key: cord-0025111-7pllwr23 authors: Wang, Cheng-Yi; Chen, Ching-Yi; Lai, Chih-Cheng title: More Analysis Needed to Minimize Confounding date: 2022-01-03 journal: J Am Coll Cardiol DOI: 10.1016/j.jacc.2021.09.1385 sha: 3757d81b8aaf74701c68c9270d51e796be8a15ec doc_id: 25111 cord_uid: 7pllwr23 nan More Analysis Needed to Minimize Confounding Finally, the no-double-blind study design may be associated with the bias in the care of the study participants, such as intensive care unit stay or extubation. In conclusion, before these issues are clarified, this study's findings should be interpreted cautiously. The authors have reported that they have no relationships relevant to the contents of this paper to disclose. Christie Ballantyne, MD, served as the Guest Editor-in-Chief for this paper. The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors' institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the Author Center. Metoprolol in critically ill patients with COVID-19 Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: a meta-analysis Clinical efficacy and safety of Janus kinase inhibitors for COVID-19: a systematic review and meta-analysis of randomized controlled trials Experimental study of the protective effect of simvastatin on lung injury in rats with sepsis Co-infections among patients with COVID-19: the need for combination therapy with non-anti-SARS-CoV-2 agents?