key: cord-0021816-n5izebk8
authors: Malik, Kanika; Ibrahim, Maliha; Bernstein, Adam; Venkatesh, Rahul Kodihalli; Rai, Tara; Chorpita, Bruce; Patel, Vikram
title: Behavioral Activation as an ‘active ingredient’ of interventions addressing depression and anxiety among young people: a systematic review and evidence synthesis
date: 2021-10-07
journal: BMC Psychol
DOI: 10.1186/s40359-021-00655-x
sha: addf233b03bf29799954d56a34d9ec09b761e960
doc_id: 21816
cord_uid: n5izebk8

BACKGROUND: Psychological interventions such as behavioral activation (BA) that focus on overt behaviors rather than complex cognitive skills may be developmentally well-suited to address youth mental health problems. The current systematic review synthesized evidence on the characteristics, effectiveness and acceptability of behavioral activation (BA) to examine its role as a potential ‘active ingredient’ for alleviating depression and anxiety among young people aged 14 to 24 years. METHODS: Evidence across the following sources were synthesized: (i) randomized control trials (RCT) evaluating interventions where BA has been used as a standalone intervention or as part of a multicomponent intervention, (ii) qualitative studies examining the acceptability of BA as an intervention or as a coping strategy among young people with lived experiences. Consultations with a youth advisory group (YAG) from India were used to draw inferences from existing evidence and identify future research priorities. RESULTS: As part of the review, 23 RCTs were identified; three studies examined BA as a standalone intervention, and the remaining studies examined multicomponent intervention where BA was a constituent element. The intervention protocols varied in composition, with the number of intervention elements ranging between 5 to 18. There was promising but limited evidence in standalone interventions for thse effectiveness of BA for depression. The impact of BA in multicomponent interventions was difficult to evaluate in the absence of focal assessment of activation outcomes. Evidence from 37 additional qualitative studies of youth lived experience literature, corroborated by the YAG inputs, indicated that young people preferred using behavioral strategies similar to BA to cope with depression in their own life. Themes indicated that the activities that are important to an individual and their socio-contextual factors need to be considered in the planning and implementing BA intervention. Evidence for the use of BA in anxiety was limited across data sources. CONCLUSIONS: Overall, there was preliminary empirical evidence for the effectiveness and acceptability of BA for youth depression. Further research is needed to examine the components and mechanisms that contribute to its effectiveness as an active intervention ingredient for depression and anxiety. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40359-021-00655-x.

Depression and anxiety are common, often co-occur, and are associated with significant disability among young people [1, 2] , indicating a need for conceptually integrated and resource-efficient interventions that can address symptoms of both conditions. Although Behavioral Activation (BA), was initially conceptualized as an 'active ingredient' of interventions for adult depression [3, 4] , its evidence for effectiveness as a transdiagnostic technique, is gradually emerging [5] . Cost-effectiveness, ease of delivery by non-specialists, and cultural sensitivity adds to the scalability of BA, particularly in the low-middle income countries (LMICs), where there is a paucity of financial and trained human resources [6] [7] [8] .

BA involves systematically increasing individuals' engagement in pleasurable activities, and in recent years the repertoire of activities has been expanded to include personally meaningful and valued activities [9] . The increased engagement with these overt behaviors is intended to bring the individual into contact with positive reinforcements in their environment, leading to more adaptive alternatives to withdrawn or avoidant behaviors, which underpin functional impairment in depression and anxiety [3, 10, 11] . The intervention elements that have been used as part of BA have varied across studies, with certain elements such as activity scheduling and selfmonitoring being consistently present, whereas other elements such as skill training, personal values, goal assessment, and functional analysis have been variably used across studies and often as secondary to the above two components [12] .

Most of the existing evidence on the utility and effectiveness of BA comes from studies with adults [13, 14] ; however, the emphasis on concrete, overt behavior rather than complex emotional or cognitive skills makes it developmentally well-suited for young people [15] . Two recent systematic reviews of randomized and non-randomized BA studies provided preliminary evidence for its effectiveness among children and adolescents (below age of 19 years) with depression, with limited evidence for its use in anxiety [16, 17] . However, the limited number of randomized control trials (RCTs) and small sample sizes were a limitation to the strength of evidence in these reviews. Moreover, young people's perception about the acceptability of BA in managing anxiety and depression, was not examined in the existing reviews.

The current rapid review was undertaken to synthesize evidence from multiple data sources (i.e., randomized control trials and lived experience literature) on the potential role of BA as an active ingredient for interventions aimed at young people with, or at risk for, depression and anxiety. The specific objectives of the study were to examine the characteristics and effectiveness of interventions where BA has been used, and the acceptability of BA among young people with, or at risk for, depression and anxiety. This rapid review was conducted as part of the Wellcome Trust's Active Ingredients commission set out to explore potential intervention ingredients that address anxiety and depression in young people aged 14-24 years [18] . The target age group in the current study overlaps but is broader than the age groups included in previous BA review studies [16, 17] .

The rapid review was carried over period of four months (June-September 2020). Rapid reviews are literature reviews conducted systematically within a limited time frame and with specific databases [19] . We addressed the study's objectives by drawing insights from two separate but complementary systematic reviews. The first review (quantitative review) was addressed objectives related to the characteristics and effectiveness of BA in depression and anxiety. Here we systematically synthesized RCTs on BA, in particular RCT studies that evaluated standalone BA interventions and multicomponent interventions with BA elements. The second review (qualitative review) addressed the objective related to the acceptability of BA in young people. In this review, we synthesized the literature on the lived experience of BA, in particular youths' experiences of participating in interventions with BA, and habitual use of BA like coping strategies to alleviate depression, anxiety, or both. We reasoned that the closer the match between what youth habitually use to cope and BA intervention might help strengthen the evidence for acceptability of BA, and any discrepancies might suggest possible adjustments that could further refine and strengthen the BA framework for young people.

Eligible RCT studies were systematically identified from the PracticeWise Evidence-Based Services (PWEBS) database. PWEBS is the largest repository of published youth (aged up to 21 years) mental health intervention research articles, identified and biannually updated through the systematic search of online databases and personal nominations submitted by trained consultants and professionals. Each article in the PWEBS database undergoes a rigorous double-coding and validation process to produce a standardized and structured interpretation of various intervention and outcome indicators [20, 21] . Since the standard PWEBS database focuses on study samples aged up to 21 years, to examine the evidence for the older age group (upto age of 24 years), we used a complementary transition age youth database.

The database was under development at the time of our review, and studies were coded using the PWEBS system but not yet validated. The databases were accessed in June-August 2020.

A full breakdown of the detailed search strategy with SPIDER elements [22] used to identify relevant RCTs across two PWEBS databases is provided in Table 1 . Based on Kanter's systematic review [12] , the standalone BA intervention was defined as an intervention that primarily used behavioral approaches, with activity scheduling and self-monitoring as essential intervention elements. Similarly, BA as an element in the multicomponent intervention was defined as the combination of activity scheduling and self-monitoring elements. We excluded studies that examined universal interventions (i.e., interventions that are offered to all young people regardless of whether or not they are at risk for, or have, mental health problems), studies limited to institute specific samples, and studies where BA was an optional element in the intervention package.

Using the PWEBS coding system [21] , indicators on sample, intervention, and outcomes were extracted for all eligible studies and summarized using narrative synthesis. The study outcome for the primary measure of depression and/or anxiety was categorized as 'superior' , 'valid equivalent' or 'non-superior' , based on the performance of the index intervention group in comparison to other study groups and the wider evidence for intervention in PWEBS database. The definition of these variables is provided in Table 2 .

PsycInfo, PubMed and Google Scholar research databases were systematically reviewed to identify qualitative and mixed-method studies that examined young people's experiences with BA in standalone/ multicomponent intervention for depression and/or anxiety (SPI-DER elements and search terms provided in the Table 1) . We also reviewed studies that examined adaptive strategies habitually used by young people to effectively cope with depression and anxiety and the extent of their alignment with BA (search terms provided in the Table 1 ). We excluded purely quantitative studies, ethnography and observational studies and qualitative studies that gather information from caregivers or providers only. These databases were accessed through period of June-August 2020. The reference sections of the randomized trial papers identified through the PWEBS search were handsearched to identify additional qualitative evaluations and authors of these papers were contacted to extract any qualitative data that might have been included as part of the randomized trials. The selection process, including search results and reasons for exclusion at each stage of screening are represented in the PRISMA flow diagram Fig. 1 . The title and abstract of identified articles were screened for potential eligibility by two project researchers (RKV, TR). The shortlisted articles were read in full by the third researcher (MI) to determine if they met the eligibility criteria. For each eligible study, the sample characteristics, findings from results and discussion sections along with participant quotes, were extracted by one of the three researchers (MI, RKV, TR) and cross-checked by another project researcher before conducting analysis. Thematic synthesis was used for analyzing and summarizing data [23, 24] . This involved line-by-line coding of data from each article by two project researchers. Any discrepancies in coding at this stage were resolved through discussion. This was followed by identification of descriptive themes, and generation of analytical themes that extended upon the descriptive themes. NVivo 12 [25] was used for coding data and grouping it into themes.

Eligible RCT studies were assessed for quality using the Cochrane Collaboration's Risk of Bias (RoB) assessment tool [26] . The following domains were rated for bias: (1) random sequence generation (selection bias), (2) allocation concealment (selection bias), (3) blinding of outcome assessment (detection bias), and (4) incomplete outcome data (attrition bias). As per the tool guidelines, the bias for each domain was rated as high, low, or unclear. Studies where self-report tools were used, detection bias was marked as not applicable (NA) and studies where intention-to-treat analysis was used, attrition bias was rated as low. In line with previous reviews [27, 28] , biases due to selective reporting (trial registry details were not available for most studies) and blinding of participants/ personnel (studies of psychological interventions are typically not able to blind participants and personnel) were not included.

Mixed Methods Appraisal Tool (MMAT) [29] was used for quality assessment of the qualitative and mixedmethod studies. Each study was rated on seven domains: clarity of stated research questions, appropriateness of the chosen approach to address the research question, adequacy of data collection methods, derivation of findings from data, quality of analyzed results, coherence between data sources and results, and interpretation of finding. For each domain, a three-point rating scale was used : 0 (low degree of confidence), 0.5 (mixed/unclear), or 1 (high degree of confidence). The maximum possible total score for each study was 7, with a higher score indicating good confidence in study findings.

For bias and quality assessments, each study was independently rated by two project researchers. Disagreements were resolved by discussion until consensus was reached, and if required, a third independent researcher went through the full text of the disputed study to check each domain for inconsistencies.

Engaging individuals who are the focus of research into the research process can lead to better outcomes and ultimately better service, in particular for young people, whose Trainability Extent to which others can be trained in an intervention; rated as high if the manual was available and treatment was delivered by non-doctoral-level practitioners; as moderate if the manual was available or treatment was delivered by non-doctoral-level practitioners; and as low if no manual was available and treatment delivered by doctoral-level practitioners only Outcome status Superior was applied when an intervention performed better than one or more other study groups (a psychosocial intervention, medication, combined psychosocial and medication, placebo, waitlist, no treatment, or other control groups) in a randomized trial on the primary outcome measure in the target symptom domain Valid equivalent was applied when an intervention had a qualifying tie with one or more evidence-based protocol in a randomized trial on the primary outcome measure in the target symptom domain Non-superior was applied when an intervention (i) performed worse than comparison groups, or (ii) performed equally against a nonevidence-based comparison group in a randomized trial on the primary outcome measure in the target symptom domain "voices" are often absent from the published literature [30, 31] . In line with the principles of participatory research, consultative workshops were held with a Youth Advisor Group (YAG) to draw inferences from published evidence and identify research priorities, specifically for LMICs like India. The youth advisors were recruited through the "It'sOkToTalk" initiative at Sangath, India (http:// itsok totalk. in/ get-invol ved/). A digital flyer highlighting the workshop's objectives and role of youth advisors was circulated through the website, inviting young people across India with selfidentified lived experience of depression and anxiety to contact the project researchers (MI and TR) through an email. Interested young people were asked to complete a demographic form and assent/ consent form to participate as advisors. For young people below the age of 18 years, additional written consent was obtained from their parent/ guardian. The demographic details of the ten members of the youth advisor group are given in the supplement section (Additional file 1). A total of three, 2-h long online workshops (using a secure video-conferencing platform) were organized with youth advisors. The consultations with YAG were structured around brief presentations on BA theory and intervention, preliminary findings from the review, and design of the dissemination materials. These presentations were followed by semi-structured group discussions, facilitated by project researchers (KM and MI), to examine advisors' perception about the utility of BA in young people, the credibility of the preliminary evidence synthesis, potential refinements, and implications for further research. The responses obtained from the youth advisors were analyzed thematically using the same framework that was developed to synthesize the qualitative studies.

A total of 23 RCT eligible studies were identified, three (13%) studies examined standalone BA interventions, and 20 studies (87%) examined multicomponent interventions with BA. The details of these studies on selected variables are presented in Table 3 . The RoB in most RCT studies was moderate, with biases related to allocation by an independent (third) party (13 out of 23 studies, 57%) and masked assessment procedure being most frequent (18 out of 23 studies, 78%). The RoB ratings for individual studies are given in Box 1.

Allocation concealment Blinding of outcome assessment Non-superior * Included anxiety as a secondary outcome, ^I ncluded functioning as a secondary outcome, # Included activation as a secondary outcome, $ In all trials with non-superior outcomes, there were no statistically significant differences between the index and the non-evidence-based comparative group. None of the trials with non-superior outcomes used the inferiority design. Study characteristics, intervention characteristics and effectiveness of standalone BA interventions. The sample size of the eligible studies varied between 60 to 470, with a total of 648 participants across three studies, recruited from clinical and university settings. All three RCTs were conducted in high-income countries (HICs). There was a greater representation of adolescents (compared with young adults) and female participants across studies ( Table 3 ).

The number of intervention elements in standalone BA intervention protocol varied across three studies (Range = 6-12, Table 3 ). BA was delivered as a brief intervention (5 sessions over 5 weeks) in one study that used psychoeducation, activity scheduling, goal setting, self-monitoring, motivation enhancement and relapse prevention to increase and maintain exposure to positive reinforcements for healthy behavior. This intervention did not focus on avoidant behaviors [32] . In the other two studies, BA was delivered as a relatively longer treatment (12-14 sessions) [33, 34] that incorporated a number of additional skills (e.g., problem-solving, functional analysis for countering avoidance, see Box 2) to address avoidance processes and other barriers that interfered with positive behavioral changes. All three interventions were delivered face-to-face, in an individual format, by specialist providers; one intervention was delivered simultaneously in individual and group format. The intervention delivery was supported by a workbook and structured material in two of three interventions [32, 34] . In all three interventions, collaboratively developed and shared home practice assignments were used to facilitate BA skills. The intervention protocol completion rate was high across all three studies (98.4% [32] , 83% [33] and 83% [34] ), with no attrition bias. The other details on format, providers, trainability, session dosage are summarized in Box 2. Depression was the primary target problem in all three studies. Anxiety was a secondary outcome in two studies [33, 34] . Additionally, functioning and activation were assessed as secondary outcomes in three [32] [33] [34] and two studies [32, 34] , respectively. The details of outcome measures are given in the Additional file 2. BA interventions were compared with four groups across three studies and achieved superior outcomes in one comparison (25%) and non-superior outcomes in the three comparisons (75%) ( Table 4 ). In the study that showed superior outcome, the brief, indicated BA intervention was compared to an inactive control group (i.e., clinical monitoring) [34] . The study also found significant intervention effects on measures of activation and functioning. In the remaining two studies [33, 34] , where the relatively longer BA treatments were compared to active interventions, including cognitive behavioral therapy, short-term psychoanalytical therapy and evidence-based practice, the outcomes did not differ significantly between the BA and comparison groups ('non-superior') for depression [33, 34] , functioning [33, 34] and activation [34] . Across three studies, there was a lack of sufficient data to establish valid outcomes on anxiety measures. (2021) 9:150 Study characteristics, intervention characteristics and effectiveness of multicomponent interventions with BA elements. The sample size of the eligible studies varied from 30 to 439 with a total of 2501 participants across 20 studies, recruited from varied settings (school, community, clinics), mostly in high-income countries (HICs). Similar to previous set of studies, there was a greater representation of adolescents and female participants across studies.

The multicomponent interventions were fairly broad and complex, comprising on average 11 (Range 7 to 18; SD = 4.08) intervention elements. The elements of multicomponent interventions are shown in Box 3. As techniques of BA, these interventions typically included generating a list of pleasurable activities, engaging in activities as per the jointly agreed schedule and monitoring its impact on their mood. Additionally, these multicomponent interventions included skill training elements (e.g., problem-solving [n = 12], social skills [n = 10], communication [n = 6] and assertiveness [n = 5]) designed to promote and overcome barriers to changes in targeted cognitions, behaviors and/or feelings. With exception of cognitive elements, most of the other elements were similar to those present in long formats of standalone BA interventions, as described previously [1] . The intervention protocol completion rate varied between 62 to 100%, with a higher attrition rate in digitally delivered intervention. The other details on format, providers, trainability, session dosage are summarized in Box 3. In five papers, this data was missing and, in another two studies, it was explicitly stated that sessions were intentionally varied and thus, it was not included in calculating the median number of sessions * For two trials, duration data was not available, and another two trials explicitly stated that duration was intentionally varied and, therefore, these four trails were not included in the calculation of the median duration Depression was the primary target problem in all 20 studies, and anxiety was a secondary outcome in five studies [35] [36] [37] [38] [39] . Additionally, functioning was assessed in seven studies [40] [41] [42] [43] [44] [45] [46] . The details of outcome measures used for assessing depression, anxiety, and functioning are given in the Additional file 2. The multicomponent interventions were compared with 35 groups and recorded a superior or equivalent outcome in 21 (60%) comparisons on a measure of depression (Table 4) . Outcomes for depression were more favorable when the multicomponent interventions were compared with the waitlist; comparisons of the multicomponent interventions with the active and attention control groups mostly resulted in a lack of significant difference in outcomes. Multicomponent interventions targeting subthreshold depression (indicated interventions) and delivered in group format were more likely to record a superior or equivalent outcome. There was no difference in the intervention length between multicomponent interventions with superior or valid equivalent outcomes and interventions with non-superior outcomes. Superior or valid equivalent outcomes for depression were accompanied by significant improvement in secondary measures of functioning [41, 43] and anxiety in a few studies [37] . None of these multicomponent studies included any focal measure of activation.

A total of 37 eligible studies were identified through two search strategies (Table 1) . Three studies [47] [48] [49] examined young people's experience of participating in an Table 4 Outcome of RCT index group in comparison to the other study groups * For one trial, the intervention duration data was not available and another one explicitly stated that sessions were intentionally varied and, therefore, these two trials were not included in the calculation of median duration NA Not applicable

No. of comparator groups

Waitlist/ no treatment/ attention control intervention with BA: one study [47] focused on 14-session standalone BA intervention that was later evaluated by McCauley and colleagues in a trial [34] ; the second study [48] examined a 10-session multicomponent BA intervention, similar to the intervention protocol evaluated by Clarke and colleagues [42] ; and the third study [49] examined experiences with internet-based multicomponent BA intervention that was later evaluated by Ip and colleagues in a RCT [36] . The remaining 34 studies examined adaptive coping in young people with lived experience of depression and anxiety. The sample size in these studies varied from 8 to 251, with a total of 1524 youth, all from HICs, with an average age of 17.16 years (SD = 1.86). The sample included 65% females. Of 37 studies, 29 were specific to depression, three focused on anxiety, and five focused on both. The other details of these studies on selected variables are presented in Table 5 .

For qualitative and mixed-method studies, the quality of most of the included studies was good (31 of 37 studies [84%] scored in full on the MMAT domains). Six studies had lower scores due to biases such as poor coherence between data sources, lack of clarity on the findings being adequately derived from data, and lack of adequate integration of study components to answer the research questions. The MMAT ratings for individual studies are given in Box 4. Improved functioning 9 "I spend much more time together with other people. Before the course, I just went home and straight to bed. Now, I force myself to socialize with friends and acquaintances … it makes me happy, and I want to do more of the things that make me feel that way …" [48] Challenging aspects Difficulty sustaining change 6 "When you're home, you want to do other things. You don't want to do assignments, which can be boring. When I'm home, I'd rather read a book of my own choosing. " [48] "They [the homework assignments] were okay, there was nothing negative about them. It just took a lot of effort doing them. " [48] Personal responsibility 3 "I felt I got a lot of responsibility for why I was depressed. And in a way, you were sitting there and saying, 'I can't help it, I didn't do it on purpose' . " [48] Aspects for improvement Staggered sessions 5 "Top-up BA sessions following the end of treatment; this may help bridge the gap between reliance on the therapist and independence at home. " [47] Simplified language 2 "Maybe use simpler language, so one can understand it better. I have noticed that there are many technical terms in the assignments. " [48] Themes from lived experience literature on adaptive habitual coping BA's alignment with habitual coping Behavioural strategies 150 "I set myself reminders in my phone (for my academic activities), I used the calendar on my phone, I might physically write things down" [54] "I found it very helpful to separate myself from whatever makes me feel depressed and relax and listen to music. Listening to music has really helped calm me down and forget about my worries. " [51] "I think that…religion might help somebody go to a counsellor or therapist because um…what if God might be telling them that how maybe if they were thinking of hurting they self or killing their self, so they need a counsellor. " [52] Cognitive restructuring 20 "So, I tell myself 'you're okay, you're okay. Stay right here. What can you deal with right now? What is it that is stressing you out? Then you answer back. You have this but you have time. You've always done it before. ' I just reassure myself" [55] Additional strategies to optimize BA Role of social support 173 "My friend reminded me that I wasn't alone. On occasions, she didn't necessarily say that much, but when I was having an anxiety attack, she would give me a hug and we would just sit, and she would help me through it and help me breathe. " [55] "My mother would always come to me whenever a problem was going on. I don't know how. I wouldn't even tell her anything was going on. She would just know something was not right. " [50] Self-acceptance and self-care 85 "When I was younger I just felt stupid, I felt like my feelings weren't valid... and now I'm in a place where I could really identify... like I do struggle with things and that's okay. But there's a way I could struggle that's helpful not hurtful to myself and to my relationships. " [53] "I don't get embarrassed like if I did something wrong. I just get up and try again. Whereas before I wouldn't. " [56] These strategies, in principle, were similar to BA intervention strategies. These strategies included engaging in pleasurable activities, preparing schedules and managing study time, setting reminders for daily tasks, engaging in religious and spiritual activities. Themes from studies on BA interventions indicated that participants liked the structure and content of BA programs and recognized its positive impact on mood and functioning (Table 6 ). YAG members also acknowledged that the strength of BA is in it being a proactive technique that could be "customized to an individual's needs". YAG members highlighted that unlike "talk therapy", the impetus on activities could help "Gives a routine, even during Covid-19 which gives a sense of comfort and normalcy" "Get satisfaction after completing a set number of things/tasks, talk therapy is helpful but doesn't provide these concrete aspects and makes me unsure of my progress"

"Therapist guidance and reminders would be helpful" Improvement in symptoms, coping and functioning 4 "Doing one thing does not do away depression, but helps cope; e.g., just taking a shower makes the entire day better. "

"Better coping, fewer anxiety attacks, being more social"

Challenging aspects Difficulty sustaining change 9 "Temporary-If I do something and feel better now, but how would I feel better over time and contribute to overall wellbeing?"

"Need to find foundational motivation within self for BA activities.

Not everyone can do that, might be too much work, which may not work for everyone, depends on a person's initial capacity and functioning. Every therapy doesn't work for everyone. "

Unintended adverse emotions 3 "Personal responsibility, not being able to complete activities might induce guilt/anxiety" Lacks sensitivity to social and contextual factors 4 "Focus is on individual as responsible -needs cognizance of structures & institutions that cause psychological distress at a systemic level"

"Also depends on the environment-access to some activities, stigma based on gender identity (e.g.: a transman attending the gym, which restroom to use safely etc.)"

Additional strategies Structure of intervention 11 "Give more clarity on key elements in BA, does activity scheduling mean you have to keep adding on more activities until it works if the first few activities don't work?"

"Activities that are more personal rather than pre-decided would be helpful. "

"Consider role of social support, spiritual coping, mindfulness etc. "

"Buddy system or accountability partners included in therapy plan"

Education and dissemination of BA 8 "Also provide MH [mental health] resources for young people, their friends and family is needed"

"If not worded properly, BA can seem like we are blaming the person for having a mental illness but what it really means is that: while the fact that we are depressed/have anxiety is not our fault, how we deal with it is up to us. Depression and anxiety, ultimately, are not crippling or out of our control. Again, not trying to paint this as a mind over matter sort of thing but rather a 'this is something we can learn to cope with' thing. "

The descriptive themes from the thematic synthesis of qualitative studies are summarized and collated under the following analytic themes: (1) Positive aspects (2) Challenging aspects (3) Aspects for improvement (4) BA's alignment with habitual coping (5) Additional strategies to optimize BA ( Table 6 ). The themes identified from workshops with YAG members were also collated using the same framework and are presented in Table 7 .

Evidence from the coping literature indicated that young people habitually used a number of behavioral strategies (over cognitive ones) in their natural environment to alleviate depression and, to some extent, anxiety. young people feel more in control, improve self-confidence, and provide satisfaction with treatment. Therapist guidance in structuring and navigating through the process of activation, collaborative stance, and use of homework assignments were valued by participants from BA intervention program (Table 6 ) and echoed by those in YAG (Table 7) .

In addition to facilitating aspects of BA, participant in these studies identified some barriers and challenges to practice of BA. These included sustaining behavior changes over time, as assigned activities were perceived as strenuous and not to their liking; and a strong emphasis on individual's actions, especially in the psychoeducation component that made a few young people feel that they were individually responsible for 'fixing' themselves (Table 6 ). Both these themes also emerged during YAG discussions (Table 7) .

Themes from qualitative studies and YAG discussion helped identify changes that can be made to improve intervention acceptability. These included using simple language during sessions and in the materials designed for young people; staggering out sessions at the end to sustain the learned techniques; utilization of supportive social networks and connections with peers who had similar lived experiences of mental health; personal acceptance of one's mental health and its management; including activities that are meaningful or important to a person rather than focusing on the prescriptive set of pleasurable activities; and disseminating information about BA in proper manner to avoid misconception around "quick-fix" and "individual's responsibility" ( Table 6, 7) .

During workshops, youth advisors highlighted various domains for future research in LMICs like India. These included the following (not in any particular order of priority): (i) examining the impact and limitations of BA across the range of depression and anxiety disorders; (ii) developing programs to implement and sustain BA interventions in educational settings; (iii) understanding the role of social-contextual factors in the effectiveness of BA; (iv) understanding factors that influence sustained behavioral changes among individuals following participation in the BA program; (iv) effectiveness of BA when delivered in different formats such as individual, groups, and digitally; (v) effectiveness of BA for varying severity and chronicity of problems; (vi) more research and implementation work in LMICs context; (vii) greater involvement of youth in planning interventions and their dissemination.

The study aimed to systematically review quantitative and qualitative studies and synthesize evidence on BA as an active intervention ingredient for addressing depression and anxiety among young people. The synthesis of evidence indicated there have not been sufficient number of good quality studies to establish the true potency of BA. The findings from a limited number of studies have indicated promising outcomes for BA in depression. Standalone BA intervention produced a superior intervention effect when compared to the inactive control condition, and comparisons to active controls showed non-significant differences between BA and other complex psychological treatments. BA has been frequently used as part of multicomponent interventions, which, excluding the cognitive elements, were similar in composition to standalone BA. These interventions similarly showed favorable outcomes, particularly for subthreshold depression (greater number of superior or valid outcomes for indicated interventions than treatment interventions). However, BA's role as an active intervention ingredient was difficult to establish in these interventions in the absence of focal assessment of activation in most studies. There was more robust evidence for the acceptability of BA in accounts by young people with lived experience of depression. Young people appreciated BA intervention programs for impetus on actions that helped improve mood and functioning across domains, notwithstanding certain concerns they had about sustaining behavioral changes and emphasizing individuals' responsibility for change. Young people frequently reported using behavioral strategies similar to BA in their habitual coping, while cognitive strategies were least frequently reported, which further helped strengthen the evidence on the acceptability of BA in this age group. Overall, these findings, in line with the previous reviews [16, 17, 57] , indicate the potential role of BA as an active intervention ingredient for depression among young people.

The current review also examined the characteristics of BA intervention protocols. Findings indicated that BA has been typically used as part of interventions that are fairly complex, comprising multiple behavioral elements that have been used for increasing reinforcements for positive behavior and overcoming challenges towards targeted changes; however, avoidance processes underlying depression have been targeted only in a few interventions. While activity scheduling, monitoring and goal setting have been most frequently used in the BA interventions, evidence synthesis indicated that two skilltraining elements, i.e., problem-solving skills and social networks and support, may play an important role in enhancing the impact of BA for this age group. Problemsolving skills have been most frequently included along with BA in both standalone and multicomponent interventions to facilitate meeting individualized goals and adopting a positive stance to overcoming barriers [e.g., 33, 34, 45] . Unlike problem-solving skills, social networks and support have been given limited attention in existing quantitative studies of BA [e.g., 41, 44] . However, insights from qualitative studies and YAG discussions have strongly indicated the importance of strengthening this element in BA interventions, as sustained behavioral change may be limited where the wider social networks are not taken into account. These are preliminary suggestions based on limited data available about intervention composition. However, as more is learned about behavioral difficulties and processes that underlie depression (such as increasing activation, reducing avoidance, reward processing), it will become increasingly possible to measure the impact of various elements on these processes, which in turn will guide the development of a comprehensive and efficient intervention structure.

We found limited use of standardized tools to assess activation and other BA related skills in this age group. Self-monitoring, on the other hand, was frequently used to examine engagement with activities and their impact on mood. This opens up a debate on the extent to which a standardized tool like Behavioral Activation for Depression Scale (BADS) [58] versus an idiographic measure or ecological momentary assessment derived from selfmonitoring can be used effectively in assessing activation. Existing literature suggests that idiographic measures are typically more sensitive to change than the standardized measures of skills assessment and more reflective of youths' "voices" in identifying and addressing health concerns [59] [60] [61] . Further, technology aids such as mobile app and wearable sensor devices can facilitate ecological momentary assessments and provide easily accessible feedback for youth and providers [62, 63] . Systematic research will be needed on how these measures can be structured throughout the intervention to assess, monitor, and evaluate activation, which in turn, helps build evidence for the role of BA as an 'active ingredient' in youth interventions.

The current review, similar to previous systematic reviews [16] , has found limited evidence on use and acceptability BA on anxiety. However, the focus on avoidance and graded behavioral hierarchies in the recent adaptations of BA [11, 64, 65] , makes it particularly appealing as a transdiagnostic intervention, for both anxiety and depression. Future research needs to examine how the progressive structure of BA can be optimized for heterogenous anxiety problems (generalized anxiety, social anxiety, phobias) that differ in presentation and degree of overlap with depression.

A number of methodological limitations need to be considered when interpreting the findings of the current study. First, there was considerable heterogeneity in the nature of studies and outcomes, which needs to be considered when interpreting the findings from the current review. Second, there was an underrepresentation of young adults (than adolescents), males (than females), and individuals from LMICs (than HICs) and this may limit generalizability to the whole age group of adolescents and young adults across cultures. Third, many of the included studies were published before reporting guidelines (such as PRISMA) existed. Thus, the risk of bias in many studies was high, indicating need for wellpowered, high-quality studies. Fourth, the main PWEBS database focused on samples aged under 21 years and we extracted data on older samples using a supplementary transition age youth database without validated codes. To improve reliability of these codes, two project researchers independently coded these studies and there was good inter-rater reliability for all categories. Fifth, there was the paucity of acceptability studies of BA among young people. We extrapolated findings from studies on coping strategies to offer implications for BA; however, more qualitative studies are needed to understand acceptability concerns from youths' perspective. Lastly, the involvement of YAG in this review was only consultative. The usage of participatory research models and collaborative data analysis can support more meaningful involvement of YAG's as co-analysts in future projects.

The results of the current review provide preliminary evidence and should promote further research on uncovering acceptability, adaptations and effectiveness of BA interventions for depression and anxiety through high-quality randomized control trials and mixed-methods studies. Majority of the existing evidence comes from studies conducted in high-income countries, with females and younger populations (in age range of 14-19 years). It is important to explore how this intervention could be applied in low-resource settings, with males and gender minorities, and young adults, given that specifics of and access to positively reinforcing activities may vary across settings and demographics. Both standalone and multicomponent BA interventions reviewed in this study consisted of multiple behavioral elements arranged in varying sequences across treatment protocols. Conducting dismantling studies will be important for identifying active intervention ingredients in these complex intervention protocols. Dismantling studies (e.g., using Interrupted Time Series and Sequential Multiple Assignment Randomized Trial designs) would enable the comparison of discrete BA elements with complex, multiple component protocols to identify the degree to which specific components add to the effectiveness of intervention and the distinctive mechanisms of change underlying their effectiveness for depression, anxiety or both. Based on current review, some of the clinically relevant topics to be investigated are: benefits of personalizing activity selection and scheduling in implementation of BA, sustaining behavioral changes over time, effectiveness of formats and modalities (individual versus group, face-to-face versus digital); and delivery of BA by non-specialists. There is preliminary evidence from both young people and adult literature that BA delivered through lay-counsellors can be effective and address the supply side of the demand-supply gap in accessing mental health care [6, 7, 47] . Further, as studies indicated BA has relevance beyond formalized therapeutic settings and can be extended to natural environment for facilitating coping with mental health problems. Thus, setting up youth activity clubs based on BA principles is an important area that needs further exploration. These research priorities are not only relevant from a clinical and research perspective but are also in line with YAG's priorities. There may be value in soliciting youth perspectives on what might be effective based on their own life experiences, which may help generate hypotheses about ways to streamline and strengthen interventions that are designed to target their mental health and well-being.

In line with previous reviews [16, 17] , the current rapid review found preliminary evidence for the effectiveness of BA in the treatment of depression, with no evidence for its use in anxiety among young people. There was more robust evidence in accounts of young people for BA as an acceptable coping strategy for improving mood and activity levels. Overall, more research is needed to examine the components and mechanisms that contribute to BA's effectiveness as an active intervention ingredient for depression and anxiety.

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Publisher's Note

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We acknowledge and thank the member of youth advisor group for their valuable inputs. We gratefully acknowledge the members from PracticeWise team who supported the process of data compilation and analysis for randomized control trials. We are thankful to the two anonymous reviewers who helped improve the manuscript's quality by providing valuable inputs.

 Study MMAT Rating (Range 0-7) ++ Arnott, 2020 3 The MMAT rating for each study ranges from 0 to 7, with a higher score indicating good confidence in study findings 

The online version contains supplementary material available at https:// doi. org/ 10. 1186/ s40359-021-00655-x.Additional file 1. Demographics and lived experience of depression and anxiety among members of project's Youth Advisory Group (YAG).

Outcome measures for depression, anxiety, functioning and activation used in RCT studies.

References of all studies included in the review.

Authors' contributions KM drafted the manuscript with critical inputs and revisions from MI, which was reviewed and approved by AB, BC and VP. KM, BC and VP designed the study. MI, AB, RKV, TR and KM were responsible for data extraction and analysis. All authors read and approved the final manuscript.

This work was funded by a Wellcome Trust Mental Health Priority Area ' Active Ingredients' commission awarded to KM at Sangath, India.

All data generated or analysed during this study are included in this manuscript and the additional files.

Permission to conduct this systematic review was obtained from the Managing Committee at Sangath (not-for-profit), India. Paid databases such as PracticeWise and PsychInfo were accessed through a subscription/ fees, as per the respective organizational norms. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institution where the study was conducted (https:// www. sanga th. in/ irb-proce dures/). Consistent with institute's requirements at the time of the study, written assent/ consent was obtained from all youth advisors participating in the project. Additionally, written consent was obtained from parents/ guardians of youth advisors below age of 18 years.

Not Applicable.

KM, MI, RKV, TR, VP declare no competing interests. AB received consulting fees from PracticeWise, LLC, a company that offered services to the database used in this study. BC is a partner in PracticeWise, LLC. Funder's input provided as part of monthly review meetings were incorporated in data analysis and drafting of the final project report. The final content in this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of either the funding organization or of PracticeWise, LLC.