id sid tid token lemma pos xs55m90367s 1 1 the the DET xs55m90367s 1 2 objective objective NOUN xs55m90367s 1 3 of of ADP xs55m90367s 1 4 this this DET xs55m90367s 1 5 dissertation dissertation NOUN xs55m90367s 1 6 was be AUX xs55m90367s 1 7 to to PART xs55m90367s 1 8 develop develop VERB xs55m90367s 1 9 novel novel ADJ xs55m90367s 1 10 classes class NOUN xs55m90367s 1 11 of of ADP xs55m90367s 1 12 mechanically mechanically ADV xs55m90367s 1 13 stable stable ADJ xs55m90367s 1 14 lipidand lipidand PROPN xs55m90367s 1 15 diblock diblock PROPN xs55m90367s 1 16 copolymer copolymer NOUN xs55m90367s 1 17 based base VERB xs55m90367s 1 18 drug drug NOUN xs55m90367s 1 19 delivery delivery NOUN xs55m90367s 1 20 vehicles vehicle NOUN xs55m90367s 1 21 . . PUNCT xs55m90367s 2 1 liposome liposome NOUN xs55m90367s 2 2 based base VERB xs55m90367s 2 3 drug drug NOUN xs55m90367s 2 4 delivery delivery NOUN xs55m90367s 2 5 vehicles vehicle NOUN xs55m90367s 2 6 were be AUX xs55m90367s 2 7 created create VERB xs55m90367s 2 8 by by ADP xs55m90367s 2 9 encapsulating encapsulate VERB xs55m90367s 2 10 a a DET xs55m90367s 2 11 polymeric polymeric ADJ xs55m90367s 2 12 actin actin NOUN xs55m90367s 2 13 matrix matrix NOUN xs55m90367s 2 14 . . PUNCT xs55m90367s 3 1 the the DET xs55m90367s 3 2 structure structure NOUN xs55m90367s 3 3 of of ADP xs55m90367s 3 4 actin actin NOUN xs55m90367s 3 5 - - PUNCT xs55m90367s 3 6 containing contain VERB xs55m90367s 3 7 liposomes liposome NOUN xs55m90367s 3 8 was be AUX xs55m90367s 3 9 studied study VERB xs55m90367s 3 10 using use VERB xs55m90367s 3 11 a a DET xs55m90367s 3 12 combination combination NOUN xs55m90367s 3 13 of of ADP xs55m90367s 3 14 static static ADJ xs55m90367s 3 15 light light ADJ xs55m90367s 3 16 scattering scattering NOUN xs55m90367s 3 17 and and CCONJ xs55m90367s 3 18 atomic atomic ADJ xs55m90367s 3 19 force force NOUN xs55m90367s 3 20 microscopy microscopy NOUN xs55m90367s 3 21 ( ( PUNCT xs55m90367s 3 22 afm afm X xs55m90367s 3 23 ) ) PUNCT xs55m90367s 3 24 . . PUNCT xs55m90367s 4 1 it it PRON xs55m90367s 4 2 was be AUX xs55m90367s 4 3 observed observe VERB xs55m90367s 4 4 that that SCONJ xs55m90367s 4 5 actin actin NOUN xs55m90367s 4 6 - - PUNCT xs55m90367s 4 7 containing contain VERB xs55m90367s 4 8 liposomes liposome NOUN xs55m90367s 4 9 possessed possess VERB xs55m90367s 4 10 the the DET xs55m90367s 4 11 ability ability NOUN xs55m90367s 4 12 to to PART xs55m90367s 4 13 adopt adopt VERB xs55m90367s 4 14 non non ADJ xs55m90367s 4 15 - - ADJ xs55m90367s 4 16 spherical spherical ADJ xs55m90367s 4 17 ellipsoidal ellipsoidal ADJ xs55m90367s 4 18 shapes shape NOUN xs55m90367s 4 19 in in ADP xs55m90367s 4 20 solution solution NOUN xs55m90367s 4 21 . . PUNCT xs55m90367s 5 1 further further ADJ xs55m90367s 5 2 experiments experiment NOUN xs55m90367s 5 3 showed show VERB xs55m90367s 5 4 that that SCONJ xs55m90367s 5 5 the the DET xs55m90367s 5 6 aspect aspect NOUN xs55m90367s 5 7 ratio ratio NOUN xs55m90367s 5 8 of of ADP xs55m90367s 5 9 these these DET xs55m90367s 5 10 ellipsoidal ellipsoidal ADJ xs55m90367s 5 11 - - PUNCT xs55m90367s 5 12 shaped shape VERB xs55m90367s 5 13 liposomes liposome NOUN xs55m90367s 5 14 was be AUX xs55m90367s 5 15 controlled control VERB xs55m90367s 5 16 by by ADP xs55m90367s 5 17 the the DET xs55m90367s 5 18 encapsulated encapsulate VERB xs55m90367s 5 19 actin actin NOUN xs55m90367s 5 20 concentration concentration NOUN xs55m90367s 5 21 . . PUNCT xs55m90367s 6 1 in in ADP xs55m90367s 6 2 vivo vivo ADJ xs55m90367s 6 3 circulatory circulatory ADJ xs55m90367s 6 4 studies study NOUN xs55m90367s 6 5 in in ADP xs55m90367s 6 6 rats rat NOUN xs55m90367s 6 7 showed show VERB xs55m90367s 6 8 greater great ADJ xs55m90367s 6 9 than than ADP xs55m90367s 6 10 50 50 NUM xs55m90367s 6 11 % % NOUN xs55m90367s 6 12 of of ADP xs55m90367s 6 13 administered administer VERB xs55m90367s 6 14 actin actin NOUN xs55m90367s 6 15 - - PUNCT xs55m90367s 6 16 containing contain VERB xs55m90367s 6 17 liposomes liposome NOUN xs55m90367s 6 18 were be AUX xs55m90367s 6 19 retained retain VERB xs55m90367s 6 20 in in ADP xs55m90367s 6 21 the the DET xs55m90367s 6 22 circulatory circulatory ADJ xs55m90367s 6 23 system system NOUN xs55m90367s 6 24 after after ADP xs55m90367s 6 25 72 72 NUM xs55m90367s 6 26 hours hour NOUN xs55m90367s 6 27 . . PUNCT xs55m90367s 7 1 actin actin NOUN xs55m90367s 7 2 - - PUNCT xs55m90367s 7 3 containing contain VERB xs55m90367s 7 4 liposomes liposome NOUN xs55m90367s 7 5 were be AUX xs55m90367s 7 6 further far ADV xs55m90367s 7 7 applied apply VERB xs55m90367s 7 8 towards towards ADP xs55m90367s 7 9 the the DET xs55m90367s 7 10 development development NOUN xs55m90367s 7 11 of of ADP xs55m90367s 7 12 a a DET xs55m90367s 7 13 long long ADV xs55m90367s 7 14 - - PUNCT xs55m90367s 7 15 circulating circulate VERB xs55m90367s 7 16 artificial artificial ADJ xs55m90367s 7 17 blood blood NOUN xs55m90367s 7 18 substitute substitute NOUN xs55m90367s 7 19 by by ADP xs55m90367s 7 20 encapsulating encapsulate VERB xs55m90367s 7 21 bovine bovine NOUN xs55m90367s 7 22 hemoglobin hemoglobin NOUN xs55m90367s 7 23 ( ( PUNCT xs55m90367s 7 24 hb hb PROPN xs55m90367s 7 25 ) ) PUNCT xs55m90367s 7 26 inside inside ADP xs55m90367s 7 27 the the DET xs55m90367s 7 28 aqueous aqueous ADJ xs55m90367s 7 29 core core NOUN xs55m90367s 7 30 of of ADP xs55m90367s 7 31 actin actin NOUN xs55m90367s 7 32 - - PUNCT xs55m90367s 7 33 containing contain VERB xs55m90367s 7 34 liposomes liposome NOUN xs55m90367s 7 35 ( ( PUNCT xs55m90367s 7 36 leachb leachb NOUN xs55m90367s 7 37 ) ) PUNCT xs55m90367s 7 38 . . PUNCT xs55m90367s 8 1 the the DET xs55m90367s 8 2 potential potential NOUN xs55m90367s 8 3 of of ADP xs55m90367s 8 4 leachb leachb NOUN xs55m90367s 8 5 dispersions dispersion NOUN xs55m90367s 8 6 to to PART xs55m90367s 8 7 function function VERB xs55m90367s 8 8 as as ADP xs55m90367s 8 9 a a DET xs55m90367s 8 10 cellular cellular ADJ xs55m90367s 8 11 hemoglobin hemoglobin NOUN xs55m90367s 8 12 - - PUNCT xs55m90367s 8 13 based base VERB xs55m90367s 8 14 oxygen oxygen NOUN xs55m90367s 8 15 carrier carrier NOUN xs55m90367s 8 16 ( ( PUNCT xs55m90367s 8 17 hboc hboc NOUN xs55m90367s 8 18 ) ) PUNCT xs55m90367s 8 19 was be AUX xs55m90367s 8 20 evaluated evaluate VERB xs55m90367s 8 21 by by ADP xs55m90367s 8 22 measuring measure VERB xs55m90367s 8 23 several several ADJ xs55m90367s 8 24 key key ADJ xs55m90367s 8 25 physical physical ADJ xs55m90367s 8 26 properties property NOUN xs55m90367s 8 27 : : PUNCT xs55m90367s 8 28 vesicle vesicle NOUN xs55m90367s 8 29 size size NOUN xs55m90367s 8 30 distribution distribution NOUN xs55m90367s 8 31 , , PUNCT xs55m90367s 8 32 hb hb PROPN xs55m90367s 8 33 encapsulation encapsulation PROPN xs55m90367s 8 34 efficiency efficiency NOUN xs55m90367s 8 35 , , PUNCT xs55m90367s 8 36 oxygen oxygen NOUN xs55m90367s 8 37 binding bind VERB xs55m90367s 8 38 properties property NOUN xs55m90367s 8 39 ( ( PUNCT xs55m90367s 8 40 as as SCONJ xs55m90367s 8 41 indicated indicate VERB xs55m90367s 8 42 by by ADP xs55m90367s 8 43 p50 p50 PROPN xs55m90367s 8 44 and and CCONJ xs55m90367s 8 45 cooperativity cooperativity NOUN xs55m90367s 8 46 coefficient coefficient NOUN xs55m90367s 8 47 ) ) PUNCT xs55m90367s 8 48 , , PUNCT xs55m90367s 8 49 encapsulated encapsulate VERB xs55m90367s 8 50 methemoglobin methemoglobin ADJ xs55m90367s 8 51 level level NOUN xs55m90367s 8 52 , , PUNCT xs55m90367s 8 53 and and CCONJ xs55m90367s 8 54 in in ADP xs55m90367s 8 55 vivo vivo ADJ xs55m90367s 8 56 circulatory circulatory ADJ xs55m90367s 8 57 half half ADJ xs55m90367s 8 58 - - PUNCT xs55m90367s 8 59 life life NOUN xs55m90367s 8 60 . . PUNCT xs55m90367s 9 1 leachb leachb NOUN xs55m90367s 9 2 exhibited exhibit VERB xs55m90367s 9 3 satisfactory satisfactory ADJ xs55m90367s 9 4 physical physical ADJ xs55m90367s 9 5 properties property NOUN xs55m90367s 9 6 and and CCONJ xs55m90367s 9 7 circulatory circulatory ADJ xs55m90367s 9 8 half half ADJ xs55m90367s 9 9 - - PUNCT xs55m90367s 9 10 life life NOUN xs55m90367s 9 11 consistent consistent ADJ xs55m90367s 9 12 with with ADP xs55m90367s 9 13 the the DET xs55m90367s 9 14 design design NOUN xs55m90367s 9 15 criteria criterion NOUN xs55m90367s 9 16 of of ADP xs55m90367s 9 17 a a DET xs55m90367s 9 18 cellular cellular ADJ xs55m90367s 9 19 - - PUNCT xs55m90367s 9 20 based base VERB xs55m90367s 9 21 artificial artificial ADJ xs55m90367s 9 22 blood blood NOUN xs55m90367s 9 23 substitute substitute NOUN xs55m90367s 9 24 . . PUNCT xs55m90367s 10 1 in in ADP xs55m90367s 10 2 the the DET xs55m90367s 10 3 second second ADJ xs55m90367s 10 4 half half NOUN xs55m90367s 10 5 of of ADP xs55m90367s 10 6 this this DET xs55m90367s 10 7 dissertation dissertation NOUN xs55m90367s 10 8 , , PUNCT xs55m90367s 10 9 amphiphilic amphiphilic ADJ xs55m90367s 10 10 diblock diblock NOUN xs55m90367s 10 11 copolymer copolymer NOUN xs55m90367s 10 12 poly(butadiene)-b poly(butadiene)-b SPACE xs55m90367s 10 13 - - PUNCT xs55m90367s 10 14 poly(ethylene poly(ethylene NOUN xs55m90367s 10 15 oxide oxide NOUN xs55m90367s 10 16 ) ) PUNCT xs55m90367s 10 17 ( ( PUNCT xs55m90367s 10 18 pb pb PROPN xs55m90367s 10 19 - - PUNCT xs55m90367s 10 20 b b PROPN xs55m90367s 10 21 - - PUNCT xs55m90367s 10 22 peo peo NOUN xs55m90367s 10 23 ) ) PUNCT xs55m90367s 10 24 self self NOUN xs55m90367s 10 25 - - PUNCT xs55m90367s 10 26 assembled assemble VERB xs55m90367s 10 27 colloids colloid NOUN xs55m90367s 10 28 , , PUNCT xs55m90367s 10 29 were be AUX xs55m90367s 10 30 investigated investigate VERB xs55m90367s 10 31 as as ADP xs55m90367s 10 32 novel novel ADJ xs55m90367s 10 33 mechanically mechanically ADV xs55m90367s 10 34 stable stable ADJ xs55m90367s 10 35 drug drug NOUN xs55m90367s 10 36 delivery delivery NOUN xs55m90367s 10 37 vehicles vehicle NOUN xs55m90367s 10 38 . . PUNCT xs55m90367s 11 1 afm afm PROPN xs55m90367s 11 2 was be AUX xs55m90367s 11 3 employed employ VERB xs55m90367s 11 4 to to PART xs55m90367s 11 5 probe probe VERB xs55m90367s 11 6 the the DET xs55m90367s 11 7 morphology morphology NOUN xs55m90367s 11 8 and and CCONJ xs55m90367s 11 9 mechanical mechanical ADJ xs55m90367s 11 10 response response NOUN xs55m90367s 11 11 of of ADP xs55m90367s 11 12 pb pb PROPN xs55m90367s 11 13 - - PUNCT xs55m90367s 11 14 b b NOUN xs55m90367s 11 15 - - PUNCT xs55m90367s 11 16 peo peo NOUN xs55m90367s 11 17 self self NOUN xs55m90367s 11 18 - - PUNCT xs55m90367s 11 19 assemblies assembly NOUN xs55m90367s 11 20 . . PUNCT xs55m90367s 12 1 it it PRON xs55m90367s 12 2 was be AUX xs55m90367s 12 3 observed observe VERB xs55m90367s 12 4 that that SCONJ xs55m90367s 12 5 the the DET xs55m90367s 12 6 structure structure NOUN xs55m90367s 12 7 of of ADP xs55m90367s 12 8 these these DET xs55m90367s 12 9 colloids colloid NOUN xs55m90367s 12 10 ranged range VERB xs55m90367s 12 11 from from ADP xs55m90367s 12 12 spherical spherical ADJ xs55m90367s 12 13 micelles micelle NOUN xs55m90367s 12 14 , , PUNCT xs55m90367s 12 15 worm worm NOUN xs55m90367s 12 16 - - PUNCT xs55m90367s 12 17 like like ADJ xs55m90367s 12 18 micelles micelle NOUN xs55m90367s 12 19 , , PUNCT xs55m90367s 12 20 to to ADP xs55m90367s 12 21 polymersomes polymersome NOUN xs55m90367s 12 22 depending depend VERB xs55m90367s 12 23 on on ADP xs55m90367s 12 24 the the DET xs55m90367s 12 25 diblock diblock NOUN xs55m90367s 12 26 composition composition NOUN xs55m90367s 12 27 and and CCONJ xs55m90367s 12 28 method method NOUN xs55m90367s 12 29 of of ADP xs55m90367s 12 30 preparation preparation NOUN xs55m90367s 12 31 . . PUNCT xs55m90367s 13 1 afm afm PROPN xs55m90367s 13 2 force force PROPN xs55m90367s 13 3 imaging imaging NOUN xs55m90367s 13 4 of of ADP xs55m90367s 13 5 closely closely ADV xs55m90367s 13 6 packed pack VERB xs55m90367s 13 7 micelles micelle NOUN xs55m90367s 13 8 on on ADP xs55m90367s 13 9 glass glass NOUN xs55m90367s 13 10 surfaces surface NOUN xs55m90367s 13 11 showed show VERB xs55m90367s 13 12 a a DET xs55m90367s 13 13 sharp sharp ADJ xs55m90367s 13 14 downward downward ADJ xs55m90367s 13 15 deflection deflection NOUN xs55m90367s 13 16 , , PUNCT xs55m90367s 13 17 which which PRON xs55m90367s 13 18 implied imply VERB xs55m90367s 13 19 the the DET xs55m90367s 13 20 existence existence NOUN xs55m90367s 13 21 of of ADP xs55m90367s 13 22 a a DET xs55m90367s 13 23 ìøåàå_transition ìøåàå_transition ADJ xs55m90367s 13 24 escapeìøåàå escapeìøåàå NOUN xs55m90367s 13 25 _ _ NOUN xs55m90367s 13 26 most most ADV xs55m90367s 13 27 probably probably ADV xs55m90367s 13 28 due due ADJ xs55m90367s 13 29 to to ADP xs55m90367s 13 30 a a DET xs55m90367s 13 31 conformational conformational ADJ xs55m90367s 13 32 change change NOUN xs55m90367s 13 33 in in ADP xs55m90367s 13 34 the the DET xs55m90367s 13 35 peo peo PROPN xs55m90367s 13 36 hydrophilic hydrophilic ADJ xs55m90367s 13 37 brush brush NOUN xs55m90367s 13 38 upon upon SCONJ xs55m90367s 13 39 afm afm PROPN xs55m90367s 13 40 tip tip PROPN xs55m90367s 13 41 compression compression NOUN xs55m90367s 13 42 . . PUNCT xs55m90367s 14 1 paclitaxel paclitaxel PROPN xs55m90367s 14 2 was be AUX xs55m90367s 14 3 successfully successfully ADV xs55m90367s 14 4 incorporated incorporate VERB xs55m90367s 14 5 into into ADP xs55m90367s 14 6 pb pb PROPN xs55m90367s 14 7 - - PUNCT xs55m90367s 14 8 peo peo PROPN xs55m90367s 14 9 polymersomes polymersome NOUN xs55m90367s 14 10 of of ADP xs55m90367s 14 11 various various ADJ xs55m90367s 14 12 molecular molecular ADJ xs55m90367s 14 13 weights weight NOUN xs55m90367s 14 14 . . PUNCT xs55m90367s 15 1 the the DET xs55m90367s 15 2 loading loading NOUN xs55m90367s 15 3 capacity capacity NOUN xs55m90367s 15 4 of of ADP xs55m90367s 15 5 paclitaxel paclitaxel PROPN xs55m90367s 15 6 inside inside ADP xs55m90367s 15 7 polymersomes polymersome NOUN xs55m90367s 15 8 ranged range VERB xs55m90367s 15 9 from from ADP xs55m90367s 15 10 6.7 6.7 NUM xs55m90367s 15 11 - - SYM xs55m90367s 15 12 13.7 13.7 NUM xs55m90367s 15 13 % % NOUN xs55m90367s 15 14 w w NOUN xs55m90367s 15 15 / / SYM xs55m90367s 15 16 w. w. PROPN xs55m90367s 15 17 paclitaxel paclitaxel PROPN xs55m90367s 15 18 - - PUNCT xs55m90367s 15 19 polymersome polymersome PROPN xs55m90367s 15 20 ( ( PUNCT xs55m90367s 15 21 ob4 ob4 NOUN xs55m90367s 15 22 ) ) PUNCT xs55m90367s 15 23 formulations formulation NOUN xs55m90367s 15 24 were be AUX xs55m90367s 15 25 colloidally colloidally ADV xs55m90367s 15 26 stable stable ADJ xs55m90367s 15 27 for for ADP xs55m90367s 15 28 4 4 NUM xs55m90367s 15 29 months month NOUN xs55m90367s 15 30 , , PUNCT xs55m90367s 15 31 and and CCONJ xs55m90367s 15 32 exhibited exhibit VERB xs55m90367s 15 33 slow slow ADJ xs55m90367s 15 34 steady steady ADJ xs55m90367s 15 35 release release NOUN xs55m90367s 15 36 of of ADP xs55m90367s 15 37 paclitaxel paclitaxel NOUN xs55m90367s 15 38 over over ADP xs55m90367s 15 39 a a DET xs55m90367s 15 40 5 5 NUM xs55m90367s 15 41 week week NOUN xs55m90367s 15 42 period period NOUN xs55m90367s 15 43 . . PUNCT xs55m90367s 16 1 evaluation evaluation NOUN xs55m90367s 16 2 of of ADP xs55m90367s 16 3 the the DET xs55m90367s 16 4 in in ADP xs55m90367s 16 5 vitro vitro X xs55m90367s 16 6 cytotoxicity cytotoxicity NOUN xs55m90367s 16 7 of of ADP xs55m90367s 16 8 paclitaxel paclitaxel NOUN xs55m90367s 16 9 - - PUNCT xs55m90367s 16 10 polymersome polymersome PROPN xs55m90367s 16 11 formulations formulation NOUN xs55m90367s 16 12 showed show VERB xs55m90367s 16 13 that that SCONJ xs55m90367s 16 14 the the DET xs55m90367s 16 15 ability ability NOUN xs55m90367s 16 16 of of ADP xs55m90367s 16 17 paclitaxel paclitaxel NOUN xs55m90367s 16 18 - - PUNCT xs55m90367s 16 19 loaded load VERB xs55m90367s 16 20 polymersomes polymersome NOUN xs55m90367s 16 21 to to PART xs55m90367s 16 22 inhibit inhibit VERB xs55m90367s 16 23 proliferation proliferation NOUN xs55m90367s 16 24 of of ADP xs55m90367s 16 25 mcf-7 mcf-7 PRON xs55m90367s 16 26 human human ADJ xs55m90367s 16 27 breast breast NOUN xs55m90367s 16 28 cancer cancer NOUN xs55m90367s 16 29 cells cell NOUN xs55m90367s 16 30 was be AUX xs55m90367s 16 31 less less ADV xs55m90367s 16 32 compared compare VERB xs55m90367s 16 33 to to ADP xs55m90367s 16 34 free free ADJ xs55m90367s 16 35 paclitaxel paclitaxel NOUN xs55m90367s 16 36 . . PUNCT xs55m90367s 17 1 by by ADP xs55m90367s 17 2 increasing increase VERB xs55m90367s 17 3 the the DET xs55m90367s 17 4 concentration concentration NOUN xs55m90367s 17 5 of of ADP xs55m90367s 17 6 paclitaxel paclitaxel NOUN xs55m90367s 17 7 in in ADP xs55m90367s 17 8 polymersomes polymersome NOUN xs55m90367s 17 9 to to ADP xs55m90367s 17 10 0.2 0.2 NUM xs55m90367s 17 11 ì_å_g ì_å_g PROPN xs55m90367s 17 12 / / SYM xs55m90367s 17 13 ml ml PROPN xs55m90367s 17 14 , , PUNCT xs55m90367s 17 15 paclitaxel paclitaxel PROPN xs55m90367s 17 16 - - PUNCT xs55m90367s 17 17 polymersome polymersome PROPN xs55m90367s 17 18 formulations formulation NOUN xs55m90367s 17 19 showed show VERB xs55m90367s 17 20 comparable comparable ADJ xs55m90367s 17 21 activity activity NOUN xs55m90367s 17 22 in in ADP xs55m90367s 17 23 inhibiting inhibit VERB xs55m90367s 17 24 the the DET xs55m90367s 17 25 growth growth NOUN xs55m90367s 17 26 of of ADP xs55m90367s 17 27 mcf-7 mcf-7 NOUN xs55m90367s 17 28 cells cell NOUN xs55m90367s 17 29 . . PUNCT