key: cord-0005710-uhsj64yk
authors: Mani, Babu Ivan; Rubel, Abdur Rahman; Chauhdary, Waqas Ahmed; Bashir, Aieman; Soe, Zar Ni; Javed, Nasir; Sharif, Shah Muhammad Alam; Hla Aye, May Thu; Chong, Vui Heng
title: Osler-Weber-Rendu Syndrome
date: 2020-03-14
journal: QJM
DOI: 10.1093/qjmed/hcaa094
sha: abfeb3eae16619eb19909b7dac5d5dc0f8ccb78c
doc_id: 5710
cord_uid: uhsj64yk

nan

A 57-year-old man with diabetes and chronic hepatitis B presented with epistaxis and symptomatic anaemia. His past medical history was relevant for recurrent presentations with epistaxis resulting in chronic iron deficiency anaemia requiring transfusions. Physical examination reviewed multiple telangiectasias affecting the tongue, lips ( Figure A) , face and scalp, digits and the palmer aspect of the hands ( Figure B ). He also has numerous telangiectasia in the nasal passage. Patient recounted that bleeding can be severe; profuse epistaxis and bleeding from finger tips and scalp with spurting that can reach the ceiling.

Upper gastrointestinal endoscopy showed several telangiectasia affecting the duodenum. 

Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome)

Pulmonary arteriovenous malformations: cerebral ischemia and neurologic manifestations

How to manage patients with hereditary haemorrhagic telangiectasia