id sid tid token lemma pos xp68kd21304 1 1 the the DET xp68kd21304 1 2 near near ADV xp68kd21304 1 3 - - PUNCT xp68kd21304 1 4 infrared infrared ADJ xp68kd21304 1 5 window window NOUN xp68kd21304 1 6 of of ADP xp68kd21304 1 7 fluorescent fluorescent PROPN xp68kd21304 1 8 heptamethine heptamethine PROPN xp68kd21304 1 9 cyanine cyanine NOUN xp68kd21304 1 10 dyes dye NOUN xp68kd21304 1 11 greatly greatly ADV xp68kd21304 1 12 facilitates facilitate VERB xp68kd21304 1 13 biological biological ADJ xp68kd21304 1 14 imaging imaging NOUN xp68kd21304 1 15 because because SCONJ xp68kd21304 1 16 there there PRON xp68kd21304 1 17 is be VERB xp68kd21304 1 18 deep deep ADJ xp68kd21304 1 19 penetration penetration NOUN xp68kd21304 1 20 of of ADP xp68kd21304 1 21 the the DET xp68kd21304 1 22 light light ADJ xp68kd21304 1 23 and and CCONJ xp68kd21304 1 24 negligible negligible ADJ xp68kd21304 1 25 background background NOUN xp68kd21304 1 26 fluorescence fluorescence NOUN xp68kd21304 1 27 . . PUNCT xp68kd21304 2 1 however however ADV xp68kd21304 2 2 , , PUNCT xp68kd21304 2 3 dye dye NOUN xp68kd21304 2 4 solubility solubility NOUN xp68kd21304 2 5 , , PUNCT xp68kd21304 2 6 aggregation aggregation NOUN xp68kd21304 2 7 , , PUNCT xp68kd21304 2 8 poor poor ADJ xp68kd21304 2 9 pharmacokinetics pharmacokinetic NOUN xp68kd21304 2 10 and and CCONJ xp68kd21304 2 11 biodistribution biodistribution NOUN xp68kd21304 2 12 , , PUNCT xp68kd21304 2 13 quenching quench VERB xp68kd21304 2 14 in in ADP xp68kd21304 2 15 water water NOUN xp68kd21304 2 16 , , PUNCT xp68kd21304 2 17 and and CCONJ xp68kd21304 2 18 instability instability NOUN xp68kd21304 2 19 are be AUX xp68kd21304 2 20 current current ADJ xp68kd21304 2 21 drawbacks drawback NOUN xp68kd21304 2 22 that that PRON xp68kd21304 2 23 limit limit VERB xp68kd21304 2 24 performance performance NOUN xp68kd21304 2 25 and and CCONJ xp68kd21304 2 26 the the DET xp68kd21304 2 27 scope scope NOUN xp68kd21304 2 28 of of ADP xp68kd21304 2 29 possible possible ADJ xp68kd21304 2 30 applications application NOUN xp68kd21304 2 31 as as SCONJ xp68kd21304 2 32 summarized summarize VERB xp68kd21304 2 33 in in ADP xp68kd21304 2 34 chapter chapter NOUN xp68kd21304 2 35 1 1 NUM xp68kd21304 2 36 . . PUNCT xp68kd21304 3 1 this this DET xp68kd21304 3 2 thesis thesis NOUN xp68kd21304 3 3 describes describe VERB xp68kd21304 3 4 a a DET xp68kd21304 3 5 series series NOUN xp68kd21304 3 6 of of ADP xp68kd21304 3 7 chemical chemical ADJ xp68kd21304 3 8 efforts effort NOUN xp68kd21304 3 9 to to PART xp68kd21304 3 10 solve solve VERB xp68kd21304 3 11 these these DET xp68kd21304 3 12 heptamethine heptamethine ADJ xp68kd21304 3 13 cyanine cyanine NOUN xp68kd21304 3 14 problems.chapters problems.chapter NOUN xp68kd21304 3 15 2 2 NUM xp68kd21304 3 16 , , PUNCT xp68kd21304 3 17 3 3 NUM xp68kd21304 3 18 , , PUNCT xp68kd21304 3 19 and and CCONJ xp68kd21304 3 20 4 4 NUM xp68kd21304 3 21 report report VERB xp68kd21304 3 22 molecular molecular ADJ xp68kd21304 3 23 design design NOUN xp68kd21304 3 24 strategies strategy NOUN xp68kd21304 3 25 that that PRON xp68kd21304 3 26 produce produce VERB xp68kd21304 3 27 new new ADJ xp68kd21304 3 28 families family NOUN xp68kd21304 3 29 of of ADP xp68kd21304 3 30 sterically sterically ADV xp68kd21304 3 31 shielded shield VERB xp68kd21304 3 32 heptamethine heptamethine ADJ xp68kd21304 3 33 dyes dye NOUN xp68kd21304 3 34 which which PRON xp68kd21304 3 35 overcome overcome VERB xp68kd21304 3 36 the the DET xp68kd21304 3 37 limitations limitation NOUN xp68kd21304 3 38 mentioned mention VERB xp68kd21304 3 39 above above ADV xp68kd21304 3 40 . . PUNCT xp68kd21304 4 1 the the DET xp68kd21304 4 2 key key ADJ xp68kd21304 4 3 design design NOUN xp68kd21304 4 4 feature feature NOUN xp68kd21304 4 5 is be AUX xp68kd21304 4 6 a a DET xp68kd21304 4 7 meso meso ADJ xp68kd21304 4 8 - - PUNCT xp68kd21304 4 9 oaryl oaryl NOUN xp68kd21304 4 10 or or CCONJ xp68kd21304 4 11 a a DET xp68kd21304 4 12 meso meso ADJ xp68kd21304 4 13 - - PUNCT xp68kd21304 4 14 aryl aryl NOUN xp68kd21304 4 15 group group NOUN xp68kd21304 4 16 that that PRON xp68kd21304 4 17 simultaneously simultaneously ADV xp68kd21304 4 18 projects project VERB xp68kd21304 4 19 two two NUM xp68kd21304 4 20 shielding shield VERB xp68kd21304 4 21 arms arm NOUN xp68kd21304 4 22 directly directly ADV xp68kd21304 4 23 over over ADP xp68kd21304 4 24 each each DET xp68kd21304 4 25 face face NOUN xp68kd21304 4 26 of of ADP xp68kd21304 4 27 a a DET xp68kd21304 4 28 linear linear ADJ xp68kd21304 4 29 heptamethine heptamethine ADJ xp68kd21304 4 30 polyene polyene NOUN xp68kd21304 4 31 . . PUNCT xp68kd21304 5 1 fluorescence fluorescence ADJ xp68kd21304 5 2 imaging image VERB xp68kd21304 5 3 experiments experiment NOUN xp68kd21304 5 4 in in ADP xp68kd21304 5 5 cells cell NOUN xp68kd21304 5 6 and and CCONJ xp68kd21304 5 7 animals animal NOUN xp68kd21304 5 8 compared compare VERB xp68kd21304 5 9 the the DET xp68kd21304 5 10 shielded shielded ADJ xp68kd21304 5 11 heptamethine heptamethine ADJ xp68kd21304 5 12 dyes dye NOUN xp68kd21304 5 13 ( ( PUNCT xp68kd21304 5 14 and and CCONJ xp68kd21304 5 15 several several ADJ xp68kd21304 5 16 peptide peptide NOUN xp68kd21304 5 17 and and CCONJ xp68kd21304 5 18 antibody antibody NOUN xp68kd21304 5 19 bioconjugates bioconjugate NOUN xp68kd21304 5 20 ) ) PUNCT xp68kd21304 5 21 to to PART xp68kd21304 5 22 benchmark benchmark VERB xp68kd21304 5 23 heptamethine heptamethine ADJ xp68kd21304 5 24 dyes dye NOUN xp68kd21304 5 25 in in ADP xp68kd21304 5 26 chapter chapter NOUN xp68kd21304 5 27 5 5 NUM xp68kd21304 5 28 , , PUNCT xp68kd21304 5 29 and and CCONJ xp68kd21304 5 30 found find VERB xp68kd21304 5 31 that that SCONJ xp68kd21304 5 32 the the DET xp68kd21304 5 33 shielded shielded ADJ xp68kd21304 5 34 systems system NOUN xp68kd21304 5 35 possess possess VERB xp68kd21304 5 36 an an DET xp68kd21304 5 37 unsurpassed unsurpassed ADJ xp68kd21304 5 38 combination combination NOUN xp68kd21304 5 39 of of ADP xp68kd21304 5 40 photophysical photophysical ADJ xp68kd21304 5 41 , , PUNCT xp68kd21304 5 42 physiochemical physiochemical ADJ xp68kd21304 5 43 and and CCONJ xp68kd21304 5 44 biodistribution biodistribution NOUN xp68kd21304 5 45 properties property NOUN xp68kd21304 5 46 that that PRON xp68kd21304 5 47 greatly greatly ADV xp68kd21304 5 48 enhance enhance VERB xp68kd21304 5 49 bioimaging bioimage VERB xp68kd21304 5 50 performance.the performance.the DET xp68kd21304 5 51 study study NOUN xp68kd21304 5 52 in in ADP xp68kd21304 5 53 chapter chapter NOUN xp68kd21304 5 54 6 6 NUM xp68kd21304 5 55 overcomes overcome VERB xp68kd21304 5 56 the the DET xp68kd21304 5 57 instability instability NOUN xp68kd21304 5 58 problem problem NOUN xp68kd21304 5 59 of of ADP xp68kd21304 5 60 fda fda PROPN xp68kd21304 5 61 - - PUNCT xp68kd21304 5 62 approved approve VERB xp68kd21304 5 63 heptamethine heptamethine PROPN xp68kd21304 5 64 dye dye NOUN xp68kd21304 5 65 , , PUNCT xp68kd21304 5 66 indocyanine indocyanine NOUN xp68kd21304 5 67 green green NOUN xp68kd21304 5 68 ( ( PUNCT xp68kd21304 5 69 icg icg NOUN xp68kd21304 5 70 ) ) PUNCT xp68kd21304 5 71 by by ADP xp68kd21304 5 72 making make VERB xp68kd21304 5 73 a a DET xp68kd21304 5 74 suitable suitable ADJ xp68kd21304 5 75 designed design VERB xp68kd21304 5 76 deuterated deuterated ADJ xp68kd21304 5 77 derivative derivative NOUN xp68kd21304 5 78 . . PUNCT xp68kd21304 6 1 the the DET xp68kd21304 6 2 deuterated deuterated ADJ xp68kd21304 6 3 dyes dye NOUN xp68kd21304 6 4 bear bear NOUN xp68kd21304 6 5 deuterium deuterium NOUN xp68kd21304 6 6 atoms atom NOUN xp68kd21304 6 7 on on ADP xp68kd21304 6 8 the the DET xp68kd21304 6 9 polymethine polymethine ADJ xp68kd21304 6 10 chain chain NOUN xp68kd21304 6 11 , , PUNCT xp68kd21304 6 12 and and CCONJ xp68kd21304 6 13 the the DET xp68kd21304 6 14 spectral spectral ADJ xp68kd21304 6 15 , , PUNCT xp68kd21304 6 16 physiochemical physiochemical ADJ xp68kd21304 6 17 , , PUNCT xp68kd21304 6 18 and and CCONJ xp68kd21304 6 19 photostability photostability NOUN xp68kd21304 6 20 properties property NOUN xp68kd21304 6 21 were be AUX xp68kd21304 6 22 quantified quantify VERB xp68kd21304 6 23 . . PUNCT xp68kd21304 7 1 a a DET xp68kd21304 7 2 notable notable ADJ xp68kd21304 7 3 mechanistic mechanistic ADJ xp68kd21304 7 4 finding finding NOUN xp68kd21304 7 5 is be AUX xp68kd21304 7 6 that that SCONJ xp68kd21304 7 7 self self NOUN xp68kd21304 7 8 - - PUNCT xp68kd21304 7 9 aggregation aggregation NOUN xp68kd21304 7 10 of of ADP xp68kd21304 7 11 icg icg NOUN xp68kd21304 7 12 in in ADP xp68kd21304 7 13 water water NOUN xp68kd21304 7 14 strongly strongly ADV xp68kd21304 7 15 favors favor VERB xp68kd21304 7 16 dye dye NOUN xp68kd21304 7 17 degradation degradation NOUN xp68kd21304 7 18 by by ADP xp68kd21304 7 19 a a DET xp68kd21304 7 20 photochemical photochemical ADJ xp68kd21304 7 21 oxidative oxidative ADJ xp68kd21304 7 22 dimerization dimerization NOUN xp68kd21304 7 23 reaction reaction NOUN xp68kd21304 7 24 that that PRON xp68kd21304 7 25 gives give VERB xp68kd21304 7 26 a a DET xp68kd21304 7 27 non non ADJ xp68kd21304 7 28 - - ADJ xp68kd21304 7 29 fluorescent fluorescent ADJ xp68kd21304 7 30 product product NOUN xp68kd21304 7 31 . . PUNCT xp68kd21304 8 1 storage storage NOUN xp68kd21304 8 2 stability stability NOUN xp68kd21304 8 3 studies study NOUN xp68kd21304 8 4 showed show VERB xp68kd21304 8 5 that that SCONJ xp68kd21304 8 6 replacement replacement NOUN xp68kd21304 8 7 of of ADP xp68kd21304 8 8 c c NOUN xp68kd21304 8 9 - - PUNCT xp68kd21304 8 10 h h NOUN xp68kd21304 8 11 with with ADP xp68kd21304 8 12 c c PROPN xp68kd21304 8 13 - - PUNCT xp68kd21304 8 14 d d NOUN xp68kd21304 8 15 slowed slow VERB xp68kd21304 8 16 the the DET xp68kd21304 8 17 dimerization dimerization NOUN xp68kd21304 8 18 rate rate NOUN xp68kd21304 8 19 constant constant ADJ xp68kd21304 8 20 by by ADP xp68kd21304 8 21 a a DET xp68kd21304 8 22 factor factor NOUN xp68kd21304 8 23 of of ADP xp68kd21304 8 24 3.1 3.1 NUM xp68kd21304 8 25 , , PUNCT xp68kd21304 8 26 and and CCONJ xp68kd21304 8 27 it it PRON xp68kd21304 8 28 is be AUX xp68kd21304 8 29 likely likely ADJ xp68kd21304 8 30 that that SCONJ xp68kd21304 8 31 many many ADJ xp68kd21304 8 32 medical medical ADJ xp68kd21304 8 33 and and CCONJ xp68kd21304 8 34 pre pre ADJ xp68kd21304 8 35 - - ADJ xp68kd21304 8 36 clinical clinical ADJ xp68kd21304 8 37 procedures procedure NOUN xp68kd21304 8 38 will will AUX xp68kd21304 8 39 benefit benefit VERB xp68kd21304 8 40 from from ADP xp68kd21304 8 41 the the DET xp68kd21304 8 42 longer long ADJ xp68kd21304 8 43 shelf shelf NOUN xp68kd21304 8 44 - - PUNCT xp68kd21304 8 45 lives life NOUN xp68kd21304 8 46 of of ADP xp68kd21304 8 47 these these DET xp68kd21304 8 48 two two NUM xp68kd21304 8 49 deuterated deuterated ADJ xp68kd21304 8 50 icg icg ADJ xp68kd21304 8 51 dyes dye NOUN xp68kd21304 8 52 . . PUNCT xp68kd21304 9 1 the the DET xp68kd21304 9 2 study study NOUN xp68kd21304 9 3 in in ADP xp68kd21304 9 4 chapter chapter NOUN xp68kd21304 9 5 7 7 NUM xp68kd21304 9 6 shows show VERB xp68kd21304 9 7 how how SCONJ xp68kd21304 9 8 supramolecular supramolecular ADJ xp68kd21304 9 9 encapsulation encapsulation NOUN xp68kd21304 9 10 of of ADP xp68kd21304 9 11 a a DET xp68kd21304 9 12 newly newly ADV xp68kd21304 9 13 designed design VERB xp68kd21304 9 14 series series NOUN xp68kd21304 9 15 of of ADP xp68kd21304 9 16 cyanine cyanine ADJ xp68kd21304 9 17 dyes dye NOUN xp68kd21304 9 18 by by ADP xp68kd21304 9 19 cucurbit[7]uril cucurbit[7]uril PROPN xp68kd21304 9 20 ( ( PUNCT xp68kd21304 9 21 cb7 cb7 PROPN xp68kd21304 9 22 ) ) PUNCT xp68kd21304 9 23 can can AUX xp68kd21304 9 24 alter alter VERB xp68kd21304 9 25 the the DET xp68kd21304 9 26 π π PROPN xp68kd21304 9 27 - - PUNCT xp68kd21304 9 28 electron electron NOUN xp68kd21304 9 29 distribution distribution NOUN xp68kd21304 9 30 within within ADP xp68kd21304 9 31 the the DET xp68kd21304 9 32 cyanine cyanine NOUN xp68kd21304 9 33 chromophore chromophore NOUN xp68kd21304 9 34 alter alter VERB xp68kd21304 9 35 fluorescent fluorescent NOUN xp68kd21304 9 36 properties property NOUN xp68kd21304 9 37 . . PUNCT xp68kd21304 10 1 for for ADP xp68kd21304 10 2 two two NUM xp68kd21304 10 3 sets set NOUN xp68kd21304 10 4 of of ADP xp68kd21304 10 5 dyes dye NOUN xp68kd21304 10 6 , , PUNCT xp68kd21304 10 7 the the DET xp68kd21304 10 8 most most ADV xp68kd21304 10 9 stable stable ADJ xp68kd21304 10 10 co co NOUN xp68kd21304 10 11 - - NOUN xp68kd21304 10 12 conformation conformation NOUN xp68kd21304 10 13 for for ADP xp68kd21304 10 14 the the DET xp68kd21304 10 15 supramolecular supramolecular ADJ xp68kd21304 10 16 complex complex NOUN xp68kd21304 10 17 locates locate VERB xp68kd21304 10 18 cb7 cb7 PROPN xp68kd21304 10 19 around around ADP xp68kd21304 10 20 the the DET xp68kd21304 10 21 center center NOUN xp68kd21304 10 22 of of ADP xp68kd21304 10 23 the the DET xp68kd21304 10 24 dye dye NOUN xp68kd21304 10 25 chromophore chromophore NOUN xp68kd21304 10 26 , , PUNCT xp68kd21304 10 27 and and CCONJ xp68kd21304 10 28 the the DET xp68kd21304 10 29 results result NOUN xp68kd21304 10 30 are be AUX xp68kd21304 10 31 nonpolar nonpolar ADJ xp68kd21304 10 32 , , PUNCT xp68kd21304 10 33 symmetric symmetric ADJ xp68kd21304 10 34 π π NOUN xp68kd21304 10 35 - - PUNCT xp68kd21304 10 36 electron electron NOUN xp68kd21304 10 37 , , PUNCT xp68kd21304 10 38 ground ground NOUN xp68kd21304 10 39 states state NOUN xp68kd21304 10 40 that that PRON xp68kd21304 10 41 produce produce VERB xp68kd21304 10 42 sharpened sharpen VERB xp68kd21304 10 43 absorption absorption NOUN xp68kd21304 10 44 bands band NOUN xp68kd21304 10 45 with with ADP xp68kd21304 10 46 enhanced enhanced ADJ xp68kd21304 10 47 fluorescence fluorescence ADJ xp68kd21304 10 48 brightness brightness NOUN xp68kd21304 10 49 . . PUNCT xp68kd21304 11 1 from from ADP xp68kd21304 11 2 the the DET xp68kd21304 11 3 perspective perspective NOUN xp68kd21304 11 4 of of ADP xp68kd21304 11 5 enhanced enhanced ADJ xp68kd21304 11 6 near near ADV xp68kd21304 11 7 - - PUNCT xp68kd21304 11 8 infrared infrared ADJ xp68kd21304 11 9 bioimaging bioimaging NOUN xp68kd21304 11 10 and and CCONJ xp68kd21304 11 11 sensing sense VERB xp68kd21304 11 12 in in ADP xp68kd21304 11 13 water water NOUN xp68kd21304 11 14 , , PUNCT xp68kd21304 11 15 the the DET xp68kd21304 11 16 results result NOUN xp68kd21304 11 17 show show VERB xp68kd21304 11 18 how how SCONJ xp68kd21304 11 19 the the DET xp68kd21304 11 20 principles principle NOUN xp68kd21304 11 21 of of ADP xp68kd21304 11 22 host host NOUN xp68kd21304 11 23 / / SYM xp68kd21304 11 24 guest guest NOUN xp68kd21304 11 25 chemistry chemistry NOUN xp68kd21304 11 26 can can AUX xp68kd21304 11 27 be be AUX xp68kd21304 11 28 employed employ VERB xp68kd21304 11 29 to to PART xp68kd21304 11 30 solve solve VERB xp68kd21304 11 31 the the DET xp68kd21304 11 32 " " PUNCT xp68kd21304 11 33 cyanine cyanine NOUN xp68kd21304 11 34 limit limit NOUN xp68kd21304 11 35 " " PUNCT xp68kd21304 11 36 problem problem NOUN xp68kd21304 11 37 . . PUNCT