key: cord-0011228-z02kt8jt
authors: Rezoagli, E.; McNicholas, B.; Pham, T.; Bellani, G.; Laffey, J. G.
title: Lung–kidney cross-talk in the critically ill: insights from the Lung Safe study
date: 2020-02-24
journal: Intensive Care Med
DOI: 10.1007/s00134-020-05962-2
sha: c146d8e5c96ccdbef125fa4e4688527119b16c73
doc_id: 11228
cord_uid: z02kt8jt

nan

Dear Editor, We read with interest the consensus report on lung-kidney 'cross-talk' in the critically ill by Joannidis and colleagues arising from the 2018 Acute Disease Quality Initiative (ADQI 21) workshop [1] . The report identified key knowledge gaps in our understanding of the mechanisms underlying lung-kidney cross-talk and prioritised research initiatives to address these gaps [1] .

Since the AQDI conference, we published a secondary analysis of the LUNG SAFE study [2] , which found that even mild-moderate AKI was associated with a substantial increase in mortality, highlighting the importance of these issues [3] . We wish to highlight some insights from that analysis, and provide additional analyses regarding the role of lung-kidney cross-talk as an injury mechanism [3] .

In the LUNG SAFE Cohort, AKI and ARDS generally developed contemporaneously rather than sequentially. AKI occurred at or within 48 h of ARDS development in 765 (39%) of 1974 ARDS patients, with a further 4.3% developing AKI on days 3-7 of ARDS. Of the 228 AKI patients (30%) that received RRT, 62% commenced within 48 h, 29% between days 3 and 7, and 9% between days 8 and 28 following ARDS development. Reassuringly, the impact of AKI on the ventilatory management of patients with ARDS appeared limited. Specifically, despite the presence of acidosis in patients with AKI, there were no differences in arterial CO 2 tension, or in tidal or minute ventilation between the groups. While our data do not exclude the potential for an impact of AKI on lung function, it does appear that 'protective' ventilatory strategies were prioritized over attempts to compensate for pH status.

A multivariate analysis of risk factors for early AKI (i.e. in the two first days of ARDS) in patients with ARDS suggests that the impact of ARDS on the development of AKI was limited (Table 1) . Specifically, no association was found between ventilatory variables (i.e. tidal volume, total respiratory rate, FIO 2 , PEEP,) or indices of lung injury severity (i.e. peak inspiratory pressure and PaO 2 / FiO 2 ) and the presence of AKI. Of importance, this analysis identified known ' ARDS risk factors' such as sepsis [4] , non-cardiogenic shock, TRALI and pancreatitis, as independent risk factors for AKI. The presence of shock was also associated with AKI development. This analysis suggests that these factors constitute common underlying injury mechanisms that drive the concomitant development of organ failures, including AKI and ARDS, in the critically ill.

In conclusion, the spatio-temporal relationships regarding acute lung and kidney failure in the critically ill remain poorly understood [5] . In the LUNG SAFE cohort, AKI and ARDS frequently evolved contemporaneously and early in the course of critical illness, likely driven by common underlying pathophysiologic processes. Our findings did not support a central role for lung-kidney 'cross talk' in mediating early AKI in patients with ARDS, with no evidence that the presence of AKI impacted ARDS management, or that the ventilatory management or ARDS severity was associated with risk of AKI development. These findings do not preclude a role for lungkidney cross-talk in the development of AKI later in the course of ARDS, or for ARDS to negatively impact the resolution of AKI. A better understanding of the roles of shared underlying risk factors such as sepsis, the overall severity of critical illness, hemodynamic instability and *Correspondence: john.laffey@nuigalway.ie 2 Regenerative Medicine Institute (REMEDI) at CÚRAM Centre for Research in Medical Devices, Biomedical Sciences Building, National University of Ireland Galway, Galway, Ireland Full author information is available at the end of the article

Variables with a P value < 0.20 at the univariate analysis were included into a multivariable logistic regression model using a stepwise selection approach. Statistical significance was considered with a P value < 0.05 (two-tailed). No ventilator variables (i.e. tidal volume per predicted body weight, total respiratory rate, peak inspiratory pressure, PEEP, PaO 2 /FiO 2 and FIO 2 ) selected at the univariate analysis was significant in the multivariate model n = 1765 BMI body mass index, SOFA sequential organ failure assessment, TRALI transfusion related acute lung injury, COPD chronic obstructive pulmonary disease 

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