id sid tid token lemma pos ww72b853r0x 1 1 increasing increase VERB ww72b853r0x 1 2 shortages shortage NOUN ww72b853r0x 1 3 of of ADP ww72b853r0x 1 4 human human ADJ ww72b853r0x 1 5 red red ADJ ww72b853r0x 1 6 blood blood NOUN ww72b853r0x 1 7 cells cell NOUN ww72b853r0x 1 8 ( ( PUNCT ww72b853r0x 1 9 hrbc hrbc INTJ ww72b853r0x 1 10 ) ) PUNCT ww72b853r0x 1 11 donations donation NOUN ww72b853r0x 1 12 is be AUX ww72b853r0x 1 13 making make VERB ww72b853r0x 1 14 the the DET ww72b853r0x 1 15 supply supply NOUN ww72b853r0x 1 16 for for ADP ww72b853r0x 1 17 transfusions transfusion NOUN ww72b853r0x 1 18 scarce scarce ADJ ww72b853r0x 1 19 and and CCONJ ww72b853r0x 1 20 expensive expensive ADJ ww72b853r0x 1 21 . . PUNCT ww72b853r0x 2 1 investigations investigation NOUN ww72b853r0x 2 2 are be AUX ww72b853r0x 2 3 ongoing ongoing ADJ ww72b853r0x 2 4 to to PART ww72b853r0x 2 5 find find VERB ww72b853r0x 2 6 acceptable acceptable ADJ ww72b853r0x 2 7 oxygen oxygen NOUN ww72b853r0x 2 8 therapeutics therapeutic NOUN ww72b853r0x 2 9 from from ADP ww72b853r0x 2 10 hemoglobin hemoglobin NOUN ww72b853r0x 2 11 modifications modification NOUN ww72b853r0x 2 12 , , PUNCT ww72b853r0x 2 13 but but CCONJ ww72b853r0x 2 14 they they PRON ww72b853r0x 2 15 have have VERB ww72b853r0x 2 16 many many ADJ ww72b853r0x 2 17 side side NOUN ww72b853r0x 2 18 affects affect NOUN ww72b853r0x 2 19 and and CCONJ ww72b853r0x 2 20 are be AUX ww72b853r0x 2 21 not not PART ww72b853r0x 2 22 able able ADJ ww72b853r0x 2 23 to to PART ww72b853r0x 2 24 replace replace VERB ww72b853r0x 2 25 red red ADJ ww72b853r0x 2 26 blood blood NOUN ww72b853r0x 2 27 cell cell NOUN ww72b853r0x 2 28 transfusions transfusion NOUN ww72b853r0x 2 29 . . PUNCT ww72b853r0x 3 1 methoxypolyethylene methoxypolyethylene PROPN ww72b853r0x 3 2 glycol glycol PROPN ww72b853r0x 3 3 ( ( PUNCT ww72b853r0x 3 4 mpeg mpeg NOUN ww72b853r0x 3 5 ) ) PUNCT ww72b853r0x 3 6 covalently covalently ADV ww72b853r0x 3 7 bound bind VERB ww72b853r0x 3 8 to to ADP ww72b853r0x 3 9 the the DET ww72b853r0x 3 10 surface surface NOUN ww72b853r0x 3 11 of of ADP ww72b853r0x 3 12 hrbcs hrbcs NOUN ww72b853r0x 3 13 has have AUX ww72b853r0x 3 14 been be AUX ww72b853r0x 3 15 shown show VERB ww72b853r0x 3 16 to to PART ww72b853r0x 3 17 decrease decrease VERB ww72b853r0x 3 18 immunological immunological ADJ ww72b853r0x 3 19 recognition recognition NOUN ww72b853r0x 3 20 of of ADP ww72b853r0x 3 21 hrbc hrbc PROPN ww72b853r0x 3 22 surface surface NOUN ww72b853r0x 3 23 antigens antigen NOUN ww72b853r0x 3 24 . . PUNCT ww72b853r0x 4 1 the the DET ww72b853r0x 4 2 goal goal NOUN ww72b853r0x 4 3 of of ADP ww72b853r0x 4 4 this this DET ww72b853r0x 4 5 study study NOUN ww72b853r0x 4 6 is be AUX ww72b853r0x 4 7 to to PART ww72b853r0x 4 8 similarly similarly ADV ww72b853r0x 4 9 pegylate pegylate VERB ww72b853r0x 4 10 the the DET ww72b853r0x 4 11 surface surface NOUN ww72b853r0x 4 12 of of ADP ww72b853r0x 4 13 bovine bovine NOUN ww72b853r0x 4 14 rbcs rbcs NOUN ww72b853r0x 4 15 ( ( PUNCT ww72b853r0x 4 16 brbcs brbc NOUN ww72b853r0x 4 17 ) ) PUNCT ww72b853r0x 4 18 to to PART ww72b853r0x 4 19 reduce reduce VERB ww72b853r0x 4 20 the the DET ww72b853r0x 4 21 demand demand NOUN ww72b853r0x 4 22 on on ADP ww72b853r0x 4 23 human human ADJ ww72b853r0x 4 24 blood blood NOUN ww72b853r0x 4 25 donations donation NOUN ww72b853r0x 4 26 needed need VERB ww72b853r0x 4 27 for for ADP ww72b853r0x 4 28 blood blood NOUN ww72b853r0x 4 29 transfusions transfusion NOUN ww72b853r0x 4 30 . . PUNCT ww72b853r0x 5 1 this this DET ww72b853r0x 5 2 study study NOUN ww72b853r0x 5 3 investigates investigate VERB ww72b853r0x 5 4 the the DET ww72b853r0x 5 5 feasibility feasibility NOUN ww72b853r0x 5 6 of of ADP ww72b853r0x 5 7 conjugating conjugate VERB ww72b853r0x 5 8 the the DET ww72b853r0x 5 9 20 20 NUM ww72b853r0x 5 10 kda kda PROPN ww72b853r0x 5 11 succinimidyl succinimidyl PROPN ww72b853r0x 5 12 ester ester NOUN ww72b853r0x 5 13 of of ADP ww72b853r0x 5 14 mpeg mpeg PROPN ww72b853r0x 5 15 propionic propionic ADJ ww72b853r0x 5 16 acid acid NOUN ww72b853r0x 5 17 ( ( PUNCT ww72b853r0x 5 18 spa spa NOUN ww72b853r0x 5 19 - - PUNCT ww72b853r0x 5 20 mpeg mpeg NOUN ww72b853r0x 5 21 ) ) PUNCT ww72b853r0x 5 22 to to ADP ww72b853r0x 5 23 the the DET ww72b853r0x 5 24 brbc brbc PROPN ww72b853r0x 5 25 's 's PART ww72b853r0x 5 26 surface surface NOUN ww72b853r0x 5 27 for for ADP ww72b853r0x 5 28 use use NOUN ww72b853r0x 5 29 as as ADP ww72b853r0x 5 30 an an DET ww72b853r0x 5 31 oxygen oxygen NOUN ww72b853r0x 5 32 therapeutic therapeutic NOUN ww72b853r0x 5 33 . . PUNCT ww72b853r0x 6 1 it it PRON ww72b853r0x 6 2 was be AUX ww72b853r0x 6 3 found find VERB ww72b853r0x 6 4 that that SCONJ ww72b853r0x 6 5 spa spa NOUN ww72b853r0x 6 6 - - PUNCT ww72b853r0x 6 7 mpeg mpeg NOUN ww72b853r0x 6 8 reacts react VERB ww72b853r0x 6 9 with with ADP ww72b853r0x 6 10 brbcs brbc NOUN ww72b853r0x 6 11 in in ADP ww72b853r0x 6 12 a a DET ww72b853r0x 6 13 dose dose NOUN ww72b853r0x 6 14 dependent dependent ADJ ww72b853r0x 6 15 manner manner NOUN ww72b853r0x 6 16 . . PUNCT ww72b853r0x 7 1 the the DET ww72b853r0x 7 2 overall overall ADJ ww72b853r0x 7 3 oxygen oxygen NOUN ww72b853r0x 7 4 binding bind VERB ww72b853r0x 7 5 affinity affinity NOUN ww72b853r0x 7 6 of of ADP ww72b853r0x 7 7 pegylated pegylated ADJ ww72b853r0x 7 8 brbcs brbc NOUN ww72b853r0x 7 9 was be AUX ww72b853r0x 7 10 moderately moderately ADV ww72b853r0x 7 11 increased increase VERB ww72b853r0x 7 12 with with ADP ww72b853r0x 7 13 greater great ADJ ww72b853r0x 7 14 initial initial ADJ ww72b853r0x 7 15 spa spa NOUN ww72b853r0x 7 16 - - PUNCT ww72b853r0x 7 17 mpeg mpeg NOUN ww72b853r0x 7 18 concentrations concentration NOUN ww72b853r0x 7 19 when when SCONJ ww72b853r0x 7 20 reacted react VERB ww72b853r0x 7 21 with with ADP ww72b853r0x 7 22 brbcs brbc NOUN ww72b853r0x 7 23 . . PUNCT ww72b853r0x 8 1 control control NOUN ww72b853r0x 8 2 brbcs brbc NOUN ww72b853r0x 8 3 exhibited exhibit VERB ww72b853r0x 8 4 a a DET ww72b853r0x 8 5 p50 p50 NOUN ww72b853r0x 8 6 of of ADP ww72b853r0x 8 7 ~28 ~28 PROPN ww72b853r0x 8 8 mmhg mmhg NOUN ww72b853r0x 8 9 , , PUNCT ww72b853r0x 8 10 while while SCONJ ww72b853r0x 8 11 brbcs brbc NOUN ww72b853r0x 8 12 reacted react VERB ww72b853r0x 8 13 at at ADP ww72b853r0x 8 14 6 6 NUM ww72b853r0x 8 15 mm mm PROPN ww72b853r0x 8 16 spa spa NOUN ww72b853r0x 8 17 - - PUNCT ww72b853r0x 8 18 mpeg mpeg NOUN ww72b853r0x 8 19 exhibited exhibit VERB ww72b853r0x 8 20 a a DET ww72b853r0x 8 21 reduced reduce VERB ww72b853r0x 8 22 p50 p50 ADJ ww72b853r0x 8 23 ~21 ~21 ADJ ww72b853r0x 8 24 mmhg mmhg NOUN ww72b853r0x 8 25 . . PUNCT ww72b853r0x 9 1 oxygen oxygen NOUN ww72b853r0x 9 2 transport transport NOUN ww72b853r0x 9 3 simulations simulation NOUN ww72b853r0x 9 4 modeling model VERB ww72b853r0x 9 5 the the DET ww72b853r0x 9 6 o2 o2 ADJ ww72b853r0x 9 7 distribution distribution NOUN ww72b853r0x 9 8 within within ADP ww72b853r0x 9 9 the the DET ww72b853r0x 9 10 capillary capillary ADJ ww72b853r0x 9 11 and and CCONJ ww72b853r0x 9 12 tissue tissue NOUN ww72b853r0x 9 13 space space NOUN ww72b853r0x 9 14 were be AUX ww72b853r0x 9 15 conducted conduct VERB ww72b853r0x 9 16 to to PART ww72b853r0x 9 17 insure insure VERB ww72b853r0x 9 18 that that SCONJ ww72b853r0x 9 19 pegylated pegylate VERB ww72b853r0x 9 20 brbcs brbc NOUN ww72b853r0x 9 21 were be AUX ww72b853r0x 9 22 capable capable ADJ ww72b853r0x 9 23 of of ADP ww72b853r0x 9 24 delivering deliver VERB ww72b853r0x 9 25 o2 o2 PROPN ww72b853r0x 9 26 to to ADP ww72b853r0x 9 27 tissues tissue NOUN ww72b853r0x 9 28 . . PUNCT ww72b853r0x 10 1 these these DET ww72b853r0x 10 2 simulations simulation NOUN ww72b853r0x 10 3 showed show VERB ww72b853r0x 10 4 that that SCONJ ww72b853r0x 10 5 spa spa NOUN ww72b853r0x 10 6 - - PUNCT ww72b853r0x 10 7 mpeg mpeg NOUN ww72b853r0x 10 8 conjugated conjugate VERB ww72b853r0x 10 9 cells cell NOUN ww72b853r0x 10 10 could could AUX ww72b853r0x 10 11 still still ADV ww72b853r0x 10 12 transport transport VERB ww72b853r0x 10 13 vital vital ADJ ww72b853r0x 10 14 o2 o2 PROPN ww72b853r0x 10 15 to to ADP ww72b853r0x 10 16 pancreatic pancreatic ADJ ww72b853r0x 10 17 islet islet NOUN ww72b853r0x 10 18 tissues tissue NOUN ww72b853r0x 10 19 and and CCONJ ww72b853r0x 10 20 maintain maintain VERB ww72b853r0x 10 21 the the DET ww72b853r0x 10 22 tissue tissue NOUN ww72b853r0x 10 23 's 's PART ww72b853r0x 10 24 o2 o2 ADJ ww72b853r0x 10 25 tension tension NOUN ww72b853r0x 10 26 above above ADP ww72b853r0x 10 27 hypoxic hypoxic NOUN ww72b853r0x 10 28 levels level NOUN ww72b853r0x 10 29 even even ADV ww72b853r0x 10 30 under under ADP ww72b853r0x 10 31 extreme extreme ADJ ww72b853r0x 10 32 conditions condition NOUN ww72b853r0x 10 33 . . PUNCT ww72b853r0x 11 1 pegylated pegylated ADJ ww72b853r0x 11 2 brbcs brbc NOUN ww72b853r0x 11 3 reconstituted reconstitute VERB ww72b853r0x 11 4 to to ADP ww72b853r0x 11 5 a a DET ww72b853r0x 11 6 physiological physiological ADJ ww72b853r0x 11 7 hematocrit hematocrit NOUN ww72b853r0x 11 8 of of ADP ww72b853r0x 11 9 40 40 NUM ww72b853r0x 11 10 % % NOUN ww72b853r0x 11 11 exhibited exhibit VERB ww72b853r0x 11 12 viscosities viscosity NOUN ww72b853r0x 11 13 on on ADP ww72b853r0x 11 14 the the DET ww72b853r0x 11 15 order order NOUN ww72b853r0x 11 16 of of ADP ww72b853r0x 11 17 ~ ~ PROPN ww72b853r0x 11 18 3 3 NUM ww72b853r0x 11 19 cp cp NOUN ww72b853r0x 11 20 , , PUNCT ww72b853r0x 11 21 similar similar ADJ ww72b853r0x 11 22 to to ADP ww72b853r0x 11 23 hrbcs hrbc NOUN ww72b853r0x 11 24 . . PUNCT ww72b853r0x 12 1 finally finally ADV ww72b853r0x 12 2 , , PUNCT ww72b853r0x 12 3 pegylated pegylated ADJ ww72b853r0x 12 4 brbcs brbc NOUN ww72b853r0x 12 5 exhibited exhibit VERB ww72b853r0x 12 6 similar similar ADJ ww72b853r0x 12 7 glass glass NOUN ww72b853r0x 12 8 capillary capillary ADJ ww72b853r0x 12 9 flow flow NOUN ww72b853r0x 12 10 characteristics characteristic NOUN ww72b853r0x 12 11 indicating indicate VERB ww72b853r0x 12 12 pegylated pegylated ADJ ww72b853r0x 12 13 brbcs brbc NOUN ww72b853r0x 12 14 retain retain VERB ww72b853r0x 12 15 most most ADJ ww72b853r0x 12 16 of of ADP ww72b853r0x 12 17 their their PRON ww72b853r0x 12 18 deformability deformability NOUN ww72b853r0x 12 19 . . PUNCT ww72b853r0x 13 1 altogether altogether ADV ww72b853r0x 13 2 , , PUNCT ww72b853r0x 13 3 this this PRON ww72b853r0x 13 4 shows show VERB ww72b853r0x 13 5 that that SCONJ ww72b853r0x 13 6 mpeg mpeg NOUN ww72b853r0x 13 7 - - PUNCT ww72b853r0x 13 8 brbcs brbc NOUN ww72b853r0x 13 9 are be AUX ww72b853r0x 13 10 physically physically ADV ww72b853r0x 13 11 capable capable ADJ ww72b853r0x 13 12 as as ADP ww72b853r0x 13 13 an an DET ww72b853r0x 13 14 oxygen oxygen NOUN ww72b853r0x 13 15 therapeutic therapeutic NOUN ww72b853r0x 13 16 . . PUNCT ww72b853r0x 14 1 unfortunately unfortunately ADV ww72b853r0x 14 2 , , PUNCT ww72b853r0x 14 3 pegylation pegylation NOUN ww72b853r0x 14 4 was be AUX ww72b853r0x 14 5 not not PART ww72b853r0x 14 6 able able ADJ ww72b853r0x 14 7 to to PART ww72b853r0x 14 8 attenuate attenuate VERB ww72b853r0x 14 9 the the DET ww72b853r0x 14 10 human human ADJ ww72b853r0x 14 11 immune immune ADJ ww72b853r0x 14 12 system system NOUN ww72b853r0x 14 13 response response NOUN ww72b853r0x 14 14 . . PUNCT ww72b853r0x 15 1 flow flow VERB ww72b853r0x 15 2 cytometry cytometry NOUN ww72b853r0x 15 3 experiments experiment NOUN ww72b853r0x 15 4 demonstrated demonstrate VERB ww72b853r0x 15 5 that that SCONJ ww72b853r0x 15 6 igg igg NOUN ww72b853r0x 15 7 and and CCONJ ww72b853r0x 15 8 igm igm NOUN ww72b853r0x 15 9 in in ADP ww72b853r0x 15 10 human human ADJ ww72b853r0x 15 11 serum serum NOUN ww72b853r0x 15 12 and and CCONJ ww72b853r0x 15 13 gs gs PROPN ww72b853r0x 15 14 - - NOUN ww72b853r0x 15 15 ib4 ib4 PROPN ww72b853r0x 15 16 were be AUX ww72b853r0x 15 17 still still ADV ww72b853r0x 15 18 able able ADJ ww72b853r0x 15 19 to to PART ww72b853r0x 15 20 recognize recognize VERB ww72b853r0x 15 21 exposed expose VERB ww72b853r0x 15 22 xenoantigens xenoantigen NOUN ww72b853r0x 15 23 and and CCONJ ww72b853r0x 15 24 aggregate aggregate VERB ww72b853r0x 15 25 the the DET ww72b853r0x 15 26 mpeg mpeg NOUN ww72b853r0x 15 27 - - PUNCT ww72b853r0x 15 28 brbcs brbc NOUN ww72b853r0x 15 29 . . PUNCT ww72b853r0x 16 1 therefore therefore ADV ww72b853r0x 16 2 , , PUNCT ww72b853r0x 16 3 this this DET ww72b853r0x 16 4 method method NOUN ww72b853r0x 16 5 of of ADP ww72b853r0x 16 6 pegylation pegylation NOUN ww72b853r0x 16 7 is be AUX ww72b853r0x 16 8 not not PART ww72b853r0x 16 9 recommended recommend VERB ww72b853r0x 16 10 to to PART ww72b853r0x 16 11 create create VERB ww72b853r0x 16 12 an an DET ww72b853r0x 16 13 oxygen oxygen NOUN ww72b853r0x 16 14 therapeutic therapeutic NOUN ww72b853r0x 16 15 . . PUNCT ww72b853r0x 17 1 future future ADJ ww72b853r0x 17 2 studies study NOUN ww72b853r0x 17 3 to to PART ww72b853r0x 17 4 knock knock VERB ww72b853r0x 17 5 out out ADP ww72b853r0x 17 6 this this DET ww72b853r0x 17 7 primary primary ADJ ww72b853r0x 17 8 xenoantigen xenoantigen PROPN ww72b853r0x 17 9 expression expression NOUN ww72b853r0x 17 10 with with ADP ww72b853r0x 17 11 sirnas sirna NOUN ww72b853r0x 17 12 are be AUX ww72b853r0x 17 13 recommended recommend VERB ww72b853r0x 17 14 to to PART ww72b853r0x 17 15 create create VERB ww72b853r0x 17 16 a a DET ww72b853r0x 17 17 universal universal ADJ ww72b853r0x 17 18 oxygen oxygen NOUN ww72b853r0x 17 19 therapeutic therapeutic NOUN ww72b853r0x 17 20 from from ADP ww72b853r0x 17 21 brbcs brbc NOUN ww72b853r0x 17 22 . . PUNCT