key: cord-0011335-t4r7te2b
authors: Wyffels, Veronique; Kariburyo, Furaha; Gavart, Sandra; Fleischhackl, Roman; Yuce, Huseyin
title: A Real-World Analysis of Patient Characteristics and Predictors of Hospitalization Among US Medicare Beneficiaries with Respiratory Syncytial Virus Infection
date: 2020-02-05
journal: Adv Ther
DOI: 10.1007/s12325-020-01230-3
sha: 0e1fd9ff4ad778d0bbb64fcc82b223856a1344ee
doc_id: 11335
cord_uid: t4r7te2b

INTRODUCTION: Little has been published on respiratory syncytial virus (RSV) among Medicare patients at high risk (HR) of RSV complications due to age or comorbidity. METHODS: Adult patients (at least 18 years of age) with at least 1 diagnostic code for RSV were identified using the 5% US Medicare database from 2011 through 2015. Patients were required to have continuous health plan enrollment for 180 days pre- and 180 days post-RSV diagnosis (baseline and follow-up periods, respectively). HR was defined as diagnosis of chronic lung disease, congestive heart failure, or weakened immune system for 180 days during the baseline period. Patients were categorized as initially hospitalized if hospitalized within 1 day of RSV diagnosis. Logistic regression models were developed to determine predictors of initial hospitalization. Healthcare utilization and costs for 180 days pre- and post-RSV diagnosis were compared. RESULTS: The study included 756 HR patients who were initially hospitalized with RSV diagnoses. Among these, 61.7% were diagnosed in the emergency department vs 15.3% in a physician’s office, with hypertension (76.3%), chronic obstructive pulmonary disease (COPD) (53.7%), and high cholesterol (52.0%) observed as the most prevalent comorbidities. Of these, COPD, congestive heart failure, chronic kidney disease, and previous evidence of pneumonia were significant predictors of hospitalization. Other significant predictors of hospitalization included older age, hematological malignancies, stroke, and baseline healthcare resource use. Among both HR and non-HR hospitalized patients, there was a significant increase in healthcare resource utilization following hospitalization, including the number of inpatient admissions and longer hospital stays post-RSV diagnosis. The total mean all-cause healthcare costs among HR hospitalized patients increased by $9210 per patient (p < 0.0001) post-RSV diagnosis. CONCLUSION: Hospitalized Medicare beneficiaries with RSV infections pose a significant healthcare burden as compared with non-hospitalized patients, mainly driven by higher comorbidity, higher likelihood of multiple inpatient admissions, and costly medical interventions.

Human respiratory syncytial virus (RSV) is common among elderly patients and can cause lower respiratory tract infection (LRTI) including pneumonia, exacerbate congestive heart failure, asthma, or chronic obstructive pulmonary disease (COPD), leading to hospitalization [1] . According to the Centers for Disease Control and Prevention (CDC), 177,000 hospitalizations yearly have been attributed to RSV infections alone among adults aged over 65 years [2] . In general, patients aged 65 years or older had 3-5 times higher hospitalization rates with longer length of stay (LOS), and twice as many emergency department (room) (ER) and ambulatory visits compared to those aged 18--49 years. RSV is also the cause for LRTI in many immunocompromised patients, such as hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients, including lung transplant recipients, and those with leukemia, lymphoma, or other cancer patients receiving chemotherapy, and those with advanced HIV [3] .

At the time of initial presentation to a healthcare provider, it is difficult to differentiate RSV from other respiratory virus infections on the basis of clinical parameters alone; therefore, it is important for healthcare providers to identify the disease so that management of RSV infection can be more effective [4] . Worldwide, no specific treatment for RSV has received marketing authorization for use in adults; therefore, the standard of care is supportive treatment, such as intravenous fluid hydration and oxygen supplementation. The only treatment options with antiviral activity are aerosolized, intravenous, or orally administered ribavirin [5] [6] [7] . Inhaled ribavirin has limited evidence of effectiveness and carries potential risks such as teratogenicity, bronchospasm, or anemia [8] for both the patient and their care providers. While approved in some countries for severely ill young children, the treatment is not generally recommended in pediatric patients [6, 9] . Ribavirin has been used in adult patients, primarily among those who are immunocompromised, but supporting data are limited [10, 11] .

The CDC has classified adult patients aged 65 years and older and those with chronic cardiac or pulmonary disease or weakened immune systems as high-risk patients who are more likely to experience serious complications due to RSV-related infection and have a higher risk of mortality [12] . Elderly patients are also more prone to RSV infections due to their decreased immunologic response to the virus [13] . The morbidity, mortality, and economic burden of RSV may therefore also be driven through the exacerbation of underlying illness as well as the infection itself [14, 15] . Current research on healthcare resource utilization of RSV-related infection focuses mainly on either pediatric or adult patients with private healthcare insurance [16] [17] [18] . Less has been published on healthcare utilization and burden of disease among elderly Medicare patients diagnosed with RSV-related infections in the USA. To address these data gaps, the purpose of this study was to identify characteristics of adult RSV-infected patients in the inpatient and outpatient setting as well as predictors of hospitalization, and to describe the current clinical and economic burden of RSV among elderly Medicare patients in the USA.

This real-world observational study was conducted using the Medicare 5% national sample administrative database from January 2011 through December 2015. All patient identifiers in the database have been fully encrypted; therefore, neither institutional review board approval nor consent was necessary for this study, as it was conducted in the USA with depersonalized claims data and does not meet criteria for studies with human participants; it is therefore exempt from approval per the provision for unidentifiable personal data in the Federal Policy for the Protection of Human Subjects (1991).

The Medicare claims data files used for this study included inpatient and outpatient (Parts A and B), Medicare carrier, prescription (Part D) drug events, skilled nursing facility (SNF), home health agency (HHA), hospice, durable medical equipment (DME), and the Medicare denominator file, which contains demographic and enrollment information of Medicare beneficiaries.

Patients with a medical claim for RSV diagnosis (International Classification of Disease, Ninth Revision, Clinical Modification [ICD-9-CM] codes 079. 6, 466.11, 480 .01 and ICD-10-CM codes B97.4, J20.5, J12.1, J21.0) were identified between July 1, 2011 and June 30, 2015. The date of the first observed RSV diagnosis during this period was designated as the index date.

Patients were required to be aged 18 years or older at the time of diagnosis, with continuous Medicare medical and pharmacy benefits for at least 180 days prior to the index date (baseline period) and at least 180 days after the index date (follow-up period). Patients who died during the follow-up period were also included in the study. Patients were excluded if they had an RSV diagnosis during the baseline period or an influenza or human metapneumovirus (hMPV) diagnosis during the study period. Patients were categorized as hospitalized if they were diagnosed with RSV during hospitalization or hospitalized within 1 day of RSV diagnosis. The hospital admission date was captured as the start of the index hospitalization.

Among patients who were hospitalized, participants were further categorized as high-risk and non-high-risk patients. High-risk patients were identified if they met any of the following criteria: diagnosis of chronic lung disease (including asthma and COPD), prior pneumonia, congestive heart failure (CHF), or immune compromise on or within 180 days before the date of RSV diagnosis. A patient was considered to be immunocompromised if they had evidence of SOT, HSCT, or hematological malignancies (leukemia, lymphoma, and plasma cell neoplasms). All conditions were identified using ICD-9-CM and ICD-10-CM codes. The nonhigh-risk patients were the remaining hospitalized patients in the study population.

Patients were categorized as outpatients if they were diagnosed with RSV in the outpatient setting and not hospitalized within 1 day of diagnosis. Patients diagnosed in the outpatient setting were also categorized into high-risk and non-high-risk cohorts.

Baseline patient demographics including age, sex, US geographic region, comorbidities, and setting of diagnosis during the 180 days prior to the index date (baseline period) were assessed for all patients. The diagnosis setting included ER (combined ER and/or inpatient setting), physician's office, or other Medicare settings (DME, HHA, hospice, SNF). Among outpatients, patients were further classified as later hospitalized (diagnosed in the outpatient setting and hospitalized at least 2 days from index diagnosis) or never hospitalized. Comorbidities including HSCT, SOT, hematological malignancies, stroke, osteoporosis, anxiety, asthma, cancer, depression, osteoarthritis, chronic kidney disease (CKD), coronary artery disease (CAD), CHF, diabetes, high cholesterol, COPD, hypertension, and previous evidence of pneumonia were identified using ICD-9-CM or ICD-10-CM codes during the baseline period (6 months prior to the index date).

Complications, all-cause mortality, death during inpatient stay, and 30-day readmission rates during the follow-up period were evaluated. Complications of interest-respiratory failure, chest pain, hypoxia, cardiac arrhythmia, cough, myocardial infarction, dyspnea, pneumonia, lower and upper respiratory tract infection (excluding influenza, RSV, and hMPV)were identified using ICD-9-CM and ICD-10-CM codes. The proportion of patients who were discharged to an SNF as well as LOS in an SNF were also evaluated.

All-cause healthcare utilization and costs during the pre-(baseline) and post-index (follow-up) periods were analyzed, including hospital LOS, number of office visits, pharmacy use, ER, inpatient (and hospital LOS across all hospitalization), and outpatient visits. Costs were adjusted to 2015 US dollars using the medical care component of the Consumer Price Index (CPI).

All baseline and outcome variables were analyzed descriptively. Percentages and counts were provided for categorical variables. Means and standard deviations (SDs) were computed for continuous variables. Healthcare costs and utilizations were analyzed descriptively and compared between 180 days pre-and post-RSV diagnosis. Bivariate comparison between preand post-index date periods were made using a paired t test to evaluate the statistical significance for continuous variables, including average number of resource utilization and costs.

Multivariate logistic regression was conducted to examine potential predictors of hospitalization among hospitalized patients vs those who were never hospitalized. Purposeful model selection was used to identify variables to be included in the logistic regression. First, all independent variables with p \ 0.25 in bivariate testing were initially included in the model. Secondly, variables with p [ 0.10 were dropped from the model sequentially unless they were identified as confounders (i.e., variables that, when dropped from the model, resulted in at least a 20% change in parameter estimates for 1 or more of the other variables, when compared to the original model). The final model included confounders, variables that had p B 0.10, and high-risk conditions. Covariates in the final model included demographics, comorbidities, previous evidence of pneumonia, number of conditions, and the number of inpatient and ER visits during the baseline period.

Statistical analyses were conducted using the Statistical Analysis System (SAS) v.9.3. (Cary, North Carolina, USA). The threshold for p value significance was set at a-level 0.05 for pre-post analysis and logistic regression.

A total of 3510 patients diagnosed with RSV were identified from the Medicare 5% national sample administrative database. Figure 1 shows the selection criteria to identify patients with RSV. After the inclusion and exclusion criteria were applied, the final analytical sample comprised 1795 patients, including 793 (44.2%) patients who were hospitalized (within 1 day of RSV diagnosis), 835 (46.5%) diagnosed in the outpatient setting (not hospitalized within 1 day of RSV diagnosis), and 167 (9.3%) diagnosed in other Medicare settings (DME, HHA, hospice, SNF). The study population included 756 (42.1%) high-risk patients who were initially hospitalized and 37 (2.1%) non-high-risk patients who were hospitalized. Among patients diagnosed in the outpatient setting, 399 (47.8%) were classified as high-risk patients, whereas 436 (52.2%) were classified as nonhigh-risk patients. Among patients diagnosed in the outpatient setting, 140 (16.8%) were later hospitalized (i.e., hospitalized after 1 day of RSV diagnosis) and 695 (83.2%) of patients were never hospitalized during the follow-up period (Fig. 1 ).

Patient characteristics and diagnosis setting are summarized in Table 1 . Among hospitalized highrisk patients, 61.7% were diagnosed in the ER setting, whereas 15.3% and 23.0% were diagnosed in a physician's office or other Medicare settings, respectively. On average, high-risk hospitalized patients were older (mean age 77 years; SD 13.4 years) than those who were not hospitalized (mean age 74 years; SD 14.5 years). Most of the total sample population were female patients residing in the southern US region. Of high-risk patients initially hospitalized, hypertension (76.3%), COPD (53.7%), high cholesterol (52.0%), diabetes (41.1%), CHF (41.1%), CAD (39.8%), CKD (31.0%), and previous evidence of pneumonia (42.3%) were among the most prevalent comorbid conditions during the baseline period. These conditions were also the most common comorbidities occurring among high-risk patients in the outpatient cohort ( Table 1) . (Fig. 2) . (77.2%), dyspnea (74.7%), and arrhythmias (51.1%) were predominant complications among high-risk hospitalized patients. These conditions were also the most common complications among hospitalized non-high-risk patients and high-risk outpatients. The complication rates were much lower in non-highrisk outpatients (Fig. 3) .

Outcomes are described in Table 2 . Mortality and readmission rates were highest in the highrisk hospitalized patients (Table 2) . Deaths during inpatient stay (hospitalization) occurred among 4.2% of the high-risk hospitalized patients and 0% among hospitalized non-highrisk patients. The all-cause mortality within 30 days of RSV diagnosis was 13.4% among highrisk hospitalized patients and 8.1% among hospitalized non-high-risk patients. Among highrisk patients discharged from a hospital, 24.7% were discharged to an SNF with a mean LOS of 7.8 days; of those, 71.1% did not reside in an SNF prior to hospitalization, whereas 13.5% of hospitalized non-high-risk patients were discharged to an SNF with a mean LOS of 5.1 days and 80% of those did not utilize an SNF prior to hospitalization. The 30-day hospital readmission rate was 20.4% and 16.2% for hospitalized high-risk and non-high-risk patients, respectively (Table 2) . Similarly, hospitalized non-high-risk outpatients incurred an increased number of inpatient visits (from 0.6 to 1.9 visits; p \ 0.001) and prolonged LOS (from 3.1 days to 11.4 days; p \ 0.001) following the RSV diagnosis. A significant difference in healthcare visits was not observed between the pre-and post-RSV diagnosis period among high-risk outpatients. However, as compared with the pre-RSV diagnosis period, incremental increases in the number of inpatient (from 0.1 to 0.2; p = 0.028), outpatient (from 10.8 to 12.3; p \ 0.001), and pharmacy visits (from 11.9 to 12.6; p = 0.029) were observed post-RSV diagnosis among non-high-risk outpatients.

Total average per patient all-cause healthcare costs increased by $9210 (p \ 0.001) for highrisk hospitalized patients, $19,141 (p \ 0.001) for hospitalized non-high-risk patients, and $2072 (p \ 0.001) for non-high-risk outpatients. Total average per patient all-cause healthcare costs were similar ($1610) for high-risk outpatients (p = 0.252). The primary cost drivers were related to all-cause hospitalization costs, which increased for hospitalized high-risk patients (from $16,604 to $23,172; p \ 0.001), hospitalized non-high-risk patients (from $6365 to $21,810; p \ 0.001), and outpatient non-highrisk patients (from $922 to $1940; p = 0.009) during the follow-up period (Table 3) .

To our knowledge, this is the first study to identify characteristics of adult patients with RSV in the inpatient and outpatient setting and Our study demonstrates that hematological malignancies, number of inpatient visits prior to hospitalization for RSV and chronic kidney disease (CKD), previous evidence of pneumonia (during the baseline period), congestive heart failure (CHF), stroke, and older age were among the predictors of hospitalization. All-cause mortality among high-risk hospitalized patients was 4.2% during inpatient stays and 13.4% within 30 days of diagnosis. Among high-risk and non-high-risk hospitalized patients, there was a significant increase in healthcare resource utilization including the number of subsequent inpatient admissions and longer hospital stays post-RSV diagnosis, as compared with nonhospitalized patients. The total mean all-cause healthcare costs among high-risk hospitalized and non-high-risk hospitalized patients increased by $9210 (p \ 0.0001) per patient and $19,141 (p \ 0.001) per patient post-RSV diagnosis, respectively. RSV leads to in significant morbidity and mortality, with 14,000 reported deaths, and more than 177,000 hospitalizations annually in the USA among adults 65 years of age and older [2] . In addition, elderly patients with underlying high-risk conditions are prone to complications related to LRTIs, resulting in prolonged hospitalization, and therefore potentially death [15, 19, 20] . Although RSV typically presents with mild cold-like symptoms, RSV can sometimes lead to more severe complications including LRTI, pneumonia, and exacerbation of underlying conditions such as CHF, asthma, and COPD [21] [22] [23] [24] [25] . Similarly, most hospitalized high-risk patients in our study were older (average age 77 years) and diagnosed with LRTI (84.3%, excluding influenza, RSV, or hMPV), and had previous evidence of pneumonia Most available research on the economic burden of RSV in the USA predominantly focuses on infants or adult patients in private insurance populations that largely comprise patients less than 65 years of age. These studies highlight the increased burden of RSV due to the higher utilization of healthcare resources including intensive care and ventilator support, and the costs incurred as a result of underlying conditions [26] . In a study by Han et al., the annual total costs related to RSV pneumonia hospitalization in all elderly patients aged 65 years and older were estimated in the range of $150-680 million [27] . Pastula et al. also indicated that the average hospitalization costs associated with RSV infection among all adults in the USA were $38,828 [28] . Amand et al. found that the incremental differences in adjusted annual healthcare costs between patients with and without RSV was higher among patients aged 65 years and older ($12,030-23,194 ) than among those aged less than 65 years old ($2251-5391) [18] . The current analysis observed significant increases in medical resource utilization after RSV diagnosis, including an increase in the number of subsequent inpatient admissions and prolonged hospital LOS among high-risk hospitalized patients. The higher resource utilization observed in this study also translated to increased healthcare costs. Total mean all-cause healthcare costs per patient increased by $9210 per patient (p \ 0.0001) for high-risk hospitalized patients, $19,141 (p \ 0.001) for hospitalized non-high-risk patients, and $2072 (p \ 0.001) for non-high-risk outpatients from the baseline period to the follow-up period, while hospitalization costs were the main cost driver (57%). This is consistent Amand et al.'s findings that patients 65 years of age and older had 3-5 times more hospitalizations as compared with those aged 18-49 years.

ER visits, hospitalizations, ICU admissions, and death due to respiratory complications play an important role in the clinical burden of RSV infection. Emergency departments are especially likely to be the first point of care for patients with RSV. Overall, 4.2% of the admitted high-risk patients died during an inpatient stay and 13.4% within 30 days of diagnosis. At discharge, 24.7% of the admitted high-risk patients in the current study were discharged to an SNF where they remained on average for 7.8 days. Among high-risk patients discharged to an SNF, 71.1% did not reside in an SNF prior to hospitalization. The burden of an RSV outbreak is high in long-term care facilities such as SNFs [29] .

Despite the substantial disease burden, the importance of RSV may not be recognized by admitting physicians, and RSV management may not be initiated promptly. This may impact health outcomes among elderly patients, increasing the burden of their disease. Rapid identification of RSV may influence decisionmaking for treatment, which in turn can [30] [31] [32] . Rapid molecular tests for viral pathogen detection have been shown to decrease hospital LOS [32] . It is important for attending physicians to identify patients with RSV who require more than the current standard of care at the time of diagnosis. The results of this study demonstrate that hematological malignancies, the number of inpatient visits, CKD, pneumonia, CHF, CAD, stroke, and older age were predictors of hospitalizations, which may help healthcare providers to treat high-risk patients more effectively.

Certain limitations should be acknowledged regarding the results of this study. As with all retrospective claims analyses, the study utilized claims data that were primarily coded for administrative purposes rather than clinical accuracy, and was therefore susceptible to coding errors and diagnosis discrepancies. In claims database analysis, only associations rather than casual inferences can be inferred. In this study specifically, the RSV diagnosis was captured on the basis of ICD-9/10-CM codes and not diagnostic testing. This methodology may have led to the underestimation or overestimation of the actual number of RSV cases, as there could be an inherent difficulty of distinguishing between RSV and RSV-like illness, although we did exclude patients with influenza and hMPV to get a more exclusive sample of patients with RSV. Complications were identified as conditions that occurred 6 months following an RSV diagnosis date (ICD-9/ICD-10 codes); therefore, we could not ascertain whether the conditions were an actual complication of RSV or a progression of an underlying disease that may have been exacerbated as a result of RSV. In addition, RSV complications related to the disease progression or exacerbation of underlying chronic conditions such as COPD or CHF were not captured because of the lack of relevant diagnostic codes in the data. Therefore, we might have underestimated the rate of complications in this population. We also could not distinguish between community-acquired and hospital-acquired RSV infection because of lack of ICD codes to differentiate between 2 settings. Moreover, this study used a fee-for-service (FFS) Medicare database that includes information on Medicare FFS beneficiaries only (approx. 69% of Medicare beneficiaries in 2015) [33] , which may limit the generalizability of the study results to patients with commercial insurance plans.

Hospitalized Medicare beneficiaries with RSV infections pose a substantial burden on the healthcare system, primarily due to comorbidities that require more intensive management related to RSV-mediated exacerbations, a higher likelihood of multiple inpatient admissions, and costly medical interventions, such as ICU admission and/or mechanical ventilation. Emergency departments and general wards are likely to be the first point of care for these patients. This study demonstrates a significant burden of RSV among elderly patients that is consistent with existing literature. The incremental all-cause total healthcare costs were estimated at $9210 post-RSV diagnosis, compared to pre-RSV diagnosis, for high-risk hospitalized patients.

RSV-infected elderly patients with high-risk underlying conditions experience greater morbidity and generate a substantial economic burden to the healthcare system. The findings from this research may help policymakers, healthcare providers, and other stakeholders in identifying patients at highest risk for hospitalization, morbidity, and mortality, so as to make more informed decisions regarding RSV management.

the data in this study and take complete responsibility for the integrity of the data and accuracy of the data analysis.

Authorship. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Medical Writing, Editorial, and Other Assistance. Research assistance in the preparation of this article was provided by Janvi Sah of SIMR, LLC. Editorial assistance was provided by Michael Kane of SIMR, LLC. This assistance was funded by Janssen Scientific Affairs, LLC.

Kariburyo is an employee of SIMR, LLC, a paid consultant to Janssen Scientific Affairs, LLC. Veronique Wyffels and Sandra Gavart are employees of Janssen Pharmaceutica NV and might be stockholders of Johnson & Johnson. Roman Fleischhackl is an employee of Janssen-Cilag Pharma and might be a stockholder of Johnson & Johnson. Huseyin Yuce has no potential conflicts to declare.

Compliance with Ethics Guidelines. Since the core study did not involve the collection, use, or transmittal of individual identifiable data, institutional review board approval was not required, as data that is de-identified a priori is exempt from the Federal Policy for the Protection of Human Subjects ([1991]; 45CFR46.101(b)(4): Existing Data & Specimens-No Identifiers), and further, does not meet the identification criteria necessary to be privileged under the Health Insurance Portability and Accountability Act of 1996 (HIPAA). Nonetheless, both the data set and the security of the premises where we kept the data set meet the requirements of HIPAA, and by default, this study is in accord with the same.

Data Availability. The datasets generated and analyzed during the current study are not publicly available due to a data licensing agreement with the Centers for Medicare & Medicaid Services (CMS).

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Funding. This study was funded, without restriction, by Janssen Scientific Affairs, LLC, including all expenses and fees associated with publication. All authors had full access to all of