id	sid	tid	token	lemma	pos
z890rr19n4s	1	1	the	the	DET
z890rr19n4s	1	2	research	research	NOUN
z890rr19n4s	1	3	in	in	ADP
z890rr19n4s	1	4	this	this	DET
z890rr19n4s	1	5	dissertation	dissertation	NOUN
z890rr19n4s	1	6	focuses	focus	VERB
z890rr19n4s	1	7	on	on	ADP
z890rr19n4s	1	8	the	the	DET
z890rr19n4s	1	9	synthesis	synthesis	NOUN
z890rr19n4s	1	10	and	and	CCONJ
z890rr19n4s	1	11	in	in	ADP
z890rr19n4s	1	12	vitro	vitro	X
z890rr19n4s	1	13	testing	testing	NOUN
z890rr19n4s	1	14	of	of	ADP
z890rr19n4s	1	15	structurally	structurally	ADV
z890rr19n4s	1	16	novel	novel	ADJ
z890rr19n4s	1	17	potential	potential	NOUN
z890rr19n4s	1	18	&	&	CCONJ
z890rr19n4s	1	19	#	#	SYM
z890rr19n4s	1	20	946;-lactam	946;-lactam	NUM
z890rr19n4s	1	21	antibiotic	antibiotic	ADJ
z890rr19n4s	1	22	mimics	mimic	NOUN
z890rr19n4s	1	23	utilizing	utilize	VERB
z890rr19n4s	1	24	a	a	DET
z890rr19n4s	1	25	heteroatom	heteroatom	NOUN
z890rr19n4s	1	26	-	-	PUNCT
z890rr19n4s	1	27	activation	activation	NOUN
z890rr19n4s	1	28	strategy	strategy	NOUN
z890rr19n4s	1	29	.	.	PUNCT
z890rr19n4s	2	1	it	it	PRON
z890rr19n4s	2	2	had	have	AUX
z890rr19n4s	2	3	been	be	AUX
z890rr19n4s	2	4	previously	previously	ADV
z890rr19n4s	2	5	demonstrated	demonstrate	VERB
z890rr19n4s	2	6	that	that	SCONJ
z890rr19n4s	2	7	isoxazolidines	isoxazolidine	NOUN
z890rr19n4s	2	8	appended	append	VERB
z890rr19n4s	2	9	with	with	ADP
z890rr19n4s	2	10	a	a	DET
z890rr19n4s	2	11	phenyl	phenyl	NOUN
z890rr19n4s	2	12	acetyl	acetyl	NOUN
z890rr19n4s	2	13	side	side	NOUN
z890rr19n4s	2	14	chain	chain	NOUN
z890rr19n4s	2	15	exhibited	exhibit	VERB
z890rr19n4s	2	16	antibacterial	antibacterial	ADJ
z890rr19n4s	2	17	activity	activity	NOUN
z890rr19n4s	2	18	when	when	SCONJ
z890rr19n4s	2	19	tested	test	VERB
z890rr19n4s	2	20	against	against	ADP
z890rr19n4s	2	21	a	a	DET
z890rr19n4s	2	22	strain	strain	NOUN
z890rr19n4s	2	23	of	of	ADP
z890rr19n4s	2	24	bacteria	bacteria	NOUN
z890rr19n4s	2	25	sensitive	sensitive	ADJ
z890rr19n4s	2	26	to	to	ADP
z890rr19n4s	2	27	&	&	CCONJ
z890rr19n4s	2	28	#	#	SYM
z890rr19n4s	2	29	946;-lactam	946;-lactam	NUM
z890rr19n4s	2	30	antibiotics	antibiotic	NOUN
z890rr19n4s	2	31	such	such	ADJ
z890rr19n4s	2	32	as	as	ADP
z890rr19n4s	2	33	e.	e.	PROPN
z890rr19n4s	2	34	coli	coli	PROPN
z890rr19n4s	2	35	x580	x580	PROPN
z890rr19n4s	2	36	.	.	PUNCT
z890rr19n4s	3	1	it	it	PRON
z890rr19n4s	3	2	was	be	AUX
z890rr19n4s	3	3	then	then	ADV
z890rr19n4s	3	4	hypothesized	hypothesize	VERB
z890rr19n4s	3	5	that	that	SCONJ
z890rr19n4s	3	6	the	the	DET
z890rr19n4s	3	7	activity	activity	NOUN
z890rr19n4s	3	8	seen	see	VERB
z890rr19n4s	3	9	with	with	ADP
z890rr19n4s	3	10	this	this	DET
z890rr19n4s	3	11	compound	compound	NOUN
z890rr19n4s	3	12	was	be	AUX
z890rr19n4s	3	13	due	due	ADJ
z890rr19n4s	3	14	to	to	ADP
z890rr19n4s	3	15	the	the	DET
z890rr19n4s	3	16	weinreb	weinreb	PROPN
z890rr19n4s	3	17	amide	amide	PROPN
z890rr19n4s	3	18	moiety	moiety	PROPN
z890rr19n4s	3	19	present	present	ADJ
z890rr19n4s	3	20	in	in	ADP
z890rr19n4s	3	21	the	the	DET
z890rr19n4s	3	22	molecule	molecule	NOUN
z890rr19n4s	3	23	and	and	CCONJ
z890rr19n4s	3	24	a	a	DET
z890rr19n4s	3	25	carefully	carefully	ADV
z890rr19n4s	3	26	positioned	position	VERB
z890rr19n4s	3	27	ionizable	ionizable	ADJ
z890rr19n4s	3	28	group	group	NOUN
z890rr19n4s	3	29	.	.	PUNCT
z890rr19n4s	4	1	this	this	DET
z890rr19n4s	4	2	moiety	moiety	NOUN
z890rr19n4s	4	3	was	be	AUX
z890rr19n4s	4	4	believed	believe	VERB
z890rr19n4s	4	5	to	to	PART
z890rr19n4s	4	6	activate	activate	VERB
z890rr19n4s	4	7	the	the	DET
z890rr19n4s	4	8	weinreb	weinreb	PROPN
z890rr19n4s	4	9	amide	amide	PROPN
z890rr19n4s	4	10	carbonyl	carbonyl	PROPN
z890rr19n4s	4	11	towards	towards	ADP
z890rr19n4s	4	12	acylation	acylation	NOUN
z890rr19n4s	4	13	in	in	ADP
z890rr19n4s	4	14	the	the	DET
z890rr19n4s	4	15	same	same	ADJ
z890rr19n4s	4	16	way	way	NOUN
z890rr19n4s	4	17	that	that	PRON
z890rr19n4s	4	18	monobactams	monobactam	NOUN
z890rr19n4s	4	19	such	such	ADJ
z890rr19n4s	4	20	as	as	ADP
z890rr19n4s	4	21	oxamazin	oxamazin	PROPN
z890rr19n4s	4	22	and	and	CCONJ
z890rr19n4s	4	23	aztreonam	aztreonam	NOUN
z890rr19n4s	4	24	are	be	AUX
z890rr19n4s	4	25	activated	activate	VERB
z890rr19n4s	4	26	by	by	ADP
z890rr19n4s	4	27	adjacent	adjacent	ADJ
z890rr19n4s	4	28	heteroatoms	heteroatom	NOUN
z890rr19n4s	4	29	.	.	PUNCT
z890rr19n4s	5	1	if	if	SCONJ
z890rr19n4s	5	2	isoxazolidines	isoxazolidine	NOUN
z890rr19n4s	5	3	are	be	AUX
z890rr19n4s	5	4	in	in	ADP
z890rr19n4s	5	5	fact	fact	NOUN
z890rr19n4s	5	6	mimicking	mimicking	NOUN
z890rr19n4s	5	7	&	&	CCONJ
z890rr19n4s	5	8	#	#	SYM
z890rr19n4s	5	9	946;-lactam	946;-lactam	NUM
z890rr19n4s	5	10	antibiotics	antibiotic	NOUN
z890rr19n4s	5	11	by	by	ADP
z890rr19n4s	5	12	exploiting	exploit	VERB
z890rr19n4s	5	13	a	a	DET
z890rr19n4s	5	14	heteroatom	heteroatom	NOUN
z890rr19n4s	5	15	-	-	PUNCT
z890rr19n4s	5	16	activation	activation	NOUN
z890rr19n4s	5	17	strategy	strategy	NOUN
z890rr19n4s	5	18	,	,	PUNCT
z890rr19n4s	5	19	then	then	ADV
z890rr19n4s	5	20	appropriate	appropriate	ADJ
z890rr19n4s	5	21	elaboration	elaboration	NOUN
z890rr19n4s	5	22	of	of	ADP
z890rr19n4s	5	23	these	these	DET
z890rr19n4s	5	24	molecules	molecule	NOUN
z890rr19n4s	5	25	may	may	AUX
z890rr19n4s	5	26	provide	provide	VERB
z890rr19n4s	5	27	a	a	DET
z890rr19n4s	5	28	more	more	ADV
z890rr19n4s	5	29	potent	potent	ADJ
z890rr19n4s	5	30	antibiotic	antibiotic	NOUN
z890rr19n4s	5	31	.	.	PUNCT
z890rr19n4s	6	1	the	the	DET
z890rr19n4s	6	2	overall	overall	ADJ
z890rr19n4s	6	3	hypothesis	hypothesis	NOUN
z890rr19n4s	6	4	of	of	ADP
z890rr19n4s	6	5	the	the	DET
z890rr19n4s	6	6	present	present	ADJ
z890rr19n4s	6	7	work	work	NOUN
z890rr19n4s	6	8	is	be	AUX
z890rr19n4s	6	9	that	that	SCONJ
z890rr19n4s	6	10	heteroatom	heteroatom	NOUN
z890rr19n4s	6	11	-	-	PUNCT
z890rr19n4s	6	12	activated	activate	VERB
z890rr19n4s	6	13	acylating	acylate	VERB
z890rr19n4s	6	14	agents	agent	NOUN
z890rr19n4s	6	15	are	be	AUX
z890rr19n4s	6	16	a	a	DET
z890rr19n4s	6	17	potential	potential	ADJ
z890rr19n4s	6	18	new	new	ADJ
z890rr19n4s	6	19	class	class	NOUN
z890rr19n4s	6	20	of	of	ADP
z890rr19n4s	6	21	antibiotic	antibiotic	ADJ
z890rr19n4s	6	22	,	,	PUNCT
z890rr19n4s	6	23	that	that	PRON
z890rr19n4s	6	24	mimic	mimic	VERB
z890rr19n4s	6	25	&	&	CCONJ
z890rr19n4s	6	26	#	#	SYM
z890rr19n4s	6	27	946;-lactam	946;-lactam	NUM
z890rr19n4s	6	28	antibiotics	antibiotic	NOUN
z890rr19n4s	6	29	.	.	PUNCT
z890rr19n4s	7	1	in	in	ADP
z890rr19n4s	7	2	order	order	NOUN
z890rr19n4s	7	3	to	to	PART
z890rr19n4s	7	4	test	test	VERB
z890rr19n4s	7	5	this	this	DET
z890rr19n4s	7	6	hypothesis	hypothesis	NOUN
z890rr19n4s	7	7	,	,	PUNCT
z890rr19n4s	7	8	three	three	NUM
z890rr19n4s	7	9	specific	specific	ADJ
z890rr19n4s	7	10	aims	aim	NOUN
z890rr19n4s	7	11	were	be	AUX
z890rr19n4s	7	12	executed	execute	VERB
z890rr19n4s	7	13	.	.	PUNCT
z890rr19n4s	8	1	first	first	ADV
z890rr19n4s	8	2	,	,	PUNCT
z890rr19n4s	8	3	side	side	NOUN
z890rr19n4s	8	4	chain	chain	NOUN
z890rr19n4s	8	5	variation	variation	NOUN
z890rr19n4s	8	6	of	of	ADP
z890rr19n4s	8	7	the	the	DET
z890rr19n4s	8	8	lead	lead	ADJ
z890rr19n4s	8	9	compound	compound	NOUN
z890rr19n4s	8	10	was	be	AUX
z890rr19n4s	8	11	explored	explore	VERB
z890rr19n4s	8	12	in	in	ADP
z890rr19n4s	8	13	order	order	NOUN
z890rr19n4s	8	14	to	to	PART
z890rr19n4s	8	15	increase	increase	VERB
z890rr19n4s	8	16	the	the	DET
z890rr19n4s	8	17	potency	potency	NOUN
z890rr19n4s	8	18	and	and	CCONJ
z890rr19n4s	8	19	broadspectrum	broadspectrum	VERB
z890rr19n4s	8	20	antibacterial	antibacterial	ADJ
z890rr19n4s	8	21	activity	activity	NOUN
z890rr19n4s	8	22	.	.	PUNCT
z890rr19n4s	9	1	additional	additional	ADJ
z890rr19n4s	9	2	isoxazolidines	isoxazolidine	NOUN
z890rr19n4s	9	3	were	be	AUX
z890rr19n4s	9	4	synthesized	synthesize	VERB
z890rr19n4s	9	5	which	which	PRON
z890rr19n4s	9	6	incorporated	incorporate	VERB
z890rr19n4s	9	7	side	side	NOUN
z890rr19n4s	9	8	chains	chain	NOUN
z890rr19n4s	9	9	analogous	analogous	ADJ
z890rr19n4s	9	10	to	to	ADP
z890rr19n4s	9	11	side	side	NOUN
z890rr19n4s	9	12	chains	chain	NOUN
z890rr19n4s	9	13	that	that	PRON
z890rr19n4s	9	14	many	many	ADJ
z890rr19n4s	9	15	effective	effective	ADJ
z890rr19n4s	9	16	&	&	CCONJ
z890rr19n4s	9	17	#	#	SYM
z890rr19n4s	9	18	946;-lactam	946;-lactam	NUM
z890rr19n4s	9	19	antibiotics	antibiotic	NOUN
z890rr19n4s	9	20	utilized	utilize	VERB
z890rr19n4s	9	21	.	.	PUNCT
z890rr19n4s	10	1	these	these	DET
z890rr19n4s	10	2	side	side	NOUN
z890rr19n4s	10	3	chains	chain	NOUN
z890rr19n4s	10	4	included	include	VERB
z890rr19n4s	10	5	phenylglycine	phenylglycine	NOUN
z890rr19n4s	10	6	and	and	CCONJ
z890rr19n4s	10	7	2-(2	2-(2	PROPN
z890rr19n4s	10	8	-	-	PUNCT
z890rr19n4s	10	9	aminothiazol-4	aminothiazol-4	PROPN
z890rr19n4s	10	10	-	-	PUNCT
z890rr19n4s	10	11	yl)-2methoxyiminoacetic	yl)-2methoxyiminoacetic	NUM
z890rr19n4s	10	12	acid	acid	NOUN
z890rr19n4s	10	13	(	(	PUNCT
z890rr19n4s	10	14	atmo	atmo	PROPN
z890rr19n4s	10	15	)	)	PUNCT
z890rr19n4s	10	16	.	.	PUNCT
z890rr19n4s	11	1	secondly	secondly	ADV
z890rr19n4s	11	2	,	,	PUNCT
z890rr19n4s	11	3	it	it	PRON
z890rr19n4s	11	4	was	be	AUX
z890rr19n4s	11	5	imperative	imperative	ADJ
z890rr19n4s	11	6	that	that	SCONJ
z890rr19n4s	11	7	the	the	DET
z890rr19n4s	11	8	minimum	minimum	ADJ
z890rr19n4s	11	9	essential	essential	ADJ
z890rr19n4s	11	10	features	feature	NOUN
z890rr19n4s	11	11	of	of	ADP
z890rr19n4s	11	12	a	a	DET
z890rr19n4s	11	13	heteroatomactivated	heteroatomactivated	NOUN
z890rr19n4s	11	14	&	&	CCONJ
z890rr19n4s	11	15	#	#	SYM
z890rr19n4s	11	16	946;-lactam	946;-lactam	NUM
z890rr19n4s	11	17	mimic	mimic	NOUN
z890rr19n4s	11	18	were	be	AUX
z890rr19n4s	11	19	established	establish	VERB
z890rr19n4s	11	20	.	.	PUNCT
z890rr19n4s	12	1	the	the	DET
z890rr19n4s	12	2	hypothesis	hypothesis	NOUN
z890rr19n4s	12	3	was	be	AUX
z890rr19n4s	12	4	accomplished	accomplish	VERB
z890rr19n4s	12	5	by	by	ADP
z890rr19n4s	12	6	synthesizing	synthesize	VERB
z890rr19n4s	12	7	three	three	NUM
z890rr19n4s	12	8	different	different	ADJ
z890rr19n4s	12	9	core	core	NOUN
z890rr19n4s	12	10	structures	structure	NOUN
z890rr19n4s	12	11	such	such	ADJ
z890rr19n4s	12	12	as	as	ADP
z890rr19n4s	12	13	an	an	DET
z890rr19n4s	12	14	acyclic	acyclic	NOUN
z890rr19n4s	12	15	,	,	PUNCT
z890rr19n4s	12	16	monocyclic	monocyclic	ADJ
z890rr19n4s	12	17	and	and	CCONJ
z890rr19n4s	12	18	bicyclic	bicyclic	NOUN
z890rr19n4s	12	19	core	core	NOUN
z890rr19n4s	12	20	.	.	PUNCT
z890rr19n4s	13	1	all	all	DET
z890rr19n4s	13	2	of	of	ADP
z890rr19n4s	13	3	which	which	PRON
z890rr19n4s	13	4	utilized	utilize	VERB
z890rr19n4s	13	5	heteroatom	heteroatom	NOUN
z890rr19n4s	13	6	-	-	PUNCT
z890rr19n4s	13	7	activation	activation	NOUN
z890rr19n4s	13	8	strategy	strategy	NOUN
z890rr19n4s	13	9	and	and	CCONJ
z890rr19n4s	13	10	contained	contain	VERB
z890rr19n4s	13	11	side	side	NOUN
z890rr19n4s	13	12	chains	chain	NOUN
z890rr19n4s	13	13	analogous	analogous	ADJ
z890rr19n4s	13	14	to	to	ADP
z890rr19n4s	13	15	those	those	PRON
z890rr19n4s	13	16	used	use	VERB
z890rr19n4s	13	17	in	in	ADP
z890rr19n4s	13	18	known	know	VERB
z890rr19n4s	13	19	&	&	CCONJ
z890rr19n4s	13	20	#	#	SYM
z890rr19n4s	13	21	946;-lactam	946;-lactam	NUM
z890rr19n4s	13	22	antibiotics	antibiotic	NOUN
z890rr19n4s	13	23	.	.	PUNCT
z890rr19n4s	14	1	in	in	ADP
z890rr19n4s	14	2	addition	addition	NOUN
z890rr19n4s	14	3	,	,	PUNCT
z890rr19n4s	14	4	the	the	DET
z890rr19n4s	14	5	current	current	ADJ
z890rr19n4s	14	6	progress	progress	NOUN
z890rr19n4s	14	7	towards	towards	ADP
z890rr19n4s	14	8	a	a	DET
z890rr19n4s	14	9	diketopiperzine	diketopiperzine	NOUN
z890rr19n4s	14	10	derived	derive	VERB
z890rr19n4s	14	11	from	from	ADP
z890rr19n4s	14	12	an	an	DET
z890rr19n4s	14	13	isoxazolidine	isoxazolidine	NOUN
z890rr19n4s	14	14	is	be	AUX
z890rr19n4s	14	15	presented	present	VERB
z890rr19n4s	14	16	which	which	PRON
z890rr19n4s	14	17	could	could	AUX
z890rr19n4s	14	18	also	also	ADV
z890rr19n4s	14	19	exhibit	exhibit	VERB
z890rr19n4s	14	20	antibacterial	antibacterial	ADJ
z890rr19n4s	14	21	activity	activity	NOUN
z890rr19n4s	14	22	.	.	PUNCT
z890rr19n4s	15	1	lastly	lastly	ADV
z890rr19n4s	15	2	,	,	PUNCT
z890rr19n4s	15	3	each	each	DET
z890rr19n4s	15	4	compound	compound	NOUN
z890rr19n4s	15	5	synthesized	synthesize	VERB
z890rr19n4s	15	6	was	be	AUX
z890rr19n4s	15	7	evaluated	evaluate	VERB
z890rr19n4s	15	8	for	for	ADP
z890rr19n4s	15	9	antibacterial	antibacterial	ADJ
z890rr19n4s	15	10	activity	activity	NOUN
z890rr19n4s	15	11	by	by	ADP
z890rr19n4s	15	12	conducting	conduct	VERB
z890rr19n4s	15	13	zone	zone	NOUN
z890rr19n4s	15	14	of	of	ADP
z890rr19n4s	15	15	inhibition	inhibition	NOUN
z890rr19n4s	15	16	assays	assay	VERB
z890rr19n4s	15	17	against	against	ADP
z890rr19n4s	15	18	a	a	DET
z890rr19n4s	15	19	broad	broad	ADJ
z890rr19n4s	15	20	range	range	NOUN
z890rr19n4s	15	21	of	of	ADP
z890rr19n4s	15	22	bacterial	bacterial	ADJ
z890rr19n4s	15	23	isolates	isolate	NOUN
z890rr19n4s	15	24	,	,	PUNCT
z890rr19n4s	15	25	determining	determine	VERB
z890rr19n4s	15	26	mic	mic	ADJ
z890rr19n4s	15	27	values	value	NOUN
z890rr19n4s	15	28	for	for	ADP
z890rr19n4s	15	29	active	active	ADJ
z890rr19n4s	15	30	compounds	compound	NOUN
z890rr19n4s	15	31	,	,	PUNCT
z890rr19n4s	15	32	and	and	CCONJ
z890rr19n4s	15	33	submitting	submit	VERB
z890rr19n4s	15	34	all	all	DET
z890rr19n4s	15	35	the	the	DET
z890rr19n4s	15	36	compounds	compound	NOUN
z890rr19n4s	15	37	for	for	ADP
z890rr19n4s	15	38	&	&	CCONJ
z890rr19n4s	15	39	#	#	SYM
z890rr19n4s	15	40	946;lactamase	946;lactamase	NUM
z890rr19n4s	15	41	inhibition	inhibition	NOUN
z890rr19n4s	15	42	assays	assay	VERB
z890rr19n4s	15	43	.	.	PUNCT