key: cord-0009257-s6s24wv3 authors: nan title: Pharmaceutical applications date: 2004-08-26 journal: Curr Opin Biotechnol DOI: 10.1016/0958-1669(92)90020-j sha: dc91dd2b0be757c23b89f5e9da09dd3a0bf0bb37 doc_id: 9257 cord_uid: s6s24wv3 nan Antigen, Devoid of the S-Protein. Biocbem J 1991, 276:411-416 Synthesis and Conformational Studies of N-Glycosylated Analogues of the HIV-1 Principal Neutralizing Determinant Characterization of Immllnodominant Epitopes of Gag and Pol Gene-Encoded Proteins of Human T-Cell Lymphotropic Virus Type-I Neutralizing Activity of Anti-Peptide Antibodies Against the Principal Neutralization Domain of Human Immunodeficiency Virus Type Immllnogentc Outer-Membrane Proteins of Haemophilus-Influenzae Type-b in Infection Replication of Human Immunodeficiency Virus Type-1 in Primary Dendritic Cell Cultures Identification of an Immunodominant Epitope within the Phosphoprotein of Rabies Virus that is Recognized by Both Class 1 Restricted and class 11 Restricted T Cells Unrestricted Replication to Human Cytomegalovirus in Hydrocortisone Treated Macrophages The Cytopathic Effect of HIV is Associated with Apoptusis Subunit-selective Mutagenesis Indicates Minimal Polymerase Activity in Heterodimer-associated PS1 I-IlV-1 Reverse Transcriptase HISCO1TJ: Differential Response of Human Interferon-beta Promoter Elements to Trans-Activation by HSV-VP16 and IRF-1. Virology Simultaneous Transient Expression Assays of the Trypanosomatid Parasite Leishmania Using Beta-Galactoaldase and Beta-Glucuronidase as Reporter Enzymes nonlaill Structure of the Human Immunodeficiency Virus Reverse Transcriptase The Mygromycin-B-Resistance-Encoding Gene as a Selectable Marker for Stable Transformation of Trypanosoma-BruceL Gene Nonrandom Distribution of Gp120 N-linked Glycosylation Sites Important for Infectivity of Human lmmunodeficiency Virus Type 1 TAP-29 -an Anti-Human Immunodeticiency Virus Protein from Trichosanthes-Kirtlowli that is Nontoxic to intact Cells A New class of Anti-HIV Agents -GAP-31, DAP-30 and DAP-32 Human Immllnodefieiency Virl~ (HIV) Type-1 can Superinfect H1V-2Jnfected Cells -Pseudotype Virions Produced with Expanded Cellular Host Range Structure-Function Relationships of Curaremimetic Neurotoxin Loop-2 and of a Structurally Similar Segment of Rabies Virus Glyeoprotein in Their Interaction with the Nicotinic Acetylcholine Receptor Antibody-Mediated Clearance of Alphavirus Infection from Neurons Recombinant Human Granulocyte-macrophage Colonystimulating Factor Ameliorates Zidovlldineinduced Neutropenia in Patients with Identification of Posttranscriptionally Active Inhibitory Sequences in Human Immunodeficicncy Virus Type 1 RNA -Novel Level of Gene Regulation The Naive • Repertoire of Human T Helper Cells Specific for Gp120 the Envelope Glycoprotein of HlV BHRF1 the Epstein Barr Virus Gene with Homology to Bc12 is Dispensible for Lymphocyte B Transformation and Virus Replication I-HV-1 Tat Protein Promotes Formation of More Procassive Elongation Complexes Purification and Characterization of Human Imnlunodeficiency Virus Type-1 Nef Gene Product Expressed by a Recombinant Baculovirus Invitro Activation of Transcription by the Human T-Cell laeukemla Virus Typc-I Tax ProteIn The SCID Hu Mouse: a Small Animal Model for HIV Infection and Pathogenesis. Annu Rev lmmuno11991 Synthetic Recombinant Vaccine Expressing Influenza Haemaggiutinin Epitope in Salmonella Flagellin Leads to Partial Protection in Mice The Mucosal Immune System -from Fundamental Concepts to Vaccine Development Protection of Mice from Lethal Influenza by Defective Interfering Virus -T-Ceil Responses Expression of Foreign Epitopcs on Recombinant Occlusion Bodies of Baculoviruses Inhibition of Transcription of HIV-1 in Infected Human Cells by Oligodeoxynueleotides Designed to Form DNA Triple Helices Invitro Mutational Analysis of Cis Acting RNA Translational Elements within the Poliovirus Type 2 5' Untranslated Region Influenza Immunization -Intranasal Live Vacelnia Recombinant Contrasted with Parenteral inactivated Vaccine Replication of Adeno-Assoclated Virus Type-2 in Hnman Lymphocytic Cells and Interaction with HIV-1 Analysis of HIV Particle Formation Using Transient Expression of Subviral Constructs in Mammalian Cells A Controlled Trial of Gancielovir to Prevent Cytoraegalovtrus Disease after Heart Transplantation The Threedimensional Structure of Reovirus Obtained by Cryo-electron Microscopy Rabbit Hemorrhagic Disease virus -Molecular Cloning and Nueleotide Sequencing of a Callcivirus Genome How Good is HlV Envelope Glycoprotein Vaccine as a T-lymphocyte Stimulant? Selective Activation of a Discrete Family of Endogeneous Proviral Elements in Normal BALB/c Lymphocytes Potential use of Human Stem Cell Factor as Adjunctive Therapy for Human Immunodeficiency Virus-related Cytopcnias Vaccine-Induced CD4+ T-Cells Against the Simian Immunodefieiency Virus Gag Protein -Epitope Specificity and Relevance to Protective Immunity. J lmmuno11991 The Establislxment of Rodent Cell Lines Persistently Producing H1V-1. Virolog~y Intravenous lmmtme Globulin for the Prevention of Bacterial Infections in children with Symptomatic Human Immunodeficiency Virus Infection Cardioviral Internal Ribosomal Entry Site is Functional in a Genetically Engineered Dicistronic Polivirus Cell-free, De Novo Synthesis of PoHovirus Direct Measurement of Soluble CD4 Binding to Human Immlmodeficiency Virus Type-1 Virions -Gp120 Dissociation and Its Implications for Virus-Cell Binding and Fusion Reactions and Their Neutralization by Soluble CD4 N1NG PA: Construction of Plasmid Vectors with a Non-Antibiotic Selection System Based on the Escherichla-Coli ThyA+ Gene -Application to Cholera Vaccine Development Adoptive Transfer of Human Lymphoid • Cells to Severely Immunodeficient Mice: Models for Normal Human Immune Function Autoimmunity, Lymphomagcnesis and AIDS Nuclear Factor I Enhances Adenovirus DNA Replication by increasing the Stability of a Preinitiation Complex Human Immunodeflciency virus Type 2 Envelope Glycoprotein -Differential CD4 interactions of Soluble Gp120 Versus the Assembled Envelope Complex Composition of the Helical internal Components of Influenza Virus as Revealed by Immunogold Labeling/Electron Microscopy A Novel Cis Acting Element that Controls Transcription of Human lmm*modeficiency Virus Type 1 DNA Depending on Cell Type A Chemically Defined Synthetic Vaccine Model for ltlV-1 Topological Analysis of the Hepatitis-B Virus Core Particle by Cysteine-Cysteine Cross-Linklng New Antiviral Strategy Using Capsid Nuelease Fusion Proteins Identification of Cis-Acting Intron and Exon Regions in Influenza Virus NS1 Messenger RNA that Inhibit Splicing and Cause the Formation of Aberrantly sedimenting Presplicing Complexes Synthetic Peptides and Anti-Pcptide Antibodies as Probes to Study interdomain Interactions Involved in Virus Assembly -the Envelope of the Human lmmunodeficiency Virus (I-IIV-1) Structural and Functional Analysis of the Ribosome Landing Specifically Block Human Immunodeficiency Virus Type-1 Replication Primate Responses to a Vaccinia-Rabies Glycoprotein Recombinant Virus Vaccine Comparative Study of the T-cell Response to Two Allelic Forms of a Malarial Vaccine Candidate Protein Synthesis of Cluster Sialoside Inhibitors for Influenza Virus Biological Characterization of Nonin£ectious HIV-1 Particles Lacking the Envelope Protein Recombinational Analysis of a Natural NoncTtopathie Human Immunodeficiency Virus Type 1 (mv-1) Isolate -Role of the Vif Gene in HIV1 Infection Kinetics and Cytopathicity Targeted Integration of Adeno-associated Virus (AAV) into Human Chromosome 19 The Efficacy in Navajo Infants of a Conjugate Vaccine Consisting of Haemophilus-Inlluenzac Type-b Polysaccharide and Neisseria-Meningitidis Outer-Membrane Protein Complex Identification of the Region Including the Epitope for a Monoclonal Antibody Which can Neutralize Humnn Parvovirus-B19 Cell-to-Celi Spread of ItIV-1 Occurs Within Minutes and May not Involve the Participation of Virus Particles Conformational Changes • Induced in the Human Immuflodeflciency Vir~s Envelope GlycoproteIn by Soluble CD4 Binding. f Exp Med Safety and Immunogenicity of Pseudomonas Aeruginosa Conjugate a Vaccine in Cystic Eibrosis Phagocytosis of Nanopat'tietes by Human Immunodeficiency Virus (HlV)-lnfected Macrophages -a Possibility for Antiviral Drug Targeting Safety of MG Made from HCVantibody-screened Plasma The Quest for Vaccines Against AIDS -Progress and Challenges -an Overview Preparation of Candidate Vaecinia-Vectored Vaccines for I-Iaemorrhagic Fever with Renal Syndrome Cloning of an NF-gB Subunit Which Stimulates HIV Transcription in Synergy with Reactive OxFgen Intermediates as Apparently Widely used Messengers in the Activation of the NF-KB Transcription Factor and HIV-1 The S Protein of Bovine Coronovirus is a Hemaggiutinin Recognizing 9-0 Acetylated Sialic Acid as a Receptor Determinant HTLV-1 Envelope Sequences from Brazil, the Caribbean, and Romania -Clustering of Sequences According to Geographic Origin and variability in an Antibody Epitope Analysis of DNA Restriction Fragments and Polymerase Chain Reaction Products Towards Detection of the AIDS (HIV-1) Virus in Blood Mechanism of Translation of Monocistronic and Mutlicistronic Human Imunodeficiency Virus Typed MRNAs Rctroviral Nucleocapsid Protein Specit~cally Recognizes the Base and the Ribose of Mononucleotides and Mononucleotide Components Use of Inactivated or Oral Poliovirus Vaccine in India Protection of Macaques with a Simian Immunodeflciency Virus Envelope Peptide Vaccine Based on Conserved Human Immunodeficiency Virus Type 1 Sequence Reversed Siderophores Act as Antlmalarial Agents Two Distinct Nuclear Transcription Factors Recognize Loop and Bulge Residues of the HIV-1 TAR RNA Hairpin Generation of a Chimeric Human and Simian Immunodeficiency Virus Infectious to Monkey Peripheral Blood Mononuelear Cells New Human Gene Encoding a Positive Modulator of HIV Tat-Mediated Transactivation Development of Immunogenic Recombinant Oka Varicella Vaccine Expressing Hepatitis-B Virus Surface Antigen Retraction: Target Platelet Antigen in Homosexual Men with Immune Thrombocytopenla Safety and Immunogenieity of Hydrogen Peroxide-Inactivated Pertussis Toxoid in 18-Month-Old Children A CD Strategy for the Study of Polypeptide Folding Unfolding -a Synthetic Footand-Mouth Disease Virus Immunogenic Peptide Oral Immunisation Against Typhoid Fever in Indonesia with Ty21A Vaccine Discontinous Sequence Change of Human Immunodeficinecy Virus (H1V) Type 1 Env Sequences in plasma Viral and Lymphocyte Associated Proviral Populations Invivo = Implications for Models of HlV Pathogenesis Prevention of Human Immunodeficiency Virus Type 1 Integrase Expression in Escherichia Coli by a Ribozyme Immunogiobulin-A-induced Shift of Epstcin-Barr Virus Tissue Tropisnx Science Ribavirin and HIV Localization of a Polynucleotide Binding Region in the HIV-1 Reverse Transcriptase -Implications for Primer Binding Mutations In the C Terminal Hydrphobic Domain of Pseudorabies Virus Gill Affect Both Membrane Anchoring and Protein Export Analysis of Herpes Simplex Virus Induced MRNA Destabilizing Activity Using an in Vivo M RNA Decay System C-Terminal Retroviral-Type Zinc Finger Domain from the HIV-1 Nucleocapsid Protein is Structurally Similar to the N-Terminal Zinc Finger Domain Clinical Evaluation of Low Dose Intradermally Administered Hepatitis-B Vaccine -a Comparison of Plasma-Derived and Recombinant Yeast-Derived Vaccines Polyacrylamides Bearing Pendant Alpha-sialoside Groups Strongly Inhibit Agglutination of ErythrocTtes by Influenza Virus A Survey of Zidovudine use in Pregnant Women with Human lmmunodeficiency Virus Infection Immunization with Tween Ether-Treated SlV Adsorbed Onto Aluminum Hydroxide Protects Monkeys Against Experimental SIV Infection Use of R~combinant Retroviruses to Characterize the Activity of Antiretroviral Compounds Formation of Hcterodimers of Human-Immunodefieiency-Virus-Type-1 Reverse Trauseriptase by Recombination of Separately Purified Subunits Prinlary Cultures of Endothelial Cells from the Human Liver Sinusoid are Permissive for Human Immunodeficiency virus Type-1 Neutralization of Divergent I-HV-1 Isolates by Conformation-Dependent Human Antibodies to Gp120 Antibodies are Produced to the Variable Regions of the External Envelope Glycoprotein of Human Immunodefidency Virus Type-1 in Chimpanzees L-xfected with the Virus and Baboons Immunized with a Candidate Recombinant Vaccine Trans Acting Viral Protease is Necessary and Sufficient for Activation of Avian Leukosis Virus Reverse Transcriptase I~e Reconstruction Reveals the Complex MolecuLar Organization of Adcnovirus Influenza Virus Hemagglutinin with Mukibasic Cleavage SRe is Activated by Furin, a Subthisin-Like Endoprotease Relative Efficacy of 2 Aeelinlar Pertussis Vaccines During 3 Years of Passive Surveillance Anti-cell Antibody in Macaques Sequence and Analysis of a Portion of the Genomes of Shope Fibroma virus and Malignant Rabbit Fibroma Virus that is important for Viral Replication in LymphocTtes Structural Alterations of Double-Stranded DNA in Complex with the Adenovirus DNA-Binding Protein -Implications for Its Function in DNA Replication Idiotope Vaccine Against Gram-Negative Bacterial Infections Virus-1 Nef Gene Product Naturally Occtm-ing Mutations Within HIV-1 V3 Genomic RNA Lead to Antigenic Variation Dependent on a Single Amino Acid Substitution Avian Retroviral Recombinant Expressing Foreign Envelope Delays Turnout Formation of ASV-A-induced Sarcomm Vaccine Temporal Aspects of Major Viral Transcript Expression in Hep G2 Cells Transfected with Cloned Hepatitis-B Virus DNA -with Emphasis on the X-Transcript Human Herpesvirus 7 -Antigenic Properties and Prevalence in children and Adults Amphotericin-B Treatment Dissociates in Vivo Replication of the Scrapie Agent from PrP Accumulation Mechanism of Inhibition of HIV-1 Infection in Vitro by Purified Extract of Prunelia-Vulgarls On the Mechanism of Inhibition of Viral and Vesicle Membrane Fusion by Carbobenzoxy-Dphenylalanyl-L-phenylalanylglycine Design of Yeast-Secreted Albumin Derivatives for Human Therapy -Biological and Antiviral Properties of a Serum Albumin-CD4 Genetic Conjugate Inhibition of P53 Transactivation Required for Tran'sformation by Adenovirus Early 1B Protein LP: C/EBP-Like Proteins Binding to the Functional Box-alpha and Box-alpha of the Second Enhancer of Hepatitis.B Virus Antibodies to MHC Class lI Peptidcs are Present in HIV-1 HIV Infected Humans But not Chimpanzees, have Circulating T Lymphocytes that Lyse Uninfected CD4 + Cells. J lmmuno11990 Emmunogenicity of Trivalent Subunit and Split Influenza Vaccines Winter Season) in Volunteers of Different Groups of Age Galactose Oxidation in the Design of Immluuogenic Vaccines The Hepatitls-B Virus S Promoter Comprises a CCAAT Motif and Two Initiation Regions Conformational and Epitope Mapping of Herpes-Simplex-Virus Typed Thymidine Kinase Using Synthetic Peptide Segments Mechanism of Human MxA Protein Action: Variants with Changed Antiviral Properties Antisense Oligonucleotides as Antiviral Agents. Trends Biotechno11992 Pharmacokinctics, Biodistribution, and Stability of Oligodeoxynucleotide Phosphorothioates in Mice Interactions of Antisense DNA Oligonucleotide Analogs with Phospholipid Membranes (liposomes) B-myb Antisense Ollgonucleotidcs Inhibit Proliferation of Human Hematopoictic Cell Lines Modulation of Eucaryotic Initiation Factor-4E Binding to 5'-Capped Oligoribonucleotides by Modified Allti-Sense Ollgonucleotides Isolation and Structure of an Intrastrand Cross-Link Adduct of Mitomycin.C and DNA Monte Carlo Docking of Oligopeptides to Proteins c-kit Expression by CD34 + Bone Marrow Progenitors and Inhibition of Response to Recombinant Human Interleukin-3 Following Exposure to C-kit Antisense Oligonucleotides Antisense Inhibition of Ras P21 Expression that is Sensitive to a Point Mutation Antlsense Oligonucleotidcs Inhibit Intercellular Adhesion Molecule 1 Expression by Two Distinct Mechanisms ME: Human Therapeutics Based on Triple Helix Technology Antisense RNA Directed Against the Major Capsid Protein of Lactococcus Lactis Subsp. Cremoris Bacteriophage 4-1 Confers Partial Resistance to the Host Oligonucleotide Therapeutics. Trends Biotecbno/1992 Medicinal Chemistry of Antisense • • Ollgonucteotides: Future Opportunities Vitro Toxicology and Pharmacokinetics • • of Antisense Oligonucleotides Therapeutic Applications of • • OBgonucleotides Association of Antisense Oligonucleotides with Ltpoprotein~ Prolongs the Plasma Half Life and Modifies the Tissue Distribution Expression of Antisense RNA Against Initiation Factor EEF-4E Messenger RNA in HeLa Ceils Results in Lengthened Cell Division Times, Diminished Translation Rates, and Reduced Levels of Both EIF-4E and the P220 Component of EII¢-4F Specific Inhibition of Transcription by Triple HelLx-Forming Oligonudeotides Antisense SCL Suppresses Self Renewal and Enhances Spontaneous Eythroid Differentiation of the Human Leukaemie Cell Line K562. EMBOJ1991 The Anti-gene Strategy: Control of Gene • • Expression by Triplex-forming-oligonudeotides Differential Antisense Transcription from the Dictyostelinm EB4 Gene Locus -Implications on Antisense-Mediated Regulation of Messenger RNA Stability Effects of Phosphorothioate Capping on Antisense Oligonucleotide Stability, Hybridization and Antiviral Efficacy Versus Herpes Simplex Virus Infection Effects of Phosphorothioate Capping on Antisense Oligonucleotide Stability, Hybridization and Amivtral Efficacy Versus Herpes Simplex Virus Infection Inhibition of Hlltman Imnlunodefieiency virus Type-1 Multiplication by Antisense and Sense RNA Expression Crystal Structure of the 2/1 Complex Between D(GAAGCYIrC) and the Ant]cancer Drug Actinomycin-D Inhibition of DNA primase and Polymerase-alpha by A*'abinofuranosyinueieoside Triphosphates and Related Compounds Cloning and Anti.sense Oligodeoxynucleotide Inhibition of a Human Homolog of Cdc2 Required in Hematopoiesis Cloning and Antisense Oligodeoxynucleotide inhibition of a Hmnan Homolog of Cdc2 Required in Hematopoiesis Structure, Expression, and Antisense Inhibition of the System In Precursor Gene Lethal Oxidative Damage to Human Immunodefieiency Virus by Human Recombinant Myeioperoxidase EGF-R Antisense RNA Blocks Expression of the Epidermal Growth Factor Receptor and Suppresses the Transforming Phenotype of a Human Carcilloma Cell Line Site-Specific DNA Cleavage by Antlsense Oligonueleotides Covalenfly Linked to Phenazine Di-N-Oxide ** Sequence Selective Recognition of DNA by Strand Displacement with a Thymine-substiinted Pulyamide DNA-drug interactions. The Crystal Structures of D(TGTACA) and D(TGATCA) Complexed with Daunomycin The Thyroliberin Receptor Interacts Directly with a Stimulatory Guanine-Nucleotide-Binding Protein in the Activation of Adenylyl Cyclase in GH3 Rat Pituitary Tunlour Cells -Evidence Obtained by the use of Antisense RNA Inhibition and Immunoblocking of the Stimulatory Guanine-Nucleotide-Binding Protein 1repaired Type H Glucocorticoid-receptor Function in Mice Bearing Antisense RNA Transgene Acute-and Chronicphase Chronic Myelogenous Leukemia Colonyforming Units are Highly Sensitive to the Growth Inhibitory Effects of C-myb Antlsense Oligodeoxynncleotides Inhibition of Human Immunodeficiency Virus Typed Replication in Human T-Cells Stably Expressing Antisense RNA Chin~eric Human Imlnunodeficiency Virlls Type 1/type 2 Reverse Transeriptases Display Reversed Sensitivity to Nonnucleoside Analog Inhibitors Resistance to DdI and Sensitivity to AZT induced Monoclonal Antibody Uptake by Human Melanoma Xenografts -Effects of Antibody Immunological Properties and Tumor Antigen Expression Levels Redirecting the Immune Response -Ligand-Mediated Itnmunogenicity Anemic Gaucher Patients with Elevated Endogenous Erythropoictin Levels May not Respond to Recombinant Erythropoietin Therapy Antitumor Effects of Interleukin-6-Pseudomonas Exotoxin Chimeric Molecules Against the Human Hepatoeellular Carcinoma, PLC/PRF/5 in Mice Immunosuppressive Analogues of Hexapeptide Tyr-Val-Pro-Leu-Phe-Pro, an Immune System Stimulant Genetic Regulation of Hun3ala Anti-malarial Antibodies in Twins CD66 Monoclonal Antibodies Recognize a Phosphotyrosine-Containing Protein Bearing a Carcinoembryonic Antigen Cross-Reacting Antigen on the Surface of Human Neutrophils. Jlmmuno11992 A Randomized Comparison of Two Doses of Human Lymphoblaatoid Interferon-c~ In Hairy Prolonged, Continuous Treatment of Hairy Cell Leukemia Patients with Recombinant Interferon-alpha2a Hunlan Interleukin 4. The Solution Structure of a Four-Helix Bundle Protein Immunization with Antigen Bound to Bispecific Antibody Induces Antibody that is Restricted in Epitope Specificity and Contains AntBdiotype Clinical and Immunologic Effects of Prolonged Infusion of Low-Dose Recombinant Interleukin-2 after Autologous and T-Cell Depleted Allogeneie Bone Marrow Transplantation Synthesis and Analysis of 506BD, a High-Affinity Ltgand for the Immunophilln FKBP Function and Evolutionary Conservation of Distinct Epitopes on the Leukocyte Adhesion Molecule-1 (TQ-1, Leu-8) that Induction of the Immune Response to Legionella-pneumophila Cytolysin by Monoclonal Anti-Idiotypic Antibodies Immunization with Tween Ether-Treated SIV Adsorbed Onto Aluminum Hydroxide Protects Monkeys Against Experimental SIV Infection Invivo Antiinmor ACtivity of a Monoclonal Antibody-Vinca Alkaloid Immunocoujugate Directed Against a Solid Tumor Membrane Antigen Characterized by Heterogeneous Expression and Nontnternalization of Antibody-Antigen Complexes Pharmacologic Doses of Recombinant Human Erythropoictin in the Treatment of Myelodysplaatic Syndromes New uses for Intravenous Immune Globulin Immunogenetie Factors in Skin Cancer Increased Immunoglobulin Transcription in Response to Antigen Plus Interleukin-5 COst Effectiveness of Prophylactic Intravenous Immune Globulin in Chronic Lymphocytic Leukemia Bispecific Anti-Idiotype Anti-CD3 Antibody Therapy of Murine B Cell Lymphoma Phase-I Evaluation of Combination Therapy with Interieukin-2 and Gamma-Interferon The Rheumatoid Factor Reactivity of a Human leg Monoclonal Autoantibody is Encoded by a Variant VkappaI1 L-Chain Gene Characterization of a Secreted Glycoprotein of the Immunoglobulin Superfamily Inducible by Mitogen and Oncogene Binding of Fluoreseein-Labeled Anaphylatoxin-CSa to Human Peripheral Blood, Spleen, and Bone Marrow Leukocytes Internalization and Action of an Immunotoxin Containing Mistletoe Lectin Achain Expression of a Human Monoclonal Anti-(Rhesus-D) Fab Fragment In Eseherichia-coli with the use of Bacteriophage-lambda Vectors T-cell Activation by Autologous Human T-ceB Leukemia Virus Type 1-infected Monoclonal Antibodies Specific for Mercuric Ions Growth-Stimulatory Monodonal Antibodies Against Human Insulin-IAke Growth Eactor-I Receptor Defining Protective Responses to Pathogens -Cytokine Profiles in Leprosy Lesions RoqT~ jA: clinical and Immunomodulatory Effects of Combination Immunotherapy with Low-Dose Interieukin-2 and Tumor NecrosIs Factor-alpha in Patients with Advanced Non-Small-Cell Lung Cancer -a Phase-I Vivo Processing of the Initiator Methionine from Recombinant Methionyl Human Interleukin-6 Synthesized in Escherichia-Coli Overproducing Aminopeptidasc-P Wild-type P53 Induces ApoptosIs of Myeloid Leukaemic Cells that is Inhibited by Interleukin-6 Cytolytic Potential of Peripheral Blood T-Lymphocytes Eoliowing Adoptive lmmunotherapy with Lymphokine-Activated Killer Cells and Low-Dose Interleukin-2 Cellular Interactions in Effector Cell Generation and Tumor Regression Mediated by Anti-CD3/Interleukln-2-Activated Tumor-Draining Lymph Node cells T-Cell Activation-Inducing Epitopes of the House Dust Mite Allergen Derp-I -Proliferation and Lymphokine Production Patterns by Der-p-I-Specific CD4+ T-Cell Clones Amino Acid Sequence and Immunological Characterization with Monoclonal Antibodies of 2 Toxins from the Venom of the Scorpion Centruroides-Noxius Hoffmann Human Combinatorial Antibody Libraries to HepatitIs-B Surface Antigen lI:4-Dependent lgE Switch in Membrane IgA-Positive Human B-Cdls Analysing Lymphokine-receptor Interactions of IL-1 and EL-2 by Recombinant-DNA Technology Pepfides, growth factors, hormones and receptors Related review: Families of twelve Amino Acid Sequence of PR-39 -Isolation from Pig Intestine of a New Member of the Family of Proline-Arginine-Rich Antibacterial Peptides Overexpression and Characterization of the Human Mineralocorticoid Receptor DNA BIndIng Analysis of Glueoeorticoid Receptor Specificity Mutants Occupancy of CDllb/CD18 Divalent Ion Binding Site(s) Induces Leukocyte Adhesion Sttucttlrally Homologous Ligand Binding of Integrin Mac-1 and Viral Glycoprotein-C Receptors Turnout NecrosIs Factor Alpha Restores Granulomas and Induces Parasite Egg-laying in Sehistosome-infected SCID Mice Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes have a Pentameric Quaternary Structure ANO~X~MOUS: Growth Factors and Cancer Chemotherapy Inhibition of the Insulin Receptor TFrosine Kinase by Sphingosine Mapping of T-Helper Cell Epitopes by Using Peptides Spanning the 19-kDa Protein of Mycobacterium-TubercnlosIs -Evidence for Unique and Shared Epitopes in the Stimulation of Antibody and Delayed-Type Hypersensitivity Responses Transcriptional Stimulation by Thyroid Hormone of a Cytosolic Thyroid Hormone Binding Protein Which Is Homologous to a Subtmit of Pyruvate Kinase-M1 Crystallization and Preliminary X-ray AnalysIs of Complexes of Peptide Inhibitors with Human Recombinant and Mouse Submandibular Renins Ligand and DNA-Dependent Phosphorylation of Human Progesterone Receptor lnvitro Purification of an Arg-Gly-Asp Selective Matrix Receptor from Brain Synaptic Plasma Membranes Human Eosinophil Cytotoxieity-Enhancing Factor. 2. Multiple Forms Synthesized by U937 Cells and Their Relationship to Thioredoxin/Adult T-Ceil Leukemia-Derived Factor. Jlmmuno11991 A Tratlsferable Silencing Domain is Present in the Thyroid Hormone Receptor, in the V-erbA Oncogene Product and in the Refinoic Acid Receptor Production and Characterization of Mammary-Derived Growth Factor-1 in Mammary Epithelial Ceil Lines The Carboxyl-Terminal Domain of the Insulin Receptor -lts Potential Role in Growth-Promoting Effects Molecular Characterization of the Interieukin-8 Receptor Neuropeptide-Y-Identification of the Binding Site Lipoprotein Ltpase Enhances the Binding of Chylomicrons to Low Density Lipoprotcin Receptor-Related Protein Functional Mapping of the Human Visual Cortex by Magnetic Resonance Imaging Immunotherapy of Human Glioma Xenografts with Unlabeled, 131I-Labeled, or 125I-Labeled Monoclonal Antibody-425 to Epidermal Growth Factor Receptor Cloning, Expression, and Chromosomal Localization of Beta-Adrenergic Receptor Kinase-2 -a New Member of the Receptor Kinase Family Production of Homogeneous Basis Fibroblast Growth Factor by Specific Enzymatic Hydrolysis of Larger Microheterogenous Molecular Forms IL-1 Receptor Antagonist Regulation of Acute Phase Protein Synthesis in Human Hepatoma Cells Synthetic Peptides for Plasmodium Vivax Malaria Sero-Epidemiology -Application of Emoc-Polyamide and Displacement Chromatography Thyroid Hormone Receptor Transcriptional Activity is Potentially Autoregnlated by Truncated Forms of the Receptor A Cblmeric Glutamate Receptor Subunit -Discrete Changes Modify the Properties of the Channel Btochem Biopbys Res Commun 125 I]RTI-55: a Potent Ligand for Dopamine Transporters. £itrJ Pharmaco11991 E: Characterization and Furifieation of Proteins Which Bind High-Density Lipoprotein -a Putative Cell-Surface Receptor Differential Interactions of Estrogens and Antiestrogens at the 17beta-Hydroxy or Counterpart Function with the Estrogen Receptor Pregnancy Hormones, Estrogen and Progesterone, Prevent HIV-1 Synthesis in Monocytes But not in Lymphocytes Insulin Hexamers -New Conformations and Applications Characterization of the R-State Insulin Hexamer AH, EDWARDS P~M, eLEMENTS JM: Purification and Analysis of Proteinase-Resistant Mutants of Recombinant Platelet-Derived Growth Factor-BB Exhibiting Improved Biological Activity Nuclear Magnetic Resonance Studies of the Snake Toxin Echistatin -H-1 Resonance Assignments and Secondary Structure Studies on Protein-DNA Interactions Using the Resonant Recognition Model -Application to Repressors and Transforming Proteins The Murine Gene Encoding Secreted Phosphoprotein-1 (Osteopontin) -Promoter Structure, Activity, and Induction Invivo by Estrogen and Progesterone Characterization of the Structure and Conformation of PlatelevDerived Growth Factor-BB (PDGF-BB) and Protcinasc-Reststant Mutants of PDGF-BB Expressed in Saccharomyces-Ccrevisiae A Phase-I Trial of Recombinant Human Interleukin-lbeta Alone and in Combination with Myelosuppressivc Doses of 5-Fluorouracil in Patients with Gastrointestinal Cancer Hypotensive Activity of Fibroblast Growth Factor Dimcrization of the Extraeellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule Identification of a Conserved Region Required for Hormone Dependent Transcriptional Activation by Steroid Hormone Receptors Characterization of a Human Recombinant Receptor-Linked Protein Tyrosine Phosphatase Antiestrogen ICI-164,384 Reduces Cellular Estrogen Receptor Content by Increasing Its Turnover Antipeptide Antibodies Differentiate Between Long and Short tsoforms of the D2 Dopamine Receptor Retinoic Acid and Transforming Growth Factor-beta Differentially Inhibit Platelct-Derived-Growt h-Factor-Induced Ito-Cell Activation The Receptor for Ciliary Neurotrophic Factor Thcfins-like Tyrostne Ktnase, a Receptor for Vascular Endothelial Growth Factor Identification and Characterization of the Neurofibromatosis Typc-1 Protein Product Structure of Growth Hormone and Its Receptor -an Unexpected Stoichiometry Production of MUC1 and MUC2 Mucins by Human Tumor Cell Lines Human Growth Hormone and Extraccllalar Domain of Its Receptor -Crystal Structure of the Complex X-ray Analysis of Peptide-inhibitor Complexes Define the Structural Basis of Specificity for Human and Mouse Renins Phospholtpasc C-mediated Hydrolysis of Phosphatidylcholine is a Target of Transforming Growth Factor-beta I inhibitory Signals Transcriptional Transactivation Functions Localized to the Glucocorticoid Receptor-N Terminus are Necessary for Steroid Induction of Lymphocyte Apoptosis Analysis of the Regulatory and Structural Defects of Troponin-C Central Helix Mutants Requirement for Mast Cell Growth Factor for Primordial Germ cell Binding Sites for Alpha-Bungarotoxin and the Noncompetitive Inhibitor Phcncyclidine on a Synthetic Peptide ComprisIng Residues 172-227 of the Alpha-Subunit of the Nicotinic Acetylchollne Receptor Unregulated Expression of C-Jun or C-Fos Proteins But not Jun D inhibits Oestrogen Receptor Activity in Human Breast Cancer Derived Cells Production of Bovine Insulin-Like Growth Factor-2 (bIGF2) in Eseherichia-Coli Hcparin Ollgosaccharides Enhance Tissue-Type Plasminogen Activator -a Correlation Between Oligosaccharide Length and Stimulation of Elasminogen Activation Effect of Inhibiting N-Glyeosylation or Oligosaecharide Processing on Vasoactive Intestinal Peptide Receptor BInding Activity and Structure Rabbit Antibodies Toward Extracellular Loops of the Membrane Spanning Region of Human Thyrotropin Receptor Possess Thyroid Stixnulating Activities Membrane Organization of the Dystrophin-Glycoprotein Complex Suppression of Chronic Myelogenous Leukemia Colony Growth by Interleukin-1 (IL-1) Receptor Antagonist and Soluble EL-1 Receptors -a Novel AppBcation for inhibiturs of IL-1 Activity Effect of Calcitonin-gene-related Peptlde in Patients with Delayed Postoperative Cerebral Ischaemia after Aneurysmal Subat'aclmoid Haemorrhage Preparation and Characterization of Spin-Labeled Derivatives of Epidermal Growth-Factor (EGF) for Investigations of the Intaractions of EGF with Its Receptor by Electron Paramaomaetic Resonance Spectroscopy Selection of Antibody Ligands from a Large Library of Oligopeptides Expressed on a Multivalent Exposition Vector Promiscuous Malaria Peptide Epitope Stilnulates CD45Ra T-Cells from Peripheral Blood of Nonexposed Donors Design and Synthesis of a Helix Heparin-Binding Peptide Recombinant Human < Cys281> Insulin-Like Growth Factor-Binding Protein-2 Inhibits Both Basal and Insulin-Like Growth Factor-I-Stimulated Proliferation and Collagen Synthesis In Fetal Rat Calvariae Nuclear Association of a T-cell Transcription Factor Blocked by FK-506 and Cyclosporin a Hutnau Interferon-g~mma Potently Induces the Synthesis of a 55-kDa ProteIn (gamma2) Highly Homologous to Rabbit Peptide Chain Release Factor and Bovine TryptophanyloTransfer RNA Synthctase Targeting Peptides and Proteins= NATO ASL Trends Biotechno11991 A 25-kDa Stretch of the Extracelhilar Domain of the Human Interferon-gamma Receptor is Required for Full Ligand Binding Capacity Stereospecific Effects of Inhalational General Anesthetic Optical Isomers on Nerve Ion channels Phorbol Ester Induces Manganese-Superoxide Dismutase in Tumor Necrosis Factor-Resistant Cells A Tyrosine Kinase Physically Associates with the Beta-Subunit of the Human EL-2 Receptor Involvement of the Epidermal Growth Factor Receptor in the Invasion of Cultured M~mmal|an cells by Salmonella Typhimuriunx Nature P~g of Influenza Virus-Specific Cytotuxic Lymphocytes-T Invivo by Short Synthetic Peptides Identification and Mapping to Chromosome I of a Susceptibility Locus for Periinsulitis in Non-obese Diabetic Mice Characterization of the Solubillzed Charybdotoxin Receptor from Bovine Aortic Smooth Muscle Pharmacological Properties of a Potent and Selective Nonpeptide Substance-P Isolation of a Clone Which Induces Expression of the Gene EncodIng the Human Tumor Necrosis Factor Receptor Regulation of Human Lymphocyte Proliferation by a Heterodimeric Cytoldne Synthesis and Properties of Chemotactic Pcptidc Analogs. 1. Crystal Structure and Molecular Conformation of HCO-Mct-Leu-Ain-OMe Successfnl In-Vitro FerOlisation and Embryo Transfer after Treatment with Recombinant Human FSH Stable Expression of High Affinity NK1 (Substance-P) and NK2 (Neurokinin-A) Receptors But Low Affinity NK3 (Ncurokinin-B) Receptors In Transfected CHO Cells Antitumor Activity of Fab' and IgG Anti Cd22 ImmtmotoxillS ill Disseminated Human Lymphoma B Grown in Mice with Severe CombIned Immunodeficiency Disease -Effect on Tumor Cells In Extranodal Sites Multiple Nucleotide-bInding Sites in the Sequence of Synein ~ Heavy Chain Regulation of Gene Expression by Rctinoic Acid Receptors Anti-Insulin Effects of Amylin and Calcitonin-Gene-Related Peptide on Isolation and Identification of a Novel Cellular Protein that Potently Activates Ca2+/Phosphollpid-Dependent Protein Kina.~e (Protein Kinase-C) Interleukin-1 Receptor Antagonist Competitively Inhibits the BInding of Interleukin-1 to the Type-H Interleukin-1 Receptor Mechanisms of Receptor Mediated Rhmovirus Neutralization Defined by Two Soluble Forms of ICAM-1 Spectroscopic Evidence for an Intermediate in the T6 to R6 Allosteric Transition of the Co(lI)-Substituted Insulin Hexamer Interleukin-1 Receptor Antagonist in Human Epidermis and Cultured Keratinocytes The Cecropin Locus -Cloning and Expression of a Antibacterial Peptides in Hyalophora-Cecropia Nueleocytoplasmic Shuttling of the Progesterone Receptor Epidermal Growth Factor Receptor-Reactive Monoclonal Antibodies -Xenograft Antitumor Activity Alone and as Drug Immtmoconjugates Pharmacological and Biochemical Characterization of Cholecystukinin Gastrin Receptors in Developing Rat Pancreas -Age-Related Expression of Distinct Receptor Glycoforms Rational Design and Pre-cllnical • Pharmacology of Drugs for Reversing Multidrug Resistance Comparison Between Synthetic Nuclear Localization Signal Peptides from the Steroid Thyroid Hormone Receptors Superfamlly Itttracellular Targeting of the lmsulin-regulatable Glucose Transporter (GLUT4) is Isoform Specific and Independent of Cell Type Biosynthesis and Partial Amino Acid Sequence of the Human NDA4 Antigen -an Activation Antigen Common to B-Cell and T-Cell Lineages A Structural Taxonomy of DNA-binding Domains The Solution Structure of Human Transforming Growth Factor-alpha Growth-Promoting Activity of Tissue Inhibitor of Metalloproteinasrs-1 (TIMP-1) for a Wide Range of Cells -a Possible New Growth Factor In Serum Cloning and Sequence Analysis of Genes Involved in Erythromycin Biosynthesis in Saecharopolyspora-Erythraea -Sequence Similarities Between EryG and a Family of S-Adenosylmethioninc-Dependent Methyltransferases A-C-B) Hm Proinsulin, a Novel Insulin Agonist and Intermediate in the Synthesis of Biosynthetic Human Insulin Scanning Mutagenesis of Interleukin-8 Identifies a Cluster of Residues Required for Receptor Binding Intravascular IL-8 -Inhibitor of Polymorphonuclear Leukocyte Accumulation .at Sites of Acute Inflammation Studies on the Variants of the Protein Toxins Ricin and Abrin Production of Interferon Gamma> Interleukin 2, Interleukin 4, and Interleukin Lymphocytes in Vivo During Healing and Progressive Murine LeishmanLa$is Functional Characterization of a Hybrid Human-Mouse interferon-gamma Receptor -Evidence for Species-Specific Interaction of the Extracellular Receptor Domain with a Putative Signal Transducer Opioid Receptor Affinity and Selectivity Effects of Second Residue and Carboxy Terminal Residue Variation in a Cyclic Disulfide-Containing Opioid Tetrapeptide Is the Multidrug • Transporter a Flippase? Inhibition of IAgand Binding and Antiproliferatlve Effects of Tumor Necrosis Factor and Lymphotoxin by Soluble Forms of Recombinant P60 and 1"80 Receptors Eplmorphin -a Mesenchymal Protein Essential for Epithelial Morphogenesis Structure and Conformation of a Novel Inhibitor of Angiotensin-I Converting Enzyme -a Tripeptide Containing Phosphonic Acid Disulfide Exchange Folding of Insulin-Like Growth Factor-I Reversible Thyroid Dysfunction During Treatment with GM-CSF Placebo-controlled, Double-blind, Crossover Trial of Growth Hormone Treatment in Prepubertal Children with Chronic Renal Failure Induction of HSP70 Gene Expression by the Antiproliferative Prostagiandin PGA2 -a Growth-Dependent Response Mediated by Activation of Heat Shock Transcription Factor Confornlational arid Functional Properties of Peptides Covering the Intersubunit Region of Influenza Virus Hemagglutinin Two Additional Protein-tyrosinc IOnases Expressed in Human Lung: Fourth Member of the Fibroblast Growth Factor Receptor Family and an intracelinlar Proteintyrosine Kinase Structure-Function Relationships in Human Epidermal Growth Factor Studied by Site-Directed Mutagenesis and H-1 ~ Biochemistry Effector Domains of Human Immunodeficiency Virus Type 1 Rev and Human T Cell Leukemia Virus Type 1 Rex are Fttnctionally interchangeable and Share all Essential Peptide Motifi Lyophilized Formulations of Recombinant Tumor Necrosis Factor Primary Structure and Origin of Schistosomin, an Anti-Gonadotropie Neuropeptide of the Pond Snail Lymnaea-Stagnalis Interactions of Factor-XIII with Fibrin as Substrate and Cofactor Generation and use of Synthetic Peptide Combinatorial Libraries for Basic Research and Drug Discovery Interaction of Phosphatidylinositol 3-Kinase-Associated P85 with Epidermal Growth Factor aud Platelet-Derived Growth Factor Receptors Receptor Binding Redefined by a Structural Switch in a Mutant Human insulin Sequence-Specific H-1 NMR Assignments, Secondary Structure, and Location of the Calcium Binding Site in the First Epidermal Growth Factor Like Domain of Blood Coagulation Factor-IX Purification and Characterization of the Ncu/erb B2 Ligand-Growth Factor from Bovine Kidney Identification and Characterization of a New Family of High-Affinity Receptors for E$cherichia-Coli Heat-Stable Entcrotoxin in Rat Intestinal Membranes Af~luity Purification of Functional Receptors for Escherichia-Coli Heat-Stable Enterotoxin from Rat Intestine Regulation of Interleukin-lbeta Production by Glucocorticoids in Human Monocytes -the Mechanism of Action Depends on the Activation Signal Alltagonism Between Retinoic Acid Receptors Activity of Membranous Dopamine Bcta-Monooxygenase Within Chromaffm Granule Ghosts -Interaction with The Nasal Delivery of Peptidcs and Proteins. Trends Biotechno11991 Identification of Three Adjacent Amino Acids of Interleukin-2 Receptor ~ Chain Which Control the Affinity and the Specificity of the Interaction with InterIeukin-2 Inlportance of Size and sulfation of Heparin in Release of Basic Fihroblast Growth Factor from the Vascular Endothelium and Extracellular Matrix Production of Recombinant Human Gincagon in the Form of a Fusion Protein in Eschericifia CoIl -Recovery of Glucagon by Sequence-Specific Digestion Search for Peptide Immunogens of the Beta-Subunit of Human Chorionie Gonadotropin (hCG) Capable of Eliciting Hormone Specific and Neutralizing Antisera -Identification of an Undecapeptide Eliciting HCG-Specific Antisera Analogues of Luteinizing Hormone-Releasing Hormone Containing Cytotoxic Groups Effects of RecombInant Transforming Growth Factor-beta1 on Hematologic Recovery after Treatment of Mice with 5-Flaorouraeli Identification of Self Peptides Bound to Purified IlIA-B27 Successful Treatment of Experimental Allergic Encephalomyelitis with Transforming Growth Factor-hera1 The Human Fibroblast Growth Factor Receptor Genes -a Common Structural Arrangement Underlies the Mechanisms for Generating Receptor Forms that Differ in Their Third lmm,tnoglobulin Domain Rusting of the Lock and Key Model for Protein-IAgand Binding A G-Protein Linked Receptor for Parathyroid Hormone and Parathyroid Hormone Related Pcptidc Chemical Modification of Human Growth Hormone with N-Acetylimidazole -Effect on Binding Capacity to Lactogenic and Somatogenie Receptors Development of a high-expression Vector (PYKIO-9 Structure, Localization and Transcriptional Properties of Two Classes of Retinoic Acid Receptor Alpha Fusion Recombinant Human Retinoic Acid Receptor-alpha -Binding of DNA and Synthetic Rctinoids to the Protein Expressed in Escheriehla-Coli The Pulmonary Suffactatu Protein-C (SP-C) Precursor is a Type-lI Transmembrane Protein Distinct Alpha-Sublmit Structures of Human Insulin Receptor-A and Rcceptor-B Variants Determine Differences in Tgrosine Kinase Activities Clonhlg and Expression of a Cocaine-Sensitlve Rat Dopamine Transporter • Transport of Cationic Amino Acids by the Mouse Ecotropic Retrovirus Receptor Isolation, Characterization, and Localization of Human Genomic DNA Encoding the Beta1 Subtttlit of the GABAA Receptor (GABRB1) Matnmallan Hormones in Microbial Cells Maxadilan -Cloning and Functional Expression of the Gene Encoding This Potent Vasodilator Peptide Dopamine Transporters in the Nucleus Aceumbens and the Striamm have Different Apparent Molecular Weights Isolation and Chemical Characterization of a Novel Insulin-Related Neuropeptide from the Freshwater Snail, Lymnaea-Stagnalis Platelet-Derived Growth Factor (PDGF)-Induced Disulfide-Linked Dtmerization of PDGF Receptor in Liming Cells Expression Cloning of an Adenylate Cyelase Coupled Calcitonin Receptor Synthesis and Enzymatic Evaluation of 2 Conformationally Restricted Trisaeeharide Analogues as Substrates for N-Aeetylgtucosaminyltransferase-V Characterization of Estrogen-Responsive Mouse Lactoferrin Promoter Intralnolecular Cyanohydrin Elaboration. Construction of Corticosteroids from 17-kctosteroids LESSLAUER W: Recombinant 55-1Oa Tumor Necrosis Factor (TNF) Receptor -Stoichiometry of Binding to TNFalpha and TNFbeta and Inhibition of TNF Activity Structure-Function Analysis of Hepatocyte Growth Factor -Identification of variants that Lack Mitogenic Activity Yet Retain High Affinity Receptor Binding Reduced MRNA a Nonsense Mutation in the Insulinreceptor Gene Produce Heritable Severe Insulin Resistance Dominant Negative Mutants of Transforming Growth Factor-beta1 Inhibit the Secretion of Different Transforming Growth Factor-bcta Isoforms Structure-Function Study of the P55 Subunit of Murine IL-2 Receptor by Epitope Mapping Urokinase-reeeptor Biosynthesis, MRNA Level and Gene Transcription are Increased by Transforming Growth Factor ~ 1 in Human A549 Lung Carcinoma Cells A Leucine to Proline Mutation at Position 233 in the Insulin Receptor Inhibits Cleavage of the Proreceptor and Transport to the Cell Surface Neither Anlino Nor Carboxyl • Termini are Required for Function of the Sodiumand Chioride-eoupled Gamma-a*ninobutyric Acid Transporter from Rat Brain The Structure of HLA-B27 Reveals Nonanaer Selfpeptides Bound in an Extended Conformation Antibodies to IL-3 and ID4 Suppress Helminth-Induced Intestinal Mastocytosts. Jlmmuno11991 USF Related Transcription Factor, HIV-TF1, Stitnulates Transcription of Human Immunodeficiency Virus Transmembrane Signalling at the Epidermal Growth Factor Receptor -Positive Regulation by the C-Terminal Phosphotyrosine Residues Reaction of Human Non-collagenous Polypeptides with Coellac Disease Autoantibodies A Randomized Controlled Trial of Recombinant Interferon-alpha in Chronic Hepatitis-C in Hemophiliacs Structure and Expression of the Bcta-Platelet-Derived Growth Factor Receptor Gene in Human Tumor Cell Lines Primary Structure and Functional Expression of The 5HT3 Receptor VANGU~SI~I1EN x~(/'F: Conformational Flexibility of Aqueous Monomeric and Dinleric Insulin -a Molecular Dynamics Study H-2RIIBP (RXR~) Hcterodimerization Provides a Mechanism for Combinatorial Diversity in the Regulation of Retinoic Acid and Thyroid Hormone Responsive Genes Identification of Cysteine-Rich Domains of the Type-1 Tumor Necrosis Factor Receptor Involved in Ligand Binding Cloning and Expression of Hepatitis-B Surface Antigen in the Yeast Kinyveromyees-Lactis Fuc-GM1 Ganglloside Mimics the Receptor Function of GM1 for Cholera Toxin Phenylmethanesulphonyl Fluoride Inhibits GP1 Anchor Biosynthesis in the African Trypanosome Effect of Steel Factor and Leukaemla Inhibitory Factor on Murine Pritlaordial Germ Cells in Culture New Protein Fold Revealed by a 2.3-4 Resolution Crystal Structure of Ncrve Growth Factor insitu Distinction Between Steroid Receptor Binding and Transactivation at a Target Gene Interleukin-2-Induced and interleukin-5-Indueed Changes in the Binding of Regulatory Factors to the J-Chain Gene Promoter SH2 Domains of the P85alpha Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors Structural Determinants within Residues 180-199 of the Rodent-alpha5 Nicotinic Acetylcholine Receptor Subunit Involved in Alpha-Bungarotoxin Binding Isolation of Mitotic P34cdc2 Apoenzyme from Human Cells. FEB3" Lett 3-Ditllensional Structures of the Ligand-Binding Domain of the Bacterial Aspartate Receptor with and Without a IAgand Suppressor T-Cells Generated by Oral Tolerization to Myelin Basic Protein Suppress Both invitro and Invivo I11amune Responses by the Release of Transforming Growth Factor-beta after Antigen-Specific Triggering Potentiation of NMDA Receptor Currents by Arachidonic Acid Disposition of the Phenyiaianlilc-B25 Side Chain During Insulin-Receptor and Insulin-Insulin Interactions Purification, Biochemical Composition, and Biosynthesis of the Mo3 Activation Antigen Expressed on the Plasma Membrane of Human Mononuclear Phagocytes Thyroid-Specific Enhancer-Binding Protein (T/EBP) -CDNA Cloning, Functional Characterization, and Structural Identity with Thyroid Transcription Eactor TTF-1. 114o1 Cell Bio11991 Solution Structure of Murine Epidermal Growth Factor Determined by NMR Spectroscopy and Refined by Energy Minimization with Restraints Computer Design of Bioactivc Molecules -a Method for Receptor-Based Dcnovo Ligand Design Study of Sequential Tumor Necrosis Eactor and Interieukin-2 in the Treatment of Spontaneous Canine Neoplasms Isolation, Amino Acid Sequence, and Synthesis of Dermaseptin, a Novel Antimicrobial Peptide of Amphibian Skin Synergistic Effect of Tumor Necrosis Factor-alpha-Mediated and Diphtheria Toxin-Mediated Cytotoxicity in Sensitive and Resistant Human Ovarian Tumor Cell Lines Evidence for the Involvement of Transforming Growth Factor-alpha and Epidermal Growth Factor Receptor Autocrine Growth Mechanism in Primary Human Ovarian Cancers Invitro EGF-R Antisense RNA Blocks Expression of the Epidermal Growth Factor Receptor and Suppresses the Transforming Phenotype of a Human Carcinoma Cell Line Pancreatic Enzyme Supplements in Cystic Fibrosis A Novel Conformationally Restricted Protein Kinasc-C Inhibitor, RO-31-8425, Inhibits Human Neutrophll Superoxide Generation by Soluble, Particulate and Post-Receptor Stimuli Atrial Natrinretic Peptide (ANP) is a High-Affinity Substrate for Rat Insulin-Degrading Enzyme Purification of Recombinant Midkine and Examination of Its Biological Activities -Functional Comparison of New Heparin Binding Factors Posttranscriptional Regulation of Rat Growth Hormone Gene Expression -Increased Message Stability and Nuclear Polyadcnyiation Accompany Thyroid Hormone Depletion CHOTttIA C: beta-Trefoil Fold. Patterns of Structure and Sequence in the Kunitz Inhibitors Interleukins-lbeta and lalpha and Fibrobiast Growth Factors Small Peptide Probes of Nicotinic Acetylcholine Receptors Interleukin-4 Blocks Parathyroid Hormone-ReLated Protein-Induced Hypercalcemia Invivo Interleukin-4 Blocks Parathyroid Hormone-Related Protdn-indueed Hypercalcemia Invivo Protein Tyrosine Kinase Activities of the Epidermal Growth Factor Receptor and ErbB Proteins -CorreLation of Oneogenie Activation with Altered Kinetics Initiation of the Extrinsic Pathway of Blood Coagulation -Evidence for the Tissue Factor Dependent Autoactivation of Human Coagulation Eactor-VIL Biochemistry Inlportance of Aliphafic Side-Chain Structure at Position-2 and Position-3 of the Insulin-A Chain in Insulin-Receptor Interactions Cloning and Sequence Analysis of a CDNA Encoding Human Non-Selective Type of Endothelin Receptor Isolation and Characterization of a Novel Glycosyl-Pho s phatidylinositol-Anchored Glycoconjugate Expressed by Developing Neurons Synthesis of the Biologically Active Beta-Sublmit of Human Nerve Growth Factor In Escherichia-Coll Structural Elements of Human Parathyroid Hormone and Their Possible Relation to Biological Activities Subunit promiscuity Among Hemopoietic Growth Factor Receptors Characterization of a Trypanosoma-Cruzi C3 Binding Protein with Functional and Genetic Similarities to the Human Complement Regulatory Protein, Decay-Accelerating Factor SCHEUER T: Fun~donal Modulation of Brain Sodium Channels by Protein Kinase-C Phosphoryiation Identification and Characterization of urokinase Receptors in Natural Killer Cells and T-Cell-Derived Lymphokine Activated Killer Cells axl, a Transforming Gene Isolated from Primary Human Myeloid Leukemia Ceils, Encodes a Novel Receptor Tyrosine Kinasc Four ATP-binding Sites in the Midregion of the ~Heavy Chain of Dynein Affmity Purification of Insulin-Degrading Enzyme and Its Endogenous Inhibitor from Rat Liver Altered Affinity of Insulin-Like Growth Factor-H (IGF-H) for Receptors and IGF-Binding Proteins, Resulting from I2mited Modifications of the IGF-I1 Molecule Inhibition of the Cellular Actions of Nerve Growth Factor by Staurosporine and K252A Results from the Attenuation of the Activity of the Trk Tyrosine Kinase Evidence for the Involvement of Protein Kinase Activity in Transforming Growth Factor-beta Signal Transductinn Inhibitory Effect of Interleukin-4 on the Invitro Growth of Phi-Positive Acute Lymphobiastic Leukemia Ceils Synergism in Cytosolic Ca2+ Mobilization Between Bradykinin and Agonists for Pertussis Toxin-Sensitive G-Protein-Coupled Receptors in NG 108-15 Cells NISHIRIOTO h Identification of a GS Activator Region of the ~2-adrenergic Receptor that is Autoregulated via Protein Kinase-A-depcndent PhosphoryLation Petrosal Sinus Sampling with and Without Corticotropin-releasing Hormone for the Differential Diagnosis of Cushing's Syndrome A Corticosteroid Receptor in Neuronal Membranes On the Interaction of Promiscuous Antigenic Peptidcs with Different DR Alleles -Identification of Common Structural Motifs High-Level Secretion of the Extracellular Domain of the Human Growth Hormone Receptor Using a Baculovirus System Characterization of a Specific Ecdysterotd Receptor-DNA Complex Reveals Common Properties for Invertebrate and Vertebrate Hormone-Recepinr DNA Interactions Expression • • Cloning of a Cocaine-and Antidepressantsensitive Human Noradrenaline Transporter A~titumor Activity of a Transforming Growth Factor Alpha-Pseudomonas Exotoxin Fusion Protein (TGFalpha-PE40) Cloning and Functional • Expression of a Mnfnmalian Na + /Nuclcoside Cotransporter Cloning aqd Expression of a Pharmacologically Unique Bovine Peripheral-Type Benzodiazepine Receptor Isoquinoline Binding Protein. fBiol Chem Mechanism of Serpin Action -Evidence that C1 Inhibitor Functions as a Suicide Substrate Genomic Targets of the Serendipity ~ and ~ Zinc Finger Proteins and Their Respective DNA Recognition Sites Binding of Verocytotoxin-1 to Its Receptor is Influenced by Differences In Receptor Fatty Acid Content Characterization of a Recombinant Exteacelluiar Domain of the Typ¢-I Tumor Necrosis Factor Receptor -Evidence for Tumor Necrosis Factoralpha Induced Receptor Aggregation Vascular Endothelial Growth Factor (VEGF) Induces piasminogen Activators and Plasminogen Activator Inhibitor-1 in Microvascular Endothelial Cells Application of Capillary Zone Electrophoresis to the Characterization of Multiple Antigen Pcptides Modulation of Progesterone Receptor Binding to Progesterone Response Elements by Positioned Nucleosomes Modulation of Progesterone Receptor Binding to Progesterone Response Elements by Positioned Nucleosomes The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone Identification and Functional Importance of Tyrosine sulfate Residues within Recombinant Factor-VHL Biochemistry Art Anti-Peptide Antibody that Recognizes the Dopamine-D2 Receptor from Bovine Striatonx The Prospects for Therapy with Turnout Necrosis Factors and Their Antagonists. Trends Biotechno11991 Dopamine Activation of an Orphan of the Steroid Receptor Superfamily Dopaminergic and Ligand-independent Activation of Steroid Hormone Receptors Effect of Polymorphism of an MItC-linked Transporter on the Peptide Assembled in a Class I Molecule C-terminal Truncated Forms of Met, the Hepatocyte Growth Factor Receptor Molecular Characterization of a Supratypic Cross-Reactive Idiotype Associated with IgM Autoantibodies. J lmmuno11991 Lipoproteins of Borreliabnrgdorferi and Treponema-pallidum Activate Cachectin/Tumor Necrosis Factor Synthesis -Axlalysis Using a CAT Reporter Construct Membrane Fusion Activity of the Influenza Virus Hemagglutinin -Interaction of HA2 N-Terminal Peptides with Phospholipid Vesicles. Biochemislry The ExtraceIlular Glycoprotein SPARC Interacts with Platelet-Derivcd Growth Factor (PDGF)-AB and (PDGF)-BB and Inhibits the Binding of PDGF to Its Receptors Sequential Dephosphorylation of a Multiply Phosphorylated Insulin Receptor Peptide by Protein Tyrosine Phosphatases Macromolecular Self-Association of a Synthetic Peptide Derived from the Hepatitis-B Surface Antigen -Construction of a Quaternary Epitope Photoafflnity Labeling of Human Serum Vitamin-D Binding Protein and Chemical Cleavages of the Labeled Protein -Identification of An 11.5-kDa Peptide Containing the Putative 25-Hydroxyvitamin-D3 Binding Site Anti-Oncogenic Activity of Signalling-Defective Epidermal Growth Factor Receptor Mutants Interleukin-2 Receptor Regulates Activation of Phosphatidyilnositol 3-Kinase Invitro Activity of CD4+ and CD8+ Lymphocytes-T from Mice Innllunized with a Synthetic Malaria Peptide Mntations in the Chatlnel Domain after Desensitization of a Neuronal Nicoth*ic Receptor Recombinant Gp120 Specifically Enhances Tumor Necrosis Factor-alpha Production and Ig Secretion in Lymphocytes-B from HIV-Infected Individuals But not from Seronegative Donors Cysteine to Serine Substitutions in Basic Fibroblast Growth Factor: Effect on Inclusion Body Formation and Proteolytic Susceptibility During in Vitro Refulding Correlation Between Antepartum Maternal Metabolism and Intelligence of Offspring Differential Phosphorylation of the Transcription Factor Oct1 During the Ceil Cycle Platelet-Derived Growth Factor-BB for the Treatment of Chronic Pressure Ulcers Binding of Neurotrophin-3 to Its Neuronal Receptors and Interactions with Nerve Growth Factor and Brain-derived Neurotrophic Factor Immunization with Synthetic Peptides Containing a Defined Malaria Epitope Induces a Highly Diverse Cytotoxie Lymphocyte-T Response -Evidence that Two Peptide Residues are Buried in the MItC Molecule cAMP-inducible Chloride Conductance in Mouse Fibroblast Lines Stably Expressing the Human Cystic Fibrosis Transmembfane Conductance Regulator Tumor Necrosis Factor Stinlulates Epithelial Tumor Cell Motility Synthesis of Fully Active Biotinylatod Analogues of Parathyroid Hormone and Parathyroid Hormone-Related Protein as Tools for the Characterization of Parathyroid Hormone Receptors Mutational Analysis of the Ligand-Bindtng Domain of the Prolactin Receptor Hulllan T-Cell Clone Identifies a Potentially Protective 54-kDa Protein Antigen of Toxoplasma-gondii Cloned and Expressed in Escherichia-coli Structural Studies on file < But-Cysl8> (19-37)-Fragment of Human Beta.Calcitonin-Gene-Related Peptide Biological Activity of a Fluorescein Human Growth Hormone Derivative Prepared by Specific Covalent Labeling of Lysine-70 Cloning and Functional Expression of Human CDNA for the ETB Endotheiln Receptor Autoerine Induction of Tumor Protease Production and Invasion by a Metallothionein-regalated TGF-~I (Ser223, 225) Direct Sequencing of the Dopamine-D2 Receptor (DRD2) in Schizophrenics Reveals Three Polymorphisms But no Structural Change in the Receptor < D-Ala2> Deltorphin-H Analogs with High Affinity and Selectivity for Delta-Opioid Receptor Protective Immunization with Invariant Peptides of the Plasmodiuam-Falciparum Antigen MSA2 On the Role of Polyalaloglycosphingolipids as Tetanus Toxin Receptors -a Study with Lipid Monolayers Biological and Clinical Effects of Intravenous Tumor Necrosis Factor-alpha Administered Three Times Weekly Agonist Pharmacology of Neonatal and Adult Glycine Receptor cz Subunits: Identification of Amino Acid Residues Involved in Taurine Activation Augmentation of Synthesis of Plasminogen Activator Inhibitor Typed by Insulin and Insulin-Like Growth Factor Type-I -Implications for Vascular Disease in Hyperinsulinemic States The 1st Step in Vision -Femtosecond Isomerization of Rhodopsin Sttalctllral and Functional Studies on the Human Hepatic interleukin-6 Receptor -Molecular Cloning and Overexpression in HepG2 Cells Cytotoxic Activity of Tumor Necrosis FaCtor is Mediated by Early Damage of Mitochondrial Functions -Evidence for the Involvement of Mitochondrial Radical Generation Beyond Zinc Fingers -Steroid Hormone Receptors have a Novel Structural Motif for DNA Recognition Analysis of Platclct-Derived Growth Factor Receptor Domain Function Using a Novel Chimeric Receptor Approach Organization of the Human Hepatocyte Growth Factor-Encoding Gene Thyroid Hormone Receptor and V-erbA -a Single Amino Acid Difference in the C-Terminal Region Influences Dominant Negative Activity and Receptor Dimer Formation Control of Scarring in Adult Wounds by Neutralising Antibody to Transforming Growth Factor Beta The Amino Terminal Helix of GM-CSF and IL5 Governs High Affinity Binding to Their Receptors. EMBOJ1991 Association Between Tumor Necrosis Factor-c~ and Disease Progression in Patients with Multiple Sclerosis Cytotoxic Properties of DAB486EGF arid DAB389EGF, Epidermal Growth Factor (EGF) Receptor-Targeted Fusion Toxins Conformational Features Responsible for the Binding of Cyclic Analogues of Enkephalin to Opioid Receptors. 3. Probable Binding Conformations of Mu-Agonists with Phenylalanine in Position-3 Effect of Derivatization of Steroids on Their Retention Behavior in Inclusion Chromatography Using Cyclodextrin as a Mobile Phase Additive Cloning and Expression of a Cocaine-Sensitive Dopamine TranspOrter Complementary DNA. Sc'i£-'nce Hepatocyte Growth Factor inhibits Growth of Hepatoceliular Carcinoma Cells Mutations at the Dimer, Hexamer, and Receptor-Binding Surfaces of Insulin Independently Affect Insulin-Insulin and lnsttlin-Receptor Interactions eDNA Cloning and Functional Expression of the Schistosoma-Mansoni Protective Antigen Triose-Phosphate Isomerase Crystal Parameters and Molecular Replacement of an Antichulera Toxin Peptide Complex Tumor Necrosis Factor-alpha Triggers Antitoxoplasmal Activity of IFN-gamma primed Macrophages Correlations Between the Conformations Elucidated by CD Spectroscopy and the Antigenic Properties of Four Peptides of the Foot-and-Mouth Disease Virus Stable Expression of the Mouse Nicotinic Acetylcholine Receptor In Mouse Fibroblasts -Comparison of Receptors in Native and Transfected Ceils Differential Rates of Conversion of Rat Prolnsulh-1-I and Proinsulin-lI -Evidence for Slow Cleavage at the B-Chain/C-Peptide Junction of Proinsulin-H Kinetics of Insulin Aggregation In Aqueous Solutions Upon Agitation in the Presence of Hydrophobic Surfaces 199:699~03. SMITH DP: Production and Biolgical Activity of Hybrid Growth Hormone-ReleasIng Hormone Propeptides Photoreceptor Deactivation and Retinal Degeneration Mediated by a Photoreceptor-Specifie ProteIn Kinase-C Euhanced Insulin-Like Growth Factor-I Gene Expression in Regenerating Rat Pancreas Tyrosyl Radicals and Their Role in Hydroperoxide-Dependent Activation and Inactivation of Prostaglandin Endoperoxide Synthase The Mechanism of Receptor-Mediated Endocytosis Olfactomedin -Purification, Characterization, and Localization of a Novel Olfactory Glycoprotein Black-market Biotechnology: Athletes Abose EPO and HGH. BiotechnoloRy All Unusual Peptide Conformation May Precipitate Amyloid Formation in Alzitelmer's Disease -Application of Solid-State NMR to the Determination of Protein Secondary Structure Glycosylinositol Phospholipid Anchors of the Scrapie and Cellular Prion Proteins Contain Sialic Acid Inactivation of Muscle Chloride Channel by Transposon Insertion in Myotonic Mice Transcriptional Repression of the GLUT4 and C/EBP Genes in 3T3-L1 Adipocytes by Tumor Necrosis Factor-alpha Confusion Over Human Insulin Bence Jones ProteIns -a Powerful Tool for the Fundamental Study of Protein Chemistry and Pathophysiology Cooperativity in the Dopamine Beta-Monooxygenase Reaction -Evidence for Ascorbate Regulation of Enzyme Activity Average Density and Size of Microclusters of Epidermal Growth Factor Receptors on A431 Cells Endocrine and Immune Systems Structure of the Insulin Receptor Substrate 1BS-1 Defines a Unique Signal Transduction Protein Regulation of Biological Functions by an insulin Receptor Monoclonal Antibody in Insulin Receptor Beta-Subuuit Mutants A Point Mutation in the Seventh Hydrophobic Domain of the Alpha-2 Adrenergic Receptor Increases Its Affinity for a Family of Beta-Receptor Antagonists Two Conserved Domains in NGF Propeptide are Necessary and Sufficient for the Biosynthesis of Correctly Processed and Biologically Active NGF Heparin is Required for Celi-free Binding of Basic Fibrobiaat Growth Factor to a Soluble Receptor and for Mitogenesis in Whole Cells Cyclosporin-Mediated InhlbRion of Bovine Caleineurin by Cyclophllins a and B Basic Fibroblast Growth Factor Enhances Nerve Growth Factor Receptor Gene Promoter Activity in Human Neuroblastoma CeLl Line CHP100 The Primary Structure and Gene Organization of Human Substance-P and Neuromedin-K Receptors ImmHnoafflnity Purification and CDNA Cloning of Human Platelet Prostaglandin Endoperoxide Synthase (Cyelooxygenase) Enhanced Bioavallability of Subcutaneously Injected Insulin by Pretreatment with Ointment Containing Protease Inhibitors Mapping the Receptor-Recognition Site of Human Transforming Growth Factor-alpha Identification of a Neutralization Epitope on the Envelope Gp46 Antigen of Human T-Cell Leukemia Virus Type-I and Induction of Neutralizing Antibody by Peptide lmmtlnization Stable Isotope Aided Nuclear Magnetic Resonance Study to Investigate the Receptor-Binding Site of Human Interleukin-lbeta Erythropoietin and Spontaneous Platelet Aggregation in Haemodialysis Patients Invivo Binding ~md Clearance of Circulating Antigen by Blspecitic Hcteropolymer-Mediated Binding to Primate Erythrocyte Complement Receptor Cloning and Sequence Analysis of CDNA Encoding Two Crustacean Hyperglycemic Hormones from the Lobster Homarus-Americanus Pituitary Pro-Opiomelanocortin Gene Expression Requires Synergistic Interactions of Several Regulatory Elements Convergent Functional Groups. 8. Flexible Model Receptors for Adenine Derivatives Isolation and Characterization of Human Thloredoxin-Encoding Genes • Glucose/Galactose Malabsorption Caused by a Defect in the Na + /Glucose Cotransporter Autigen Responsive Antibody Receptor Ktnase Chimera Crystals of the Complex Between Human Growth Hormone and the Extracellular Domain of Its Receptor Binding of Myotuxin-A to Sarcoplasmic Rcticulum Ca2+-ATlPase -a Structural Study Volume Regulated Chloride Channels Associated with the Human Multidrug-reslstance P-glycoprotein Multiple Dopamine D4 Receptor Variants in the Human Population HUNTER T: Tyrosine-706 and Tyroalne-807 Phosphorylation Site Mutants in the Murine Colony-Stimulating Factor-1 Receptor are Unaffected in Their Ability to Bind or Phosphorylate Phosphatidylinositol-3 Kinase But Show Differential Defects in Their Ability to Induce Early Response Gene Transcription A Vitronectin-Receptor-Ralated Molecule in Human Placental Brush Border Membranes Antiandrogens and the Mutated Androgen Receptor of LNCaP Cells -Differential Effects on Binding Affinity, Heat-Shock Protein Interaction, and Transcription Activation The B-cell Antigen Receptor of the Five lmmunoglobulin Classes Sccond-T~ulester Maternal Serum Alpha-Fetoprotcin Levels and the Risk of Subsequent Fetal Death The Insulin-A and Insulin-B Chains Contain Sufficient Structural Information to Form the Native Molecule. 7}'ends Cellsurface Receptor for Ecotropic Murine Retrovirusrs is a Basic Amino Acid Transporter Human Recombinant Migration Inhibitory Factor Activates Human Macrophages to Kill Leishmanla-donovanL J :mmuno11991 Heteronuclear 2D NMR Studies of an Engineered insulin Monomer -Assignment and Characterization of the Receptor-Binding Surface by Selective H-2 and C-13 Labeling with Application to Protein Design Diphtheria Toxin-Related Mpha-Melanocyte-Stimulating Hormone Fusion Toxin -Internal In-Frame Deletion from Thr387 to HIS485 Results in the Formation of a Highly Potent Fusion Toxin Which is Resistant to Proteolytic Degradation Site-directed Mutageneals of the M3 Muscarinic Receptor: Identification of a Series of Threonine and Tyrosine Residues Involved in Agonist But not Antagonist Binding Transforming Growth Factor-beta Induces Selective Increase of Proteoglycan Production and Changes In the Copolymeric Structure of Dermatan Sulphate in Human Skin Fibroblasts The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysls by Tumor Necrosis Factor-alphm POO12v1~ JT: T-Cell Recognition of Nelsseria-meningitidis Outer Membrane Proteins -Identification of T-Cell Epitopes with Selected Synthetic Peptides and Determination of HLA Restriction Elemcnts 3-Dimensional Structure of the LDL Receptur-Binding Domain of Human Apolipoprotein-E. Science Design of Constructs for the Expression of Biologically Active Recombinant Human Factor-X and Factor-Xa -Kinetic Analysis of the Expressed Proteins Receptor-Mediated Gene Delivery Invivo -Partial Correction of Genetic Analbuminemia in Nagase Rats Restoration of Hypoglycaemia Awareness by Human Recombinant Growth Hormone Receptur-Induced Conformation Change of the Immuuosuppressant Cyclosporin-A. Science 1%)1 Human Recombinant ID3 is a Growth Factor for Normal B-Cells Growth-Stimulatory Monoclonal Antibodies Against Human Insulin-Like Growth Factor-I Receptor A Membrane-Bound Metallo-Endopeptidase from Rat Kidney Hydrolyzhig Parathyroid Hormone -Purification and Characterization Identification of Transcriptional Suppressor Proteins that Bind to the Negative Regulatory Element of the Human Immunodeficiency Virus Type I. Nucleic Acids Ree Cloning of a Betaine Transporter that is Regulated by Hypertonicity Disruption of Cysteine-Rich Repeats of the P75 Nerve Growth Factor Receptor Leads to LOSS of Hgand Binding Expression of Insulin-Like Growth Factor-I, Its Binding Proteins, and Its Receptor In Ovarian Cancer Identification of a New BindIng Protein for Crotoxin and Other Ncurotoxic Phospholipase-A2s on Brain Synaptic Membranes Identification of a Novel Amino Acid, ortho-Bromo-L-Phenylalanine, in Egg-Associated Peptides that Activate Spermatozoa Tissue-Specific and Hormonal Regulation of Human Prostate-Specific Glandular Kallikrein Tyrosine Mutations Within the Alpha-PLatelet-Derived Growth Factor Receptor Kinase Insert Domain Abrogate Receptor-Associated Phosphatidylinos Kinase Activity Without Affecting Mitugenic or Chemotactic Signal Transduction Synthesis and Invitro and Invivo Activity of Analogs of Growth Hormone-Releasing Hormone (GH-RH) with C-Terminal Agmatine Early Gene Responses to Transforming Growth Factor-beta in Cells Lacking Growth-Suppressive Rb Function A Region of the Insulin Receptor Important for Ligand BInding (Residues 450-601) is Recognized by Patients' Autoimmune Antibodies and Inhibitory Monoclonal Antibodies Chemical Modification of Prostaglandin-H Synthase wRh Diethyl Pyrocarbonate Retinoid X Receptor is an Auxiliary Protein for Thyroid Hormone and Retinoic Acid Receptors Novel Pathway for Thyroid Hormone Receptor Action Through Interaction with Jun and Fos Oncogene Activities Suppression of Diabetes in Nonobese Diabetic Mice by Oral Administration of Porcine Insulin Structure and Domain Organization of the CD19 Antigen of Human, Mouse, and Guinea Pig Lymphocytes-B -Conservation of the Extensive Cytoplasmic Domain Conformational and Epitope Mapping of Herpes-Simplex-Virus Type-1 Thymidine Kinase Using Synthetic Pcptidc Segments Genetic probes, disease states and transgenic studies Related review: Alzheimer's disease: transgenic models to test new chemicals and pharmaceuticals Segregation Analysis Detects a Major Gene Controlling Blood Infection Levels in Human Malaria Correction by Erythropoietin of Anaemia in Autonomic Failure Defective Acidification of Intracellular Organdies in Cystic Fibrosis Down-Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Gene Expression by Agents that Modulate IntraceUular Divalent Cations Solution Conformations and Aggregational Properties of Synthetic Amyloid Bcta-Peptides of Alzheimer's Disease -Analysis of Circutar Dichroism Spectra Transgenic Mice and Alzheimer's Disease. In Alzheimer's Disease.. Basic Mechanisms, Diagnosis and Therapeutic Strategies Reversed-Phase Liquid Chromatographic Method for the Simultaneous Determination of the Antimalarial Drugs Sulfadoxine, Pyrimethamine, Mefloquine and Its Major Carboxylic Metabolite in Plasma Gaucher Disease -New Molecular Approaches to Diagnosis and Treatment The Switch of Tau Protein to an Alzheimerlike State Includes the Phosphorylation of Two Scrine-proliaxe Motifs Upstream of the Microtubule Binding Region Restin: a Novel Intermediate Filamentassociated Protein Highly Expressed In the Reed-Steruberg Cells of Hodgkin's Disease. EM/30 J 1992 Lqvivo Administration of Anti-CD3 Monoclonal Antibodies or Immunotoxins in Murine Recipients of Allogexxeic T-Ceil-Depleted Marrow for the Promotion of Engraftment Role of Apolipoprotein E and B Gene Variation in Determining Response of Lipid, Lipoprotein, and Apolipoprotein Levels to Increased Dietary Cholesterol A m A Module of the DnaJ Heat Shock Proteins Found in Malaria Parasites Early-onset Alzheimet~s Disease Caused by Mutations at Codon 717 of the ~-Amyloid Precursor Protein Gene Analysis of Anti-Tumor Antibodies In Mice and Rabbits Induced by Monoclonal Anti-Idiotope Antibodies Phosphorylation of Transfected Wild Type and Mutated Progesterone Receptors Chimaeric Anti-CD4 Monoclonal Antibody for Rekapsing Polychondritis Carrier Detection and Prenatal Diagnosis in Duchenne and Becket Muscular Dystrophy Families, Using Dinucleotide Repeat Polymorphisms Altered Chloride Ion Channel Kinetics Associated with the DeltaFS08 Cystic Fibrosis Mutation Gene Expression in Leishmania -Analysis of Essential 5' DNA Sequences Transgettic Expression of a Variant of Human Tissue-Type plasmtnogen Activator In Goat Milk -Purification and Characterization of the Recombinant Enzyme Production of Cystic Fibrosis Transmembrane Conductance Regulator in the Milk of Transgenic Mice Infectious Diseases -a Dead Specialty Revives The Matrix Metalloproteinases and Their Natural Inhibitors: Prospects for Treating Degenerative Tissue Diseases Mitogen Activated Protein (MAP) Kinase Transforms Tau Protein into an Alzheimer-like State Transgentc Production of a Variant of Human Tissue-Type Plasminogen Activator in Goat Milk -Generation of Transgenic Goats and Analysis of Expression DNA Typing and Genetic Mapping with T~meric and Tetrameric Tandem Repeats Treatment of Inflammatory Bowel Disease with Anto CD4 Monoclonal Antibody Metacyclic Form-Specific Variable Surface GlycoproteIn-Encoding Genes of Trypanosoma-(Nannomonas)-Congolense Substitution Therapy for C1 Esterase Deficiency Effects of Injected Alzheimer Beta-Amyloid Cores in Rat Brain Transmission-Blocking Antibodies Recognize Microfilarial Chitinase in Brugian Lymphatic Filariasis T-Cell Responsiveness to an Oncogenic Peripheral Protein and Spontaneous Autoimmunity in Transgenic Mice Epitope Map of 2 Polyclonal Antibodies that Recognize Amyloid Lesions in Patients with Alzhchner's Disease Expression of Biologically Active Human Corticoateroid Binding Globnlln by insect Cells -Acquisition of Function Requires Glycosylation and Transport Bone Marrow Transplantation for Severe Aplastic Anemia -Influence of Conditioning and Graft-Versus-Host Disease Prophylaxis Regimens on Outcome Segregation of a Missense Mutation in the Amyloid Precursor Protein Gene with Familial Alzheimer's Disease Transgenic Mouse Mammary Tumor Virus Superantigen Expression Prevents Viral Infection Expression and Genomic Structure of the Genes Encoding FdI, the Major Allergen 13eom the Domestic Cat A Single Alnino Acid Substitution Strongly Modulates the Activity and Substrate Specificity of the Mouse Mdrl and Mdr3 Drug Efllux Pumps Anttdiabetogenic Effect of Glucagon-like Peptide-1 (7-36)Amide in Normal Subjects and Patients with Diabetes Mellitus Reduced lmm,mogenicity and Improved Pharmacokinettes of Humanized Anti-Tac in Cynomolgas Monkeys Protection of Cotton Rats by Imm,mization with the Human Parainfluenza Virus Type-3 Fusion (F) Glycoprotein Expressed on the Surface of Insect Cells Infected with a Recombinant Baculovirus Amyloid Deposition as the Central • • Event in the Aetiology of Alzheimer's Disease Failure to Detect Cytomegalovirus DNA in Pancreas in Type 2 Diabetes Sequential NMR Resonance Assignment and Structure Determination of the Kunitz-Typc inhibitor Domain of the Alzheimer's Beta-Amyloid Precursor Protein Multidrug Resistance in Leishmania-Donovani is Conferred by Amplification of a Gene Homologous to the Mammalian Mdr-1 Gene Trypanosoma-Cruzt 5S RRNA Genes -Molecular Cloning, Structure and Chromosomal Organization Use of Site-Directed Mutagenesis to Enhance the Epitope-Shielding Effect of Covalent Modification of Proteins with Isolation and Structural Characterization of an insulin-Related Molecule, a Predominant Neuropeptide from Locusta-Migratoria Polytnorphism of ApoHpoprotein-A-iI (apoA-H) Among inbred Strains of Mice -Relationship Between the Molecular Type of ApoA-H and Mouse Senile Amyloidosis HunJhan and Rodent Sequence Analogs of Alzheimer's Amyloid BetaA4 Share Similar Properties and can be Carbohydrate-Based Therapeutics Mouse Model of Neurodegeneration: Atrophy of Basal Forebrain Cholinergic Neurons in Trisomy 16 Transplants Linkage of the Gene for an X-linked Mental Retardation Disorder to a Hypervariable (AGAT)n Repeat Motif Within the Human Hypoxanthine Phosphoribosyltransferase (HPRT) Locus (Xq26) Structural Characterization of the N-Glycans of a Recombinant Hepatitis-B Surface Antigen Derived from yeast A Bioluminescence Assay for Gene Expression by Continuously Growing Mammalian Cells -Application for Detection of Human Immunodeficiency Virus Type-1 (HIV-1) Identification of Polymerized-Albumin Receptor Domain in the Pre-S2 Region of Hepatitis B Virus Surface Antigen M Protein Determination of Small Drug Molecules by Capillary Electrophoresis Atmospheric Pressure Ionization Mass Spectrometry Structure of Human Cyclophllin and Its Binding Site for Cyclosporin-A Determined by X-Ray Crystallography and NMR Spectroscopy Transgenic Mice that Express a Mini-Gene Version of the Human Gene for Typc-I Procollagen (COLIA1) Develop a Phenotype Resembling a Lethal Form of Osteogenesis Inlperfecta Complete Amino Acid Sequence Determinations Demonstrate Identity of the Urinary Bence Jones Protein (BJP-DIA) and the Amyloid Fibril Protein (AL-DIA) in a Case of AL-Amyloidosis Sonlatic Reversion/Suppression in Duchenne Muscular Dystrophy (DMD): Evidence Supporting a Fratne-restoring Mechanism in Rare Dystrophin-positive Fibers Cooperative Protein-DNA interactions -Effects of KCI on Lam~j da-cI Binding to OR Alternating Zinc Fingers in the Human Male Associated Protein ZFY -Refinement of the NMR Structure of an Even Finger by Selective Deuterium Labeling and Implications for DNA Recognition Animal Models Point the Way to Human Clinical Trials Progressive Glomerulosclerosis and Enhanced Renal Accumulation of Basement Membrane Components in Mice Transgenic for Human Imlnunodeficiency Virus Type-1 Genes Alzheimer's Disease -a Cell Biological Perspective In Vitro Guide RNA/mRNA Chimaera Formation in Trypanosoma Brucei RNA Editing Guide RNAs for Transcripts with Developmentally Regulated RNA Editing are Present in Both Life Cycle Stages of Trypanosom~-Brucei Abnormal Brown and white Fat Development in Transgenie Mice Overexpreasing Glycerol 3-phosphate Dehydrogenase Transfection of Wild-type CFTR into Cystic Fibrosis Lymphocytes Restores Chloride Conductance at G I of the Cell Cycle Prostagiandin Synthesis in Human Trisomy 21, Transfected Cells and Transgenic Mice Mapping the Polarity Profiles of General Anesthetic Target Sites Using Normal-Alkane-(alpha,omega)-Diols Generation and Specificity of Monoclonal Anti-Idiotypic Antibodies Against Human H1V-Specific Antibodies. 1. Cross-Reacting Idiotopes are Expressed in Subpopulations of HIV-infected individuals Antigen-Induced Apoptotie Death of Ly-1 B Cells Responsible for Autoimmnne Disease in Transgenic Mice A Mutation • in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease Enzyme-Linked Immunosorbetu Assay for Rapid Detection of Toxins from Clostridium-Perfringens Alu-Prtnled Polymerase Chain Reaction for Regional Assignment of 110 Yeast Artificial Chromosome Clones from the Httman x-Chromosome -Identification of Clones Associated with a Disease Locus Imaging of Haemodialysisassociated Amyluidosis with 123I-serum Amyloid P Component CD4 Antibody Treatment of Severe Psoriasis Alzheimer-beta/A4 Amyloid Precursor Protein in Human Brain -Aging-Associated Increases in HoloproteIn and in a Proteolytic Fragment Human Beta-Galactosidase Gene Mutations in Morquio-B Disease Pancreatic Enzyme Supplement Dosage in C~tic Fibrosis PF~>-imoxication of Cultured Cells by Cholera Toxin -Evidence for Different Pathways when Bound to Ganglioside-G(M1) or Neoganglioproteins Expression in Eseheriehia-coll and Characterization of the Fatty-Acid-Binding Protein from Human Muscle Development of New Thrombolytic Agents Using Recombinant DNA Technology Identification Of 2 Distinct Galactosyltransfeease Activities Acting on the Variant Surface Glycoprotein of Trypanosoma-Brucei C~eric CD4 Monodonal Antibody in Treatment of Generalised Pustular Psoriasis Formation of ~-Amyloid Protein Deposits in the Brains of Transgenic Mice Anti-CD4 Therapy of Acute Rejection in Long-term Renal Allograft Recipients Transplants of Mouse Trisomy Hippocampus Provide a Model of Alzheimer's Disease Neuropathology Rapid Switching to Multiple Antigenic and Adhesive Phenotypes in Malaria Point Mutations in the I)ystrophin Gene HLunalt T-Cell Clone Identifies a Potentially Protective 54-kDa Protein Antigen of Toxoplasma-gondli Cloned and Expressed in Escherichla-coli Mouse Model for Exoerythrocytic Stages of Plasmodium Falciparum Malaria Parasite Expression of the • Human ~-Amyloid Protein of Alzheimer's Disease Specifically in the Brains of Transgenic Mice Gene Inactivation of Pill-1 of Plasmodium Faleiparum by Chromosome Breakage and Healing: Identification of a Gametocyte-specific Protein with a Potential Role in Gametogenesis Recovery from Experimental Parkinsonism in Primates with GM1 Gangliostde Treatment Production of Hepatitis B Surface Antigen (PreS2 + S) by Highcell Density Cultivations of a Recombinant Yeast Rapid Mapping by Transposon Mutagenesis of Epitopes On the Muscular Dystrophy Protein Specificity of Glucose Transport in Trypanosoma-Brucei -Effective Inhibition by Phloretin and Cytochalasin-B. Eur JBiochem t991 Overexpressinn of Apolipoprotein-E in Tratmgeuic Mice -Marked Reduction in Plasma Lipoproteins Except High Density Lipoprotein and Resistance Against Diet-Indnced Hypercholesterolemia Structure-Function Analysis of the Histidine Permease and Comparison with Cystic Fibrosis Mutations Conversion of the Alzheimer'R Beta-Amyloid Precursor Protein (APP) Kunitz Domain into a Potent Human Neutrophil Elastase Inhibitor A Protease Activity Associated with Acetylcholinesterase Releases the Membrane-Bound Form of the Amyloid Protein Precursor of Alzheimer's Disease Monoelonal Antibody HA-1A for Gramnegative Shock Excess Brain Protein Oxidation and Enzyme Dysfunction In Normal Aging and in Alzheimer Disease Molecular Characterization of a teishmanta-Donovani-Infantum Antigen Identified as Histone H2A An Unusual Peptide Conformation May Precipitate Amyloid Formation in Alzheimer's Disease -Application of Solid-State NMR to the Determination of Protein Secondary Structure A Maternal Serum Screen for Trisomy-18 -an Extension of Maternal Serum Screening for Down Syndrome Identification of Potentially Neurotoxie Pyridinium Metabolite in the Urine of Schizophrenic Patients Treated with Susceptibility of ~ 2-microgiobuiin-deflciem Mice to Trypanosoma Cruzi Infection Selection of Unrelated Donors for Bone Marrow Transplantation is Improved by HIA Claas-H Genotyping with OHgonucleotide Hybridization Decreased Levels of Soluble Amy/oid Beta-Protein Precursor in Cerebrospinal Fluid of Live Alzheimer Disease Patients Comparative Sequence Analysis of the Clostridinm-Diffieile Toxin-A and Toxin-B Isolation and Characterization of New Highly Polymorphic DNA Markers from the Huntington Disease Region Invitro and Invivo DNA Bonding by the CC-1065 Analogue U-73975 Proton Proton Overhauser Effects of Receptor-Bound Cyclosporin-A Observed with the use of a Heteronuelear-Resoived Half-Filter Experiment All unlikely Sugar Substrate Site in the 1.65 a Structure of the Human Aldose Reductase Holoenzyme Implicated in Diabetic Complications Regulatory Region of Human Amyloid Precursor Protein (APP) Gene Promotes Neuron-specific Gene Expression in the CNS of Transgenic Mice Deposits of Amyloidbeta Protein in the Central Nervous System of Transgenie Mice Synthesis of a Gene for Rat Liver Fatty-Acid-Binding Protein and Its Expression in Escherichia-coli Antibody variable Region Glycosylation: Position Effects on Antigen Binding and Carbohydrate Structure High Level Expression of Active Human Alpha-l-Antitrypsin in the Milk of Transgenic Sheep Single Anlino Acid Substitutions Dissociate Fibrinogen-Clotting and Thrombomodulin-Binding Activities of Hunla~ Thrombin Site-Directed Mutagenesis of the Pseudomonas-aeruginosa Cytotoxin for Probing Toxic Activity Transgenic Mice for the Amyloid Precursor Protein 695 have Impaired Spatial Memory Structural Determination of Ollgosaecharides Derived from Lipooligosaecharide of Neisseria-Gonorrhoeae F62 by Chemical, Enzymatic, and Two-Dimensional NMR Methods Expression of Human Factor IX in Rat Capillary Endothelial Cells: Toward Somatic Gene Therapy for Hemophilia B Single-base Mutational Analysis of Cancer and Genetic Diseases Using Membrane Bound Modified Oligonucleotides A Cluster of Higltiy Polymorphic Dinucleotide Repeats in Intron 17b of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene. AmJHum Shigella Flexneri induces Apoptosis in Infected Macrophages Colony-stimulating factors Related review: Colony-stimulating factors in the clinic Biological and Antitumor Effects of Recombinant Human Macrophage Colony-Stimulating Factor in Mice BEAM Regimen and C~CSF in HTLV-I-associated T-cell Lymphoma Simultaneous Administration of Granulocyte-macrophage Colony Stimulating Factor and Cytosine Arabinoside for the Treatment of Relapsed Acute Myeloid Leukemia G-CSE and Peripheral Blood Progenitor Cells Effect of Macrophage Colony Stimulating Factor on In Vitro Osteoclast Generation and Bone Resorption Reduction by Granulocyte Colony Stimulating Factor of Fever and Neutropenia Induced by Chemotherapy in Patients with small Cell Lung Cancer The Capacity of Peripheral Blood Stem Cells Mobilised with Chemotherapy Plus C~CSF to Repopulate Irradiated Marrow Stroma In Vitro is Similar to that of Bone Marrow Recombinant Hunian Granulocyte-macrophage colony Stimulating Factor Accelerated Neutrophil and Monocyte Recovery after Allogeneic T-cell Depleted Bone Marrow Transplantation Novel Fold and Putative Receptor Binding Site of Granulocytemacrophage Colony-stimulating Factor A Colony-stimulating Factor-1 (CSF-1) Receptor/Piatelet-derived Growth Factor-beta Receptor Gcne Fusion Confers CSF-1 Independence and Tumorigenicity on a C-myc-Immortalized Monocyte Cell Line Treatment of Newly Diagnosed Acute Myelogenous Leukemia with Ganulocytemacrophage Colony-atimulating Factor (GM-CSF) Before and During Continuous-infusion High-dose Ara-C+ Daunorubtchm Comparison to Patients Treated Without GM-CSF Model Using a Peptide with Carrier Function for Vaccination against Different Pathogens Autotransplantation of Peripheral Blood Stem Cells Mobllised by Chemotherapy and Recombinant Human Granulocyte Colony Stimulating Factors in childhood Neuroblastoma and Non-Hodgkin's Lymphomm BrJ IIaematol ETAL: In ViVO Effects of Granulocyte-maerophage Colony Stimulating Factor and Interleukin 3 on Clonal and Nonelonal Cell Populations in Patients with Clonal Hematopoietic Disorders Sequential in Vivo Treatment with Two Recombinant Human Hematopietic Growth Factors (interieukin-3 and Granulocyte-Maerophage Colony-Stimulating Factor) as a New Therapeutic Modality to Stimulate tlematupoiesis: Results of a phase I Study The 1L-6 Signal Transducer, Gpl30, an Oncostatin M Receptor and Affinity Converter for the IAF Receptor Recombinant Human Granulocyte-colony Stimulating Factor in the Treatment of Patients with Chronic Benign Granulocytopenia and Congenital Agranulocytosis (Kostmann's Syndrome) ETAL: Macrophage Colony Stimulating Factor Prevents the Progression of Atheroselerosis in Watanabe Heritable Hyperlipidemic Rabbits Synergistic Effects of Interieukin-l(x on the Expansion of Human Hematopoietic Progenitor Cells in Liquid Cultures Recombinant Hi*man Granulocyte-maerophage Colonystimulating Factor Ameliorates Zidovudineinduced Neutropenia in Patients with Acquired Immunodeficiency Syndrome (AIDS)/AIDS-related Complex Drug Therapy: Granulocyte Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulationg Factor (First of Two Parts) Drug Therapy: Granulocyte Colony-stimulating Factor and Granulocytemacrophage Colony-stimulating Factor (Second of TWo Parts) A Comparison of Therapeutic Schedules for Administering Granulocyte Colonystimulating Factor to Nonhuman Primates after High-Dose Chemotherapy Potential use of Human Stem Cell Factor as Adjunctive Therapy for Httman inlmunodeficiency Virus-related Cytopenias Combined Therapy with Recombinant Granulocyte Colony Stimulating Factor and Erythropoietin Decreases Hematological Toxicity from Gidovudine Characterization of the Mouse Granulocyte-macrophage Colonystimulating Factor (GM-CSF) Gene ]~rornoter --Nuclear Factors that Interact with an Element Shared by Three Lymphokine Genes --those for GM-CSF Recombinant Granulocyte-Macrophage Colony-Stimulating Factor after Autologous Bone Marrow Transplantation for Lymphoid Cancer Phase H Trial of Recombinant Human Granulocyte-Maerophage Colony-Stimulating Factor in Patients Undergoing ARogeneic Bone Marrow Transplantation from Unrelated Donors Administration of lmerleukin-6 stimulates Multilineage Hematupoiesis and Accelerates Recovery from Radiation-induced Hematopoietic Depression G-CSF and Peripheral Blood Progenitor Cells Identification of Critical Amino Acid Residues in Human and Mouse Granulocyte-Macrophage Colony-Stimulating Factor and Their Involvement in Species Specificity Effect of Peripheral-blood Progenitor Cells Mobilised by Filgrastim (G-CSF) on Platelet Recovery after High-dose Chemotherapy Inhibitory Effect of Granulocyte-macrophage Colonystimulating Factor Therapy on the Generation of Nanzral Killer Cells Structural and Functional Analyses of Glycosylatlon on the Distinct Molecules of Human GM-CSF Receptors G-CSF and Peripheral Blood Progenitor Cells Blastocyst Implantation Depends on Maternal Expression of Leukaemia Inhibitory Factor Pharmacokinctics of Recombinant Human Granulocyte Colony-Stimulating Factor Conjugated to Polyethylene Glycol in Rats Induction of Cytokine Messenger RNA and Secretion in Alveolar Macrophages and Blood Monocytes from Patients with Lung Cancer Receiving Granulocyte-Macrophage Colony-Stimulating Factor Therapy Fever in Nemropenic Patients Treated with GM-CSF Representhag Enhanced Host Defenee 3-Dimensional Structure of Recombinant Human Granuloeyte-Macrophage Colony-Stimulating Factor Random Mutagenesis of CSF-1 Receptor (FMS) Reveals Multiple Sites for Activating Mutations within the Extraeeliular Domain Hematopoietic Effects • . of a Granulocyte Macrophage Colony Stimulating Faetor/Interleukin 3 Fusion Protein Dcternaination of Some Drugs by Micellar Eleetrokinetic Capillary Chromatography -the Pseudo-Effective Mobility as Parameter for Screening Protein-Solvent Interactions in Pharmaceutical Formulations Development of Af~nity Labeling Agents Based on Nonsteroidal Aaxti-Inflummatory Drugs -Labeling of the Nonsteroidal Anti-Inflammatory Drug Binding Site of 3-alpha-Hydroxysteroid Dehydrogenase The Kinetic Mechanism Catulysed by Homogeneous Rat Liver 3-alpha-Hydroxyateroid Dehydrogenase -Evidence for Binary and Ternary Dead-End Complexes Containing Non-Steroidal Anti-Inflammatory Drugs S~liatoxin, a Blocker of Ca2+-Activated K+ Channels -Structure-Function Relationships and Brain Localization of the Binding Sites Delivering Peptides to the Central Nervous System -Dllemmug and Strategies DA h Illltibitiou of the Interaction Between Lipoproteins and Amphotericin-B by Some Delivery Systems Biopharmaeeuticals and Conventional Drugs: Clinical Success Rates Reconstituted Viral Envelopes --'Trojan Horses' for Drug Delivery and Gene Therapy? Trends Biotechno11991 Tantazoles -Unusual Cytotoxic Alkaloids from the Bhie-Green Alga Scytonema-Mirabile Expression of Rulnan IL-l-beta in Salnaonelia-Typhixnuriutn -a Model System for the Delivery of Recombinant Therapeutic Invivo Dexamethasone Prevents the Growth Inhibitory Effects of Recombinant Tumor Necrosis Factor in a Rat Hepatoma Cell Line Reuber-RC-3 -an Association with the Changes in the Messenger RNA Levels for Multidrug Resistance Gene Expression and Activity of P-Glycoprotein, a Multidrug Efllux Pump, in Human Hematopoietie Stem Cells Fatty Acid Acylated Fab-Fragments of Antibodies to Neurospecific Proteins as Carriers for Neuroleptic Targeted Delivery in Brain E-Dimensional NMR Studies of D(GGTTAATGCGGT)Bulletd(ACCGC~TTAACC) Complexed with the Minor Groove BInding Drug SN-6999 Suppression of Thronlboxane A2 But not of Systemic Prostacyclin by Controlled-release Aspirin The Pharmacokinetics Of, and Humoral Responses To, Antigen Delivered by Microencapsniated Liposomes Effects of the Antitumor Antibiotic Mithramycin on the Structure of Repetitive DNA Regions Adjacent to Its GC-Rieh Binding Site Treatment of Murine B-Ce ll Lymphoma with Bispecific Monoclonal Antibodies (Anti-Idlotype X Anti-CD3) Rational Design of Quinazoline-Based Irreversible Inhibitors of Hummn Erythrocyte Purine Nucleoside Phosphorylase Biochelnical Ethanol Effects Affected by a Non-Steroidal Anti-Inflamttnatory Drug Heparin Prevents the Binding of Phospholipase-A2 to Phosphollptd Micelies -Itnportance of the Amino-Terminus An Analog of Myristic Acid with Selective Toxicity for African Trypanosomes Monoclonal Antibody-Targeted Superantigens -a Different Class of Anti-Tumor Agents Stimulation of Dihydrofolate Reductase Promoter Activity by Antinletabolic Drugs How Sweet it Is: Selectin-Mediating Drugs Design, Synthesis, and Kinetic Evaluation of a Unique Class of Elaatase Inhibitors, the Peptidyl Alpha-Ketobenzoxazoles, and the X-Ray Crystal Structure of the Covalent Complex Between Porcine Pancreatic Elastase and Ae-Ala-Pro-Val-2-Benzoxazole Liquid Chromatographic Arialysis of a Potential Polylneric-Pendant Drug Delivery System for Peptides -Application of High-Perfortnance Size-Exclusion Clxromatography, Reversed-Phase High-Performance Liquid Chromatography and Ion Chromatography to the Evaluation of Biodegradable Poly< (Chloromethoxytrialanine Methyl Ester) Phosphazenes> Genetic Transfer of Non-P-Glycoprotein-Mediated Multidrug Resistance (MDR) in Somatic Cell Fusion -Dissection of a Compound MDR Phenotype Multiplicity of Acidic Subunit Isoforms of Crotoxin, the Phospholipase-A2 Neurotoxin from Crotalus-Durissus-Terrificus Venom, Results from Posttranslational Modifications Metabolism of Low-Density Lipoprotein Free Chulesterol by Human PLasma Lecithin-Cholesterol Acyltransferase LOw Molecular Weight Proteins as Carriers for Renal Drug Targeting -Naproxen-LysozTlne Purification and Biochemical Characterization of Recombinant Simian Immunodefieiency Virus Protease and Comparison to Human Immunodeficiency Virus Type-1 Protease Invitro Evaluation of the Plasma and Blood Compatibility of a Parenteral Formulation for Ditekiren, a Novel Renin Inhibitor Pseudopeptide The Screening of Selected Microorganisnls for use as Models of M~mmMian Drug Metabolism Environmental Regulation of Bacterial Virulence --Implications for Vaccine Design and Production Lipophilic Cations -a Group of Model Substrates for the Multidrug-Resistanee Transporter Stability of Interleukin-lbeta (IL-lgamma) in Aqueous Solution -Analytical Methods, Kinetics, Products, and Solution Formulation Implications Assessment of Capillary Electrophoresis In Pharmaceutical Applications -Analysis and Quantification of a Recombinant Cytokine in an Injectable Dosage Form Cloning and Invitm Expression of a Melanoma-Associated Antigen Ilammunogenic in Patients with Melanoma Is the Mnitidrug Transporter a Flippase Common West African I-ILA Antigens are Associated with Protection from Severe Malarim Nature Lyophilized Formulations of Recombinant Tumor Necrosis Factor Generation and use of Synthetic Peptide Combinatorial Libraries for Basic Research and Drug Discovery Application of Neural Computing in Pharlnaceatieal Product Development Hulnan Immunodeficiency Vlrns-1 Protease. 2. use of PH Rate Studies and Solvent Kinetic Isotope Effects to Elucidate DetaiLs of Chemical Mechanism Hunlan Immunodelictency Virus-1 Protease. 1. Initial Velocity Studies and Kinetic Characterization of Reaction Intermediates by O-18 Isotope Exchange Structure of Pyrrolosine -a Novel Inhibitor of RNA Synthesis, from the Actinomycete Streptumyces-Albus Demonstration of an Antigenic Protein Specific for salmonelia-Yyphi Production, Delivery Systems, and Survival in Soil of 4 Fungi with Disease Biocontrol Potential Enzyme Microb Techno11991 Identification of 3-and 4-repeat Tau Isoforms within the PHF in Alzheimer's Disease Determination of Small Drug Molecules by Capillary Electrophoresis Atmospheric Pressure Ionization Mass Spectrometry Sustained Delivery of Interleukin-2 from a Poloxamer Gel Matrix Following Intraperitoneal Injection in Mice Drug Action of Thapsigargin on the Ca2+ Pump Protein of Sarcoplasmic Reticulum Retroelement Particles as Purification, Presentation and Targeting vehicles Acyl Pyrophosphates -Activated Analogues of Pyrophosphate Monoesters Permitting New Designs for Inactivation of Targeted Enzymes Chemical Structure of the Carbohydrate Backbone of Responsive Polymer Systems for Controlled Delivery of Therapeutics Insulill Aggregation in Aqueous Media and Its Effect on Alpha-Chymotrypsin-Medlated Proteolytic Degradation Calctneurin is a Common Target of Cyclophilin-Cyelosporin-A and FKBP-FKS06 Complexes Glucose Analogue Inhtbitors of Glycogen Phosphorylase -the Design of Potential Drugs for Diabetes Theoretical Approach to Drug Design. 2. Relative Thernlodynamics of Inhibitor Binding by Chicken Difiydrofolate Reductase to Ethyl Derivatives of Trimethoprim Substituted at 3'-Pusifion, 4'-Position, And 5'-Position A Theoretical Approach to Drug Design. 3. Relative Thermodynamics of Inhibitor Binding by EoColi Dihydrofolate Reductase to Ethyl Derivatives of Trimethoprim Substituted at the 3'-Position, 4'-Position, And 5'-Position Poor Little Rich Drugs Interaction of Forskolin with the P-Glycoprotein Multidrug Transporter 63C~63d. NACLERIO RM: Drug Therapy: Allergic Rhinitis. N EnglJ ivied Mechanisms of Inactivation of Gamma-Aminobutyric Acid Aminotransferase by the Antiepllepsy Drug Gamma-Vinyl GABA (Vigabatrin) Importance of Hydrogen Bond Acceptor Ability in Design of Host Molecules Capable of Molecular Recognition Minor-Groove Width and Accessibility ill B-DNA Drug and Protein Complexes Link Protein as a Monitor Insitu of Endogenous Proteolysis in Adult Human ArticuLar Cartilage DNA-drug Interactions. The Crystal Structures of D(TGTACA) and D(TGATCA) Complexed with Daunomycin The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone Recombinant 43-kDa USE Binds to DNA and Activates Transcription In a Manner Indistinguishable from that of Natural 43/44-kDa USF Direct Access to Serum Macromolecules by Intraerythrocytic MaLaria Parasites Molecular Biology for Erwina: from Soft-rot to Antilcukaemics Basal Body Movements as a Mechanism for Mitochondrial Genome Segregation in the Trypanosome Cell Cycle Neonatal Diagnosis of HlV Infection Loops and Secondary StruCture Mimctics: Development and Application In Basic Science and Rational Drug Design Cycloheximide Inhibits Cellular, But not SV40 Molecular Mapping of Osp-A Mediated Immunity Against Borrelia-burgdorferi, the Agent of Lyme Disease The Roles of the Subuults in the Function of the Calcium channeL Science Kinetics of Insulin Aggregation in Aqueous Solutions Upon Agitation In the Presence of Hydrophobtc Surfaces Predicting Antigenic Sites on Proteins. Trends Biotechno11991 Mixed Micelles as a Proliposomal. Lymphotropic Drug Carrier Implication of the Multidrug Resistance Gene Pfmdrl in Plasmodium-Falciparum Has Arisen as Multiple Independent Events A Possible Role for a M~mmaHan Facilitative Hexose Transporter in the Development of Resistance to Drugs The Effect of Botulinum Toxin Type-D on the Triggered and Constitutive Exocytosis Endocytosis Cycles in Cultures of Bovine Adrenal Medullary Cells Invitro Evaluation of Sustained Drug Release from Biodegradable ELastomer Molecular Studies on Trypanothione Reductase, a Target for Antiparasitic Drugs Lecithin Organogeis as Matrix for the Transdermal Transport of Drugs Human Monoclonal Antibody Homodimers -Effect of Valency on Invttro and Invivo Antibacterial Activity. Jlmmuno11992 Ly-49 Multigene Family -New Members of a Superfamily of Type-H Membrane Proteins with Lectin-Like Domains. Jlmmuno11991 The use of Digoxin-specific Fab Fragments for Severe Digitalis Intoxication in Children Isolation and Characterization of Drosophila Muhidrug Resistance G~ne Homologs Anti-rctroviral Therapy of Human Immunodcficiency Virus Infection: Current Strategies and Challenges for the Future Use of Reconlbinant Human Interleukin 2 in Conjunction with Syneniee Bone Marrow Transplantation in Mice as a Model for Control of Minimal Residual Disease in Malignant Hematologic Disorders Use of Adoptive Transfer of Tumor-Infiltrating LymphoeTtes Alone or in Combination with Cisplatin-Containing Chemotherapy in Patients with Epithelial Ovarian Cancer Glycolipid Changes in Murine Myelogenous Leukemias -Neutral Glycolipids as Markers for Specific Populations of Leukemias Intravesical Administration of Radiolabeled Antitumor Monoclonal Antibody In Bladder Carcinoma Toward a Cure for Multiple Myeloma A Retroviral Oncogene, Akt, Encoding a Serine-Threoninc Kinase Containing an SH2-Like Region DNA Unwinding Produced by Site-Specific Intrastrand Cross-Links of the Antitumor Drug CIS-Di2mmi~edichioroplatinum(H) Moloney Murine Leukemia virus Tolerance in Anti-CD4 Monoclonal Antibody-Treated Adult Mice Sllral~l isaan Inhibitor of DNA Topoisomerase-ll Invitro and in Chinese Hamster Fibrosarcoma Cells Pregnancy Hormones, Estrogen and Progesterone, Prevent HIV-1 Synthesis in Monocytes But not in Lymphocytes. FEBS I.ett N-Myr~toyl-Transfera~e Activity in Cancer Cells -Solubillzation, Specificity and Enzymatic Inhibition of a N-Myrtstoyl Transferasc from L1210 Microsomes Detection and Characterization of a Glycoprotein Encoded by the Mouse mamma*'y Tumor Virus Long Terminal Repeat Gene B3(Ev)-PE38KDEL, a Single-Chain Immunotoxin that Causes Complete Regression of a Human Carcinoma in Mice Treatment of Mice Bearing BCL1 Lymphoma with Btspecific Antibodies Recotubinatlt HuLtnan Granulocyte Macrophage Colony Stimulating Factor after Chemotherapy in Patients with Acute Myeloid Leukemia at Higher Age or after Relapse Degradation of Extracelinlar-Matrix Proteins by Human Cathepsin-B from Normal and Tumour Tissues Drug Therapy -the use of Intravenous lmmune Globulin in Immunodefieiency Diseases. NEng Phase-I Trial of Natural Human Interferon-beta in Metastatic Malignancy Clinical Results and Characterization of Tumor-Infiltrating Lymphocytes with or Without RecombInant Interleukin-2 in Human Metastatic Renal Cell Carcinoma Humanization of an Anti-p185HF~2 Antibody for Human Cancer Therapy Purification and Characterization of the Cytosollc NADP+-Dependent Malic Enzyme from Human Breast Cancer Cell Line Immunoconjugates Containing Novel Maytansinoids -Promising Anticancer Drugs. CancerRes EL-12 -Monoclonal Antibodies Specific for the 40-kDa Subunit Block Receptor Binding and Biologic Activity on Activated Human Lymphoblasts Specific Isoprenoid Modification is Required for Function of Normal, But not Oncogeulc, Ras Protein The Ras Oncoprotein and M-Phase Activity mast Crisis in a Murine Model of Chronic Myelogenous Leukemia LAMPARELLI T: Hairy Cell Leukemia -Splenectomy after Alpha-Interferon Therapy Varacin -a Novel Benzopeotathiepin from Lissocltnum-Vareau that is Cytotoxic Toward a Human Colon Tumor Flare Up of Rheumatoid Arthritis During GM-CSF Treatment after Chemotherapy Inhibition of Tumor Invasion of Smooth Muscle Cell Layers by Recombinant Human Mctalloproteinase Inhibitor Antiproliferative Effects of Interleukin-4 on Freshly Isolated Non-Hodgkin Malignant B-lymphoma Cells Interaction of Mithramycin with DNA -Evidence that MithramycIn Binds to DNA as a Dimer in a Right-Handed Screw Conformation The Breast Tumor Associated Epitope Defined by Monoclonal Antibody 3E1.2 is an O Linked Mucin carbohydrate Containing N Gylcolyineuraminic Acid 4-Diamino-7-Hydroxy-Pteridines, a New Class of Catabolites of Mcthotrexate Systemic Treatment of Early Breast Cancer by Hormonal, Cytotoxic, or Immune Therapy Taxol: Out of the Woods Conquering Multidrug Resistance in Cancer Chemotherapy Involvement of Gap Junctions in Tumorigenesis -Transfection of Tumor Cells with Connexin-32 CDNA Retards Growth Invivo Phase-I Trial of Intravenously Administered Endotoxin (SalmonelLa-Abortus-Eqni) in Cancer Patients Immunological Effects of Treatment with Sequential Administration of Recombinant Interferon-gnmmu and Interferon-alpha in Patients with Metastatic Renal Cell Carcinoma During a Phase-I Inhibition of Acute Myelogenous Leukemia Blast Proliferation by interleukin-1 (EL-l) Receptor Antagonist and Soluble EL-1 Receptors Polyinosinlc-Polycytidylic Acid Complexed with Poly-L-lysine and Carboxymcthylcellulose in Combination with Interleukin-2 in Patients with Cancer -Clinical and Imnlunological Effects Efficacy of an Anti-CD7-Ricln-A Chain Immtmoconjugate in a Novel Murine Model of Human T-Cell Leukemia Peripheral Blood and Bone Marrow Immunophenotypie and Functional Modifications Induced in Acute Leukemia Patients Treated with Interieukin-2 -Evidence of Invivo Lymphokine Activated Killer Cell Generation A 4I-Kilodalton Protein is a Potential Substrate for the P210hcr-abl Protein-Tyrosine Kinase in Chronic Myelogenous Leukemia Cells Cooperative Mixtures of Bispecific F(ab')2 Antibodies for Delivering Saporin to Lymphoma Invitro and Invivo Molecular Structure of a DNA Decamer Containing an Anticancer Nucleoside Aa'abinosylcytosine -Conformational Perturbation by Arabinosyleytosine in B-DNA Carcinoell~thr~ronic Antigen Has a Different Molecular Weight in Normal Colon and In Cancer Cells Due to N-Glycosylation Differences Targeting of Hexokinase-1 to Liver and Hepatoma Mitochondria Antibody-Targeted Interleukin-2 Stimulates T-Cell Killing of Autologous Tumor Cells Antitumour Effects of Human Recombinant Interleukin-6 on Acute Mycloid Leukemia in Mice and in Cell Cultures Bone Marrow Transplantation for Severe Aplastic Anemia -Influence of Conditioning and Grail-Versus-Host Disease Prophylaxis Regimens on Outcome Characterization of a Zinc Finger Gene Disrupted by the T(15,17) in Acute Promyelocytic Leukemia High Resistance to Cisplatin in Human Ovarian Cancer Cell Lines is Associated with Marked increase of Glutathione Synthesis Treatment of Estahllshed Renal Cancer by Tumor Cells Engineered to Secrete Interleuldn-4 Serotherapy of B-cell Neoplasms Wih Anti-B4-blocked Ricin: a Phase I Trial of Daily Bolus Infusion Three Dimensional Structure of the Transmembrane Region of the Proto Oncogene Forms of the Ncu Protein. EMBOJ 1992, 11:4348. GUNZBURG WIt, SALMONS B: Factors Controlling the Expression of Mouse Mammat'y Tumour Virus Prophylaxis with Carbon-adsorhed Mitomycin Against Peritoneal Recurrence of Gastric Cancer A Monoclonal Antibody Against the C-erbB-2 Protein Enhances the Cytotoxicity of Cis-D~ammlnedichloroplatinum Against Human Breast and Ovarian Tumor Cell Lines Number of Accessible Sugar Epitopes Defined with Monoclonal Antibody AM-3 on Colonic Mucins is Associated with Malignant Transformation of Colonic iueosa Mitoxantrone Resistance in HL-60 Leukemia Cells -Reduced Nuclear Topoisomerase-H Catalytic Activity and Drug-induced DNA Cleavage in Association with Reduced Expression of the Topoisomerase-II Bcta-Isoform Deregulation of a Homeobox Gene, HOXll, by the T(10-14) in T-Cell Leukemia Viruses in Humma Cancers Toward the Primary Prevention of Cancer Recombinant Interleukin-2 and Lymphokine-Activated Killer Ceil Treatment of Advanced Bladder Cancer -clinical Results and Immunological Effects p53 Mutations In Human Cancers Retroviralmediated Gene Therapy for the Treatment of Hepatocellular Carcinoma: an Innovative Approach for Cancer Therapy DNA-Activated Protein Kinase in Burkitt,Raji Lymphoma CeLls -Phosphorylation of C-Myc Oncoprotein Preclinical Assessments of Y-90-Labeled CII0 Antigen Immunotoxin -a Therapeutic Immunoconjugate for Human Colon Cancer Successful Treatment of Human Acute T-Cell Leukemia in SCID Mice Using the Anti-CD7-Deglycosylated Ricin A-Chain Immunotoxin Da7. CancerRes Antagonistic Effect of AcLarubicln on Daunorubicin-Induced Cytotoxicity in Human Small Cell Lung Cancer Cells -Relationship to DNA integrity and Topoisomerase-H Therapy of an Animal Model of Human Gastric Cancer Using a Combination of Anti-erbB-2 Monoclonal Antibodies Effects of Target Antigen Competition on Distribution of Monoclonal Antibody to Solid Tumors Antiproliferative Effect of lnterleukin-1 on Human Ovarian Carcinoma Ceil Line (NIH:OVCAR-3) Murine Anti interleukin 6 Monoclonal Antibody Therapy for a Patient with Plasma Cell Leukemia Acute Effects of Tumor Necrosis Factoralpha or Lymphotoxin on Global Blood Flow, Laser Doppler Flux, and Bioenergetic Status of Subcutaneous Rodent Tumors Restoration of All-trans Retinoic Acid Sensitivity by interferon in Acute Promyelocytic Leukaemia Allclotyping of Human Prostatic Adenocarcinoma Biochemical and Kinetic Characteristics of the interaction of the Antitumor Antibiotic Sparsomycin with Prokaryotic and Eukaryotic Ribosomes Recombialant Granulocyte-maerophage Colony-stLmularing Factor after Autologous Bone Marrow TranspLantation for ReLapsed Non-Hodgkin's Lymphoma: Blood and Bone Marrow Progenitor Growth Studies: a Phase II Eastern Cooperative Oncology Group Trial Blood Enhanced Tumor Uptake of Maeromoleeules Induced by a Novel Vasoactive Interleukin-2 Immunoconjugate Anthracycline Binding to DNA -High-Resolution Structure of D(TGTACA) Complexed with 4'-Epiadriamycin Enrichment in Tumor-Reactive CD8+ Lymphocytes-T by Positive Selection from the Blood and Lymph Nodes of Patients with Head and Neck Cancer Cytokine Responses to Intraventricular Injection of Interleukin-2 into Patients with Leptomeningeal Careinomatosis -Rapid induction of Tumor Necrosis Factor-alpha, Interleukin-lbeta, Inter~eukin-6, Gamma-Interferon, and Soluble Interleukin-2 Receptor (Mr55,000-Protein). CancerRes Synthetic and Mechanistic Studies on the Antitumor Antibiotics Esperamiein-A1 and Calicheamicin-gammal -Oxidative Functionalization of The 13-Ketobicyclo< 7.3.1> Tridecenediyne Core Structure -Construction of the AllyHc Trisulfide Trigger Synthesis of the Antitumor Bisindole Alkaloid Vinblaatine -Diastereoselectivity and Solvent Effect on the Stereochemistry of the Crucial C-15-C-18' Bond The Antitumor Agent CC-1065 Inhibits Hellcase-Catalyzed Unwinding of Duplex DNA Inhibition of Tumor Growth in Mice by an Analogue of Platelet Factor-4 that Lacks Affinity for Heparin and Retains Potent Angiostatic Activity Mutt Protein Specifically Hydrolyses a Potent Mutagenic Sobstrate for DNA Synthesis Major Alterations in the Nucleotide Structure of DNA in Cancer of the Female Breast Cyclic AMP Response Element-Binding Protein and the Catalytic Subunit of Protein Kinase-A are Present in F9 Embryonal Carcinoma Cells But are Unable to Activate the Somatostatin Promoter Effect of Tumor Size on the Enhancement by Gamma-Interferon of the Localization of Radiolabeled F(ab')2 Fragments of Antiintereelldiar Adhesion Molecule-1 Monoelonal Antibodies in Human Colon Carcinoma Ceils Grafted in Nude Mice Selective Radiation of Hematolymphoid Tissue Delivered by Anti-CD45 Antibody DNA Metal Binding by Antitumor-Active Metalloeene Dichlorides from Inductively Coupled Plasma Spectroscopy Analysis -Titanocene Dichloride Fornls DNA Cp2Ti or DNA CpTi Adducts Depending on PH Inhibition of Tumor Cefi Invasion by a Highly Conserved Peptide Sequence from the Matrix Metalloproteinase Enzyme ProsegmenL Cancer Res Probing Intercalation and Conformational Effects of the Anticancer Drug 2-Methyl-9-Hydroxyellipticinium Acetate in DNA Fragments with Circular Dichroism Augmented Binding of Radiolabeled Monoclonal Antibodies to Melanoma Cells Using Specific Antibody Combinations Heteronuclear C-13-H-1 NMR Investigation of the Effects on an Ollgodeoxyribonucleotide of Intrastrand Cross-Linking by a Pt Anticaneer Drug -a Large Shifi of C3' Accompanies an S-Conformational In N-Conformational Change Direct Intralymphatic Injection of Radiolabeled In-Ill-T101 in Patients with Cutaneous T-Cell Lymphoma MAR/ANICOSTANI1NI R: Regional Heterogeneity and Complementation in the Expression of the Tumor-Associated Glycoprotein-72 Epitopes in Colorectal Cancer Purification and Characterization of a Vimentin-Specific Protease in Mouse Myeloid Leukemia Cells -Regulation During Differentiation and Identity with Cathepsin-G Invivo Targeting of OV-TL-3 lmmunoliposomes to Ascitic Ovarian Carcinoma Cells (OVCAR-3) in Athymic Nude Mice DNA Cleavage and Antitumor Activity of Designed Molecules with Conjugated Phosphine Oxide-Afiene-Ene-Yne Fuoctionallties Galactose-Conjogated Antibodies in Cancer Therapy -Properties and Principles of Action Mirt|m~l Residual Disease in Patients with Chronic Myelogenous Leukemia Undergoing Long-term Treatment with Recombinant Interferon ~-2b Alone or in Combination with Interferon Y-Blood Three Step Monoclonal Antibody Tumor Targeting in Carrinoembryonic Antigen Positive Patients Recombinant Toxins for Cancer Treatment Thermodynamics of Interaction of a Fluorescent DNA Ollgomer with the Anti-Tumour Drug Netropsin Isolation of the Neu/HER-2 Stimulatory IAgand -a 44kd Glycoprotein that Induces Differentiation of Mammary Tumor Cells Tumor Selective Reactivity of a Monoclonal Antibody Prepared Against a Recombinant Peptide Derived from the DF3 Human Breast Carcinoma-Associated Antigen Nature of Protamine-DNA Complexes. A Special Type of IAgand Binding Co-operativity Rapid Detection of Inducers of Enzymes that Protect Against Carcinogens Expression of Higia-Affmity Interleuldn-4 Receptors on Murine Sarcoma Cells and Receptor-Mediated Cytotoxicity of Tumor Cells to Chimeric Protein Between Interieukin-4 and Pseudomonas Exotuxin Identification of a Growth Suppression Domain Within the Retinoblastoma tT~ene Product Modulation of Cell Proliferation and Cytokine Production in Acute Myeloblastic Leukemia by Interleukin-1 Receptor Antagonist and Lack of Its Expression by Leukemic Cells Structural Basis of Protein Kinase-C Activation by Diacylglycerols and Tumor Promoters Expression of class-H Major Histocompatibility Complex Molecules Correlates with Human Colon Tumor Vaccine Et~cacy Thermodynamic Characterization of Daunomycin-DNA Interactions -Microcalorimetric Measurements of D~unomycin-DNA Binding Enthalpies Interferons and Interleukin-6 Suppress Phosphorylation of the Retinoblastuma Protein in Growth-Sensitive Hematopoietic Cells Antitumor Immune Response and interieukin-2 Production Induced In Colorectal Cancer Patients by lmmtlnization with Human Monoelonal Anti-Idiotypic Antibody Antitumor Immune Response and Interieukin-2 Production Induced in Colorectal Cancer Patients by Immtlnization with Human Monoclonal Anti-Idiotypic Antibody Therapy of Human Cervical Carcinoma with Monoclonal Antibody-Pseudomonas Exotoxin Conjugates Urinary Aflatoxin Biomarkers and Risk of Hepatocellular Carcinoma Inhibition of Friend Leukemia Cell Visceral Metastases by a New Monoclonal Antibody and Role of the Immune System of the Host in Its Action Increased Expression of The 67kDa-I amiqin Receptor Gene in Human Small Cell Lung Cancer Extracdlular Matrix and the Patterns of Differentiation of Human Endometrial Carcinomas Invitro and Invivo Targeted Degradation of the Retinoblastoma Protein by Human Papillomavtrus-E7-E6 Fusion Proteins. ~BOJ1992 Therapeutic Advantage of High-Affinity Anticarcinoma Radioimmunoconjugates Monoelonal Antibody-Based Therapy of a Human Tumor Xenograft with a Lutetium-177-Labeled Immunoconjugate Radiotherapy in Mice with Yttrium-90-Labeled AJrtti-Lyl Monoclonal Antibody -Therapy of the T-Cell Lymphoma-EL4 Cytokines and Infection in Cancer Patients HELLSTROM h All Unmodified Anticarcinoma Antibody, BR96, Localizes to and Inhibits the Outgrowth of Human Tumors in Nude Mice Short Term Treatment with G~mm~ Interferon Induces Stable Reversion of Ras Transformed Mouse Fibroblasts Deregulated C-myb Disrupts Interlettkin-6-Induced or Leukemia Inhibitory Factor-Induced Myeloid Differentiation Prior to C-myc -Role in Leukemogenesis Hepatocyte Growth Factor Inhibits Growth of Hepatocellular Carcinoma Cells Spatial Distribution of Timaor-Specific Monoclonal Antibodies in Human Melanoma Xenografts A Quantitative Analysis of Tumor-Specific Monoclonal Antibody Uptake by Human Melanoma Xenografts -Effects of Antibody Immunological Properties and Tumor Antigen Expression Levels Antitumor Effects of Interleukin-6-Pseudomonas Exotoxin Chimeric Molecules Against the Human Hepatocellular Carcinoma, PLC/PRF/5 in Mice Escherichla-Coll Expressing a Neisseria-Gonorrhoeae Opacity-Associated Outer Membrane Protein Invade Human Cervical and Endomctrial Epithelial Ccfi Lines Thyroid Hormone Dependent Pituitary Tumor Cell Growth In Serum-Free Chemically Defined Culture -a New Regulatory Role for Apotransferrin A Randomized Comparison of Two Doses of Human Lymphoblastoid Interferon-c~ in Hairy Cell Leukemia Prolonged, Continuous Treatment of Hairy Cell Leukemia Patients with Recombinant Interferon-alpha2a Invivo Antitumor Activity of a Monoclonal Antibody-Vinca Alkaloid Imnlunoconjugate Directed Against a Solid Tumor Membrane Antigen Characterized by Heterogeneous Expression and Noninternalization of Antibody-Antigen Complexes Autocrine Growth Induced by Kinase Type Oncogenes in Myeloid Cells Requires AP1 and NFM a Myeloid Specific C/EBP Like Factor The Phosphorylated and or Sulfated Structure of the Carbohydrate Protein-Linkage Region Isolated from Chondroltin Sulfate in the Hybrid Proteogiycans of Engelbrcth-Holm-Swarm Mouse Tumor Predicted and Observed Effects of Antibody Affinity and Antigen Density on Monoclonal Antibody Uptake in Solid Tumors Effects of Recombinant Alpha-interferon Gelatin Conjugate on Invivo Murine Tumor Cell Growth Indnction of Antigen-Specific Immune Response with use of Anti-Idiotypic Monoclonal Antibodies to Anti-Carcinoembryonic Antigen Antibodies Vivo Efficacy orB43 (anti CD19) Auto1ogous Bone Marrow Transplantation in High-risk Remission B-lineage Acute Lymphoblastic Leukemia Using a Cocktail of Three Monoclonal Antibodies (BA-1/CD24, BA-2/CD9, and BA-3/CDIO) Plus Complement and 4-hydroperoxycyelophosphamide for Ex Vlvo Bone Marrow Purging Lymphoblastic Leukemia in Mice with Severe Combined Immunodefieiency Complement Activation in Cancer Patients Undergoing Immunotherapy with Interleukin-2 (ED2) -Binding of Complement and C-Reactive Protein by 11:2-Activated Lymphocytes Synergistic Antitumor Effects of Rat G~mm~-interferon and Human Tumor Necrosis Factoralpha Against Androgen-Dependent and Androgen-independent Rat Prostatic Tumors Mechanism of Interferon Action in Hairy Ceil Leukemia -a Model of Effective Cancer Biotherapy local Activation of tramline Response in Bladder Cancer Patients Treated with Intraarterial Infusion of Recombinant Interleukin-2 Phase-I Immunotoxin Trial in Patients with B-Cell Lymphoma Effective Natural Interferon-alpha Therapy in Recombinant Interferon-alpha Resistant Patients with Hairy Cell Leukemia High Risk of Squatnous Ceil Carcinoma of the Cervix for Women with HLA-DQw3 Cost Effectiveness of Prophylactic Intravenous Immune Globulin in Chronic Lymphocytic Leukemia Bispecific Anti-Idiotype Anti-CD3 Antibody Therapy of Murine B CeB Lymphoma Phase-I Evaluation of Combination Therapy with Interleukin-2 and Gamma-Interferon The N-Myc Oncoprotein is Associated in Vivo with the Phosphoprotein Max(p20/22) in Human Neuroblastoma Cells Induction of Mammalian DNA Topoisomerase-I and Topoisomerase-R Mediated DNA Cleavage by Saintopin, a New Antiinmor Agent from Fungus clinical and lmm~lnomodulatory Effects of Combination Immunotherapy with Low-Dose interleukin-2 and Tumor Necrosis Factor-alpha in Patients with Advanced Non-Small-Cell Lung Cancer -a Phase-I Nonisotopic SSCP and Competitive PCR for DNA Quantification: P53 in Breast Cancer Cells Cellular Interactions in Effector Ceil Generation and Tumor Regression Mediated by Anti-CD3/Interleukin-2-Activated Tunlor-Drailling Lymph Node Cells Adenovirus-Ela Prevents the Retinoblastoma Gene Product from Repressing the Activity of a Celhdar Transcription Factor Segregation Analysis Detects a Major Gene Controlling Blood Infection Levels in Human Malaria Induction of Thromboses within Renal Grafts by High-dose Prophylactic OKT3 Sequential H-1 NMR Assignments of Kistrin, a Potent Platelet Aggregation Inhibitor and Glycoprotein-nb-ERa Antagonist Binding of Hirudin to Human Alpha, Beta and Gamma Throlnbin. A Comparative Kinetic and Thermodynamic Study The N-Terminul Domain of Antithrombin-IR is Essential for Heparin Binding and Complex-Formation With, But not Cleavage By, Alpha-Thrombin Prevention of High-altitude Poh~onary Edema by Nifedipine. NEnglJMed i991 Selective Inactivation of the Arg-Gly-Asp-Ser (RGDS) Binding Site in Von wlllebrand Factor by Site-Directed Mutagenesls pH Dependence of the Interaction of Hirudin with Thrombin Interaction of the N-Terminal Region of Hirudin with the Active-Site Cleft of Thrombin Free Fatty Acids Activate a High-Affinity Saturable Pathway for Degradation of Low-Density Lipoproteins in Fibroblasts from a Subject Homozygous for Fam|l|al Hypereholesterolemia Selection of Singie-atranded DNA Molecules that Bind and inhibit Human Thrombin Expression of Recombinant Human Plasmtnogen in Mammalian Cells is Augmented by Suppression of Plasmin Activity Protcolytic Dissection of the Isolated Platelet Fibrinogen Receptor, Integrin-GPRb/IRa -Localization of GPE[b alld GPIlla Sequences Putatively Involved in the Subtmit Interface and in Intrasubunit and Intrachain Contacts Subcutaneous Erythropoietin for Treatment of Refractory Anemia in Hematologic Disorders -Results of a Phase-I/R Clinical Trial Blood A Low Molecular Weight Platelct Inhibitor of Factor-Xaa -Purification, Characterization, and Possible Role in Blood Coagulation Modulation of Thrombin-Fibrinogen Interaction by Specific Ion Effects A Mutation in the Human Apoilpoprotein-A-I Gene -Dominant Effect on the Level and Characteristics of Plasma High Density Lipoproteins Crystal Structure of the Kringle-2 Domain of Tissue Plasminogen Activator at 2.4-A Resolution A Comparison of Two Doses of Aspirin (30 Mg VS. 283 Mg a Day) in Patients after a Transient Ischemie Attach or Minor Ischemic Stroke A Region of Tissue Plasminogen Activator that Affects Plasminogen Activation Differentially with Various Fibrin(ogen)-Related Stitnulators Proteolysis of Von Willebrand Factor after Thrombolytic Therapy in Patients with Acute Myocardial Infarction Design and Synthesis of a Helix Heparin-Binding Peptide Invitro Evaluation of the Plasma and Blood Compatibility of a Parenteral Formulation for Diteldren, a Novel Renin Inhibitor Pseudopeptide Interaction of Cholesterol with Synthetic Sphingomyelin Derivatives in Mixed Monolayers Low Molecular Weight Heparin Thrombospondin is a Slow Tight-Binding inhibitor of Plasmin BM-1, a platelct Aggregation Inhibitor from Mackerel H-1 1NrMR Spectroscopic Studies on the Interactions Between Human Plasma Antithrombin-lll and Defined Low Molecular Weight Heparin Fragments SotventJdetergent-treated Plasma: a virus-inactivated Substitute for Fresh Frozen Plasma Structure of Human CycIophifin and Its Binding Site for Cydosporin-A Determined by X-Ray Crystallography and NMR Spectroscopy Developing RDNA Products for Treatment of Hemophilia A. Trends Biotecbno11991 Expression and Mutagenesis of Thrombospondin Glu-192-> Gin Substitution in Thrombin Mimics the Catalytic Switch Induced by Thrombomodulln Calcitonin Gene-Related Peptide and Fluid Overload in Congestive Heart Failure A Peptide Model for the Hepartn Binding Site of Antithrombin-Bl The ThrombIn High-Affinity Binding Site on Platelets is a Negative ReguLator of Thrombin-Induced Platelet Activation -Structure-Function Studies Using Two Mutant Thrombins, Quick-I and Qnick-H. Biochemistry A Human Recombinant Haemoglobin Designed for use as a Blood Substitute Location of Potential Binding Sites on Deoxy Hemoglobin for the Design of Antigelling Agents Kinetics and Physiologic Relevance of the Inactivation of Alphal-Proteinase Inhibitor, Alphal-Antichymotrypsin, and Antithrombin-Hi by Matrix Metalloproteinases-1 (Tissue Collagenase), Metalloproteinases-2 (72-kDa Gelatinase Type-IV Collagenase), and Metalloproteinases-3 (Stromelysin) Ornatins -Potent Glycoprotein-Hb-IHa Antagonists and Platelet Aggregation Inhibitors from the Leech Placobdella-Ornata Mambin, a Potent Glycoprotein-Hb-Hia Antagonist and Platelct Aggregation Inhibitor Structurally Related to the Short Neurotoxins Antithrolnbin Hi and Arterial Disease Apple-4 in Human Blood Coagulation Factor-XI Mediates Dimcr Formation Aspirin, the Ageless Remedy? Isolation and Characterization of the Complement-Inhibiting Protein CD59 Antigen from Platelet Membranes Feedback Regulation of Hepatic 3-Hydroxy-3-Methylgltaaryl-CoA Reductase Activity by Dietary Cholesterol is not Duc to Altered Messenger RNA Levels Conformational Stability of a Thrombin-Binding Peptide Derived from the Hirudin C-Terminus Conformational Similarities Between One-Chain and 2-Chain Tissue Plasminogen Activator (t-PA) -Implications to the Activation Mechanism on One-Chain T-PA RecombInant Human Erythropoictin for Autulogous Blood Donation Inactivation of Factor-VIII by Factor-lXa Inhibition of Factor-X, Factor-V and Prothrombin Activation by the Bis(Iactohionic Acid Amide) LW10082 Recombinant Haemoglobin in the Development of Red-blood-cell Substitutes Recombinant Human Thrombomodulln -Regulation of Cofactor Activity and Anticoagulant Function by a Glycosaminoglycan Side Chain Alboaggregin-B -a New Platelct Agonist that Binds to Platelct Membrane Glycoprotein-Ib Platelct Activation and Subsequent Inhibition by Plasmin and Recombinant Tissue-Type Plasminogen Activator Differential Inhibition of Rat Mast Cell Proteinase-I and Proteinase-ll by Members of the Alpha-1-Proteinase Inhibitor Family of Serine Proteinase Inhibitors Production and Functional Characterization of a Recombinant Fragment of Vonwillebrand Factor (vWF) -an Antagonist to Platelet Receptor GP-lb 31:2273 2278. ~vETZIOS AD, ~VLAd~ND FS: Purification, Characterization, and Fibrinogen Cleavage Sites of 3 Fibrinolytic Enzymes from the Venom of Crotalus-Basiliscus-Baslliscus The Effect of High Doses of Calcinm-Channel Blockers on Survival in Primary Pulmonary Hypertension A Recombinant Chilneric Plasminogen Activator with High Afiqnity for Fibrin Has Increased Thrombolytic Potency Invitro and Invivo Defective Anion Transport Activity of the Abnormal Band 3 in Hereditary Ovalocytic Red Blood Cells Basis of Unique Red Cell Membrane Properties in Hereditary Ovalocytosis Molecular Cloning of a CDNA Encoding CD34, a Sialomucin of Htlman Hematopoietic Stem Cells Experience with Protein A-immunoadsorption in Treatmentresistant Adult Imtnllne Thrombocytopenic The Ca2+ Ion and Membrane Binding Structure of the Gla Domain of CA-Prothrombin Fragment-1 Primary Structure and Function of Novel O-Glycosylated Hirndins from the Leech Hirudinaria-manillensis The Oxidative Inactivation of Plasminogen Activator Inhibitor Type-1 Results from a Conformational Change in the Molecule and Does not Require the Involvement of the PI' Methionine The Interaction of Thrombin with Fibrinogen -a Structural Basis for Its Specificity Recombinant Human Erythropoietin for Autologous Blood Donation: Effects on Perioperative Red-blood-cell and Serum Erythropoietin Production ISIS-3: a Randomised Comparison of Streptokinase Vs Tissue Plasminogen Activator Vs Anistreplase arfd of Aspirin Plus Heparin Vs Aspirin Alone Mong 41 299 Cases of Suspected Acute Myocardial Infarction The Efficiency of the Uncleared Secretion Signal in the Plasminogen Activator Inhibitor Type-2 Protein can be Enhanced by Point Mutations that Increase Its Hydrophobicity Domains Specifying Thrombin-receptor Interaction Hepatocyte-Dirccted Gene Transfer Invivo Leads to Transient Improvement of Hypercholesterulemia in Low Density Lipoprotein Receptor-Deficient Rabbits Localization in the Fibrinogen Gamma-Chain of a New Site that is Involved in the Acceleration of the Tissue-Type Plasminogen Activator-Catalysed Activation of Plasminogen Analogues of Diadenosine 5',5" -P1, P4-tetraphosphate (Ap4A) as Potential Anti-plateletaggregation Agents Kirromycin Drastically Reduces the Aftinity of EschcrichtaoColi Elongation Factor Tu for Aminoacyl-Transfer RNA Acyltransferas¢ Activities of the High-Molecular-Mass Essential Penicillin-Binding Proteins Three-Dimensional Solution Structure of Apo-Neocarzinostatin from Str eptomyees-Carzinost aticus Determined by NMR Spectroscopy Unscrambling the Puzzle of Biological Machines -the Inlportance of the Details Cloning and Nucleotide Sequencing of a Novel 7beta-(4 -carboxybut anamido)cephalosporanic Acid Acylase Gene of Bacillus-Laterosporus and Its Expression in Escherichla-Coli and Bacillus-Subtilis Sequence Specificity of the Binding Of 9-Aminoacridine-Carboxamide and Amsacrine-4-Carboxamide to DNA Studied by DNase-I Footprinting Trypanosoma Brucei Glycosomal Glyceraldehydc-3-phosphate Dehydrogenase Genes are Stageregulated at the Structural Requirements of Lyngbyatoxin-A for Activation and Downregulation of Protein Kinase-C Calciutn Supplementation to Prevent Hypertensive Disorders of Pregnancy The Binding Site on ICAM-1 for Plasmodium Falciparum Infected Erythrocytes Overlaps, But is Distinct From, the LFA-1-Binding Site Modifications of Hepatic Alpha-l-Acid Glycoprotein and Albumin Gene Expression in Rats Treated with PhenobarbitaL EurJBiochem alphaB-Crystallin Exists as an Independent Protein in the Heart and In the Lens K: Isolation of CDNA Clones Encoding Proteins of Complex Structure -Analysis of the Trypanosoma-brucei Cytoskeleton Evidence Favouring the Hypothesis of a Conserved 3'-5' Exonuclease Active Site in DNA-Dependent DNA Polynlerases The Chemistry of Cyclic Vinyl Ethers. 6. Total Synthesis of Polyether Ionophore Antibiotics of the Calcinlyein (A-23187) Class Duoearmycin Pyrindamycin DNA Alkylation Properties and Identification, Synthesis, and Evaluation of Agents Incorporating the Pharmacophore of the Duocarmycin Pyrindamycin Alkylation Subunit -Identification of the CC-1065-Duocarmyein Common Pharmacophore The Mutation Lys234His Yields a Class-A Beta-Lactamase with a Novel PH-Dependence Potentiation of Mliomycin-C and Poriflromycin Antitumor Activity In Solid Tumor Models by Recombinant Human Interleukin 1-alpha Molecular Basis for Vancomycin Resistance in Enterocoecus-Faecinm BM4147 -Biosynthesis of a Depsipeptide Peptidoglycan Precursor by Vancomycin Resistance Proteins VanH and VatlA Class-3 Porin Protein of Neisseria-Meningitidis -Cloning and Structure of the Gene Transcriptional Organization and Regulation of an Antibiotic Export Complex in the Producing Streptomyces Culture Variant Specific Glycoprotein of Trypanosoma Brocei Consists of Two Domains Each Having an Independently Conserved Pattern Cystein Residues Damage-Recognition Proteins as a Potential Indicator of DNA-Damage-Mediated Sensitivity or Resistance of Human Cells to Ultraviolet Radiation Proton NMR Assignments and Secondary Structure of the Snake Venom Protein Eehistatin The Crystal Structure of Diphtheria Toxin Tolerance to a Self-Protein Involves Its Immunodominant But Does not Involve Its Subdominant Determinants Replication Inhibition and Translesion Synthesis on Templates Containing Site-Specifically Placed Cis-Diammhledichloroplatinum(II) DNA Adducts Requirement of GTP Hydrolysis for Dissociation of the Signal Recognition particle from Its Receptor Molecular Container Compounds Lichen-forming Fungi: Potential Sources of Novel Metabolites. Trends Biotechno11991 Analysis of SmalI Nuclear Ribonucleoproteins (RNPs) in Trypanosoma-Brucel -Structural Organization and Protein Components of the Spliced Leader RNP Deletion by Invivo Recombination Shows that the 28-Kilodalton Cytolytic Pulypeptide from Baetllas-Thurtngiensis Subsp Israelensis is not Essential for Mosquitocidal Activity Interaction of Mithramycin with DNA -Evidence that Mithramyein Binds to DNA as a Dimer in a Right-Handed Screw Conformation Host properties of Cyclodextrins Toward Anion Constituents of Antigenic Determinants -a Thermodynamic Study in Water and in N,N-Dimethylformamide Diatamycin Induced Inhibition of Homeodomain DNA Complexes Enzymic Activity of salivary Amylase when Bound to the Surface of Oral Streptococci Mechanism of Action of Vitamin-IG JAm Chem 3~c Application of Crystallographic and Modeling Methods In the Design of Purine Nueleoside Phosphorylase Inhibltors The Enteroeoccus-Hirae R40 Penicillin-Binding Protein-5 and the M ethicillin-Reststant St aphyloco eeus-Aur eus Penicillin-Binding Protein 2' are S;mil=~ ~J: Total Synthesis of the Macrolide Antibiotic Cytovaricin Synthetic Studies in the Lysocellin Family of Polyether Antibiotics -the Total Synthesis of Ferenalmycin-B Mollusc-Specific Toxins from the Venom of Conus-Textile-Neovicarius Bacterial Entry into Eukaryotic Cells Dictyoatelittm-Discoideuxn as an Expression Host for the Circumsporozoite Protein of Plasmodium-Falciparlmm Gene The ACt Cluster Contains Regulatory and Antibiotic Export Genes, Direct Targets for Translational Control by the BldA Transfer RNA Gene of Streptomyces Transport and Anchoring of Beta-Lactamase to the External Surface of Escherichia-Coli Rectproeal Regulation of Adipogenesis by Myc and C/EBPalpha Total Synthesis of (+/-)-FR-900482 Site-Specific Binding Constants for Actinomycin-D on DNA Determined from Footprinting Studies Alteration of an Amino Acid Residue Outside the Active Site of the Ricin A-Chain Reduces Its Toxicity Towards Yeast Ribosomes Invitro Selection and Affinity Maturation of Antibodies from a Naive Combinatorial lmm~lnoglobulin Library The Cecropin Locus -Cloning and Expression of a Antibacterial Peptides in Hyalophora-Cecropia Drug Binding to a DNA BZ Molecule -Analysis by Chemical Footprinting Structures of the Efrapeptins -Potent Inhibitors of Mituchondrial ATPase from the Fungus Tolypocladium-Niveu1IL Targeting of CelLsurface ~-amyloid Precursor Protein to Lysosomcs: Alternative Processing into Anlyloid-bearing Fragments Mammalian Stress Proteins liSP70 and HSP28 Coinduced by Nicotine and Either Ethanol or Heat Inhibition of the Uptake of Oxidized Low-Density Lipoprotein in Macrophage-J774 by the Antibiotic Ikarugamycin The salmonella-Typhimurium Virlflence Plasmid Complement Resistance Gent Rck is Homologous to a Family of Virulence-Related Outer Membrane Protein Genes, Including PagC and AlL Nutritional Control of Nikkomycin and Juglomycin Production by Streptumyces Tendae in Continuous Culture Growth, Sporulation and Enterotoxin Production by Clostridium-Perfringens Type-A in the Presence of Human Bile Salts Leishmanial Protein Kinases Phosphorylate Components of the Complement System Glycolytic Pathway of the Human Malaria Parasite Plasmodium-Falclparum -Primary Sequence Analysis of the Gene Encoding 3-Phosphoglyceratc Kinase and Chromosomal Mapping Studies Mouse Small Eye Results from Mutations in a Paired Like Homeobox Containing Gene An integrated Approach to Studying Regulation of Production of the Antibiotic Methylenomycin by Streptomyccs-coelicolor A3(2) The 65-kDa Protein from Pig Heart -a New Substrate for Clostridium-Botulinum ADP-Ribosyltransferase (Exoenzyme-C3 The Rctinoblaatoma Protein Physically Associates with the Human Cde2 Kinase H-1-NMR Studies on D(GCITAAGC)2 and Its Complex with Berenil The Nucleotidc Sequence of RpsL and Its Flanking Regions in salmonella-Typhimurium Mechanism of Altered Renal Glutaminase Gene Expression in Response to Chronic Acidosis Hennoxazoles -Bioactive Bisoxazoles from a Marine Sponge Functional Modification by Cholera-Toxin-Catalyzed ADP-Ribosylation of a Guanine-Nucleotide-Binding Regulatory Protein Serving as the Substratc of Pertussis Toxin Total Synthesis of the Anthclmintic Agent Hikizimycin The Steroid 15alpha-Hydroxylase of Penictllium-Raistriekii 1-477 is Inducible A Polymerase Chain Reaction Based Method to Detect Cisplatin Adducts in Specific Genes Antagonistic Effect of Aclarubiein on Daunorubicin-induced Cytotoxicity in Human Small Ceil Lung Cancer Cells -Relationship to DNA Integrity and Topoisomerase-II Self-Transloeation of Diphtheria Toxin Across Model Membranes Salmonella Plasmids of the Preantibiotic Era Prepeptide Sequence of Cinnamycin (Ro 09-0198) -the First Structural Gene of a Duramycin-Type Lantibiotic Differential Development of Progenitor Activity for 3 B-Cell Lineages The Safety of Foods Developed by Biotechnology Strong Suppression of Chloramphenicol Acetyltransferase Expression by Inducing T7 RNA Polymerase SET Photochemistry of Flavin Cycloprupylami,le Systems -Models for Proposed Monoamine Oxidase Inhibition Mechanisms Heat-Shock Responsive Elements in the Induction of the Multidrug Resistance Gene (MDR1) Isolation and Structural Characterization of Novel Neutral Oligosaccharide-Alditols from Respiratory-Mucus Glycoproteins of a Patient Suffering from Bronchiectasis Oligosaccharides Having the GlcNAcbeta(1-> 3)Galbetu(1-> 4)GlcNAcbeta(1-> 6)GalNAc-ol Structural Element in Common A Model for Penicillin Production with and without Temperature Shift after the Growth Phase Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-dependent Protein Kinase Intestinal Absorption of Bcta-Lactam Antibiotics and Oligopeptides -Functional and Stereospecific Reconstitntion of the Oligopeptide Transport System from Rabbit Small Intestine Ammodytin-L, a Myotoxie Phospholipase-A2 Homologne from Vipera-Ammodytes Venom Alnino Acid and CDNA Sequences of a Neutral Pbospholipase A2 from the Long-Nosed Viper (Vipera-Ammodytes-Ammodytes) Venom Action of Brefeldin a Blocked by Activation of a Pertussis-toxinsensitive G protein P Pill in Uropathogenic E. Coli are Composite Fibres with Distinct Fibrillar Adhesive Tips Recognition of Specific DNA Sequences by Mitomycin-C for Alkylation Cloning of the Complete Biosynthetic Gene Cluster for an Amtnonucleoside Antibiotic, Puromycin, and Its Regulated Expression in Heterologous Hosts Characterization of the Bla(CARB-3) Gene Encoding the carbenictllinase-3 Betu-Lactamase of Pseodomonas-Aeruginosa Mechanism of Acyl Transfer by the Class-A Serine Beta-Lactamase of Streptomyccs-Albus-G The Ah Receptor and the Mechanism of Dioxin Toxicity Inhibition of Bacterial protein Synthesis by Elongation-Factor-to-Binding Antibiotics MDL-62,879 and Efrotomycin Biochemical and Kinetic characteristics of the Interaction of the Antitumor Antibiotic Sparsomycin with Prokaryotic and Eukaryotic Ribosomes Activation of Extracellalar Signal-regulated Kinase, ERK2, by P21ras Oeoprotein Inhibition of Food-Borne Bacterial Pathogens by Bacteriocins from Lactic Acid Bacteria Isolated from Meat Isolation and Structure Determination of Diazonamide-A and Diazonamtde-B, Unusual Cytotoxic Metabolites from the Marine Ascidian Diazona-Chinensis Refolding and Assembly of Penicillin Acylase, an Enzyme Composed of 2 Polypeptide Chains that Result from Proteolytic Activation Glycoprotein Pharmaceuticals: Scientific and Regulatory Considerations and the US orphan Drug Act. Trends Biotechno11992 Common Principles in Protein Folding and Antigen Presentation. Trends Biotechno11991 Synthetic and Mechanistic Studies on the Antitumor Antibiotics Esperamicin-A1 and calicheatnicin-gammal -Synthesis of 2-Ketobicyclo< 7.3.1> Enediyne And 13-Ketocyclo< 7.3.1> Enediyne Cores Mediated by Eta2 Dicobalt Hexacarbonyl Alkyne Complexes -Cycloaromatization Rate Studies Synthetic and Mechanistic Studies on the Antitumor Antibiotics Espcramicin-A1 and Calicheamicin-gnmmal -Oxidative Functionalization of The 13-Kctohicyclo< 7.3.1> Tridecenediyne Core Structure -Construction of the Allylic Trisulfide Trigger FRENOYJP: Interactions of Ricin with Sinusoldal Endothelial Rat Liver Cells -Different involvement of Two Distinct Carbohydrate-Specific Mechanisms in Surface Binding and Internalization Genetics of Streptomycin Production in Streptomyces-Griseus -Nucleotide Sequence of Five Genes, StrFGItEK. Including a Phosphatase Gene The Role of Bactericidal/lPer me ability-iner easing Protein as a Natural Inhibitor of Bacterial Endotoxin Novel Maerolactontzation Strategy for the Synthesis of Erythromycin Antibiotics Identification of a Unique Specificity Determinant of the Colicin E3 Immunity Protein Expansolide-A and Expansoitde-B -Tetracyclic Sesquiterpene Lactones from Pcnicillium-Expansut~x Environmental Signals Controlling Expression of Virulence Determinants in Bacteria A Fungal Gene for Antibiotic Resistance on a Dispensable Cloning Vectors, Mutagenesis, and Gene Disruption (erroR) for the Erythromycinproducing Bacterium Aeromtcrobium-Erythreum NMR Studies of the Active Site of Isopeniciliin-N Synthase, a Non-Heine Iron(H) Enzynle Analysis of the CbhE' plasmid Gene from Acute Disease-Causing Isolates of Coxiella-BurnetiL Gene P-type Calcium Channels Blocked by the Spider Toxin Omega-Aga-lVA Interleukin-4 Proliferative Signal Transductioll Involves the Activation of a Tyrosine-Specific Phosphatase and the Dephosphorylation of an 80-kDa Protein Antimicrobial Peptides in the Stomach of Xenopus-Laevis Identification and Characterization of the I.antibiotic Nlsin-Z, a Natural Nlsin Variant Ion Channels for Communication Between and Within Cells Conformational Differences Between Surface-Bound and Fluid-Phase Complement-Component-C3 Fragments -Epitope Mapping by CDNA Expression Plasmodium Falctparum-Infected Erythrocytes Bind ICAM-1 at a Site Distinct from LFA-1, Mac-l, and Human Rhinovirus incorporation and Degradation by Kidney Lysosomes of Cystatinalpha injected Intravenously Eponemycin, a Novel Antibiotic, is a Highly Powerful Angiogenesls Inhibitor A Novel T-Cruzi lteparin-Binding Protein Promotes Fibroblast Adhesion and Penetration of Engineered Bacteria and Trypanosomes into m~mmallan Cells Implications of a Consensus Recognition Site for Phosphatidylcholine Separate from the Active Site in Cobra Venom Phospholipases-A2 Amino Acid Sequence of the Penicillin-Binding Protein/DD-Peptidase of Streptomyces-K15 -Predicted Secondary Structures of the Low-Mr Peuicillin-Binding Proteins of Class-A Transformation of Vibrio-Cholerae by Plasmid DNA Total Synthesis of (+)-Ikarugamycin. 2. Elaboration of the Macrocyclic Lactam and Tetramic Acid Substructures and Complete Assembly of the Antibiotic Total Synthesis of (+)-lkarugamycin. 1. Stereocontrolled Construction of the Deeahydro-As-Indacene Subunit EnZymatic Transformation of Desacetyl-lanatoside-A into Digitoxin by Beta-Glucosidase Action in Cyclodextrin Solutions Transcriptional Analysis of the Isopeniclilin-N Synthase-Encoding Gene of Streptomyces-Clavuligerus Genetics of Streptomycin Production in Streptomyces-Griseus -Molecular Structure and Putative Function of Genes StrELMB2N Kinetics and Mechanism of Binding of Specific Peptides to Vancomyein and Other Glycopeptide Antibiotics Potentiation of Thermal Inactivation of Glycer aldehyde-3 -Phosphate Dehydrogenase by Photodynamic Treatment -a Possible Model for the Synergistic Interaction Between Photodynamic Therapy and Hyperthermia Effect of B-Ring Substituents on Absorption and Circular Dichroic Spectra of Colchicine Analogues Distribution of Insertion Sequence IS1 ha Multiple-Antibiotic Resistant Clinical Enterobacteriaceae Strains Signals Through the EnvZ Receptor to Change the DNA Binding Affinity of the Transcriptional Activator Protein OmpR Assimilation of Cholesterol by Some Cultures of Lactic Acid Bacteria and Bifidobacteria Purification of a New Galactanase from PeniciIlinm-Oxalieum Catalysing the Hydrolysis of Beta-(1-> 5)-Galactofuran Linkages DNA-Binding Properties of the E1A-Associated 300-Kilodalton Protein Chronic Central Nervous System Effects of Acute Organophosphate Pesticide Intoxication Quantitation of Hepatic Glycogenolysis and Glueoneogenesis in Fasting Humans with C-13 NMIL Science The Molecular Mechanism of Ecstasy < 3,4-methylenedioxy-methamphctamine (MDMA)>-Serotonin Transporters are Targets for MDMA-indueed Serotonin Release Camptothecha Cytotoxicity In Mammalian Cells is Associated with the Induction of Persistent Double Strand Breaks ha Replicating DNA Recognition of the Highly Conserved GTPase Center of 23-S Ribosomal RNA by Ribosomal Protein-L11 and the Antibiotic Thlostrepton Cell Surface Sulfhydryls are Required for the Cytotoxicity of Diphtheria Toxin But not of Ricin in chinese Hamster Ovary Cells Wheat and Barley Allergens Associated with Baker's Asthma -Glycosylated Subunits of the Alpha-Amylase-Inhibitor Family have Enhanced IgE-Binding Capacity A New Approach to CycHtols Based on Rabbit Muscle Aldolase (RAMA) Analysis of Genes Involved ha the Biosynthesis of Lantibiotic Epidermin Human Complement Factor-H -Tissue Specificity in the Expression of Three Different Messenger RNA Species A Spectroscopic and Conformational Study of Pertussis Toxin Interaction of the Anthracycline Antibiotic Nogalamycin with the Hexamcr Duplex D(5'-GACGTC)2 -an NMR and Molecular ModeBing Study Isotachophorctic Analysis of Flavonoids and Phenolcarboxylic Acids of Relevance to Phytopharmaccutical Industry Purification and Characterization of Two Highly Different Group-II Phospholipase-A2 Isozymes from a SIngle Viperid (Eristocophis-Macmahoni) Venom Structure Elucidation of a Novel Antibiotic of the Vancomycin Group -the Influence of Ion Dipole Interactions on Peptide Backbone Conformation Mechanism of Inhibition of Microtubule Polymerization by Colehichae -Inhibitory Potencies of Unliganded Colchlcine and Tubulin-Colchlcine Complexes base Pairs Stabilized by MInor Groove Binding Drugs: Molecular Structure of D(CGC[e6G]AATTCGCG) Complexed with Hoechst 33258 or Hoechst 33342. EMBOJ1992, 11:225 232 Crystal Structure of the Cell-binding B Ohgomer of Verotoxin-1 from E. CoB [Letter] Substitution of Cysteine for Glycine-alpha-l-691 ha the Proalpha-l(I) Chain of Type-I Procollagen in a Proband with Lethal Osteogenesis Imperfecta Destabilizes the Triple Helix at a Site C-terminal to the Substitution Yershaia-Enterocolitica Produces Superantigenie Activity Solution Structure of Neuronal Rungarotoxin Determined by Two-Dimensional NMR Spectroscopy -Calculation of Tertiary Structure Using Systematic Homologous Model Ruilding, Dynamical Simulated Annealing, and Restrained Molecular Dynamics Identification of Three Human Pseudogenes for Subunit-VIb of Cytochrome-c Oxidase -a Molecular Record of Gene Evolution Modulation of the Time Course of Fast EPSCs and Glutamate Channel Kinetics by Aniraectam Metabolic Activation of the Pneumotoxin, 3-Methylindole, by Vacciniaexpressed Cytochrome P450s Simple High-Performaoee Liquid Chromatographic Method for the Determination of a New Phytoehemical Drug, Fellavine, and Its Metabolites in Human and Rat Plasma and Urine Myeloma Based Expression System for Production of Large Mammalian Proteins DNA Sequence of a SaLmonella-Specific DNA Fragment and the use of Oligonucleotide Probes for Salmonella Detection Production of Hemagglutinins and Pili by Vibrio-mlmicus and Its Adherence to Human and Rabbit Small Intestines Invitco Heat-Induced DNA Cleavage by Esperamiein Antitumor Antibiotics Selective DNA Cleavage by ElsamicIn-A and Switch Function of Its Amino Sugar Group Volume-regulated Chloride Channels Associated with the Human Multidrug-resistance P-glycoprotcin Cytoplasmic High-Level Expression of a Soluble, Enzymatically Active Form of the Escherichia-Coli Penicillin-Binding Protein-5 and Purification by Dye Chromatography NMR Studies of Lantibiotics -the Structure of Nisin ha Aqueous Solution Isolation and Structural Characterization of Novel Neutral OUgosaccharide-Alditols from Respiratory-Mucus Glycoproteins of a Patient Suffering from Bronchiectasis. 2. Structure of Twelve Heptato-Nonasaccharides The Importance of the Negative Charge of Beta-Lactam Compounds in the Interactions with Active-Site Serine DD-Peptidases and Beta-Lactamascs Biological Activity of Hib Conjugates. Vaccine Interaction of Bcta-Lactammse-I and Beta-LaCtarn~*e-ll from BaciLlus-Cereus with Semisynthetic Cephamycins -Kinetic Studies. Biocbem J1991 Penicillin Binding Protein 2 is Dispensable in Eseheriehia Cold when PpGpp Synthesis is Induced Antibiotic Inhibition of Group 1 Ribozyme Function Stimulation of Intrachromosomal Homologous Recombination in Marnmallaq Cells by aft Inhibitor of Poly(ADPribosylation) Mitochondrial Genetics -a Paradigm for Aging and Degenerative Diseases Salt-Dependent and Protein-Concentration-Dependent Changes in the Solution Structure of the DNA-Binding Histone-Like Protein, HBsu, from Bacillus-Subtilis Structure of Recombinant Human Rheumatoid Arthritic Synovial Fluid Phospholipase-A2 at 2.2 a Resolution The Complete Amino Acid Sequence of the Clostridium-botulinum Type-E Neuroinxin, Derived by Nucleotide-Sequence Analysis of the Encoding Gene Effects of Repeated Doses of Ivermectin on Ocular Onchocerciasis: Community-based Trial ha Sierra Leone Interaction of Axttibioties with A-and P-sitespecific Bases in 168 Ribosomal RNA Cloning and Expression of the CDNA for Human yglutamyl Carboxylase Identification and Characterization of Ref-1, a Nuclear Protein that Facilitates AP-1 DNA-binding Activity. ~9i/30 J 1992 Characterization of INF56, a Gene Expressed During Infection Structure Development of Uromyces-appendiculatus A Route to Optically Pure (-)-Huperzine-A -Molecular Modeling and Invitro Pharmacology Cloning and Structure of the Monocylglycerol and Diacylglycerol Lipase-Encoding Gene from Penicillium-Camembertii 1.1-150 Separation of Antibiotics by High-Performance Capillary Elcctrophoresis with Photodiode-Array Detection Isolation of a Ribosome-Inactivating and Abortifaeient Protein from Seeds of Luffa-Aeutangala Characterization of Functional Human Erythrocyte-Type Glucose Transporter (GLUT1) Expressed ha Insect Cells Using a Recombinant Baculovirus Molecular Basis of Mycoplasma Surface Antigenic Variation: a novel Set of Divergent Genes Undergo Spontaneous Mutation of Periodic Coding Regions and 5' Regulatory Sequences Binding of Tachyplesin-I to DNA Revealed by Footprinting Analysis -Significant Contribution of Secondary Structure to DNA Binding and Inlplication for Biological Action SingJe-base Mutational Analysis of Cancer and Genetic Diseases Using Membrane Bound Modified Oligonucleotides Alphaamanitin-resistant Transcription Units in Trypanosomes: a Comparison of Promoter Sequences for a VSG Gene Expression Site and Forf the Ribosonaal RNA Genes