardiac structure or function. Clinically, it is characterized by impaired ejection ability, pulmonary congestion, dyspnea, and insufficient perfusion of organs and tissues [1] . Chronic heart failure (CHF) is the most common type of heart failure in the clinic, which is the terminal stage of most cardiovascular diseases. CHF can be caused by various factors (acute events or chronic diseases), such as hypertension, coronary heart disease, diabetes, and viral infections [2] [3] [4] . Chronic stable HF (CSHF) is defined when the symptoms of CHF are stable for more than 1 month. CSHF has a high prevalence and morbidity, which seriously affects the work and life of patients and even threatens their life safety [5] . e death modes of CHF can be mainly divided into three types: (1) unexpected sudden death; (2) sudden death on the basis of deterioration of cardiac function; (3) death caused by various complications [6, 7] . Comprehensive analysis of many clinical studies has corroborated that ACE inhibitors, β-adrenergic receptor blockers, cardiotonics, vasodilators, and diuretics could ameliorate long-term prognosis of CHF patients, enhance patient comfort, and attenuate the risk of death and hospitalization [8] [9] [10] . However, due to the adverse reactions of multiple drugs, drug contraindications, and difficulty in improving symptoms as a whole, its clinical application is limited. In view of the severe situation of CSHF development in China as well as worldwide, it is necessary to explore reasonable and effective treatment methods for the prevention and treatment of CSHF. e treatment of CHF by traditional Chinese medicine (TCM) can be traced back to 1000 years ago. e original chronicles on prevention and therapy for CHF were discovered in the book conceived by Sun Simiao, a proverbial ancient Chinese doctor [11] . Syndrome differentiation and treatment (SDT) is the basic principle of Chinese medicine treatment.

e integration of disease and syndrome is a pivotal principle of Chinese medicine clinical treatment. Syndrome originates from Chinese medicine, which is a reaction state that describes the essential organic relationship of disease location, etiology, disease nature, disease situation, and the strength of the body's disease resistance ability in a certain stage of the disease process, and it can be manifested as clinically observable symptoms. SDT is a comprehensive analysis of the clinical information acquired from the four diagnostic methods of Chinese medicine (looking, listening, asking, and feeling the pulse) and serves as the guidance of prescription principles [12] . Many clinical researches have manifested the efficacy of TCM on HF [13] [14] [15] . However, in these studies, the symptoms of HF patients were stable, and the formulation of TCM was in the form of granules, pills, or injection. ey cannot fully reflect the efficacy of SDT in Chinese medicine.

At present, the treatment of CHF with integrated traditional Chinese and Western medicine (TCWM) is widely popular in China. Of the 684 randomized controlled trials, 442 studies (64.62%) used integrated TCWM in the treatment group, which aimed to maximize the advantages of the two therapies and weaken the incidence of adverse reactions [16] . erefore, in this research, on the basis of conventional cardiac rehabilitation (CCR) (Western medicine treatment, health education, and cardiovascular exercise testing (CPET)), TCM decoction, acupoint acupuncture, acupoint moxibustion, and auricular acupuncture were given according to SDT to evaluate the clinical efficacy and the changes of related indexes of the two groups before and after treatment. is study provides objective basis and new ideas for TCM in the treatment of CHF.

Our experimental protocol has been empowered by the ethics committee of Hangzhou Fuyang Hospital of Traditional Chinese Medicine (2019060075).

is study complies with the principles of the Helsinki Declaration and the principles of good clinical practice. All participants voluntarily signed informed consent.

A total of 90 CSHF patients admitted to our hospital from October 2019 to October 2020 were included in this study. e grouping method adopts the random table method. Independent statisticians were doctors (n � 3) from Hangzhou Fuyang Hospital of Traditional Chinese Medicine who did not know the experimental design and utilized the statistical analysis system (SAS) to generate random tables. Ninety patients were randomly assigned to the cardiac rehabilitation group (control group, n � 45) and the Chinese medicine dialectical comprehensive group (treatment group, n � 45) at a ratio of 1 : 1. e general clinical data of the two groups of patients are shown in Table 1 . ere were no statistically significant differences in gender, age, education, New York Heart Association (NYHA) cardiac function classification, and underlying diseases between the two groups.

e inclusion criteria were as follows [14, 17] : NYHA functional classification of II-IV; participants with qi deficiency and blood stasis type, yang deficiency and blood stasis type, or blockade of phlegm-turbidity type based on SDT; patients with diagnosis for CHF confirmed by X-ray and coronary angiography; left ventricular ejection fraction (LVEF) ≤40% and N-terminal pro-B-type natriuretic peptide (NT-proBNP) ≥450 pg/mL; and the subjects or their family members are informed and voluntarily participate in clinical research.

e exclusion criteria were stated as follows [14, 18] : (i) people with allergic constitution and allergy to drugs; (ii) patients with death-prone diseases such as cardiogenic shock, infarct cardiomyopathy, constrictive pericarditis, etc.; (iii) poor compliance and noncompliance with treatment requirements and patient's compliance when measured with the Eight-Item Morisky Medication Adherence Scale (MMAS-8) [19] had a score less than 6 points indicating poor compliance; (iv) those who cannot determine the efficacy or have insufficient data due to various reasons; (v) CHF caused by the failure of vital organs such as the lung, kidney, liver, and other important organ functions; (vi) patients with severe deafness and consciousness disorders; (vii) women who are preparing for pregnancy or are pregnant or lactating.

e diagnosis of Western medicine was made according to the Chinese guidelines for the diagnosis and treatment of heart failure in 2018 [20] .

e diagnosis of Chinese medicine was made based on the expert consensus on diagnosis and treatment of TCM in CHF in 2002 and guiding principles for the clinical study of new drugs in TCM released in 2014 [21, 22] .

erapeutic Methods. Patients in both groups were treated according to the Chinese guidelines for the diagnosis and treatment of heart failure in 2014 [23] . In the control group, patients were subjected to Western medicine treatment, health education, and CPET as below: (1) patients received the low-salt and low-fat diabetic diet and underwent weight loss, with daily monitoring of blood pressure and blood glucose. Besides, patients received furosemide tablets (Shanghai Zhaohui Pharmaceutical Co., Ltd., H31021074), 20 mg qd; spironolactone tablets (Zhejiang Yatai Pharmaceutical Co., Ltd., H33020111), 20 mg qd; isosorbide mononitrate tablets (Lunan Beite Pharmaceutical Co., Ltd, H10940039), 20 mg bid; atorvastatin calcium tablets (Pfizer Pharmaceuticals Limited, H20051408), 20 mg qn; aspirin enteric-coated tablets (Bayer HealthCare Manufacturing S.r.l., H20160684), 100 mg qd; metoprolol succinate sustained-release tablets (AstraZeneca AB, Sweden, H20140780), 0.5 tablet qd; and irbesartan tablets (Hanhui pharmaceuticals co., LTD, H20040996), 150 mg qd, orally. e above-mentioned drugs were administered in a reasonable combination during the course of treatment and continued for 8 weeks. (2) At the same time of medication, health education was conducted for each patient, including introduction of the cardiac rehabilitation department, the rehabilitation process, popular science knowledge and education of coronary heart disease, hypertension, diabetes, and related drugs, safety education, fall prevention education, self-first aid education, fatigue management, diet selfmanagement, etc. Health education was conducted three times a week for 10 minutes each. (3) CPET was performed for each patient. All subjects in this study were tested using the CPETsystem (Schiller CS-200, Switzerland). e exercise equipment was a power bicycle, an incremental power exercise program was adopted, and a suitable power load was selected according to the subject's cardiopulmonary function status and daily activity ability. Under the supervision of doctors, the maximum number of symptomlimited CPETs was carried out to encourage patients to exercise until the respiratory exchange rate exceeded 1.05. Meanwhile, the gas exchange index, heart rate, blood pressure, electrocardiogram, and oxygen saturation were measured and recorded with each breath. Patients exercised for 40 minutes each time (5 minutes during warm-up, 30 minutes during exercise, and 5 minutes during recovery), 3 times per week.

On the basis of the control group, the treatment group was given TCM decoction orally, acupoint acupuncture, acupoint moxibustion, and ear acupuncture treatments according to SDT. Firstly, patients with qi deficiency and blood stasis were treated with Baoyuan Decoction combined with Taohong Siwu Decoction. TCM prescription is as follows: Astragali Radix 18 g, Paeoniae Rubra Radix 10 g, Codonopsis Radix 15 g, Ziziphi Spinosae Semen 15 g, Angelicae Sinensis Radix 10 g, Dioscoreae Rhizoma 15 g, Salviae Miltiorrhizae Radix et Rhizoma 15 g, Ophiopogonis Radix 12 g, Schisandrae chinensis Fructus 10 g, Cinnamomi ramulus 15 g, Carthami flos 6 g, Persicae Semen 6 g, and Glycyrrhizae Radix et Rhizoma 6 g. On the basis of the abovegiven administration, patients received acupuncture (Xinshu (BL 15), Xuehai (SP 10), Danzhong (RN 17), or Yinxi (HT 06)), moxibustion (Qihai (RN 6) or Guanyuan (RN 4)), and ear acupuncture treatment (heart, small intestine, sympathetic, or subcortical). Secondly, patients with yang deficiency and blood stasis were treated with Zhenwu Decoction combined with Xuefu Zhuyu Decoction. TCM prescription is as follows: Poria 15 g, Achyranthis Bidentatae Radix 12 g, Aconiti lateralis praeparata Radix 6 g, Zingiberis Rhizoma 3 g, Paeoniae Alba Radix 12 g, Rehmanniae Radix 10 g, Angelicae Sinensis Radix 10 g, Carthami flos 6 g, Persicae Semen 6 g, Aurantii Fructus 6 g, Paeoniae Rubra Radix 6 g, Platycodonis Radix 6 g, Chuanxiong Rhizoma 9 g, Rhizoma Atractylodis Macrocephalae 15 g, and Bupleuri Radix 6 g. On the basis of the above-given administration, patients received acupuncture (Neiguan (PC 6), Tongli (HT 5), Xuehai (SP 10), or Xinshu (BL 15)), moxibustion (Shenque (RN 8) or Shenshu (BL 23)), and ear acupuncture treatment (heart, small intestine, sympathetic, or subcortical). irdly, patients with a syndrome of blockade of phlegm-turbidity were treated with Gualou Xie Banxia Decoction. TCM prescription is as follows: Semen Trichosanthis 12 g, (PC5)), moxibustion (Shenque (RN8) or Shuifen (RN 9)), and ear acupuncture treatment. Ear acupuncture treatment was mainly performed with the heart, small intestine, sympathetic and subcortical regions, supplemented by the lung, liver, chest, antihypertensive sulcus, excitement, and acupuncture strong stimulation. In the above acupoint therapy, 3-5 acupoints were selected each time, the needle was retained for one hour, once every other day, and a period of two weeks was a course of treatment. e above-mentioned Chinese herb plants were obtained from the Chinese Medicine Pharmacy of Zhejiang Hospital and were uniformly decocted by the decocting room, bagged and sealed. One dose per day was taken twice in the morning and evening for continuous treatment for 8 weeks.

e efficacy standard of cardiac function was evaluated in accordance with the guiding principles for clinical research of new drugs of traditional Chinese medicine. CHF basic control or cardiac function improvement of more than grade 2 was markedly effective; the improvement of cardiac function by grade 1 but less than grade 2 was effective; the improvement of cardiac function of less than 1 grade was invalid. e total effective rate is the percentage of effective and markedly effective people.

Before the cardiac rehabilitation program and after 8 weeks of treatment, the patients underwent color Doppler echocardiography to assess cardiac function. Color Doppler ultrasound (EPIQ7) was bought from Philips and utilized to estimate LVEF. e dynamic electrocardiogram system (DigiTrak XT) was bought from Philips and utilized to examine myocardial ischemia threshold (MIT) [21] .

Before the cardiac rehabilitation program and after 8 weeks of treatment, fasting venous blood were drawn from the two groups of patients. After treatment, the NT-proBNP ELISA kit (C01XX-1, Meso Scale Discovery, USA) was utilized to determine the level of NT-proBNP in vivo based on the manufacturer's instructions [25] .

e 6MWD experiment was conducted in a 30-meter-long corridor. Participants were instructed to walk at a maximum comfortable speed for 6 minutes. In this study, the score was based on the meter of six-minute walk [26] .

e resting heart rate, peak heart rate, resting systolic pressure, peak systolic pressure, resting diastolic pressure, peak diastolic pressure, anaerobic threshold (AT), peak oxygen uptake (VO 2 Peak), peak oxygen pulse (VO 2 Peak/HR), and peak power were measured by CPET in the observation group and the control group.

Adverse reactions of the two groups were recorded at any time during treatment.

Analysis. SPSS 20.0 software was utilized to statistical analysis. e measurement data were expressed as mean ± standard deviation. e t-test was employed for comparison between groups. e enumeration data were analyzed with χ 2 test. e grade data were analyzed by Ridit, and P < 0.05 was considered statistically significant.

Groups. After 8 weeks of treatment in the two groups, the total effective rate of the treatment group was higher than that of the control group and the total effective rate of clinical treatment was 86.67%, which was significantly better than the 66.67% of the control group. e data differences between the groups were highly comparable (P < 0.05, Table 2 ).

Two Groups. Before treatment, there was no statistically significant difference in the levels of LVEF and NT-proBNP between the two groups (P > 0.05, Table 3 ). After treatment, the level of plasma NT-proBNP in both groups was lower than that before treatment and the decrease in plasma NT-proBNP in the treatment group was more obvious than that in the control group (P < 0.05, Table 3 ). After treatment, the LVEF of the two groups was higher than that before treatment and the LVEF of the treatment group rose more significantly than that of the control group (P < 0.05, Table 3 ).

Before treatment, there was no statistically significant difference between the two groups of MIT changes and 6MWD cardiac function indexes (P > 0.05, Table 4 ). After treatment, the change level of MIT in the two groups was lower than before treatment and the change level of MIT in the treatment group decreased more notably than that in the control group (P < 0.05, Table 4 ). After treatment, the 6MWD of the two groups was higher than that before treatment and the 6MWD of the treatment group enhanced more evidently than that of the control group (P < 0.05, Table 4 ).

ere was no difference in resting heart rate, peak heart rate, resting diastolic pressure, and peak diastolic pressure before and after treatment between the two groups ( Table 5 ). Before treatment, there was no difference in resting systolic pressure, peak systolic pressure, AT, VO 2 Peak, VO 2 Peak/HR, and Peak power between the two groups ( Table 5) . After treatment, resting systolic pressure and peak systolic pressure of the two groups decreased notably compared with before treatment; AT, VO 2 Peak, VO 2 Peak/HR, and Peak power were evidently higher than before treatment (P < 0.05, Table 5 ). More importantly, the downregulation of resting systolic pressure and peak systolic pressure and the upregulation of AT, VO 2 Peak, VO 2 Peak/HR, and Peak power in the treatment group were more significant than those in the control group (P < 0.05, Table 5 ).

ere were no obvious adverse reactions in the control group and the treatment group during the trial, and there were no abnormalities in the liver, kidney, or hematopoietic functions.

It was currently considered that coronary heart disease, cardiomyopathy, and myocardial infarction were crucial factors leading to CHF [27] [28] [29] . With the development of modern medical technology, the clinical application of TCM is more reasonable and scientific. Many prominent classical prescriptions of TCM have the ascendancy of notable curative effect and fewer adverse reactions and are widely used in CHF [16] . Clinical studies have corroborated that the combination of TCWM has evident curative effect in the treatment of CHF [13, 30] . ere is still insufficient testimony to support the efficacy of syndrome differentiation and treatment of Chinese medicine. In TCM treatment, different treatment methods were adopted according to the SDT of patients. is study was the first randomized clinical trial based on CCR to treat CSHF with oral TCM decoction, acupoint acupuncture, acupuncture moxibustion, and ear acupuncture.

TCM is a treatment method based on the theory of yin and yang and the five elements [31] . In TCM, yin and yang are two contradictory but interdependent concepts. In the human body, the "skin," "back," and "Qi" belong to the category of yang, and "muscle and bone," "abdomen," and "blood" belong to the category of yin [32] . Besides, in TCM, the theory of five elements is used to interpret the relationship between the physiology and pathology of the human body and the natural environment. For example, "Wood" stands for the liver and gall bladder; "Fire" stands for the heart and small intestine; "Earth" stands for the spleen and stomach; "Metal" stands for the lung and large intestine; and "Water" stands for the kidney and urinary bladder [32] . When the human body suffers from a disease, the dynamic balance of yin-yang and five elements are disturbed [33] ; therefore, in order to correct this disturbance, TCM adopts an overall method (i.e., SDT) to make a specific treatment plan for the disease [34, 35] . And, the expert consensus on TCM diagnosis and treatment of CHF published in 2014 gradually unified the classification of TCM syndrome types of HF, which divided HF into three basic syndrome types (qi deficiency and blood stasis type, qi and yin deficiency and blood stasis type, and yang qi deficiency and blood stasis type) [36] . In recent years, SDT of TCM has evident advantages and characteristics in the treatment of CHF. According to the pathogenesis of CHF, the clinical manifestations of CHF patients with qi deficiency and blood stasis type are mainly palpitation, short breath, dim and blackish complexion, or chest and flank pain [21] . According to the relevant study, the treatment of Modified Baoyuan Decoction combined with Taohong Siwu Decoction could effectively improve the clinical treatment effect and improve the clinical symptoms of CHF patients with qi deficiency and blood stasis [37] . e treatment of qi deficiency and blood stasis type was to benefit qi for activating blood circulation; thus, we chose Baoyuan Decoction combined with Taohong Siwu Decoction. e clinical manifestations of CHF patients with yang deficiency and blood stasis type are mainly cold chills limbs, palpitations, chest tightness, or chest pain [38] . Zhenwu Decoction is a representative prescription for treating the syndrome of water overflowing due to yang deficiency; Xuefu Zhuyu Decoction is a representative prescription for treating the syndrome of blood stasis in the chest. e treatment of yang qi deficiency and blood stasis type was to benefit qi, warm yang, and activate blood circulation; thus, we chose Zhenwu Decoction combined with Xuefu Zhuyu Decoction. Moreover, the clinical manifestations of CHF patients with blockade of phlegm-turbidity type are mainly headache, sluggish look, limb twitch, and vomiting of phlegm and drool [39] . e study manifested that Gualou Xiebai Banxia Decoction was effective in treating CHF [40] . e treatment of blockade of phlegmturbidity type was dissipating phlegm for resuscitation and relieving spasm by calming endogenous wind; thus, we chose Gualou Xiebai Banxia Decoction. Patients with CSHF received decoction therapy according to SDT, combined with acupoint acupuncture, acupoint moxibustion, and auricular acupuncture treatment. Acupuncture and moxibustion (A&M) is a key treatment method based on the theory of Chinese medicine, which acts on certain acupoints on the human body surface through acupuncture and moxibustion and modulate the viscera, qi, and blood, thereby achieving the purpose of preventing and curing diseases [41] . Acupuncture refers to inserting a needle into patients' body at a certain angle under the guidance of TCM theory and using acupuncture techniques such as twisting, lifting, and inserting to stimulate specific parts of the human body [42] . Moxibustion refers to using preheated Chinese mugwort to burn or fumigate on certain acupoints on the body surface, thus producing thermal stimulation to prevent and treat diseases [43] . Among them, Danzhong has the effects of benefiting heart qi and invigorating heart yang; Neiguan and Tongli have the effects of dredging collaterals, which can prevent too much tonic benefit [44] . Many animal experiments have researched the mechanism of A&M in the treatment of HF and discovered that A&M could repress sympathetic nerve activity, prevent fibrosis, modulate inflammation, reduce myocardial damage, restrain myocardial hypertrophy, and reverse ventricular remodeling [45] [46] [47] [48] [49] . Scientific research clarified that A&M could ameliorate the heart function of HF patients [45, 50] . In this research, for the first time, we discovered that the overall clinical effective rate of TCM decoction combined with A&M treatment was higher than that of the CCR treatment.

In the process of diagnosis and treatment of CHF patients, the clinical treatment effect of the patients was generally evaluated by LVEF, NT-proBNP, and 6MWT [51] . LVEF in echocardiogram reflects left ventricular function and can guide clinical treatment, which is an objective index to evaluate the therapeutic effect [52] . It is pointed out in the 2017 US HF management guidelines that NT-proBNP can not only be used to diagnose and exclude HF but also it has a very high negative expectation value and can be used for prognostic judgment and risk stratification [53] . One study confirmed that the addition of Shenfu injection on the basis of conventional western medicine treatment is beneficial to ameliorate the heart function of patients with HF, enhance the total clinical effective rate, and improve the heart rate, NT-proBNP level, and 6MWD of patients [54] . Our study demonstrated that TCM decoction combined with A&M treatment evidently elevated the LVEF, NT-proBNP level, and 6MWD of CSHF patients compared with the CCR treatment, revealing that the addition of TCM decoction and A&M together with CCR can further improve the exercise endurance and quality of life of patients with CSHF.

In CCR treatment, we performed CPET and evaluated the cardiopulmonary function status of the control group and the treatment group. Among them, VO 2 Peak and AT are some of the best indicators to detect early cardiac dysfunction and to evaluate the degree of improvement of cardiac function in HF patients. VO 2 Peak/HR is the amount of oxygen that can be transported by the heart per stroke, which can reflect the ability of the heart to deliver oxygen per stroke [55] [56] [57] . In this research, TCM decoction combined with A&M treatment further improved AT, VO 2 Peak, VO 2 Peak/HR, and Peak power and weakened resting systolic pressure and peak systolic pressure in the treatment group than in the control group, indicating that TCM decoction combined with A&M treatment can further improve cardiac function on the basis of CCR.

Because all the data in this study are from Zhejiang hospitals, there is inevitably selection bias and the results may be affected by the regional climate characteristics. Another limitation of this study is the small sample size, we will expand the sample size and continue clinical observation to obtain more clinical data and research data in the future. In short, on the basis of CCR, TCM decoction combined with A&M treatment according to SDT can effectively ameliorate the heart function of patients and strengthen the clinical treatment effect, which is worthy of clinical application.

Data Availability e analyzed data sets generated during the study are available from the corresponding author on reasonable request.

e authors declare no conflicts of interest.

Pathophysiology of heart failure

Risk following hospitalization in stable chronic systolic heart failure

Changing characteristics and mode of death associated with chronic heart failure caused by left ventricular systolic dysfunction

Pathophysiology, causes and epidemiology of chronic heart failure

Role of cardiac 123I-mIBG imaging in predicting arrhythmic events in stable chronic heart failure patients with an ICD

What causes sudden death in patients with chronic heart failure and a reduced ejection fraction?

Sudden cardiac death in patients with diabetes mellitus and chronic heart failure

Chinese Society of Cardiology of Chinese Medical Association; Editorial Board of Chinese Journal of Cardiology

Long-term trends in first hospitalization for heart failure and subsequent survival between

Traditional Chinese medicine injections for heart failure: a protocol for systematic review and network meta-analysis of randomised controlled trials

Standardized Research on the Name of Diseases of Traditional Chinese Medicine

A review of Chinese herbal medicine for the treatment of chronic heart failure

A multi-center, randomized, double-blind, placebo-parallel controlled trial for the efficacy and safety of shenfuqiangxin pills in the treatment of chronic heart failure (Heart-Kidney yang deficiency syndrome)

Safety and efficacy of Qishen granules in patients with chronic heart failure: study protocol for a randomized controlled trial

Randomized, doubleblinded, multicenter, placebo-controlled trial of shenfu injection for treatment of patients with chronic heart failure during the acute phase of symptom aggravation (yang and qi deficiency syndrome)

Clinical practice of traditional Chinese medicines for chronic heart failure

Shenmai injection improves energy metabolism in patients with heart failure: a randomized controlled trial

Chinese herbal medicine in the treatment of chronic heart failure: three-stage study protocol for a randomized controlled trial

e 8-item Morisky Medication Adherence Scale: validation of a Brazilian-Portuguese version in hypertensive adults

Chinese Society of Cardiology of Chinese Medical Association and Editorial Board of Chinese Journal of Cardiology

League of traditional Chinese medicine clinical study on coronary artery disease, cardiovascular diseases committee of Chinese association of integrative medicine, Chinese society of cardiology of China association of Chinese medicine, cardiovascular diseases committee, doctor society of integrative medicine, and Chinese medical doctor association, "expert consensus on diagnosis and treatment of traditional Chinese medicine in chronic heart failure

Guiding Principles for the Clinical Study of New Drugs for Use in Traditional Chinese Medicine

Chinese Society of Cardiology of Chinese Medical Association; Editorial Board of Chinese Journal of Cardiology

A cost analysis of a pancreatic cancer screening protocol in high-risk populations

Noninvasive prognostic biomarkers for left-sided heart failure as predictors of survival in pulmonary arterial hypertension

Validity and reliability of the 6-minute walk test in a cardiac rehabilitation population

Chronic heart failure

Heart failure: preventing disease and death worldwide

Comparison of the efficacy and safety of different ACE inhibitors in patients with chronic heart failure

A multicenter, randomized, double-blind, parallel-group, placebo-controlled study of the effects of qili qiangxin capsules in patients with chronic heart failure

Traditional Chinese Medicine and western medicine share similar philosophical approaches to fight COVID-19

Current evaluation of the millennium phytomedicine-ginseng (II): collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine

Global mapping of traditional Chinese medicine into bioactivity space and pathways annotation improves mechanistic understanding and discovers relationships between therapeutic action (Sub) classes

Study of the multidimensional perspectives on the theory of syndrome differentiation and treatment with acupuncture and moxibustion

Differentiation syndrome in acute promyelocytic leukaemia

Expert consensus on TCM diagnosis and treatment of chronic heart failure

Clinical observation on baoyuan decoction and Taohong Siwu decoction in the treatment of heart failure of qi deficiency and blood stasis

Influence of Zhenwu decoction and Xuefu Zhuyu decoction on cardiac function and plasma NT-proBNP in patients with heart failure induced by coronary heart disease

Guidelines for Clinical Research of New Chinese Medicine (trial), China Medical Science and Technology Press

34 cases of chronic heart failure treated with Gualou Xiebai Banxia decoction combined with Western Medicine

Acupuncture and cardiovascular disease

History of acupuncture research

e thermal performance of biological tissue under moxibustion therapy

Effects of Yi Qi Tong Luo needling method on cardiac function and serum NT-proBNP and inflammatory factors in patients with chronic heart failure of Qi deficiency and blood stagnation pattern

Acupuncture in the treatment of heart failure

Protective effect of acupuncture on heart in mice with hyperlipemia and its mechanism

Effects of electroacupuncture on inflammatory response of cardiac muscle tissue in mice with acute myocardial ischemia

Effect of moxibustion stimulation of "feishu" (BL 13) and "xinshu" (BL 15) on expression of myocardial MyD 88 protein and caspase 3 mRNA in chronic heart failure rats

Acupuncture at PC6 prevents cardiac hypertrophy in isoproterenol-treated mice

Acupuncture for heart failure: a systematic review of clinical studies

Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry

Epidemiology and long-term outcome in outpatients with chronic heart failure in Northwestern Europe

2017 ACC/AHA/ HFSA focused update of the 2013 ACCF/AHA guideline for the management of heart failure

Chinese medicine shenfu injection for heart failure: a systematic review and meta-analysis

Cardiopulmonary exercise testing and its application

Beyond peak oxygen uptake

Design and validation of an interpretative strategy for cardiopulmonary exercise tests