id sid tid token lemma pos xw42n586h61 1 1 in in ADP xw42n586h61 1 2 vertebrates vertebrate NOUN xw42n586h61 1 3 , , PUNCT xw42n586h61 1 4 the the DET xw42n586h61 1 5 recognition recognition NOUN xw42n586h61 1 6 of of ADP xw42n586h61 1 7 pathogens pathogen NOUN xw42n586h61 1 8 is be AUX xw42n586h61 1 9 carried carry VERB xw42n586h61 1 10 out out ADP xw42n586h61 1 11 by by ADP xw42n586h61 1 12 two two NUM xw42n586h61 1 13 distinct distinct ADJ xw42n586h61 1 14 types type NOUN xw42n586h61 1 15 of of ADP xw42n586h61 1 16 immune immune ADJ xw42n586h61 1 17 receptors receptor NOUN xw42n586h61 1 18 . . PUNCT xw42n586h61 2 1 the the DET xw42n586h61 2 2 adaptive adaptive ADJ xw42n586h61 2 3 immune immune ADJ xw42n586h61 2 4 system system NOUN xw42n586h61 2 5 is be AUX xw42n586h61 2 6 characterized characterize VERB xw42n586h61 2 7 by by ADP xw42n586h61 2 8 the the DET xw42n586h61 2 9 generation generation NOUN xw42n586h61 2 10 of of ADP xw42n586h61 2 11 antibodies antibody NOUN xw42n586h61 2 12 and and CCONJ xw42n586h61 2 13 t t PROPN xw42n586h61 2 14 - - PUNCT xw42n586h61 2 15 cell cell NOUN xw42n586h61 2 16 receptors receptor NOUN xw42n586h61 2 17 which which PRON xw42n586h61 2 18 have have VERB xw42n586h61 2 19 the the DET xw42n586h61 2 20 capacity capacity NOUN xw42n586h61 2 21 to to PART xw42n586h61 2 22 recognize recognize VERB xw42n586h61 2 23 an an DET xw42n586h61 2 24 innumerable innumerable ADJ xw42n586h61 2 25 repertoire repertoire NOUN xw42n586h61 2 26 of of ADP xw42n586h61 2 27 allogenic allogenic ADJ xw42n586h61 2 28 molecules molecule NOUN xw42n586h61 2 29 . . PUNCT xw42n586h61 3 1 on on ADP xw42n586h61 3 2 the the DET xw42n586h61 3 3 other other ADJ xw42n586h61 3 4 hand hand NOUN xw42n586h61 3 5 , , PUNCT xw42n586h61 3 6 innate innate VERB xw42n586h61 3 7 immunity immunity NOUN xw42n586h61 3 8 relies rely VERB xw42n586h61 3 9 on on ADP xw42n586h61 3 10 a a DET xw42n586h61 3 11 restricted restricted ADJ xw42n586h61 3 12 number number NOUN xw42n586h61 3 13 of of ADP xw42n586h61 3 14 genotypically genotypically ADV xw42n586h61 3 15 encoded encode VERB xw42n586h61 3 16 molecules molecule NOUN xw42n586h61 3 17 such such ADJ xw42n586h61 3 18 as as ADP xw42n586h61 3 19 tlrs tlrs PROPN xw42n586h61 3 20 , , PUNCT xw42n586h61 3 21 integrins integrin NOUN xw42n586h61 3 22 , , PUNCT xw42n586h61 3 23 scavenger scavenger NOUN xw42n586h61 3 24 receptors receptor NOUN xw42n586h61 3 25 etc etc X xw42n586h61 3 26 . . X xw42n586h61 4 1 ( ( PUNCT xw42n586h61 4 2 known know VERB xw42n586h61 4 3 as as ADP xw42n586h61 4 4 pattern pattern NOUN xw42n586h61 4 5 recognition recognition NOUN xw42n586h61 4 6 receptors receptor NOUN xw42n586h61 4 7 , , PUNCT xw42n586h61 4 8 prrs prrs PROPN xw42n586h61 4 9 ) ) PUNCT xw42n586h61 4 10 to to PART xw42n586h61 4 11 recognize recognize VERB xw42n586h61 4 12 and and CCONJ xw42n586h61 4 13 respond respond VERB xw42n586h61 4 14 to to ADP xw42n586h61 4 15 pathogens pathogen NOUN xw42n586h61 4 16 or or CCONJ xw42n586h61 4 17 their their PRON xw42n586h61 4 18 pathogen pathogen NOUN xw42n586h61 4 19 - - PUNCT xw42n586h61 4 20 associated associate VERB xw42n586h61 4 21 molecular molecular ADJ xw42n586h61 4 22 patterns pattern NOUN xw42n586h61 4 23 ( ( PUNCT xw42n586h61 4 24 pamps pamp NOUN xw42n586h61 4 25 ) ) PUNCT xw42n586h61 4 26 . . PUNCT xw42n586h61 5 1 the the DET xw42n586h61 5 2 innate innate ADJ xw42n586h61 5 3 immune immune ADJ xw42n586h61 5 4 receptors receptor NOUN xw42n586h61 5 5 can can AUX xw42n586h61 5 6 only only ADV xw42n586h61 5 7 recognize recognize VERB xw42n586h61 5 8 a a DET xw42n586h61 5 9 limited limited ADJ xw42n586h61 5 10 number number NOUN xw42n586h61 5 11 of of ADP xw42n586h61 5 12 ligands ligand NOUN xw42n586h61 5 13 . . PUNCT xw42n586h61 6 1 however however ADV xw42n586h61 6 2 , , PUNCT xw42n586h61 6 3 in in ADP xw42n586h61 6 4 contrast contrast NOUN xw42n586h61 6 5 to to ADP xw42n586h61 6 6 t t PROPN xw42n586h61 6 7 and and CCONJ xw42n586h61 6 8 b b NOUN xw42n586h61 6 9 cell cell NOUN xw42n586h61 6 10 receptors receptor NOUN xw42n586h61 6 11 , , PUNCT xw42n586h61 6 12 the the DET xw42n586h61 6 13 activation activation NOUN xw42n586h61 6 14 of of ADP xw42n586h61 6 15 different different ADJ xw42n586h61 6 16 prrs prr NOUN xw42n586h61 6 17 by by ADP xw42n586h61 6 18 their their PRON xw42n586h61 6 19 respective respective ADJ xw42n586h61 6 20 ligands ligand NOUN xw42n586h61 6 21 may may AUX xw42n586h61 6 22 activate activate VERB xw42n586h61 6 23 distinct distinct ADJ xw42n586h61 6 24 intracellular intracellular ADJ xw42n586h61 6 25 signaling signal VERB xw42n586h61 6 26 pathways pathway NOUN xw42n586h61 6 27 . . PUNCT xw42n586h61 7 1 this this PRON xw42n586h61 7 2 may may AUX xw42n586h61 7 3 result result VERB xw42n586h61 7 4 in in ADP xw42n586h61 7 5 specific specific ADJ xw42n586h61 7 6 changes change NOUN xw42n586h61 7 7 in in ADP xw42n586h61 7 8 gene gene NOUN xw42n586h61 7 9 expression expression NOUN xw42n586h61 7 10 and and CCONJ xw42n586h61 7 11 production production NOUN xw42n586h61 7 12 of of ADP xw42n586h61 7 13 cytokines cytokine NOUN xw42n586h61 7 14 and and CCONJ xw42n586h61 7 15 other other ADJ xw42n586h61 7 16 immune immune ADJ xw42n586h61 7 17 mediators mediator NOUN xw42n586h61 7 18 by by ADP xw42n586h61 7 19 leukocytes leukocyte NOUN xw42n586h61 7 20 that that PRON xw42n586h61 7 21 will will AUX xw42n586h61 7 22 alarm alarm VERB xw42n586h61 7 23 the the DET xw42n586h61 7 24 host host NOUN xw42n586h61 7 25 about about ADP xw42n586h61 7 26 the the DET xw42n586h61 7 27 presence presence NOUN xw42n586h61 7 28 of of ADP xw42n586h61 7 29 a a DET xw42n586h61 7 30 particular particular ADJ xw42n586h61 7 31 type type NOUN xw42n586h61 7 32 of of ADP xw42n586h61 7 33 pathogen pathogen PROPN xw42n586h61 7 34 . . PUNCT xw42n586h61 8 1 the the DET xw42n586h61 8 2 vertebrate vertebrate ADJ xw42n586h61 8 3 immune immune ADJ xw42n586h61 8 4 system system NOUN xw42n586h61 8 5 has have AUX xw42n586h61 8 6 been be AUX xw42n586h61 8 7 studied study VERB xw42n586h61 8 8 mainly mainly ADV xw42n586h61 8 9 in in ADP xw42n586h61 8 10 mammals mammal NOUN xw42n586h61 8 11 , , PUNCT xw42n586h61 8 12 and and CCONJ xw42n586h61 8 13 data datum NOUN xw42n586h61 8 14 on on ADP xw42n586h61 8 15 the the DET xw42n586h61 8 16 immune immune ADJ xw42n586h61 8 17 response response NOUN xw42n586h61 8 18 of of ADP xw42n586h61 8 19 non non ADJ xw42n586h61 8 20 - - ADJ xw42n586h61 8 21 mammalian mammalian ADJ xw42n586h61 8 22 vertebrates vertebrate NOUN xw42n586h61 8 23 remains remain VERB xw42n586h61 8 24 relatively relatively ADV xw42n586h61 8 25 scant scant ADJ xw42n586h61 8 26 . . PUNCT xw42n586h61 9 1 therefore therefore ADV xw42n586h61 9 2 , , PUNCT xw42n586h61 9 3 a a DET xw42n586h61 9 4 major major ADJ xw42n586h61 9 5 goal goal NOUN xw42n586h61 9 6 of of ADP xw42n586h61 9 7 this this DET xw42n586h61 9 8 dissertation dissertation NOUN xw42n586h61 9 9 research research NOUN xw42n586h61 9 10 was be AUX xw42n586h61 9 11 to to PART xw42n586h61 9 12 characterize characterize VERB xw42n586h61 9 13 the the DET xw42n586h61 9 14 response response NOUN xw42n586h61 9 15 of of ADP xw42n586h61 9 16 trout trout NOUN xw42n586h61 9 17 macrophages macrophage NOUN xw42n586h61 9 18 to to PART xw42n586h61 9 19 pamps pamp NOUN xw42n586h61 9 20 by by ADP xw42n586h61 9 21 analyzing analyze VERB xw42n586h61 9 22 the the DET xw42n586h61 9 23 changes change NOUN xw42n586h61 9 24 in in ADP xw42n586h61 9 25 the the DET xw42n586h61 9 26 expression expression NOUN xw42n586h61 9 27 of of ADP xw42n586h61 9 28 known know VERB xw42n586h61 9 29 immune immune ADJ xw42n586h61 9 30 - - PUNCT xw42n586h61 9 31 relevant relevant ADJ xw42n586h61 9 32 genes gene NOUN xw42n586h61 9 33 . . PUNCT xw42n586h61 10 1 in in ADP xw42n586h61 10 2 addition addition NOUN xw42n586h61 10 3 , , PUNCT xw42n586h61 10 4 a a DET xw42n586h61 10 5 subtractive subtractive ADJ xw42n586h61 10 6 cloning cloning NOUN xw42n586h61 10 7 approach approach NOUN xw42n586h61 10 8 was be AUX xw42n586h61 10 9 employed employ VERB xw42n586h61 10 10 to to PART xw42n586h61 10 11 isolate isolate VERB xw42n586h61 10 12 and and CCONJ xw42n586h61 10 13 identify identify VERB xw42n586h61 10 14 additional additional ADJ xw42n586h61 10 15 genes gene NOUN xw42n586h61 10 16 that that PRON xw42n586h61 10 17 may may AUX xw42n586h61 10 18 be be AUX xw42n586h61 10 19 regulated regulate VERB xw42n586h61 10 20 upon upon SCONJ xw42n586h61 10 21 activation activation NOUN xw42n586h61 10 22 of of ADP xw42n586h61 10 23 trout trout NOUN xw42n586h61 10 24 macrophages macrophage NOUN xw42n586h61 10 25 by by ADP xw42n586h61 10 26 lipopolysaccharide lipopolysaccharide PROPN xw42n586h61 10 27 . . PUNCT xw42n586h61 11 1 the the DET xw42n586h61 11 2 results result NOUN xw42n586h61 11 3 indicate indicate VERB xw42n586h61 11 4 that that SCONJ xw42n586h61 11 5 although although SCONJ xw42n586h61 11 6 the the DET xw42n586h61 11 7 pamp pamp NOUN xw42n586h61 11 8 - - PUNCT xw42n586h61 11 9 modulated modulate VERB xw42n586h61 11 10 gene gene NOUN xw42n586h61 11 11 expression expression NOUN xw42n586h61 11 12 is be AUX xw42n586h61 11 13 similar similar ADJ xw42n586h61 11 14 between between ADP xw42n586h61 11 15 mammalian mammalian ADJ xw42n586h61 11 16 and and CCONJ xw42n586h61 11 17 fish fish NOUN xw42n586h61 11 18 leukocytes leukocyte NOUN xw42n586h61 11 19 , , PUNCT xw42n586h61 11 20 there there PRON xw42n586h61 11 21 also also ADV xw42n586h61 11 22 appear appear VERB xw42n586h61 11 23 to to PART xw42n586h61 11 24 be be AUX xw42n586h61 11 25 certain certain ADJ xw42n586h61 11 26 differences difference NOUN xw42n586h61 11 27 in in ADP xw42n586h61 11 28 the the DET xw42n586h61 11 29 pamps pamp NOUN xw42n586h61 11 30 recognition recognition NOUN xw42n586h61 11 31 between between ADP xw42n586h61 11 32 mammalian mammalian PROPN xw42n586h61 11 33 and and CCONJ xw42n586h61 11 34 non non ADJ xw42n586h61 11 35 - - ADJ xw42n586h61 11 36 mammalian mammalian ADJ xw42n586h61 11 37 vertebrates vertebrate NOUN xw42n586h61 11 38 . . PUNCT xw42n586h61 12 1 in in ADP xw42n586h61 12 2 particular particular ADJ xw42n586h61 12 3 , , PUNCT xw42n586h61 12 4 the the DET xw42n586h61 12 5 activation activation NOUN xw42n586h61 12 6 of of ADP xw42n586h61 12 7 trout trout NOUN xw42n586h61 12 8 macrophages macrophage NOUN xw42n586h61 12 9 required require VERB xw42n586h61 12 10 treatments treatment NOUN xw42n586h61 12 11 with with ADP xw42n586h61 12 12 lps lps PROPN xw42n586h61 12 13 concentrations concentration NOUN xw42n586h61 12 14 that that PRON xw42n586h61 12 15 were be AUX xw42n586h61 12 16 several several ADJ xw42n586h61 12 17 orders order NOUN xw42n586h61 12 18 of of ADP xw42n586h61 12 19 magnitude magnitude NOUN xw42n586h61 12 20 higher high ADJ xw42n586h61 12 21 as as SCONJ xw42n586h61 12 22 compared compare VERB xw42n586h61 12 23 to to ADP xw42n586h61 12 24 mammals mammal NOUN xw42n586h61 12 25 . . PUNCT xw42n586h61 13 1 these these DET xw42n586h61 13 2 observations observation NOUN xw42n586h61 13 3 , , PUNCT xw42n586h61 13 4 together together ADV xw42n586h61 13 5 with with ADP xw42n586h61 13 6 additional additional ADJ xw42n586h61 13 7 data datum NOUN xw42n586h61 13 8 from from ADP xw42n586h61 13 9 in in ADP xw42n586h61 13 10 vitro vitro X xw42n586h61 13 11 and and CCONJ xw42n586h61 13 12 in in ADP xw42n586h61 13 13 silico silico NOUN xw42n586h61 13 14 analyses analysis NOUN xw42n586h61 13 15 , , PUNCT xw42n586h61 13 16 led lead VERB xw42n586h61 13 17 to to ADP xw42n586h61 13 18 the the DET xw42n586h61 13 19 hypothesis hypothesis NOUN xw42n586h61 13 20 that that SCONJ xw42n586h61 13 21 the the DET xw42n586h61 13 22 mechanisms mechanism NOUN xw42n586h61 13 23 for for ADP xw42n586h61 13 24 endotoxin endotoxin NOUN xw42n586h61 13 25 recognition recognition NOUN xw42n586h61 13 26 , , PUNCT xw42n586h61 13 27 that that PRON xw42n586h61 13 28 have have AUX xw42n586h61 13 29 been be AUX xw42n586h61 13 30 described describe VERB xw42n586h61 13 31 in in ADP xw42n586h61 13 32 mammals mammal NOUN xw42n586h61 13 33 , , PUNCT xw42n586h61 13 34 may may AUX xw42n586h61 13 35 not not PART xw42n586h61 13 36 be be AUX xw42n586h61 13 37 present present ADJ xw42n586h61 13 38 in in ADP xw42n586h61 13 39 non non ADJ xw42n586h61 13 40 - - ADJ xw42n586h61 13 41 mammalian mammalian ADJ xw42n586h61 13 42 vertebrates vertebrate NOUN xw42n586h61 13 43 . . PUNCT xw42n586h61 14 1 it it PRON xw42n586h61 14 2 is be AUX xw42n586h61 14 3 possible possible ADJ xw42n586h61 14 4 that that SCONJ xw42n586h61 14 5 the the DET xw42n586h61 14 6 tlr4 tlr4 NOUN xw42n586h61 14 7 - - PUNCT xw42n586h61 14 8 mediated mediate VERB xw42n586h61 14 9 recognition recognition NOUN xw42n586h61 14 10 of of ADP xw42n586h61 14 11 endotoxin endotoxin PROPN xw42n586h61 14 12 arose arise VERB xw42n586h61 14 13 in in ADP xw42n586h61 14 14 mammals mammal NOUN xw42n586h61 14 15 , , PUNCT xw42n586h61 14 16 or or CCONJ xw42n586h61 14 17 in in ADP xw42n586h61 14 18 their their PRON xw42n586h61 14 19 immediate immediate ADJ xw42n586h61 14 20 predecessors predecessor NOUN xw42n586h61 14 21 , , PUNCT xw42n586h61 14 22 as as ADP xw42n586h61 14 23 a a DET xw42n586h61 14 24 result result NOUN xw42n586h61 14 25 of of ADP xw42n586h61 14 26 the the DET xw42n586h61 14 27 integration integration NOUN xw42n586h61 14 28 of of ADP xw42n586h61 14 29 initially initially ADV xw42n586h61 14 30 unrelated unrelated ADJ xw42n586h61 14 31 bacterial bacterial ADJ xw42n586h61 14 32 and and CCONJ xw42n586h61 14 33 viral viral ADJ xw42n586h61 14 34 recognition recognition NOUN xw42n586h61 14 35 mechanisms mechanism NOUN xw42n586h61 14 36 . . PUNCT