key: cord-0005071-vdacrq9k authors: Yamada, J.; Kuramoto, T.; Serikawa, T. title: A rat genetic linkage map and comparative maps for mouse or human homologous rat genes date: 1994 journal: Mamm Genome DOI: 10.1007/bf00292332 sha: 40a823986d26ab0b31a44b64baa98225a1a6df5e doc_id: 5071 cord_uid: vdacrq9k nan lists in alphabetical order 539 rat loci assigned to a particular chromosome and 8 loci that were not yet as-Correspondence to: T. Serikawa signed to any chromosomes and remained in linkage groups (LG III, XI, XII, and XIII of Hedrich's map). There are now 547 entries; a substantial increases from the 214 of 370 of their 1992 list. A rat genetic linkage map is shown in Fig. 1 . Out of 539 loci assigned to particular chromosomes, 276 are located on each linkage map. The loci assigned to chromosomes by methods other than linkage analysis are listed separately and alphabetically under each chromosome. The numbers of loci on each chromosome are as follows: (no. loci located on the linkage map/no, loci assigned to the chromosome in total), Chr 1, 40/69; Chr 2, 18/33; Chr 3, 21/40; Chr 4, 19/35; Chr 5, 16/38; Chr 6, 10/23; Chr 7, 6/23; Chr 8, 11/26; Chr 9, 2/17; Chr 10, 20/32; Chr 11, 4/10; Chr 12, 7/11; Chr 13, 8/19; Chr 14, 20/28; Chr 15, 0/9; Chr 16, 3/5; Chr 17, 5/16; Chr 18, 14/17; Chr 19, 27/31; Chr 20, 15/34; Chr X, 10/22; Chr Y, 0/1. On Chrs 6, 8, 11, 12, and 14, respectively, two, three, two, two , and two linkage groups are seen. As for Chrs 4, 8, 14, 19, 20 , and X, two linkage groups aligned in parallel because of discord in the locus order, distance in the references, or absence of anchor loci by which the orientations of maps are determined. For the discussion of comparative mapping, we have applied the chromosome terminology of ISCN (1978) ; that is, rat chromosomes are designed by the prefix RNO (Rattus norvegicus), mouse chromosomes by MMU (Mus musculus), and human chromosomes by HSA (Homo sapiens). As shown in Fig. 2 , we assigned mouse homologous rat genes on the mouse chromosomes, and they are shown by the mouse symbols. Location of the mouse loci have been referred from the mouse locus map of Hillyard and associates (1993) . With a few exceptions MMU2, 3, 4, 6, 7, 8, 9, 11, 12, 14, 15, 16, 18 , and X were homologous with glutathione HYD IC IA IDHI IFNA IFNB1 IGFJ IGF2 1GFBP IGHt IGH2 1GH3 1GHE IGK 1GL IL3 1L6 IL6RI INHA INSI INS2 IRJHM 1TGA4 ITGA5 ITGB1 ITPA 1VD K KAL KCPVD KRAS2 LALBA LAP1 LCA LCK1 LCK2 LDHA LDHB LDR1 LG Szpirer et al. (1989b , 1990 ) Szpirer et al. (1989b , 1990 Yoshida (1984a) Yasue et ai. (1991) Stole, Gill (1983) Griinberg ( Fang et al. (1985) homolog (v-sis) peptidase 2 peptidase 3 peptidase 4 peptidase 7 peripberin platelet factor 4 phosphofructokinase 2 6-phosphofructo-2-kinase/fructose-2,6bisphosphatase, liver and muscle 6-phosphofi'ucto-2-kinase/fructose-2,6bisphosphatase, heart profilagrin pepsinogen 1 pepsinogen 2 phosphogluconate dehydrogenase phosphoglycerate kinase phosphoglucomutase 1 P-glycoprotein l/multi drug resistance I alpha 1-antitrypsin proviral integration, MCF peroxisomal 3-ketoacyl-CoA thiolase protein kinase C type I protein F1 (substrate of protein kinase C) pyruvate kinase, L-type placental antigen 2 phospholipase C-delta 1 Nahon et al. (1992 ) Szpirer et al. (1989b , 1990 ; Serikawa et al. (1992b) ; Kunieda et al. (1992a) ; Kuramoto et al. (1993b) Kohoutova et al. (1980 ) Lobel, Cramer (1981 Kunz et al. (1982) Owen ( [962) ; Palm (1962) ; Pravenec et al. (1992 ) Brdicka, Frenzl (1978 Kren et aL (1973) Kren et ah (1973) ; Kren (1975 ) DeWitt, McCullough (1975 Kunz et al. (1985 ) Kunz et al. (1989 ) Wonigeit (1979 Kondo et al. (1987 ) Kondo et al. (1987 ) Greaves, Ayres (1969 Castle ( E "_ ~_Cd45 (LCA, R13) ' _ Cf-5 (F5, R13) Pk-1 (P~, ~) Rnulb-1 (RmYl, RZ) .egg (R2) ~a (t13) Ada (R3) sw4 (R3) ~_ Pck-1 (R3) zck (RS) Fuca (R5) _Ahd-1 (R5) Pgd (R5) Pnd (R5) Eno-1 (RS) Ak-2 (RS) Acp-2 (R3) Bmyc (MYCB, Gpi-1 Mtp-1 (1tl) : "-C ebp I(~TP1, R1). RNO3, 2, 5, 4, 1, 19, 8, 10, 6, 15, 7, 11, 18 , and X, respectively. It seems that MMU1 consists of a homologous RNO9 (centromeric half) and RNO13 (telomeric half); this has already been deduced from the G-banding patterns by Levan and coworkers (1991) . Conserved linkage of homologous genes between MMU7 and RNO1, and between MMUll and RNO10, were confirmed. On MMU5, 10, 13, 16, and 17, the rat homologs belong to two or three different chromosomes. Although the gene orders on homologous chromosomes or chromosomal segments between the two species are fairly well preserved, a few genes are ordered in the opposite direction in the two species, and only one rat homolog was assigned on MMU19 and MMUY. In order to compare more precisely the gene orders among the different species, we have to wait to obtain a more complete rat gene map. Resemblance between mouse and rat maps is considered to reflect the phylogenically close relationships between the two species. In Fig. 3 , we assigned human homologus rat genes to the human chromosomes, shown by the human symbols. Lo-cation of the human loci have been referred from the 1991 catalog of human mapped genes of McAlpine and associates (1991). All of the human homologous rat genes shown on HSA17 and HSAX locate on RNO10 and RNOX, respectively. In the other human chromosomes, human homologous rat genes are divided into two or more rat chromosomes. Out of 218 human homologous rat genes in this map, 169 genes (77.5%) are known also in the mouse. The remaining 49 human homologous rat genes (22.5%) have not been reported yet in the mouse. This suggests that the rat makes considerable contributions in the area of biomedical research, as well as the mouse. In fact, the rat provides a variety of models for human disease, including hypertension, diabetes, various cancers, and so on. In order to make comparisons of the rat genes with those of mouse and human homologs, we have performed searches that were as precise as possible. There is a possibility, however, that there may be some misunderstandings or misreading of the homologs. If this is the case, we hope that they will be quickly corrected by new studies. We can now use chromosome numbers instead of linkage groups in rat gene mapping, as in the mouse or human. We have no doubt that the rat genetic linkage map will be furnished with more newly assigned genes within the next couple of years, by currently available techniques and Comparative map for human homologous rat genes. The gene symbols on the chromosomes are indicated with the human symbols and are followed by the rat chromosome numbers (R1 to R20, RX). Location of the human loci were referred from McAlpine and coworkers (1991) . When the human symbols are quite different from the rat symbols, the rat symbols are shown in parentheses. newly developed DNA teclmologies. In this way, comparisons of genes among rat-mouse-human will become easier and also more precise. Enzyme markers in inbred rat strains: genetics of new markers and strain profiles Chromosomal assignment of 4 rat genes coding for the spermatid-specific proteins proacrosin (ACR) The gene for the C4b-binding protein ~-chain (C4BPB) is located on chromosome 1, band 1q32 in human and on chromosome 13 in the rat Structures and chromosomal localizations of two human genes encoding synaptobrevins I and 2 A genetically controlled esterase in rat prasma Androgen metabolism and mechanism of action in male pseudohermaphroditism: a study of testicular feminization Allotypes of rat imraunoglobutins. I. An allotype at the alpha-chain locus Provirus insertion in Tpl-1, and Ets-1 related oncogene, is associated with tumor progression in Mo-MuLV induced rat thymic lymphomas Allotypes of rat immunoglobulins llI: an allotype of the 22[3-chain locus ) 9 Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications Genetic variation of an acid phosphatase (Acp-2) in the laboratory rat: possible homology with mouse AP-1 and human ACP2 The R 1 factor, a histocompatibility antigen in the rat The chromosome I of the laboratory rat (Rattus norvegicus) Linkage of alloantigenic locus H-3 and plasma esterase locus Es-2 in the Norway rat The thyroglobulin gene resides on chromosome 8 in man and on chromosome 7 in the rat Close linkage of peripheral T-lymphocyte antigen A (PtaA) to the hemoglobin variant Hbb on linkage group I of the rat Allelic and tissue variation of rat fumarate hydratase (E.C. 4.2.1.2.) Phosphogluconate dehydrogenase polymorphism in British wild rats Genetic mapping of the athymic nude (RNU) locus in the rat to a region on chromosome 10 Silver, a mutation of the rat Linkage studies of the rat (Rattus norvegicus) V. Proc. Natl. Acad. Sci. USA Linkage studies of the rat (Rattus norvegicus) VI Linkage studies of the rat (Rattus norvegicus) VII. Shaggy, a new dominant Linkage studies of the rat X Linkage of l ll3-hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat Localization of rat genes on fractionated chromosomes by molecular hybridization The related genes encoding growth hormone and prolactin have been dispersed to chromosome 10 and 17 in the rat The rat vitamin D binding protein (Gc-globulin) gene is syntenic with the rat albumin and alpha-fetoprotein genes on chromosome 14 Genetic variation of urinary pepsinogen and its probable linkage to albinism in the rat Linkage of quantitative variation of a serum protein (Sp) to the major histocompability complex of the rat Linkage of loci encoding a kidney endothelial antigen and fumarate hydratase (Fh-1) in the rat Biochemical markers in rats: linkage relationships of aconitase (Acon-]), aldehyde dehydrogenases (Adh-2 and Ahd-c), alkaline phosphatase (Akp-1), and hydroxyacid oxidase (Hao-1) Assignment of a gene for coagulation factor V to chromosome 1 in man and to chromosome 13 in the rat Characterization and chromosomal assignment of a gene for rat 6-phosphofructo-2-kinase Molecular cloning and characterization of prolactin-like protein C complementary deoxyribonucleic acid All six rat gamma-crystallin genes are located on chromosome 9 Ag-F: serological and genetic identification of a new locus in the rat governing lymphocyte membrane antigens Localization of the rat T-cell receptor I]-chain and carboxypeptidase A1 loci to chromosome 4 Electrophoretic variation in low molecular weight lens erystallins from inbred stains of rats Linkage in rats between factors determining a pathological condition and a coat color The most frequently lost allelic site in human renal cell carcinoma (D3FI5S2) on the short arm of chromosome 3 has homologous sequences on rat chromosome 8 Primary structure of the rat gene encoding an inhibitor of the insulin receptor tyrosine kinase Chromosomal mapping of rat cellular oncogenes and growth factor genes Linkage between a hemoglobin locus and albinism in the Norway rat Attempt to determine blood groups in rats Assignment of the rat genes coding for phenylalanine hydroxylase, tyrosine aminotransferase and pyruvate kinase to chromosomes, 6, 19 and 2 respectively Assignment of the rat genes coding for o:l-antitrypsin (P/), phosphoenolpyruvate carboxykinase (PEPCIO, alcohol dehydrogenase (ADH), and fructose-1,6-bisphosphatase (FDP) Structural variants of the or gene in different inbred strains of rat Seminal vesicle protein in rats: a gene in the fourth linkage group determining electrophomtic variants Gene complex controlling growth and fertility linked to the major histocompatibility complex in the rat Orientation of loci in the major histocompatibility complex of the rat and its comparison to man and the mouse Genetic map of 12 polymorphic loci on rat chromosome 1 Chromosomal assignments of the genes for glucocorticoid receptor, myelin basic protein, leucocyte common antigen, and TRPM2 in the rat Characterization of the aldose reductase-encoding gene family in rat Genetic polymorphism of the sixth component (C6) of rat complement Linkages between genes for coat colour and resistance to warfarin in Rattus norvegicus Inheritance of Scottish-type resistance to warfarin in the Norway rat Unifactorial inheritance of warfarin resistance in Rattus nora, egicus from Denmark An hereditary absence of the incisor teeth The linkage relations of a new lethal gene in rat (Rattus notwegicus) New genetic factors that affect fertility in the male rat A new polymorphic pepsinogen locus (Pg-2) in the rat (Rattus norvegicus) Localization of the MDR 170kDa P-glycoprotein locus to chromosome 4 and the Mlvi-4 locus to chromosome 7 in the rat Assignment of two rat dihydrofolate reductase (DHFR) genes to chromosome 2 and 4 Genetic Monitoring of Inbred Strains of Rats Re-evaluation of LGV of the rat and assignment of 12 carboxylesterases to two gene clusters Biochemical genetics of Es-14 (formerly Es-Si) and a new esterase variation, Es-15, of the laboratory rat (Rattus norvegicus): biochemistry, tissue expression, and linkage to Es-1 in linkage group V Genetic analysis of coronavirus induced demyelination encephalomyelitis Gene for parathyroid hormone-like peptide is on rat chromosome 2 Genetic control of haemaglutinin production against an MI-IC determined alloantigen in rats. Immunogenetics Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats Human and rat chromosomal localization of two genes for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase by analysis of somatic ceil hybrids and in situ hybridization Locus map of mouse with comparative points of human on mouse Mapping ofLmyc andNmyc to rat chromosome 5 and 6 Rat c-rafoncogene is located on chromosome 4 and may be activated by sequences from chromosome 13. Somatic Ce11 Moh Genet Structure and expression of B-myc, a new member of the myc gene family An International System for Human Cytogenetic Nomenclature A gene for the suppression of anchorage independence is located in rat chromosome 5 bands @2-23, and rat alpha interferon locus maps at the same region Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat Genetic dissection of autoimmune type 1 diabetes in the BB rat The location of ribosomal cistrons (rDNA) in chromosomes of the rat Hypotensive effect associated with a phospholipase C-8l gene mutation in the spontaneously hypertensive rat Glucose phosphate dehydrogenase polymorphism and the genetics of linkage group I in the Norway rat (Rattus norvegicus) A waltzing mutation in the white rat Analysis of a mini library of DNA fragments from microdissected chromosome pieces of RNO5, band q22-23 Infantile ichthyosis in rats: a new model of hyperkeratotic skin disease Polymorphism detected in variable number of tandem repeats (VNTR) of the seminal vesicle secretion (SVS) IV gene in inbred rats Linkage among esterase-6 (Es-6), neural cell adhesion molecule (NCAM), and apolipoprotein C-III (apoc-3) genes on rat chromosome 8 The Mlvi-I locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical Polymorphisms of erythrocyte 6-phosphogluconate dehydrogenase and phosphoglucomutase in Rattus norvegicus in Japan Genetic definition of a further gene region and identification of at least three different histocompatibility genes in the rat major histocompatibility system Male urinary protein (Mup-]) expression in the female rat Two polymorphic genetic loci of rat tear proteins Genetic polymorphism of tear proteins in the rat Second genetic polymorphism of tear proteins in the rat (Rtp-2) DNA segments mapped by reciprocal use of microsatellite primers between mouse and rat A new mutation of primary ciliary dyskinesia (PCD) with visceral inversion (Karthagenr's syndrome) and hydrocephalus Genetics of the polydactyly-luxuate syndrome in the Norway rat, Rattus norvegicus Rat alloantigenic systems defined through congenic strain production Restriction fragment length polymorphisms detected in N-ras-related sequences of rats and their linkage analysis Localization of the interleukin-3 gene to rat chromosome 10 by linkage analyses with a variable number of tandem repeats Polymorphic microsatellite loci of the rat The identification and mapping of a second class I locus in the major bistocompatibility complex of the rat Production of monoclonal antibodies against RT2 antigens of the rat and definition of a new locus, RT9, linked to RT2 A unique pla-centa1 antigen controlled by an MHC-Iinked locus RT11 Regional mapping of the Rowett nude gene (RONU) to rat chromosome 10q24 ~ q32 by localizing linked SYB2 and GH loci A strategy for rapid construction of genetic and physical maps in the rat Assignment of retinal dystrophy (rdy) to linkage group IV of the rat Recent status of chromosome localization of rat genes The rat gene map 1989 The gene map of the Norway rat (Rattus norvegicus) and comparative mapping with mouse and man Rat gene map I992 Regional mapping of the c-fos oncogene to rat chromosmne 6@1-@3. Cytogenet Molecular genetics of the SA-gene: cosegregation with hypertension and mapping to rat chromosome i Demonstration of a new genetic locus in the major histocompatibility system of the rat The rat major histocompatibility complex and the cystathionine beta-synthase gene are synthetic and map to chromosome 20 Genetic identification of a locus linked to the rat MHC that codes for a membrane antigen detectable with cytotoxic lymphocytes The LEW.BN (2R) strain: a recombinant in the rat MHC Chromosomal localization of human and rat Ao~, BI3, and 7 fibrinogene genes by in situ hybridization The control of specificity of cytotoxic T lymphocytes by the major histocompatiblity complex (AG-B) in rats and identification of a new alloantigen system showing no Ag-B restriction Localization of the gene for glutathione S-transferase P on rat chromosome 1 at band q43 New polymorphism of esterase 7 and esterase 8 in inbred stains of rats: tissue expression and linkage studies A new genetic variation of the malate dehydrogenase-like enzyme (MDL-I) in inbred rats and its possible linkage Mapping of the genes for tubular basement membrane antigen and submaxillary gland protease in the rat Chromosomal assignment of retinoic acid receptor (RAR) genes in the humans, mouse, and rat genomes The 1991 catalog of mapped genes and report of the nomenclature committee MHC class I antigens in rat pregnancy: biochemical comparison between the pregnancy-associated (Pa) antigen and the class I MIIe antigen RT1. A*a in the rat Characterization of pregnancy-associated rat MIlC class I antigen Pa by mating studies and by peptide mapping Genetic variation of pancreatic (x-amylase in the rat, Rattus norvegicus A glutaminase (Gls) gene maps to mouse chromosome 1, rat chromosome 9, and human chromosome 2 Restriction fragment length polymorphism of the angiotensinogen gene in inbred rat strains and mapping of the gene on chromosome 19q Localization of the rat insulin I gene (INS1) to chromosome 1@5 by fluorescence in situ hybridization Instability of the minisatellite sequence in the first intron of the rat renin gene Assignment of the rat genes coding for substance P receptor, substance K receptor and nenromedin K receptor to chromosome 4, 20 and 2, respectively A single serine: pyruvate aminotransferase gene on rat chromosome 9q34-q36 Preliminary characterization of a skeletal mutant, Tal-2, and a comment on linkage group I to which it maps Linkage of the hypodactyly and incisorless genes in the Norway rat Biochemical polymorphism in the rat (Rattus norvegicus): genetic study of four markers Linkage of a plasma protein marker (Gl-1) and the hooded locus in the rat (Rattus norvegicus) Hypodactyly, a new recessive mutation in the Norway rat X-and Y-linked transplantation antigens in rats Chromosomal assignments of genes for rat glutathione S-transferase Yb 1 (GSTA3) and Yb2 (GSTA4) subnnits. Cytogenet Promelanin-concentrating hormone gene (PMCH) is localized on human chromosome 12q and rat chromosome 7 Male urinary protein-1 (MUP-t) in the rat Linkage of the gene for uncoupling protein to esterase-1,2 and haptoglobnlin in the rat Earlier studies of blood groups in the rat Primary structure and assignment to chromosome 6 of three closely related rat genes which encode serine protease inhibitors expressed in liver Current status of blood groups in rats Immunogenetic analysis of Ag-B histocompatibility antigens in rats Fuzzy, a hypotrichotic mutant in linkage group I of the Norway rat Localization of the rat immunoglobulin heavy chain locus to chromosome 6 The rat immnnoglobulin kappa light chain locus is on chromosome 4. lmmunogenetics Expression of rat hepatocyte plasma membrane antigens in hybrid clones: assignment of genes coding for two antigens of the basolateral domain to chromosome 11 and 13. Cytogenet Assignment of Es-6 locus to linkage group VII of the rat (Rattus norvegicus) by the use of HXB recombinant inbred rat strains The rat renin gene: assignment to chromosome 13 and linkage to the regulation of blood pressure Assignment of rat linkage group V to chromosome 19 by singlestrand conformation polymorphism analysis of somatic cell hybrids Structures and chromosomal localizations of two rat genes encoding s-adenosylmethionine decarboxylase Mapping of genes for cytochromes P-450b, P450e, and P-450h in the rat A new rat mutant with defective overhairs and spongy degeneration of the central nervous system: clinical and pathological studies Genetic map of nine polymorphic loci comprising a single linkage group on rat chromosome 10: evidence for linkage conservation with human chromosome 17 and mouse chromosome I i Map of seven polymorphie markers on rat chromosome 14: linkage conservation with human chromosome 4 Linkage map of seven polymorphic markers on rat chromosome 18 Linkage in the Norway rat (Rattus norvegicus) Decidual prolactin-related protein Characterization of silver stained nucleolus organizer regions (Ag-NORs) in 16 inbred strains of the Norway rat Regional assignment of rat androsterone UDP-glucuronosyltransferase gene (UGT2B2) to chromosome 14p21.2-p22 Chromosome segregation and expression of rat immunoglobulins in rat/mouse hybrid myelomas Polymorphisms revealed by PCR with single, short-sized, arbitrary primers are reliable markers for mouse and rat gene mapping Rat gene mapping using PCR-analyzed microsatellilets Genetically determined susceptibility of Fischer 344 rats to propylnitrosourea-induced thymic lymphomas Linkage of the analbuminemia locus (alb) and the hooded locus in the rat, Rattus norvegicus Mapping of hooded, Gc protein, and albumin gene loci in linkage group VI of the laboratory rat Assignment of the chromogranin A (Chga) locus to homologous regions on mouse chromosome 12 and rat chromosome 6 Linkage of the locus encoding the A chain of o~-crystal]in (Acry-1) to the major histocompatibility complex in the rat RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon Genetic recombination in the major histocompatibility complex (H-l, Ag B) of the rat Linkage of diabetes insipidus and agouti genes in the rat Linkage of hooded and hooded modifier genes in the rat Linkage and polymorphism of gene controlling lactate dehydrogenase in the rat The linkage of glyoxylase-1 to the major histocompatibility complex in the rat Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver: identification of a transcript formed by trans splicing Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6.7) chromosomal translocation Localization of 5S RNA and rRNA genes in the Norway rat The rat gene map Assignment of the rat genes coding for medium-chain acyl-Co-A carboxylsase, isovaleryl-CoA dehydrogenase, and the [3 subunit of propionyl-Co-A carboxylase to chromosome 2,3, and 8, respectively The rat gene map: assignment of 10 loci to chromosome 5, and homoiogy of rat chromosome 5 with mouse chromosome 4, human chromosome 9, and human chromosome arm lp Assignment of 12 loci to rat chromosome 5: evidence that this chromosome is homologus to mouse chromosome 4 and to human chromosome 9 and 1 (lp arm) Assignment of the rat parathyroid hormone-like peptide gene (PTHLH) to chromosome 4: evidence for conserved synteny between human chromosome 12, mouse chromosome 6 and rat chromosome 4 Chromosomal assignment of five cancer-associated rat genes: two thyroid hormone receptor (ERBA) genes, two ERBB genes and the retinoblastoma gene Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP and transcription factor 1, TCF1, respectively) and of the hepatic growth factor/scatter factor gene (HGF) Assignment of three rat integrin genes to chromosome 19 (1TGB1), chromosome 3 (ITGA4), and chromosome 7 (ITGAS) Gene mapping in the rat by mouse-rat somatic cell hybridization: synteny of the albumin and c~-fetoprotein genes and assignment to chromosome 14 Assignment of three rat cellular RAS oncogenes to chromosomes 1,4, and X. Somatic Ceil Mol Recent chromosomal assignments of rat genes fibrinogen (p-chain), aldolase B, transferrin, C3, ERBA and ERBB. Cytogenet Assignment of three rat genes coding for plasma proteins: transferrin, third component of complement and beta-fibrinogen to chromosome 8, 9 lc). The interleukin-6-dependent DNA binding protein gene (transcription factor-5-TCF5) rat chromosome 2, and the rat IL6 gene to rat chromosome 4 The Spl transcription factor gene (SP1) and the 1,25-dihydroxy vitamin-D3 receptor gene (VDR) are localized on human chromosome arm 12q and rat chromosome 7q Secondary activation of c-abl may be related to translocation to the nucleolar organizer region in an in vitro cultured rat leukemia cell line (K3D) Rat obesity gene fatty (/Ca) maps to chromosome 5: evidence for homology with mouse gene diabetes Cellular DNA regions involved in the induction of rat thymic lymphomas (Mlvi-1, Mlvi-2, Mlvi-3, and c-Myc) represent independent loci as determined by their chromosomal map location in the rat Activation of multiple genes by provirus integration in the MIvi-4 locus in T cell lymphomas induced by Moloney murine leukemia virus Biochemical polymorphism in the rat: genetics of three electrophoretic variants and characterization of inbred strains Assignment of Lap-1 to linkage group I of the rat Assignment of the rat genes coding for DOPA decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2) Comparative analysis of coronavirus JHM-induced demyelinating encephalomyelitis in Lewis and Brown Norway rats Polymorphism and mapping of the component gene C4 in the rat Non-random chromosomal changes involving chromosomes 6 and 7 in spontaneous rat immunocytomas Generic control of an esterase of digestive tract tissues in Rattus norvegicus Biochemical genetics of rat esterases: polymorphism, tissue expression and linkage of four loci Peptidase-3 (Pep-3), dipeptidase variant in the rat homologous to mouse Pep-3 (Dip-3) and human PEP-C Comparative autosomal linkage in mammals: genetics of esterases in Mus musculus and Rattus norvegicus Definition lymphocyte antigens in rats: RT-Ly-1, RT-Ly-2, and a new MHC-linked antigen system Localization of heat shock protein 70 genes inside the rat major histocompatibility complex close to class III gene. Immunogenetics 30 Linkage analyses among five esterase loci in the laboratory rat (Rattus norvegicus) Genetic studies of RBC catalase in the rat (Rattus norvegicus) Assignment of body tremulous mutant gene zitter (zi) to linkage group IV of the rat (Rattus norvegicus) Chromosomal assignments of genes for rat glutathione s-transferase Ya (GSTA1) and Yc subunits (GSTA2). Cytogenet Chromosomal assignments of 23 biochemical loci of the rat by using rat • mouse somatic cell hybrids Chromosomal assignments of 17 structural genes and 11 related DNA fragments in rats (Rattus norvegicus) by Southern blot analysis of rat • mouse somatic cell hybrid clones New markers, D16FCI and Tpl2, differentiate between rat chromosomes 16 and 17 Rat gene mapping by rat-mouse somatic cell hybridization and a comparative Q banding analysis between rat and mouse chromosomes Synteny of the genes for adenylate kinase and phosphoglucomutase in the rat and their assignment to rat chromosome 5 Assignment of the syntenic genes AK2, ENO1, PGD, and PGM2 to rat chromosome 5 Assignment of GDH and FUCA to rat chromosome 5: evidence for homoglous linkage groups in rat, mouse, and man Linkage map of 10 polymorphic markers on rat chromosome 2 Mapping of rat prostatic binding protein genes C1, C2 and C3 to rat chromosome 5 by in situ hybridization Localization of the PRR 1 gene coding for rat prostatic proline-rich polypeptides to chromosome 10 by in situ hybridization Serikawa et al. (1992b) ; Jacob et al. (1992) ; Dissen et al. (1993) Hilbert et al. (1991) ; Serikawa et al. (1992b) Goldmuntz et al. (1993) Skow et al. (1985) Donner et al. (1985) ; DenDunnen et al. (1987); Hilbert et al. (1991) ; Serikawa et al. (1992b ) Donner et al. (1985 ; DenDunnen et al. (1987) Donner et al. (1985) ; DenDunnen et al. (1987) Donner et al. (1985) ; DenDunnen et al. (1987 ) Donner et al. (1985 ; DenDunnen et al. (1987 ) Donner et al. (1985 ; DenDunnen et al. (1987 ) Yamada et al. (1981 ; Kendall (1985) Remmers et al. (1993b ) Hilbert et al. (1991 ; Serikawa et al. (1992b ) Marshak et al. (1977 ) Hilbert et al. (1991 ; Serikawa et al. (1992b ) Castle, King (1944 , 1947 Yoshida (1978 Yoshida ( , 1982 Hilbert et ah (1991); Serikawa et al. (1992b) Levan et al. (1991) Acknowledgments. The authors thank Dr. Jean-Louis Gu6net, Institut Pasteur de Paris, and Dr. Mark Lathrop, C.E.P.H., France, for their valuable comments. This study was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, in Japan.