id sid tid token lemma pos zs25x636341 1 1 despite despite SCONJ zs25x636341 1 2 the the DET zs25x636341 1 3 lofty lofty ADJ zs25x636341 1 4 goal goal NOUN zs25x636341 1 5 of of ADP zs25x636341 1 6 eradication eradication NOUN zs25x636341 1 7 , , PUNCT zs25x636341 1 8 malaria malaria NOUN zs25x636341 1 9 is be AUX zs25x636341 1 10 one one NUM zs25x636341 1 11 of of ADP zs25x636341 1 12 the the DET zs25x636341 1 13 leading lead VERB zs25x636341 1 14 causes cause NOUN zs25x636341 1 15 of of ADP zs25x636341 1 16 mortality mortality NOUN zs25x636341 1 17 in in ADP zs25x636341 1 18 sub sub ADJ zs25x636341 1 19 - - ADJ zs25x636341 1 20 saharan saharan ADJ zs25x636341 1 21 african african ADJ zs25x636341 1 22 children child NOUN zs25x636341 1 23 . . PUNCT zs25x636341 2 1 significant significant ADJ zs25x636341 2 2 reduction reduction NOUN zs25x636341 2 3 in in ADP zs25x636341 2 4 the the DET zs25x636341 2 5 number number NOUN zs25x636341 2 6 of of ADP zs25x636341 2 7 annual annual ADJ zs25x636341 2 8 deaths death NOUN zs25x636341 2 9 have have AUX zs25x636341 2 10 been be AUX zs25x636341 2 11 realized realize VERB zs25x636341 2 12 in in ADP zs25x636341 2 13 recent recent ADJ zs25x636341 2 14 years year NOUN zs25x636341 2 15 due due ADP zs25x636341 2 16 to to ADP zs25x636341 2 17 the the DET zs25x636341 2 18 widespread widespread ADJ zs25x636341 2 19 use use NOUN zs25x636341 2 20 of of ADP zs25x636341 2 21 artemisinin artemisinin ADJ zs25x636341 2 22 combination combination NOUN zs25x636341 2 23 therapies therapy NOUN zs25x636341 2 24 . . PUNCT zs25x636341 3 1 recent recent ADJ zs25x636341 3 2 reports report NOUN zs25x636341 3 3 from from ADP zs25x636341 3 4 the the DET zs25x636341 3 5 thai thai PROPN zs25x636341 3 6 / / SYM zs25x636341 3 7 cambodia cambodia PROPN zs25x636341 3 8 border border PROPN zs25x636341 3 9 clearly clearly ADV zs25x636341 3 10 show show VERB zs25x636341 3 11 the the DET zs25x636341 3 12 emergence emergence NOUN zs25x636341 3 13 of of ADP zs25x636341 3 14 artemisinin artemisinin ADJ zs25x636341 3 15 resistance resistance NOUN zs25x636341 3 16 , , PUNCT zs25x636341 3 17 re re VERB zs25x636341 3 18 - - VERB zs25x636341 3 19 emphasizing emphasize VERB zs25x636341 3 20 an an DET zs25x636341 3 21 urgent urgent ADJ zs25x636341 3 22 need need NOUN zs25x636341 3 23 to to PART zs25x636341 3 24 prevent prevent VERB zs25x636341 3 25 or or CCONJ zs25x636341 3 26 slow slow VERB zs25x636341 3 27 the the DET zs25x636341 3 28 spread spread NOUN zs25x636341 3 29 of of ADP zs25x636341 3 30 drug drug NOUN zs25x636341 3 31 resistance resistance NOUN zs25x636341 3 32 . . PUNCT zs25x636341 4 1 success success NOUN zs25x636341 4 2 in in ADP zs25x636341 4 3 this this DET zs25x636341 4 4 endeavor endeavor NOUN zs25x636341 4 5 will will AUX zs25x636341 4 6 require require VERB zs25x636341 4 7 deeper deep ADJ zs25x636341 4 8 understanding understanding NOUN zs25x636341 4 9 of of ADP zs25x636341 4 10 the the DET zs25x636341 4 11 basic basic ADJ zs25x636341 4 12 biology biology NOUN zs25x636341 4 13 and and CCONJ zs25x636341 4 14 adaptation adaptation NOUN zs25x636341 4 15 mechanisms mechanism NOUN zs25x636341 4 16 of of ADP zs25x636341 4 17 the the DET zs25x636341 4 18 malaria malaria NOUN zs25x636341 4 19 parasite parasite NOUN zs25x636341 4 20 . . PUNCT zs25x636341 5 1 much much ADJ zs25x636341 5 2 of of ADP zs25x636341 5 3 this this DET zs25x636341 5 4 biology biology NOUN zs25x636341 5 5 is be AUX zs25x636341 5 6 complex complex ADJ zs25x636341 5 7 , , PUNCT zs25x636341 5 8 subtle subtle ADJ zs25x636341 5 9 , , PUNCT zs25x636341 5 10 and and CCONJ zs25x636341 5 11 currently currently ADV zs25x636341 5 12 unexplored.gene unexplored.gene ADJ zs25x636341 5 13 expression expression NOUN zs25x636341 5 14 is be AUX zs25x636341 5 15 a a DET zs25x636341 5 16 crucial crucial ADJ zs25x636341 5 17 step step NOUN zs25x636341 5 18 in in ADP zs25x636341 5 19 the the DET zs25x636341 5 20 process process NOUN zs25x636341 5 21 of of ADP zs25x636341 5 22 turning turn VERB zs25x636341 5 23 dna dna NOUN zs25x636341 5 24 into into ADP zs25x636341 5 25 observable observable ADJ zs25x636341 5 26 phenotypes phenotype NOUN zs25x636341 5 27 like like ADP zs25x636341 5 28 drug drug NOUN zs25x636341 5 29 resistance resistance NOUN zs25x636341 5 30 . . PUNCT zs25x636341 6 1 transcriptional transcriptional ADJ zs25x636341 6 2 regulation regulation NOUN zs25x636341 6 3 is be AUX zs25x636341 6 4 a a DET zs25x636341 6 5 malleable malleable ADJ zs25x636341 6 6 process process NOUN zs25x636341 6 7 ; ; PUNCT zs25x636341 6 8 responsive responsive ADJ zs25x636341 6 9 to to ADP zs25x636341 6 10 changes change NOUN zs25x636341 6 11 in in ADP zs25x636341 6 12 dna dna PROPN zs25x636341 6 13 sequence sequence NOUN zs25x636341 6 14 , , PUNCT zs25x636341 6 15 environmental environmental ADJ zs25x636341 6 16 fluctuations fluctuation NOUN zs25x636341 6 17 , , PUNCT zs25x636341 6 18 and and CCONJ zs25x636341 6 19 alterations alteration NOUN zs25x636341 6 20 in in ADP zs25x636341 6 21 the the DET zs25x636341 6 22 overall overall ADJ zs25x636341 6 23 abundance abundance NOUN zs25x636341 6 24 of of ADP zs25x636341 6 25 many many ADJ zs25x636341 6 26 other other ADJ zs25x636341 6 27 cellular cellular ADJ zs25x636341 6 28 and and CCONJ zs25x636341 6 29 molecular molecular ADJ zs25x636341 6 30 components component NOUN zs25x636341 6 31 . . PUNCT zs25x636341 7 1 variation variation NOUN zs25x636341 7 2 in in ADP zs25x636341 7 3 transcript transcript NOUN zs25x636341 7 4 levels level NOUN zs25x636341 7 5 , , PUNCT zs25x636341 7 6 even even ADV zs25x636341 7 7 among among ADP zs25x636341 7 8 genetically genetically ADV zs25x636341 7 9 identical identical ADJ zs25x636341 7 10 individuals individual NOUN zs25x636341 7 11 , , PUNCT zs25x636341 7 12 provides provide VERB zs25x636341 7 13 an an DET zs25x636341 7 14 important important ADJ zs25x636341 7 15 foothold foothold NOUN zs25x636341 7 16 for for ADP zs25x636341 7 17 adaptation adaptation NOUN zs25x636341 7 18 and and CCONJ zs25x636341 7 19 evolution evolution NOUN zs25x636341 7 20 . . PUNCT zs25x636341 8 1 to to PART zs25x636341 8 2 explore explore VERB zs25x636341 8 3 some some PRON zs25x636341 8 4 of of ADP zs25x636341 8 5 the the DET zs25x636341 8 6 mechanisms mechanism NOUN zs25x636341 8 7 that that PRON zs25x636341 8 8 contribute contribute VERB zs25x636341 8 9 to to ADP zs25x636341 8 10 parasite parasite NOUN zs25x636341 8 11 adaptation adaptation NOUN zs25x636341 8 12 , , PUNCT zs25x636341 8 13 i i PRON zs25x636341 8 14 investigate investigate VERB zs25x636341 8 15 variation variation NOUN zs25x636341 8 16 in in ADP zs25x636341 8 17 transcript transcript NOUN zs25x636341 8 18 abundance abundance NOUN zs25x636341 8 19 within within ADP zs25x636341 8 20 single single ADJ zs25x636341 8 21 clone clone NOUN zs25x636341 8 22 cultures culture NOUN zs25x636341 8 23 and and CCONJ zs25x636341 8 24 the the DET zs25x636341 8 25 role role NOUN zs25x636341 8 26 differential differential ADJ zs25x636341 8 27 variation variation NOUN zs25x636341 8 28 may may AUX zs25x636341 8 29 play play VERB zs25x636341 8 30 in in ADP zs25x636341 8 31 the the DET zs25x636341 8 32 parasite parasite NOUN zs25x636341 8 33 fitness fitness NOUN zs25x636341 8 34 and and CCONJ zs25x636341 8 35 competitive competitive ADJ zs25x636341 8 36 growth.this growth.this NOUN zs25x636341 8 37 dissertation dissertation NOUN zs25x636341 8 38 describes describe VERB zs25x636341 8 39 previously previously ADV zs25x636341 8 40 unrecognized unrecognized ADJ zs25x636341 8 41 features feature NOUN zs25x636341 8 42 of of ADP zs25x636341 8 43 gene gene NOUN zs25x636341 8 44 expression expression NOUN zs25x636341 8 45 in in ADP zs25x636341 8 46 the the DET zs25x636341 8 47 malaria malaria NOUN zs25x636341 8 48 parasite parasite NOUN zs25x636341 8 49 . . PUNCT zs25x636341 9 1 chapter chapter NOUN zs25x636341 9 2 2 2 NUM zs25x636341 9 3 comprehensively comprehensively ADV zs25x636341 9 4 evaluates evaluate VERB zs25x636341 9 5 several several ADJ zs25x636341 9 6 sources source NOUN zs25x636341 9 7 of of ADP zs25x636341 9 8 variation variation NOUN zs25x636341 9 9 and and CCONJ zs25x636341 9 10 quantifies quantifie NOUN zs25x636341 9 11 the the DET zs25x636341 9 12 contribution contribution NOUN zs25x636341 9 13 of of ADP zs25x636341 9 14 each each DET zs25x636341 9 15 source source NOUN zs25x636341 9 16 to to ADP zs25x636341 9 17 the the DET zs25x636341 9 18 total total ADJ zs25x636341 9 19 variation variation NOUN zs25x636341 9 20 for for ADP zs25x636341 9 21 each each DET zs25x636341 9 22 gene gene NOUN zs25x636341 9 23 in in ADP zs25x636341 9 24 plasmodium plasmodium NOUN zs25x636341 9 25 falciparum falciparum NOUN zs25x636341 9 26 . . PUNCT zs25x636341 10 1 this this DET zs25x636341 10 2 variation variation NOUN zs25x636341 10 3 is be AUX zs25x636341 10 4 then then ADV zs25x636341 10 5 repeatedly repeatedly ADV zs25x636341 10 6 measured measure VERB zs25x636341 10 7 for for ADP zs25x636341 10 8 parasite parasite NOUN zs25x636341 10 9 clones clone NOUN zs25x636341 10 10 across across ADP zs25x636341 10 11 the the DET zs25x636341 10 12 parents parent NOUN zs25x636341 10 13 and and CCONJ zs25x636341 10 14 progeny progeny NOUN zs25x636341 10 15 of of ADP zs25x636341 10 16 a a DET zs25x636341 10 17 genetic genetic ADJ zs25x636341 10 18 cross cross NOUN zs25x636341 10 19 in in ADP zs25x636341 10 20 chapter chapter NOUN zs25x636341 10 21 3 3 NUM zs25x636341 10 22 . . PUNCT zs25x636341 11 1 in in ADP zs25x636341 11 2 this this DET zs25x636341 11 3 chapter chapter NOUN zs25x636341 11 4 , , PUNCT zs25x636341 11 5 the the DET zs25x636341 11 6 heritability heritability NOUN zs25x636341 11 7 and and CCONJ zs25x636341 11 8 regulatory regulatory ADJ zs25x636341 11 9 elements element NOUN zs25x636341 11 10 that that PRON zs25x636341 11 11 contribute contribute VERB zs25x636341 11 12 to to ADP zs25x636341 11 13 transcriptional transcriptional NOUN zs25x636341 11 14 variation variation NOUN zs25x636341 11 15 are be AUX zs25x636341 11 16 characterized characterize VERB zs25x636341 11 17 at at ADP zs25x636341 11 18 the the DET zs25x636341 11 19 level level NOUN zs25x636341 11 20 of of ADP zs25x636341 11 21 individual individual ADJ zs25x636341 11 22 genes gene NOUN zs25x636341 11 23 using use VERB zs25x636341 11 24 quantitative quantitative ADJ zs25x636341 11 25 trait trait NOUN zs25x636341 11 26 loci loci NOUN zs25x636341 11 27 mapping mapping NOUN zs25x636341 11 28 . . PUNCT zs25x636341 12 1 chapter chapter NOUN zs25x636341 12 2 4 4 NUM zs25x636341 12 3 investigates investigate VERB zs25x636341 12 4 the the DET zs25x636341 12 5 genotypic genotypic NOUN zs25x636341 12 6 and and CCONJ zs25x636341 12 7 transcriptional transcriptional ADJ zs25x636341 12 8 changes change NOUN zs25x636341 12 9 that that PRON zs25x636341 12 10 accompany accompany VERB zs25x636341 12 11 drug drug NOUN zs25x636341 12 12 selection selection NOUN zs25x636341 12 13 , , PUNCT zs25x636341 12 14 and and CCONJ zs25x636341 12 15 how how SCONJ zs25x636341 12 16 these these DET zs25x636341 12 17 changes change NOUN zs25x636341 12 18 impact impact VERB zs25x636341 12 19 in in ADP zs25x636341 12 20 vitro vitro X zs25x636341 12 21 parasite parasite NOUN zs25x636341 12 22 fitness fitness NOUN zs25x636341 12 23 for for ADP zs25x636341 12 24 single single ADJ zs25x636341 12 25 clones clone NOUN zs25x636341 12 26 and and CCONJ zs25x636341 12 27 multiple multiple ADJ zs25x636341 12 28 clone clone NOUN zs25x636341 12 29 cultures culture NOUN zs25x636341 12 30 . . PUNCT zs25x636341 13 1 cumulatively cumulatively ADV zs25x636341 13 2 , , PUNCT zs25x636341 13 3 this this DET zs25x636341 13 4 project project NOUN zs25x636341 13 5 addresses address VERB zs25x636341 13 6 the the DET zs25x636341 13 7 hypothesis hypothesis NOUN zs25x636341 13 8 that that SCONJ zs25x636341 13 9 existing exist VERB zs25x636341 13 10 variation variation NOUN zs25x636341 13 11 in in ADP zs25x636341 13 12 gene gene NOUN zs25x636341 13 13 expression expression NOUN zs25x636341 13 14 , , PUNCT zs25x636341 13 15 both both PRON zs25x636341 13 16 among among ADP zs25x636341 13 17 parasite parasite NOUN zs25x636341 13 18 cells cell NOUN zs25x636341 13 19 with with ADP zs25x636341 13 20 identical identical ADJ zs25x636341 13 21 sequences sequence NOUN zs25x636341 13 22 , , PUNCT zs25x636341 13 23 and and CCONJ zs25x636341 13 24 between between ADP zs25x636341 13 25 genetically genetically ADV zs25x636341 13 26 distinct distinct ADJ zs25x636341 13 27 parasite parasite NOUN zs25x636341 13 28 strains strain NOUN zs25x636341 13 29 , , PUNCT zs25x636341 13 30 provides provide VERB zs25x636341 13 31 a a DET zs25x636341 13 32 foundation foundation NOUN zs25x636341 13 33 for for SCONJ zs25x636341 13 34 malaria malaria NOUN zs25x636341 13 35 parasites parasite NOUN zs25x636341 13 36 to to PART zs25x636341 13 37 adapt adapt VERB zs25x636341 13 38 to to ADP zs25x636341 13 39 new new ADJ zs25x636341 13 40 environments environment NOUN zs25x636341 13 41 . . PUNCT