key: cord-0026981-sql5knwu
authors: Miall, Annie; McLellan, Rio; Dong, Krista; Ndung'u, Thumbi; Saberi, Parya; Sauceda, John A.; Dubé, Karine
title: Bringing social context into global biomedical HIV cure-related research: An urgent call to action
date: 2021-12-28
journal: J Virus Erad
DOI: 10.1016/j.jve.2021.100062
sha: f18f30724347e3e3d927a848d18aa311990cbc39
doc_id: 26981
cord_uid: sql5knwu

Advances in science have ushered in a wave of new potential curative and control strategies for HIV that could eliminate the current requirement for life-long antiretroviral therapy (ART) for people living with HIV (PLWH). In this article, we argue that it is critical to consider social contexts in the development of HIV cure trial protocols. The biological and behavioral risk factors for HIV acquisition by study participants are inseparable from the social context in which these participants live. The article discusses an example of a cohort established to further HIV cure research that included social context, called the FRESH Acute HIV study, which combines a sociostructural intervention while conducting HIV prevention, treatment and cure-related research in Durban, South Africa. We make an urgent call to action to include sociobehavioral components as instrumental in future HIV cure trials in global context.

Social sciences HIV cure research Women South Africa A B S T R A C T Advances in science have ushered in a wave of new potential curative and control strategies for HIV that could eliminate the current requirement for life-long antiretroviral therapy (ART) for people living with HIV (PLWH). In this article, we argue that it is critical to consider social contexts in the development of HIV cure trial protocols. The biological and behavioral risk factors for HIV acquisition by study participants are inseparable from the social context in which these participants live. The article discusses an example of a cohort established to further HIV cure research that included social context, called the FRESH Acute HIV study, which combines a sociostructural intervention while conducting HIV prevention, treatment and cure-related research in Durban, South Africa. We make an urgent call to action to include sociobehavioral components as instrumental in future HIV cure trials in global context.

Advances in science have ushered in a wave of new potential curative and control strategies for HIV that could eliminate the current requirement for life-long antiretroviral therapy (ART) for people living with HIV (PLWH). 1 These strategies, proposed to be applied mostly as combination therapies include early treatment initiation to reduce the size of the HIV reservoir and preserve antiviral immune responses, latency reversal agents, HIV transcriptional silencing ("block and lock"), immunotherapies to enhance existing immune responses, and gene therapies to engineer HIV-specific immunity in T-cells or alter cellular susceptibility to HIV infection. 2 With the advent of new biomedical therapeutic strategies, there emerges a parallel need for consideration of acceptability, accessibility, and scalability of these potential curative strategies. 3 Globally, many vulnerable populations are disproportionately affected by HIV. It is therefore critical to consider social contexts in the development of HIV cure trial protocols. This will ensure optimal recruitment, retention, fidelity to the protocol (e.g., adhering to treatment and other trial requirements), and efficacy at scale within current HIV endemic areas. For example, in the United States (US), gay, bisexual, and other men in same gender relationships are the most affected demographic by HIV. 4 However, 70% of the global HIV burden is borne by sub-Saharan Africa (SSA) with the highest rates of infection occurring in adolescent girls and young women (AGYW) who are up to six times more likely to have HIV compared to their male peers. 5 Most current HIV cure clinical trial designs and related social support strategies (emotional, informational, instrumental) included to improve study success, are aimed at US demographics and may not translate to those in low and middle-income countries (LMICs) given the disparities between affected populations. 6 For example, men in the same gender relationships in the US may experience different relationship dynamics than women in SSA face with their male partners. Many women report not feeling comfortable or safe disclosing their status or seeking treatment due to fear of gender-based violence (GBV) or discrimination. 7, 8 Implementing a generalized approach in supporting adult men in same gender relationships in the US versus AGYW trial participants in SSA may have consequences on research participation and patient/partner safety differential effects due to regional-specific challenges, beliefs, resources, HIV-associated stigma, and other factors related to setting, age, or social context.

Biological and behavioral risk factors for HIV acquisition by AGYW in SSA are inseparable from the social context in which these young women live. 9 This environment presents regional-specific challenges for AGYW including heightened poverty risk compared to their male counterparts, GBV, and unequal gender-power dynamics. 5 For instance, exposure to intimate partner violence (IPV) and poor partner communication are key deterrents governing a woman's ability to negotiate condom usage. Adolescent pregnancy and domestic responsibilities additionally limit the ability to complete secondary education which further impacts health, options for employment, and ability to achieve economic independence. 10 Challenges such as these serve as barriers to enrolling in and completing clinical trials while contributing to intergenerational cycles of poverty, low levels of education as well as unemployment. 10 Failing to consider the social contexts that AGYW lives within limit the ability to include them in HIV cure research studies. Therefore, in developing interventions and designing the structure of trials to assess them, the inclusion of socio-behavioral research to identify AGYW-specific concerns may inform future HIV cure-related research on the feasibility, acceptability, and tolerability of participation.

An example of a cohort established to further HIV cure research that included social context in its design is the FRESH Acute HIV study. 11 FRESH, Females Rising through Education, Support and Health, was launched in 2012 in KwaZulu-Natal South Africa, in a community with one of the highest HIV infection rates in the world. 12 The study recruits young sexually active women who are at high risk of HIV acquisition to undergo frequent HIV testing and biological sampling. Enrolled in groups of 20-30 women from a community where teen pregnancy, food insecurity, school drop-out, and limited access to jobs is the norm, study participants are co-enrolled in a 9-month life skills and empowerment program that coincides with their study visits. In groups designed to promote a sense of belonging, participants learn about self-esteem, communication, budgeting, basic computer skills, resume writing, interview strategies, and go on field trips to explore work options. At the same time, routine monitoring of mental health, sexual risk behavior, and risk perception for HIV infection are evaluated while providing pre-exposure prophylaxis (PrEP) to reduce the risk of HIV infection, and PrEP is provided along with intensive prevention counseling. The FRESH program has an over 80% placement rate of participants in jobs, internships, return to school, or starting their own business within 1 year of completing the program. To date, this approach has enabled the identification of 94 acute HIV infections, mostly during Fiebig stage I, within a median of 4 days since the last negative HIV RNA test and initiation of ART within 1 day of detection. 11 The FRESH approach of incorporating a social intervention within the clinical research protocol has been effective at addressing participant needs that would otherwise present as barriers to enrollment in clinical trials. It also contributed toward the establishment and successful long-term follow-up of a cohort of women living with HIV who have limited viremia, reservoir size, and viral diversity due to early detection and treatment, who are ideal candidates for HIV cure-related clinical trials. 13 This model provides investigators with a real-world test ground for HIV prevention, treatment and cure-related interventions in an area of the world where the need continues to be disproportionately high.

Participation in HIV cure studies includes additional psychosocial and biological risks and ethical challenges. An example is a need for analytical treatment interruption (ATI) -or the temporary stopping of ARTto determine whether HIV cure interventions are effective. ATIs risk negative health and personal outcomes in requiring the stopping of treatment, disclosure of HIV and ATI status to partners/family members, and negotiation of protection measures with sexual partners while participants are off ART (e.g. referral for PrEP) to prevent HIV transmission. 14, 15 In negotiating issues of disclosure and partner protections, attention must be paid upfront to gender and relationship power dynamics, equity, and GBV approaches in the design of these trials. 16 This can only be accomplished through the intentional and proactive collection, reporting, and incorporation of socio-behavioral research findings into the design of trials. In order to adequately address individualized factors influencing research participation by PLWH, HIV cure-related research must expand beyond standard biomedical outcomes to better align ethical risk/ benefit ratios with needs and context for AGYW. This alignment will ensure that any potential future community benefits promised by the study outweigh any risks to participant safety and health. 17 Integration of biomedical and socio-behavioral science positions PLWH and other key stakeholders, such as intimate partners and family members, as active contributors in advancing the cure field. This approach takes into consideration their expertise and lived experience throughout the development pipeline, from conceptualization of interventions, to study design and support strategy development as opposed to a generalized approach where one size does not fit all. Because PLWH live within complex contexts, we must anticipate social-structural factors directly affecting the successful implementation of clinical trials. Therefore, we make a call to action to include socio-behavioral components as instrumental in future HIV cure trials.

International AIDS Society global scientific strategy: towards an HIV cure 2016

Cell and gene therapy for HIV cure

Applying the behavioural and social sciences research (BSSR) functional framework to HIV cure research

Putting women in the centre of the global HIV response is key to achieving epidemic control!

Social support and HIV-related risk behaviors: a systematic review of the global literature

Exploring the use of oral preexposure prophylaxis (PrEP) among women from Durban, South Africa as part of the HIV prevention package in a clinical trial

Prevalence and factors associated with intimate partner violence among the adolescent girls and young women in South Africa: findings the 2017 population based cross-sectional survey

Lactobacillus-deficient cervicovaginal bacterial communities are associated with increased HIV acquisition in young South African women

Prevalence of first adolescent pregnancy and its associated factors in sub-Saharan Africa: a multi-country analysis

A FRESH approach: combining basic science and social good

Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study

How does the timing of antiretroviral therapy initiation in acute infection affect HIV reservoirs?

Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting

Operationalizing human immunodeficiency virus cure-related trials with analytic treatment interruptions during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic: a collaborative approach

Considerations for increasing racial, ethnic, gender, and sexual diversity in HIV cure-related research with analytical treatment interruptions: a qualitative inquiry

Putting participants at the centre of HIV cure research

For ensuring that women are represented in HIV cure research, we thank the FRESH study participants, the 

The authors would like to thank all participants in the FRESH (Female Rising through Education, Support and Health) cohort, as well as the HIV Pathogenesis Programme (HPP) Community Advisory Board.