Distortion at the inlet to diffusers is very common in internal flow applications. Inlet velocity distortion influences the pressure recovery and flow regimes of diffusers. This work introduced a centerline wake at the square inlet of a plane wall diffuser in two orthogonal orientations to investigate its influence on the diffuser performance. Two different wakes were generated. One was from a mesh strip which produced a velocity deficit with low turbulence intensity and two shear layers. The other wake generator was a D-shaped cylinder which produced a wake with high turbulence intensity and large length scales. These inlet conditions were generated for a diffuser with a diffusion angle of three degrees and six degrees. A pair of RANS simulations were used to investigate the influence of the orthogonal inlet orientations on the solution. The inlet conditions were taken from the inlet velocity field measured for the mesh strip. The flow development and exit conditions showed some similarities and some differences with the experimental results.The performance of a diffuser is typically measured through the static pressure recovery coefficient and the total pressure losses. The definition of these metrics commonly found in the literature were insufficient to discern differences between the wake orientations. New metrics were derived using the momentum flux profile parameter which related the static pressure recovery, the total pressure losses, and the velocity uniformity at the inlet and exit of the diffuser. These metrics revealed a trade-off between the total pressure losses and the uniformity of the velocity field.