id	sid	tid	token	lemma	pos
x346d221g19	1	1	this	this	DET
x346d221g19	1	2	dissertation	dissertation	NOUN
x346d221g19	1	3	describes	describe	VERB
x346d221g19	1	4	the	the	DET
x346d221g19	1	5	design	design	NOUN
x346d221g19	1	6	and	and	CCONJ
x346d221g19	1	7	optimization	optimization	NOUN
x346d221g19	1	8	of	of	ADP
x346d221g19	1	9	several	several	ADJ
x346d221g19	1	10	multivalent	multivalent	ADJ
x346d221g19	1	11	nanomedicines	nanomedicine	NOUN
x346d221g19	1	12	for	for	ADP
x346d221g19	1	13	use	use	NOUN
x346d221g19	1	14	in	in	ADP
x346d221g19	1	15	allergies	allergy	NOUN
x346d221g19	1	16	and	and	CCONJ
x346d221g19	1	17	cancer	cancer	NOUN
x346d221g19	1	18	.	.	PUNCT
x346d221g19	2	1	targeted	target	VERB
x346d221g19	2	2	nanomedicines	nanomedicine	NOUN
x346d221g19	2	3	can	can	AUX
x346d221g19	2	4	improve	improve	VERB
x346d221g19	2	5	diagnostics	diagnostic	NOUN
x346d221g19	2	6	and	and	CCONJ
x346d221g19	2	7	therapeutics	therapeutic	NOUN
x346d221g19	2	8	for	for	ADP
x346d221g19	2	9	many	many	ADJ
x346d221g19	2	10	diseases	disease	NOUN
x346d221g19	2	11	.	.	PUNCT
x346d221g19	3	1	yet	yet	ADV
x346d221g19	3	2	,	,	PUNCT
x346d221g19	3	3	despite	despite	SCONJ
x346d221g19	3	4	decades	decade	NOUN
x346d221g19	3	5	of	of	ADP
x346d221g19	3	6	research	research	NOUN
x346d221g19	3	7	,	,	PUNCT
x346d221g19	3	8	most	most	ADJ
x346d221g19	3	9	nanomedicines	nanomedicine	NOUN
x346d221g19	3	10	fail	fail	VERB
x346d221g19	3	11	in	in	ADP
x346d221g19	3	12	clinical	clinical	ADJ
x346d221g19	3	13	trials	trial	NOUN
x346d221g19	3	14	.	.	PUNCT
x346d221g19	4	1	the	the	DET
x346d221g19	4	2	addition	addition	NOUN
x346d221g19	4	3	of	of	ADP
x346d221g19	4	4	targeting	target	VERB
x346d221g19	4	5	to	to	ADP
x346d221g19	4	6	nanomedicines	nanomedicine	NOUN
x346d221g19	4	7	may	may	AUX
x346d221g19	4	8	improve	improve	VERB
x346d221g19	4	9	their	their	PRON
x346d221g19	4	10	efficacy	efficacy	NOUN
x346d221g19	4	11	,	,	PUNCT
x346d221g19	4	12	yet	yet	CCONJ
x346d221g19	4	13	each	each	DET
x346d221g19	4	14	component	component	NOUN
x346d221g19	4	15	and	and	CCONJ
x346d221g19	4	16	characteristic	characteristic	ADJ
x346d221g19	4	17	must	must	AUX
x346d221g19	4	18	be	be	AUX
x346d221g19	4	19	tuned	tune	VERB
x346d221g19	4	20	to	to	PART
x346d221g19	4	21	make	make	VERB
x346d221g19	4	22	precision	precision	NOUN
x346d221g19	4	23	medicines	medicine	NOUN
x346d221g19	4	24	.	.	PUNCT
x346d221g19	5	1	this	this	PRON
x346d221g19	5	2	requires	require	VERB
x346d221g19	5	3	understanding	understanding	NOUN
x346d221g19	5	4	of	of	ADP
x346d221g19	5	5	complex	complex	ADJ
x346d221g19	5	6	parameters	parameter	NOUN
x346d221g19	5	7	such	such	ADJ
x346d221g19	5	8	as	as	ADP
x346d221g19	5	9	selectivity	selectivity	NOUN
x346d221g19	5	10	over	over	ADP
x346d221g19	5	11	avidity	avidity	NOUN
x346d221g19	5	12	and	and	CCONJ
x346d221g19	5	13	navigating	navigate	VERB
x346d221g19	5	14	immune	immune	ADJ
x346d221g19	5	15	system	system	NOUN
x346d221g19	5	16	involvement.first	involvement.first	NOUN
x346d221g19	5	17	,	,	PUNCT
x346d221g19	5	18	two	two	NUM
x346d221g19	5	19	allergy	allergy	NOUN
x346d221g19	5	20	systems	system	NOUN
x346d221g19	5	21	are	be	AUX
x346d221g19	5	22	studied	study	VERB
x346d221g19	5	23	here	here	ADV
x346d221g19	5	24	,	,	PUNCT
x346d221g19	5	25	exploring	explore	VERB
x346d221g19	5	26	improvements	improvement	NOUN
x346d221g19	5	27	to	to	ADP
x346d221g19	5	28	diagnostics	diagnostic	NOUN
x346d221g19	5	29	and	and	CCONJ
x346d221g19	5	30	therapeutics	therapeutic	NOUN
x346d221g19	5	31	via	via	ADP
x346d221g19	5	32	multivalent	multivalent	ADJ
x346d221g19	5	33	nanomedicines	nanomedicine	NOUN
x346d221g19	5	34	.	.	PUNCT
x346d221g19	6	1	chapter	chapter	NOUN
x346d221g19	6	2	two	two	NUM
x346d221g19	6	3	covers	cover	VERB
x346d221g19	6	4	cephalosporin	cephalosporin	NOUN
x346d221g19	6	5	antibiotic	antibiotic	ADJ
x346d221g19	6	6	(	(	PUNCT
x346d221g19	6	7	i.e.	i.e.	X
x346d221g19	6	8	,	,	PUNCT
x346d221g19	6	9	small	small	ADJ
x346d221g19	6	10	molecule	molecule	NOUN
x346d221g19	6	11	drug	drug	NOUN
x346d221g19	6	12	)	)	PUNCT
x346d221g19	6	13	allergies	allergy	NOUN
x346d221g19	6	14	,	,	PUNCT
x346d221g19	6	15	while	while	SCONJ
x346d221g19	6	16	chapter	chapter	NOUN
x346d221g19	6	17	3	3	NUM
x346d221g19	6	18	studies	study	NOUN
x346d221g19	6	19	house	house	NOUN
x346d221g19	6	20	dust	dust	NOUN
x346d221g19	6	21	mite	mite	PROPN
x346d221g19	6	22	(	(	PUNCT
x346d221g19	6	23	hdm	hdm	PROPN
x346d221g19	6	24	)	)	PUNCT
x346d221g19	6	25	protein	protein	NOUN
x346d221g19	6	26	allergies	allergy	NOUN
x346d221g19	6	27	.	.	PUNCT
x346d221g19	7	1	multivalent	multivalent	ADJ
x346d221g19	7	2	liposomal	liposomal	PROPN
x346d221g19	7	3	nanoallergens	nanoallergens	PROPN
x346d221g19	7	4	are	be	AUX
x346d221g19	7	5	used	use	VERB
x346d221g19	7	6	to	to	PART
x346d221g19	7	7	determine	determine	VERB
x346d221g19	7	8	the	the	DET
x346d221g19	7	9	immunogenic	immunogenic	ADJ
x346d221g19	7	10	structures	structure	NOUN
x346d221g19	7	11	of	of	ADP
x346d221g19	7	12	the	the	DET
x346d221g19	7	13	drug	drug	NOUN
x346d221g19	7	14	and	and	CCONJ
x346d221g19	7	15	protein	protein	NOUN
x346d221g19	7	16	allergens	allergen	NOUN
x346d221g19	7	17	.	.	PUNCT
x346d221g19	8	1	these	these	DET
x346d221g19	8	2	immunogenic	immunogenic	ADJ
x346d221g19	8	3	structures	structure	NOUN
x346d221g19	8	4	inform	inform	VERB
x346d221g19	8	5	the	the	DET
x346d221g19	8	6	design	design	NOUN
x346d221g19	8	7	of	of	ADP
x346d221g19	8	8	improved	improve	VERB
x346d221g19	8	9	allergy	allergy	NOUN
x346d221g19	8	10	diagnostics	diagnostic	NOUN
x346d221g19	8	11	and	and	CCONJ
x346d221g19	8	12	therapeutics	therapeutic	NOUN
x346d221g19	8	13	.	.	PUNCT
x346d221g19	9	1	in	in	ADP
x346d221g19	9	2	chapter	chapter	NOUN
x346d221g19	9	3	four	four	NUM
x346d221g19	9	4	,	,	PUNCT
x346d221g19	9	5	multivalent	multivalent	ADJ
x346d221g19	9	6	inhibitor	inhibitor	NOUN
x346d221g19	9	7	designs	design	NOUN
x346d221g19	9	8	are	be	AUX
x346d221g19	9	9	evaluated	evaluate	VERB
x346d221g19	9	10	in	in	ADP
x346d221g19	9	11	vitro	vitro	X
x346d221g19	9	12	for	for	ADP
x346d221g19	9	13	two	two	NUM
x346d221g19	9	14	protein	protein	NOUN
x346d221g19	9	15	allergy	allergy	NOUN
x346d221g19	9	16	systems	system	NOUN
x346d221g19	9	17	:	:	PUNCT
x346d221g19	9	18	peanut	peanut	NOUN
x346d221g19	9	19	and	and	CCONJ
x346d221g19	9	20	hdm	hdm	PROPN
x346d221g19	9	21	.	.	PUNCT
x346d221g19	10	1	several	several	ADJ
x346d221g19	10	2	covalent	covalent	ADJ
x346d221g19	10	3	heterobivalent	heterobivalent	ADJ
x346d221g19	10	4	inhibitors	inhibitor	NOUN
x346d221g19	10	5	,	,	PUNCT
x346d221g19	10	6	containing	contain	VERB
x346d221g19	10	7	various	various	ADJ
x346d221g19	10	8	peanut	peanut	NOUN
x346d221g19	10	9	and	and	CCONJ
x346d221g19	10	10	hdm	hdm	PROPN
x346d221g19	10	11	immunogenic	immunogenic	ADJ
x346d221g19	10	12	epitopes	epitope	NOUN
x346d221g19	10	13	,	,	PUNCT
x346d221g19	10	14	are	be	AUX
x346d221g19	10	15	evaluated	evaluate	VERB
x346d221g19	10	16	for	for	ADP
x346d221g19	10	17	inhibition	inhibition	NOUN
x346d221g19	10	18	of	of	ADP
x346d221g19	10	19	cellular	cellular	ADJ
x346d221g19	10	20	allergic	allergic	ADJ
x346d221g19	10	21	response	response	NOUN
x346d221g19	10	22	and	and	CCONJ
x346d221g19	10	23	compared	compare	VERB
x346d221g19	10	24	to	to	ADP
x346d221g19	10	25	a	a	DET
x346d221g19	10	26	covalent	covalent	NOUN
x346d221g19	10	27	monovalent	monovalent	NOUN
x346d221g19	10	28	inhibitor.second	inhibitor.second	PROPN
x346d221g19	10	29	,	,	PUNCT
x346d221g19	10	30	this	this	DET
x346d221g19	10	31	work	work	NOUN
x346d221g19	10	32	studies	study	VERB
x346d221g19	10	33	multivalent	multivalent	ADJ
x346d221g19	10	34	nanomedicines	nanomedicine	NOUN
x346d221g19	10	35	in	in	ADP
x346d221g19	10	36	the	the	DET
x346d221g19	10	37	design	design	NOUN
x346d221g19	10	38	and	and	CCONJ
x346d221g19	10	39	optimization	optimization	NOUN
x346d221g19	10	40	of	of	ADP
x346d221g19	10	41	targeted	target	VERB
x346d221g19	10	42	nanoparticle	nanoparticle	NOUN
x346d221g19	10	43	systems	system	NOUN
x346d221g19	10	44	for	for	ADP
x346d221g19	10	45	delivering	deliver	VERB
x346d221g19	10	46	chemotherapeutics	chemotherapeutic	NOUN
x346d221g19	10	47	to	to	ADP
x346d221g19	10	48	cancer	cancer	NOUN
x346d221g19	10	49	.	.	PUNCT
x346d221g19	11	1	chapter	chapter	NOUN
x346d221g19	11	2	five	five	NUM
x346d221g19	11	3	evaluates	evaluate	VERB
x346d221g19	11	4	two	two	NUM
x346d221g19	11	5	targeted	target	VERB
x346d221g19	11	6	nanoparticle	nanoparticle	NOUN
x346d221g19	11	7	systems	system	NOUN
x346d221g19	11	8	(	(	PUNCT
x346d221g19	11	9	cd38	cd38	PROPN
x346d221g19	11	10	versus	versus	ADP
x346d221g19	11	11	cd138	cd138	PROPN
x346d221g19	11	12	)	)	PUNCT
x346d221g19	11	13	for	for	ADP
x346d221g19	11	14	delivery	delivery	NOUN
x346d221g19	11	15	of	of	ADP
x346d221g19	11	16	a	a	DET
x346d221g19	11	17	doxorubicin	doxorubicin	NOUN
x346d221g19	11	18	-	-	PUNCT
x346d221g19	11	19	prodrug	prodrug	NOUN
x346d221g19	11	20	to	to	ADP
x346d221g19	11	21	multiple	multiple	ADJ
x346d221g19	11	22	myeloma	myeloma	NOUN
x346d221g19	11	23	.	.	PUNCT
x346d221g19	12	1	in	in	ADP
x346d221g19	12	2	vitro	vitro	X
x346d221g19	12	3	and	and	CCONJ
x346d221g19	12	4	in	in	ADP
x346d221g19	12	5	vivo	vivo	ADJ
x346d221g19	12	6	optimization	optimization	NOUN
x346d221g19	12	7	of	of	ADP
x346d221g19	12	8	the	the	DET
x346d221g19	12	9	targeted	target	VERB
x346d221g19	12	10	nanoparticles	nanoparticle	NOUN
x346d221g19	12	11	show	show	VERB
x346d221g19	12	12	opposite	opposite	ADJ
x346d221g19	12	13	trends	trend	NOUN
x346d221g19	12	14	,	,	PUNCT
x346d221g19	12	15	due	due	ADP
x346d221g19	12	16	to	to	ADP
x346d221g19	12	17	the	the	DET
x346d221g19	12	18	poor	poor	ADJ
x346d221g19	12	19	selectivity	selectivity	NOUN
x346d221g19	12	20	of	of	ADP
x346d221g19	12	21	the	the	DET
x346d221g19	12	22	cd138	cd138	SPACE
x346d221g19	12	23	-	-	PUNCT
x346d221g19	12	24	targeted	target	VERB
x346d221g19	12	25	nanoparticles	nanoparticle	NOUN
x346d221g19	12	26	in	in	ADP
x346d221g19	12	27	vivo	vivo	PROPN
x346d221g19	12	28	.	.	PUNCT
x346d221g19	13	1	chapter	chapter	NOUN
x346d221g19	13	2	six	six	NUM
x346d221g19	13	3	explores	explore	VERB
x346d221g19	13	4	the	the	DET
x346d221g19	13	5	complexity	complexity	NOUN
x346d221g19	13	6	of	of	ADP
x346d221g19	13	7	targeting	target	VERB
x346d221g19	13	8	metastatic	metastatic	ADJ
x346d221g19	13	9	ovarian	ovarian	ADJ
x346d221g19	13	10	cancer	cancer	NOUN
x346d221g19	13	11	,	,	PUNCT
x346d221g19	13	12	with	with	ADP
x346d221g19	13	13	a	a	DET
x346d221g19	13	14	combination	combination	NOUN
x346d221g19	13	15	of	of	ADP
x346d221g19	13	16	nontargeted	nontargete	VERB
x346d221g19	13	17	(	(	PUNCT
x346d221g19	13	18	np	np	PROPN
x346d221g19	13	19	)	)	PUNCT
x346d221g19	13	20	and	and	CCONJ
x346d221g19	13	21	grp78	grp78	PROPN
x346d221g19	13	22	-	-	PUNCT
x346d221g19	13	23	targeted	target	VERB
x346d221g19	13	24	(	(	PUNCT
x346d221g19	13	25	tnpgrp78pep	tnpgrp78pep	PROPN
x346d221g19	13	26	)	)	PUNCT
x346d221g19	13	27	nanoparticles	nanoparticle	NOUN
x346d221g19	13	28	displaying	display	VERB
x346d221g19	13	29	optimal	optimal	ADJ
x346d221g19	13	30	drug	drug	NOUN
x346d221g19	13	31	delivery	delivery	NOUN
x346d221g19	13	32	of	of	ADP
x346d221g19	13	33	a	a	DET
x346d221g19	13	34	novel	novel	ADJ
x346d221g19	13	35	dm1	dm1	NOUN
x346d221g19	13	36	-	-	PUNCT
x346d221g19	13	37	prodrug	prodrug	NOUN
x346d221g19	13	38	in	in	ADP
x346d221g19	13	39	vivo	vivo	PROPN
x346d221g19	13	40	.	.	PUNCT
x346d221g19	14	1	further	far	ADV
x346d221g19	14	2	,	,	PUNCT
x346d221g19	14	3	the	the	DET
x346d221g19	14	4	prodrug	prodrug	NOUN
x346d221g19	14	5	-	-	PUNCT
x346d221g19	14	6	loaded	load	VERB
x346d221g19	14	7	nanoparticles	nanoparticle	NOUN
x346d221g19	14	8	enhance	enhance	VERB
x346d221g19	14	9	immune	immune	ADJ
x346d221g19	14	10	cell	cell	NOUN
x346d221g19	14	11	involvement	involvement	NOUN
x346d221g19	14	12	.	.	PUNCT
x346d221g19	15	1	we	we	PRON
x346d221g19	15	2	propose	propose	VERB
x346d221g19	15	3	two	two	NUM
x346d221g19	15	4	mechanisms	mechanism	NOUN
x346d221g19	15	5	of	of	ADP
x346d221g19	15	6	action	action	NOUN
x346d221g19	15	7	for	for	ADP
x346d221g19	15	8	the	the	DET
x346d221g19	15	9	np	np	PROPN
x346d221g19	15	10	and	and	CCONJ
x346d221g19	15	11	tnpgrp78pep	tnpgrp78pep	PROPN
x346d221g19	15	12	components	component	NOUN
x346d221g19	15	13	to	to	PART
x346d221g19	15	14	function	function	VERB
x346d221g19	15	15	synergistically	synergistically	ADV
x346d221g19	15	16	,	,	PUNCT
x346d221g19	15	17	which	which	PRON
x346d221g19	15	18	are	be	AUX
x346d221g19	15	19	largely	largely	ADV
x346d221g19	15	20	dependent	dependent	ADJ
x346d221g19	15	21	on	on	ADP
x346d221g19	15	22	their	their	PRON
x346d221g19	15	23	multivalent	multivalent	ADJ
x346d221g19	15	24	targeting	targeting	NOUN
x346d221g19	15	25	or	or	CCONJ
x346d221g19	15	26	lack	lack	NOUN
x346d221g19	15	27	thereof	thereof	ADV
x346d221g19	15	28	.	.	PUNCT
x346d221g19	16	1	these	these	DET
x346d221g19	16	2	chapters	chapter	NOUN
x346d221g19	16	3	demonstrate	demonstrate	VERB
x346d221g19	16	4	the	the	DET
x346d221g19	16	5	complexity	complexity	NOUN
x346d221g19	16	6	of	of	ADP
x346d221g19	16	7	optimizing	optimize	VERB
x346d221g19	16	8	multivalent	multivalent	ADJ
x346d221g19	16	9	nanomedicines	nanomedicine	NOUN
x346d221g19	16	10	in	in	ADP
x346d221g19	16	11	vivo	vivo	PROPN
x346d221g19	16	12	.	.	PUNCT
x346d221g19	17	1	collectively	collectively	ADV
x346d221g19	17	2	,	,	PUNCT
x346d221g19	17	3	this	this	DET
x346d221g19	17	4	dissertation	dissertation	NOUN
x346d221g19	17	5	emphasizes	emphasize	VERB
x346d221g19	17	6	the	the	DET
x346d221g19	17	7	necessity	necessity	NOUN
x346d221g19	17	8	of	of	ADP
x346d221g19	17	9	a	a	DET
x346d221g19	17	10	detailed	detailed	ADJ
x346d221g19	17	11	understanding	understanding	NOUN
x346d221g19	17	12	of	of	ADP
x346d221g19	17	13	the	the	DET
x346d221g19	17	14	diseases	disease	NOUN
x346d221g19	17	15	of	of	ADP
x346d221g19	17	16	interest	interest	NOUN
x346d221g19	17	17	and	and	CCONJ
x346d221g19	17	18	of	of	ADP
x346d221g19	17	19	systematically	systematically	ADV
x346d221g19	17	20	optimizing	optimize	VERB
x346d221g19	17	21	multivalent	multivalent	ADJ
x346d221g19	17	22	nanomedicine	nanomedicine	NOUN
x346d221g19	17	23	designs	design	NOUN
x346d221g19	17	24	to	to	PART
x346d221g19	17	25	fit	fit	VERB
x346d221g19	17	26	the	the	DET
x346d221g19	17	27	disease	disease	NOUN
x346d221g19	17	28	.	.	PUNCT