Wind tunnel experiments were performed with active flow control using a dielectric barrier discharge (DBD) plasma actuator to determine the effects of flow control in a test section simulating the bend in a centrifugal compressor. These experiments were performed over a range of pressures and Mach numbers to determine the applicability of plasma actuators under the extreme conditions of compressor flows. Vortex generators were also examined as an easily quantifiable disturbance to test the sensitivity of the system. Significant 3-D effects were discovered in the experiment that were not predicted to be present in centrifugal compressors. Vortices were found to form in the corners of the bend test section which promoted mixing through the section. This caused significant changes to the velocity profile through the bend test section compared to that predicted by 2-D and fully azimuthal simulations. Despite these differences, the results of the experiment remain valid for predicting the effectiveness of plasma actuators in high pressure flows. While previous work has been performed investigating the effects of pressure on plasma actuators and the force generated by plasma actuators, this experiment examines plasma actuators as flow control devices in high pressure flows. Plasma actuators are shown to improve the performance of the system by as much at 5%. The effectiveness of DBD actuators is seen to increase with pressure for a constant applied voltage to a maximum beyond which effectiveness is reduced. From the results of the simulations, it is suggested that by increasing the plasma actuator flow control authority, the performance of the system can be improved beyond that of the present work.