key: cord-0005818-7tykr1pn authors: Lazzeri, Chiara; Bonizzoli, Manuela; Cianchi, Giovanni; Batacchi, Stefano; Peris, Adriano title: H1N1-related ARDS requiring veno-venous extracorporeal membrane oxygenation and the heart date: 2018-10-23 journal: Intensive Care Med DOI: 10.1007/s00134-018-5422-3 sha: c6dbefea67ba5c6fde96ab9b8c0a1627c45a5181 doc_id: 5818 cord_uid: 7tykr1pn nan Cardiovascular involvement in influenza infection, mainly reported in observational small series [1] , is thought to occur through the direct effect of the virus in the myocardium or through exacerbating preexisting cardiovascular disease [2] . Since severe acute respiratory distress syndrome (ARDS) needing veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a known complication of influenza infection even in young people, we specifically addressed cardiovascular involvement (by means of serial echocardiograms) in 22 consecutive patients with H1N1-related ARDS treated with VV-ECMO admitted to our ECMO referral center (January 2016-April 2018). Echocardiographic examination (transesophageal/ transthoracic) was performed before and during ECMO implantation [3] , during ECMO support and ICU stay (according to the physician's judgment), and at discharge. The study was approved by our institutional ethical board and performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Table 1 shows echocardiographic findings before ECMO start. Right ventricle (RV) dilatation was detected in 14 patients (63.6%) while left ventricle (LV) dysfunction (< 50%) only in 3 patients (13.6%). During ECMO support, 176 echocardiograms were performed (mean 8 ± 4.1, range 3-15), among which 22 exams (2.8%) were to verify cannula position. RV dysfunction documented before ECMO start completely resolved in all patients within the first 24 h after ECMO start. Among the three patients with LV dysfunction before ECMO, two patients normalized LVEF in the first 24 h after ECMO start, while one patient showed a significant improvement (LVEF 45% vs 32%). Acute cor pulmonale (ACP) was observed before ECMO implantation in 1 patient (4.5%) and completed resolved 3 h after ECMO start. During ECMO support ACP developed in 6 patients (27.2%). Three of these patients died showing ACP on ECMO support: two patients because of septic shock and bronchopleural fistula and the third one because of severe pulmonary fibrosis and concomitant infection from Acinetobacter baumannii. The remaining three patients exhibited transient ACP while on ECMO support, treated with dobutamine infusion in two cases and with iNO in one case. None of these patients needed vasoactive drugs. All three of these patients were successfully weaned from ECMO support and discharged alive. Prone position was performed in 9 patients (41%). Echocardiograms at discharge documented systolic pulmonary arterial pressure of at least 45 mmHg in 83% (15/18) of the survivors. The novelty of the present investigation is that in severe H1N1-related ARDS supported by ECMO, the dynamic *Correspondence: lazzeric@libero.it Intensive Care Unit and Regional, ECMO Referral Centre Emergency Department, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 1, 50134 Florence, Italy changes in cardiac function (LV systolic function) and cardiopulmonary interactions (RV dimensions and function) were assessed by means of serial echocardiograms during ECMO support and throughout ICU stay. This study design allowed the early detection of abnormalities such as ACP potentially susceptible to efficacious treatment, including the possibility of switching from VV to veno-arterial ECMO in the presence of acute RV failure and shock [4, 5] . At discharge, systolic pulmonary hypertension is the commonest finding, suggesting that an echocardiographic follow-up should be performed to assess the pulmonary circulation and RV function after the complete resolution of lung alterations. Table 1 Blood gas analysis and echocardiographic findings before ECMO start PEEP positive end-expiratory pressure, TTE transthoracic echocardiography, TEE transesophageal echocardiography, sPAP systolic pulmonary arterial hypertension, TAPSE tricuspid annular plane excursion, LVEF left ventricular ejection fraction, RV right ventricle, Tn I troponin I, NT pro BNP N-terminal pro brain natriuretic peptide Values Cardiac manifestations in patients with pandemic (H1N1) 2009 virus infection needing intensive care Cardiovascular manifestations associated with influenza infections Right ventricle dilation as a prognostic factor in refractory ARDS requiring VV-ECMO Prevalence and prognostic value of acute cor pulmonale and patent foramen ovale in ventilated patients with early acute respiratory distress syndrome: a multicenter study Experts' opinion on management of hemodynamics in ARDS patients focus on the effects of mechanical ventilation