This thesis compares one-hop routing and two-hop routing in simple networks consisting of two mobile nodes and a single destination (base) node. The networks under consideration use time division multiple access (wherein the nodes co-operate only in that they do not try to access the channel simultaneously) for multi-hop transmission to mitigate interference and include a linear network (with unequal spacing) and a simple two-dimensional network. We first use capacity arguments to demonstrate the advantage of one-hop routing in the high SNR (high spectral efficiency) regime; we then simulate practical coding schemes whose performance support the capacity arguments. Finally, we examine how the cross-over rate (the rate at which the optimal number of hops changes) varies in the presence of an end-to-end delay using the sphere packing bound.