id sid tid token lemma pos ww72b853p7q 1 1 leishmaniases leishmaniases PROPN ww72b853p7q 1 2 is be AUX ww72b853p7q 1 3 a a DET ww72b853p7q 1 4 group group NOUN ww72b853p7q 1 5 of of ADP ww72b853p7q 1 6 vector vector NOUN ww72b853p7q 1 7 borne bear VERB ww72b853p7q 1 8 parasitic parasitic ADJ ww72b853p7q 1 9 diseases disease NOUN ww72b853p7q 1 10 that that PRON ww72b853p7q 1 11 affects affect VERB ww72b853p7q 1 12 approximately approximately ADV ww72b853p7q 1 13 12 12 NUM ww72b853p7q 1 14 million million NUM ww72b853p7q 1 15 people people NOUN ww72b853p7q 1 16 worldwide worldwide ADV ww72b853p7q 1 17 and and CCONJ ww72b853p7q 1 18 results result NOUN ww72b853p7q 1 19 in in ADP ww72b853p7q 1 20 diverse diverse ADJ ww72b853p7q 1 21 clinical clinical ADJ ww72b853p7q 1 22 pathologies pathology NOUN ww72b853p7q 1 23 , , PUNCT ww72b853p7q 1 24 the the DET ww72b853p7q 1 25 initiating initiate VERB ww72b853p7q 1 26 species specie NOUN ww72b853p7q 1 27 often often ADV ww72b853p7q 1 28 dictates dictate VERB ww72b853p7q 1 29 these these DET ww72b853p7q 1 30 disease disease NOUN ww72b853p7q 1 31 outcomes outcome NOUN ww72b853p7q 1 32 . . PUNCT ww72b853p7q 2 1 visceral visceral ADJ ww72b853p7q 2 2 leishmaniasis leishmaniasis NOUN ww72b853p7q 2 3 , , PUNCT ww72b853p7q 2 4 the the DET ww72b853p7q 2 5 fatal fatal ADJ ww72b853p7q 2 6 form form NOUN ww72b853p7q 2 7 of of ADP ww72b853p7q 2 8 the the DET ww72b853p7q 2 9 disease disease NOUN ww72b853p7q 2 10 , , PUNCT ww72b853p7q 2 11 results result VERB ww72b853p7q 2 12 from from ADP ww72b853p7q 2 13 infection infection NOUN ww72b853p7q 2 14 with with ADP ww72b853p7q 2 15 leishmania leishmania PROPN ww72b853p7q 2 16 donovani donovani PROPN ww72b853p7q 2 17 parasites parasite NOUN ww72b853p7q 2 18 while while SCONJ ww72b853p7q 2 19 cutaneous cutaneous ADJ ww72b853p7q 2 20 leishmaniasis leishmaniasis NOUN ww72b853p7q 2 21 generally generally ADV ww72b853p7q 2 22 develops develop VERB ww72b853p7q 2 23 following follow VERB ww72b853p7q 2 24 infection infection NOUN ww72b853p7q 2 25 with with ADP ww72b853p7q 2 26 leishmania leishmania PROPN ww72b853p7q 2 27 major major ADJ ww72b853p7q 2 28 parasites parasite NOUN ww72b853p7q 2 29 . . PUNCT ww72b853p7q 3 1 in in ADP ww72b853p7q 3 2 the the DET ww72b853p7q 3 3 majority majority NOUN ww72b853p7q 3 4 of of ADP ww72b853p7q 3 5 l. l. PROPN ww72b853p7q 3 6 major major ADJ ww72b853p7q 3 7 cases case NOUN ww72b853p7q 3 8 , , PUNCT ww72b853p7q 3 9 lesions lesion NOUN ww72b853p7q 3 10 heal heal VERB ww72b853p7q 3 11 within within ADP ww72b853p7q 3 12 several several ADJ ww72b853p7q 3 13 months month NOUN ww72b853p7q 3 14 and and CCONJ ww72b853p7q 3 15 provide provide VERB ww72b853p7q 3 16 life life NOUN ww72b853p7q 3 17 - - PUNCT ww72b853p7q 3 18 long long ADJ ww72b853p7q 3 19 immunity immunity NOUN ww72b853p7q 3 20 pending pende VERB ww72b853p7q 3 21 re re NOUN ww72b853p7q 3 22 - - NOUN ww72b853p7q 3 23 introduction introduction NOUN ww72b853p7q 3 24 of of ADP ww72b853p7q 3 25 the the DET ww72b853p7q 3 26 disease disease NOUN ww72b853p7q 3 27 . . PUNCT ww72b853p7q 4 1 the the DET ww72b853p7q 4 2 source source NOUN ww72b853p7q 4 3 of of ADP ww72b853p7q 4 4 this this DET ww72b853p7q 4 5 protective protective ADJ ww72b853p7q 4 6 immunity immunity NOUN ww72b853p7q 4 7 to to ADP ww72b853p7q 4 8 leishmaniasis leishmaniasis NOUN ww72b853p7q 4 9 is be AUX ww72b853p7q 4 10 largely largely ADV ww72b853p7q 4 11 influenced influence VERB ww72b853p7q 4 12 by by ADP ww72b853p7q 4 13 host host NOUN ww72b853p7q 4 14 cellular cellular ADJ ww72b853p7q 4 15 events event NOUN ww72b853p7q 4 16 leading lead VERB ww72b853p7q 4 17 to to ADP ww72b853p7q 4 18 a a DET ww72b853p7q 4 19 robust robust ADJ ww72b853p7q 4 20 il-12 il-12 PROPN ww72b853p7q 4 21 driven drive VERB ww72b853p7q 4 22 t t NOUN ww72b853p7q 4 23 - - PUNCT ww72b853p7q 4 24 helper helper NOUN ww72b853p7q 4 25 1 1 NUM ww72b853p7q 4 26 ( ( PUNCT ww72b853p7q 4 27 th1 th1 NOUN ww72b853p7q 4 28 ) ) PUNCT ww72b853p7q 4 29 mediated mediate VERB ww72b853p7q 4 30 response response NOUN ww72b853p7q 4 31 that that PRON ww72b853p7q 4 32 produces produce VERB ww72b853p7q 4 33 high high ADJ ww72b853p7q 4 34 levels level NOUN ww72b853p7q 4 35 of of ADP ww72b853p7q 4 36 ifn-γ ifn-γ PROPN ww72b853p7q 4 37 ; ; PUNCT ww72b853p7q 4 38 which which PRON ww72b853p7q 4 39 ultimately ultimately ADV ww72b853p7q 4 40 promotes promote VERB ww72b853p7q 4 41 antimicrobicidal antimicrobicidal ADJ ww72b853p7q 4 42 production production NOUN ww72b853p7q 4 43 of of ADP ww72b853p7q 4 44 nitric nitric NOUN ww72b853p7q 4 45 oxide oxide NOUN ww72b853p7q 4 46 ( ( PUNCT ww72b853p7q 4 47 no no INTJ ww72b853p7q 4 48 ) ) PUNCT ww72b853p7q 4 49 and and CCONJ ww72b853p7q 4 50 reactive reactive ADJ ww72b853p7q 4 51 oxygen oxygen NOUN ww72b853p7q 4 52 species specie NOUN ww72b853p7q 4 53 ( ( PUNCT ww72b853p7q 4 54 ros ros PROPN ww72b853p7q 4 55 ) ) PUNCT ww72b853p7q 4 56 that that PRON ww72b853p7q 4 57 destroy destroy VERB ww72b853p7q 4 58 invading invading NOUN ww72b853p7q 4 59 pathogens pathogen NOUN ww72b853p7q 4 60 . . PUNCT ww72b853p7q 5 1 macrophages macrophage NOUN ww72b853p7q 5 2 ( ( PUNCT ww72b853p7q 5 3 mps mps PROPN ww72b853p7q 5 4 ) ) PUNCT ww72b853p7q 5 5 and and CCONJ ww72b853p7q 5 6 dendritic dendritic ADJ ww72b853p7q 5 7 cells cell NOUN ww72b853p7q 5 8 ( ( PUNCT ww72b853p7q 5 9 dcs dcs PROPN ww72b853p7q 5 10 ) ) PUNCT ww72b853p7q 5 11 are be AUX ww72b853p7q 5 12 major major ADJ ww72b853p7q 5 13 producers producer NOUN ww72b853p7q 5 14 of of ADP ww72b853p7q 5 15 il-12 il-12 PROPN ww72b853p7q 5 16 . . PUNCT ww72b853p7q 6 1 in in ADP ww72b853p7q 6 2 this this DET ww72b853p7q 6 3 work work NOUN ww72b853p7q 6 4 , , PUNCT ww72b853p7q 6 5 the the DET ww72b853p7q 6 6 overall overall ADJ ww72b853p7q 6 7 goal goal NOUN ww72b853p7q 6 8 of of ADP ww72b853p7q 6 9 my my PRON ww72b853p7q 6 10 research research NOUN ww72b853p7q 6 11 dissertation dissertation NOUN ww72b853p7q 6 12 was be AUX ww72b853p7q 6 13 to to PART ww72b853p7q 6 14 investigate investigate VERB ww72b853p7q 6 15 the the DET ww72b853p7q 6 16 role role NOUN ww72b853p7q 6 17 of of ADP ww72b853p7q 6 18 both both DET ww72b853p7q 6 19 host host NOUN ww72b853p7q 6 20 cell cell NOUN ww72b853p7q 6 21 and and CCONJ ww72b853p7q 6 22 pathogenic pathogenic ADJ ww72b853p7q 6 23 features feature NOUN ww72b853p7q 6 24 that that PRON ww72b853p7q 6 25 contribute contribute VERB ww72b853p7q 6 26 to to ADP ww72b853p7q 6 27 the the DET ww72b853p7q 6 28 il-12 il-12 NOUN ww72b853p7q 6 29 response response NOUN ww72b853p7q 6 30 elicited elicit VERB ww72b853p7q 6 31 during during ADP ww72b853p7q 6 32 leishmania leishmania PROPN ww72b853p7q 6 33 infection infection NOUN ww72b853p7q 6 34 . . PUNCT ww72b853p7q 7 1 to to ADP ww72b853p7q 7 2 this this DET ww72b853p7q 7 3 end end NOUN ww72b853p7q 7 4 in in ADP ww72b853p7q 7 5 vitro vitro X ww72b853p7q 7 6 mp mp PROPN ww72b853p7q 7 7 and and CCONJ ww72b853p7q 7 8 dc dc PROPN ww72b853p7q 7 9 infection infection NOUN ww72b853p7q 7 10 assays assay NOUN ww72b853p7q 7 11 coupled couple VERB ww72b853p7q 7 12 with with ADP ww72b853p7q 7 13 host host NOUN ww72b853p7q 7 14 cell cell PROPN ww72b853p7q 7 15 microarray microarray PROPN ww72b853p7q 7 16 based base VERB ww72b853p7q 7 17 technologies technology NOUN ww72b853p7q 7 18 and and CCONJ ww72b853p7q 7 19 molecular molecular ADJ ww72b853p7q 7 20 genetics genetic NOUN ww72b853p7q 7 21 approaches approach NOUN ww72b853p7q 7 22 were be AUX ww72b853p7q 7 23 employed employ VERB ww72b853p7q 7 24 to to PART ww72b853p7q 7 25 address address VERB ww72b853p7q 7 26 the the DET ww72b853p7q 7 27 interplaying interplaye VERB ww72b853p7q 7 28 host host NOUN ww72b853p7q 7 29 and and CCONJ ww72b853p7q 7 30 pathogen pathogen NOUN ww72b853p7q 7 31 determinants determinant VERB ww72b853p7q 7 32 influencing influence VERB ww72b853p7q 7 33 the the DET ww72b853p7q 7 34 il-12 il-12 NOUN ww72b853p7q 7 35 response response NOUN ww72b853p7q 7 36 . . PUNCT ww72b853p7q 8 1 interestingly interestingly ADV ww72b853p7q 8 2 , , PUNCT ww72b853p7q 8 3 previous previous ADJ ww72b853p7q 8 4 studies study NOUN ww72b853p7q 8 5 have have AUX ww72b853p7q 8 6 demonstrated demonstrate VERB ww72b853p7q 8 7 a a DET ww72b853p7q 8 8 general general ADJ ww72b853p7q 8 9 suppression suppression NOUN ww72b853p7q 8 10 of of ADP ww72b853p7q 8 11 il-12 il-12 NOUN ww72b853p7q 8 12 production production NOUN ww72b853p7q 8 13 in in ADP ww72b853p7q 8 14 leishmania leishmania PROPN ww72b853p7q 8 15 infected infect VERB ww72b853p7q 8 16 macrophages macrophage NOUN ww72b853p7q 8 17 that that PRON ww72b853p7q 8 18 is be AUX ww72b853p7q 8 19 tightly tightly ADV ww72b853p7q 8 20 controlled control VERB ww72b853p7q 8 21 at at ADP ww72b853p7q 8 22 the the DET ww72b853p7q 8 23 level level NOUN ww72b853p7q 8 24 of of ADP ww72b853p7q 8 25 il-12p40 il-12p40 PROPN ww72b853p7q 8 26 transcription transcription NOUN ww72b853p7q 8 27 . . PUNCT ww72b853p7q 9 1 in in ADP ww72b853p7q 9 2 chapter chapter NOUN ww72b853p7q 9 3 2 2 NUM ww72b853p7q 9 4 , , PUNCT ww72b853p7q 9 5 we we PRON ww72b853p7q 9 6 demonstrated demonstrate VERB ww72b853p7q 9 7 that that SCONJ ww72b853p7q 9 8 l. l. PROPN ww72b853p7q 9 9 major major ADJ ww72b853p7q 9 10 inhibited inhibited ADJ ww72b853p7q 9 11 promoter promoter NOUN ww72b853p7q 9 12 activity activity NOUN ww72b853p7q 9 13 in in ADP ww72b853p7q 9 14 raw264.7 raw264.7 PROPN ww72b853p7q 9 15 mps mps PROPN ww72b853p7q 9 16 that that PRON ww72b853p7q 9 17 stably stably ADV ww72b853p7q 9 18 express express VERB ww72b853p7q 9 19 ets et NOUN ww72b853p7q 9 20 binding bind VERB ww72b853p7q 9 21 sites site NOUN ww72b853p7q 9 22 in in ADP ww72b853p7q 9 23 the the DET ww72b853p7q 9 24 presence presence NOUN ww72b853p7q 9 25 of of ADP ww72b853p7q 9 26 ( ( PUNCT ww72b853p7q 9 27 ifn-γ ifn-γ PROPN ww72b853p7q 9 28 ;) ;) PROPN ww72b853p7q 9 29 or or CCONJ ww72b853p7q 9 30 lipopolysacchride lipopolysacchride NOUN ww72b853p7q 9 31 ( ( PUNCT ww72b853p7q 9 32 lps lps PROPN ww72b853p7q 9 33 ) ) PUNCT ww72b853p7q 9 34 stimulation stimulation NOUN ww72b853p7q 9 35 , , PUNCT ww72b853p7q 9 36 suggesting suggest VERB ww72b853p7q 9 37 l. l. PROPN ww72b853p7q 9 38 major major PROPN ww72b853p7q 9 39 may may AUX ww72b853p7q 9 40 be be AUX ww72b853p7q 9 41 inhibiting inhibit VERB ww72b853p7q 9 42 macrophage macrophage NOUN ww72b853p7q 9 43 production production NOUN ww72b853p7q 9 44 of of ADP ww72b853p7q 9 45 il-12 il-12 NOUN ww72b853p7q 9 46 by by ADP ww72b853p7q 9 47 specifically specifically ADV ww72b853p7q 9 48 targeting target VERB ww72b853p7q 9 49 the the DET ww72b853p7q 9 50 ets et NOUN ww72b853p7q 9 51 promoter promoter NOUN ww72b853p7q 9 52 element element NOUN ww72b853p7q 9 53 . . PUNCT ww72b853p7q 10 1 remarkably remarkably ADV ww72b853p7q 10 2 , , PUNCT ww72b853p7q 10 3 human human PROPN ww72b853p7q 10 4 dcs dcs X ww72b853p7q 10 5 exhibit exhibit VERB ww72b853p7q 10 6 a a DET ww72b853p7q 10 7 dynamic dynamic ADJ ww72b853p7q 10 8 range range NOUN ww72b853p7q 10 9 in in ADP ww72b853p7q 10 10 il-12 il-12 NOUN ww72b853p7q 10 11 production production NOUN ww72b853p7q 10 12 in in ADP ww72b853p7q 10 13 response response NOUN ww72b853p7q 10 14 to to ADP ww72b853p7q 10 15 leishmania leishmania PROPN ww72b853p7q 10 16 infection infection NOUN ww72b853p7q 10 17 . . PUNCT ww72b853p7q 11 1 il-12 il-12 NOUN ww72b853p7q 11 2 is be AUX ww72b853p7q 11 3 generally generally ADV ww72b853p7q 11 4 enhanced enhance VERB ww72b853p7q 11 5 during during ADP ww72b853p7q 11 6 l. l. PROPN ww72b853p7q 11 7 major major ADJ ww72b853p7q 11 8 infections infection NOUN ww72b853p7q 11 9 , , PUNCT ww72b853p7q 11 10 in in ADP ww72b853p7q 11 11 contrast contrast NOUN ww72b853p7q 11 12 to to ADP ww72b853p7q 11 13 , , PUNCT ww72b853p7q 11 14 l. l. PROPN ww72b853p7q 11 15 donovani donovani PROPN ww72b853p7q 11 16 infections infection NOUN ww72b853p7q 11 17 which which PRON ww72b853p7q 11 18 do do AUX ww72b853p7q 11 19 not not PART ww72b853p7q 11 20 induce induce VERB ww72b853p7q 11 21 il-12 il-12 PROPN ww72b853p7q 11 22 . . PUNCT ww72b853p7q 12 1 in in ADP ww72b853p7q 12 2 chapter chapter NOUN ww72b853p7q 12 3 3 3 NUM ww72b853p7q 12 4 , , PUNCT ww72b853p7q 12 5 our our PRON ww72b853p7q 12 6 microarray microarray X ww72b853p7q 12 7 analysis analysis NOUN ww72b853p7q 12 8 of of ADP ww72b853p7q 12 9 l. l. PROPN ww72b853p7q 12 10 major major PROPN ww72b853p7q 12 11 infected infect VERB ww72b853p7q 12 12 human human PROPN ww72b853p7q 12 13 dcs dcs X ww72b853p7q 12 14 ( ( PUNCT ww72b853p7q 12 15 2 2 NUM ww72b853p7q 12 16 , , PUNCT ww72b853p7q 12 17 4 4 NUM ww72b853p7q 12 18 , , PUNCT ww72b853p7q 12 19 8 8 NUM ww72b853p7q 12 20 , , PUNCT ww72b853p7q 12 21 and and CCONJ ww72b853p7q 12 22 24 24 NUM ww72b853p7q 12 23 hrs hrs NOUN ww72b853p7q 12 24 ) ) PUNCT ww72b853p7q 12 25 revealed reveal VERB ww72b853p7q 12 26 a a DET ww72b853p7q 12 27 distinct distinct ADJ ww72b853p7q 12 28 type type NOUN ww72b853p7q 12 29 i i PRON ww72b853p7q 12 30 ifn ifn ADJ ww72b853p7q 12 31 associated associate VERB ww72b853p7q 12 32 transcriptomic transcriptomic ADJ ww72b853p7q 12 33 signature signature NOUN ww72b853p7q 12 34 including include VERB ww72b853p7q 12 35 upregulation upregulation NOUN ww72b853p7q 12 36 of of ADP ww72b853p7q 12 37 irf2 irf2 NOUN ww72b853p7q 12 38 , , PUNCT ww72b853p7q 12 39 irf7 irf7 PROPN ww72b853p7q 12 40 , , PUNCT ww72b853p7q 12 41 irf9 irf9 PROPN ww72b853p7q 12 42 , , PUNCT ww72b853p7q 12 43 and and CCONJ ww72b853p7q 12 44 stat1/2 stat1/2 PROPN ww72b853p7q 12 45 . . PUNCT ww72b853p7q 13 1 l. l. PROPN ww72b853p7q 13 2 major major PROPN ww72b853p7q 13 3 infected infect VERB ww72b853p7q 13 4 human human PROPN ww72b853p7q 13 5 dcs dcs X ww72b853p7q 13 6 pre pre ADJ ww72b853p7q 13 7 - - VERB ww72b853p7q 13 8 treated treat VERB ww72b853p7q 13 9 with with ADP ww72b853p7q 13 10 a a DET ww72b853p7q 13 11 neutralizing neutralizing ADJ ww72b853p7q 13 12 type type NOUN ww72b853p7q 13 13 i i PRON ww72b853p7q 13 14 ifn ifn ADJ ww72b853p7q 13 15 pathway pathway NOUN ww72b853p7q 13 16 inhibitor inhibitor NOUN ww72b853p7q 13 17 , , PUNCT ww72b853p7q 13 18 b18r b18r SPACE ww72b853p7q 13 19 , , PUNCT ww72b853p7q 13 20 induced induce VERB ww72b853p7q 13 21 fewer few ADJ ww72b853p7q 13 22 il-12p40 il-12p40 PROPN ww72b853p7q 13 23 mrna mrna PROPN ww72b853p7q 13 24 levels level NOUN ww72b853p7q 13 25 . . PUNCT ww72b853p7q 14 1 furthermore furthermore ADV ww72b853p7q 14 2 , , PUNCT ww72b853p7q 14 3 in in ADP ww72b853p7q 14 4 the the DET ww72b853p7q 14 5 context context NOUN ww72b853p7q 14 6 of of ADP ww72b853p7q 14 7 l. l. PROPN ww72b853p7q 14 8 donovani donovani PROPN ww72b853p7q 14 9 infections infection NOUN ww72b853p7q 14 10 type type VERB ww72b853p7q 14 11 i i PRON ww72b853p7q 14 12 ifn ifn ADJ ww72b853p7q 14 13 genes gene VERB ww72b853p7q 14 14 irf2 irf2 ADP ww72b853p7q 14 15 , , PUNCT ww72b853p7q 14 16 irf7 irf7 NOUN ww72b853p7q 14 17 , , PUNCT ww72b853p7q 14 18 and and CCONJ ww72b853p7q 14 19 ifit5 ifit5 PROPN ww72b853p7q 14 20 were be AUX ww72b853p7q 14 21 not not PART ww72b853p7q 14 22 induced induce VERB ww72b853p7q 14 23 , , PUNCT ww72b853p7q 14 24 a a DET ww72b853p7q 14 25 trend trend NOUN ww72b853p7q 14 26 analogous analogous ADJ ww72b853p7q 14 27 to to ADP ww72b853p7q 14 28 the the DET ww72b853p7q 14 29 il-12p40 il-12p40 PROPN ww72b853p7q 14 30 gene gene NOUN ww72b853p7q 14 31 expression expression NOUN ww72b853p7q 14 32 elicited elicit VERB ww72b853p7q 14 33 by by ADP ww72b853p7q 14 34 this this DET ww72b853p7q 14 35 species specie NOUN ww72b853p7q 14 36 . . PUNCT ww72b853p7q 15 1 these these DET ww72b853p7q 15 2 data datum NOUN ww72b853p7q 15 3 indicated indicate VERB ww72b853p7q 15 4 that that SCONJ ww72b853p7q 15 5 the the DET ww72b853p7q 15 6 l. l. PROPN ww72b853p7q 15 7 major major PROPN ww72b853p7q 15 8 induced induce VERB ww72b853p7q 15 9 il-12 il-12 NOUN ww72b853p7q 15 10 response response NOUN ww72b853p7q 15 11 is be AUX ww72b853p7q 15 12 dependent dependent ADJ ww72b853p7q 15 13 upon upon SCONJ ww72b853p7q 15 14 a a DET ww72b853p7q 15 15 type type NOUN ww72b853p7q 15 16 i i PRON ww72b853p7q 15 17 ifn ifn ADJ ww72b853p7q 15 18 response response NOUN ww72b853p7q 15 19 . . PUNCT ww72b853p7q 16 1 in in ADP ww72b853p7q 16 2 chapter chapter NOUN ww72b853p7q 16 3 4 4 NUM ww72b853p7q 16 4 , , PUNCT ww72b853p7q 16 5 we we PRON ww72b853p7q 16 6 investigated investigate VERB ww72b853p7q 16 7 the the DET ww72b853p7q 16 8 role role NOUN ww72b853p7q 16 9 of of ADP ww72b853p7q 16 10 pathogenic pathogenic ADJ ww72b853p7q 16 11 surface surface NOUN ww72b853p7q 16 12 molecules molecule NOUN ww72b853p7q 16 13 on on ADP ww72b853p7q 16 14 the the DET ww72b853p7q 16 15 ' ' PUNCT ww72b853p7q 16 16 highil-12 highil-12 NOUN ww72b853p7q 16 17 inducing induce VERB ww72b853p7q 16 18 ' ' PUNCT ww72b853p7q 16 19 l. l. ADJ ww72b853p7q 16 20 major major ADJ ww72b853p7q 16 21 background background NOUN ww72b853p7q 16 22 strain strain VERB ww72b853p7q 16 23 fv1 fv1 SPACE ww72b853p7q 16 24 . . PUNCT ww72b853p7q 17 1 parasite parasite PROPN ww72b853p7q 17 2 lipophosphoglycan lipophosphoglycan PROPN ww72b853p7q 17 3 ( ( PUNCT ww72b853p7q 17 4 lpg lpg NOUN ww72b853p7q 17 5 ) ) PUNCT ww72b853p7q 17 6 was be AUX ww72b853p7q 17 7 previously previously ADV ww72b853p7q 17 8 characterized characterize VERB ww72b853p7q 17 9 as as ADP ww72b853p7q 17 10 a a DET ww72b853p7q 17 11 virulence virulence NOUN ww72b853p7q 17 12 determinant determinant NOUN ww72b853p7q 17 13 associated associate VERB ww72b853p7q 17 14 with with ADP ww72b853p7q 17 15 subverting subvert VERB ww72b853p7q 17 16 host host NOUN ww72b853p7q 17 17 cell cell NOUN ww72b853p7q 17 18 immune immune ADJ ww72b853p7q 17 19 mechanisms mechanism NOUN ww72b853p7q 17 20 including include VERB ww72b853p7q 17 21 complement complement NOUN ww72b853p7q 17 22 mediated mediate VERB ww72b853p7q 17 23 lysis lysis NOUN ww72b853p7q 17 24 , , PUNCT ww72b853p7q 17 25 phagolysosomal phagolysosomal ADJ ww72b853p7q 17 26 maturation maturation NOUN ww72b853p7q 17 27 , , PUNCT ww72b853p7q 17 28 and and CCONJ ww72b853p7q 17 29 leukocyte leukocyte NOUN ww72b853p7q 17 30 migration migration NOUN ww72b853p7q 17 31 . . PUNCT ww72b853p7q 18 1 lpg lpg NOUN ww72b853p7q 18 2 modulates modulate VERB ww72b853p7q 18 3 cytokine cytokine VERB ww72b853p7q 18 4 secretion secretion NOUN ww72b853p7q 18 5 in in ADP ww72b853p7q 18 6 host host NOUN ww72b853p7q 18 7 cells cell NOUN ww72b853p7q 18 8 , , PUNCT ww72b853p7q 18 9 however however ADV ww72b853p7q 18 10 , , PUNCT ww72b853p7q 18 11 the the DET ww72b853p7q 18 12 role role NOUN ww72b853p7q 18 13 of of ADP ww72b853p7q 18 14 fv1 fv1 NOUN ww72b853p7q 18 15 lpg lpg NOUN ww72b853p7q 18 16 on on ADP ww72b853p7q 18 17 the the DET ww72b853p7q 18 18 human human PROPN ww72b853p7q 18 19 dc dc PROPN ww72b853p7q 18 20 il-12 il-12 PROPN ww72b853p7q 18 21 response response NOUN ww72b853p7q 18 22 remained remain VERB ww72b853p7q 18 23 to to PART ww72b853p7q 18 24 be be AUX ww72b853p7q 18 25 elucidated elucidate VERB ww72b853p7q 18 26 . . PUNCT ww72b853p7q 19 1 parasite parasite NOUN ww72b853p7q 19 2 mutants mutant VERB ww72b853p7q 19 3 lacking lack VERB ww72b853p7q 19 4 lpg lpg NOUN ww72b853p7q 19 5 alone alone ADV ww72b853p7q 19 6 or or CCONJ ww72b853p7q 19 7 all all DET ww72b853p7q 19 8 pgs pgs NOUN ww72b853p7q 19 9 were be AUX ww72b853p7q 19 10 generated generate VERB ww72b853p7q 19 11 through through ADP ww72b853p7q 19 12 the the DET ww72b853p7q 19 13 inactivation inactivation NOUN ww72b853p7q 19 14 of of ADP ww72b853p7q 19 15 the the DET ww72b853p7q 19 16 galactosylfuranose galactosylfuranose NOUN ww72b853p7q 19 17 , , PUNCT ww72b853p7q 19 18 lpg1 lpg1 PROPN ww72b853p7q 19 19 or or CCONJ ww72b853p7q 19 20 the the DET ww72b853p7q 19 21 golgi golgi PROPN ww72b853p7q 19 22 gdp gdp PROPN ww72b853p7q 19 23 - - PUNCT ww72b853p7q 19 24 mannose mannose NOUN ww72b853p7q 19 25 nucleotide nucleotide NOUN ww72b853p7q 19 26 sugar sugar NOUN ww72b853p7q 19 27 transporter transporter NOUN ww72b853p7q 19 28 , , PUNCT ww72b853p7q 19 29 lpg2 lpg2 NOUN ww72b853p7q 19 30 , , PUNCT ww72b853p7q 19 31 respectively respectively ADV ww72b853p7q 19 32 . . PUNCT ww72b853p7q 20 1 we we PRON ww72b853p7q 20 2 demonstrated demonstrate VERB ww72b853p7q 20 3 that that SCONJ ww72b853p7q 20 4 infection infection NOUN ww72b853p7q 20 5 with with ADP ww72b853p7q 20 6 the the DET ww72b853p7q 20 7 lpg lpg NOUN ww72b853p7q 20 8 - - PUNCT ww72b853p7q 20 9 null null PROPN ww72b853p7q 20 10 fv1 fv1 NOUN ww72b853p7q 21 1 lpg1mutant lpg1mutant PROPN ww72b853p7q 21 2 resulted result VERB ww72b853p7q 21 3 in in ADP ww72b853p7q 21 4 little little ADJ ww72b853p7q 21 5 to to ADP ww72b853p7q 21 6 no no DET ww72b853p7q 21 7 il-12p40 il-12p40 PROPN ww72b853p7q 21 8 mrna mrna PROPN ww72b853p7q 21 9 , , PUNCT ww72b853p7q 21 10 indicating indicate VERB ww72b853p7q 21 11 lpg lpg NOUN ww72b853p7q 21 12 is be AUX ww72b853p7q 21 13 essential essential ADJ ww72b853p7q 21 14 for for ADP ww72b853p7q 21 15 stimulating stimulate VERB ww72b853p7q 21 16 il-12 il-12 NOUN ww72b853p7q 21 17 . . PUNCT ww72b853p7q 22 1 curiously curiously ADV ww72b853p7q 22 2 , , PUNCT ww72b853p7q 22 3 infection infection NOUN ww72b853p7q 22 4 with with ADP ww72b853p7q 22 5 the the DET ww72b853p7q 22 6 pg pg PROPN ww72b853p7q 22 7 - - PUNCT ww72b853p7q 22 8 null null ADJ ww72b853p7q 22 9 lpg2- lpg2- PROPN ww72b853p7q 22 10 , , PUNCT ww72b853p7q 22 11 led lead VERB ww72b853p7q 22 12 to to ADP ww72b853p7q 22 13 an an DET ww72b853p7q 22 14 increase increase NOUN ww72b853p7q 22 15 in in ADP ww72b853p7q 22 16 il-12p40 il-12p40 PROPN ww72b853p7q 22 17 mrna mrna PROPN ww72b853p7q 22 18 levels level NOUN ww72b853p7q 22 19 implicating implicate VERB ww72b853p7q 22 20 pgs pgs PROPN ww72b853p7q 22 21 and and CCONJ ww72b853p7q 22 22 other other ADJ ww72b853p7q 22 23 lpg2 lpg2 NOUN ww72b853p7q 22 24 - - PUNCT ww72b853p7q 22 25 depedent depedent NOUN ww72b853p7q 22 26 metabolites metabolite NOUN ww72b853p7q 22 27 may may AUX ww72b853p7q 22 28 suppress suppress VERB ww72b853p7q 22 29 il-12 il-12 SPACE ww72b853p7q 22 30 . . PUNCT ww72b853p7q 23 1 moreover moreover ADV ww72b853p7q 23 2 , , PUNCT ww72b853p7q 23 3 the the DET ww72b853p7q 23 4 effect effect NOUN ww72b853p7q 23 5 of of ADP ww72b853p7q 23 6 lpg lpg NOUN ww72b853p7q 23 7 was be AUX ww72b853p7q 23 8 also also ADV ww72b853p7q 23 9 observed observe VERB ww72b853p7q 23 10 for for ADP ww72b853p7q 23 11 irf8 irf8 PROPN ww72b853p7q 23 12 and and CCONJ ww72b853p7q 23 13 tnf-α tnf-α ADP ww72b853p7q 23 14 ; ; PUNCT ww72b853p7q 23 15 , , PUNCT ww72b853p7q 23 16 suggesting suggest VERB ww72b853p7q 23 17 lpg lpg NOUN ww72b853p7q 23 18 targets target VERB ww72b853p7q 23 19 irf8 irf8 PROPN ww72b853p7q 23 20 for for ADP ww72b853p7q 23 21 transcriptional transcriptional NOUN ww72b853p7q 23 22 regulation regulation NOUN ww72b853p7q 23 23 of of ADP ww72b853p7q 23 24 il-12 il-12 NOUN ww72b853p7q 23 25 and and CCONJ ww72b853p7q 23 26 tnf-α tnf-α ADV ww72b853p7q 23 27 ; ; PUNCT ww72b853p7q 23 28 . . PUNCT ww72b853p7q 24 1 together together ADV ww72b853p7q 24 2 , , PUNCT ww72b853p7q 24 3 these these DET ww72b853p7q 24 4 data datum NOUN ww72b853p7q 24 5 reflect reflect VERB ww72b853p7q 24 6 the the DET ww72b853p7q 24 7 ability ability NOUN ww72b853p7q 24 8 of of ADP ww72b853p7q 24 9 leishmania leishmania PROPN ww72b853p7q 24 10 molecules molecule NOUN ww72b853p7q 24 11 to to PART ww72b853p7q 24 12 differentially differentially ADV ww72b853p7q 24 13 impact impact VERB ww72b853p7q 24 14 the the DET ww72b853p7q 24 15 host host NOUN ww72b853p7q 24 16 cell cell NOUN ww72b853p7q 24 17 il-12 il-12 ADP ww72b853p7q 24 18 immune immune ADJ ww72b853p7q 24 19 response response NOUN ww72b853p7q 24 20 during during ADP ww72b853p7q 24 21 infection infection NOUN ww72b853p7q 24 22 . . PUNCT ww72b853p7q 25 1 in in ADP ww72b853p7q 25 2 summary summary NOUN ww72b853p7q 25 3 , , PUNCT ww72b853p7q 25 4 challenges challenge NOUN ww72b853p7q 25 5 still still ADV ww72b853p7q 25 6 remain remain VERB ww72b853p7q 25 7 that that PRON ww72b853p7q 25 8 hinder hinder VERB ww72b853p7q 25 9 a a DET ww72b853p7q 25 10 complete complete ADJ ww72b853p7q 25 11 understanding understanding NOUN ww72b853p7q 25 12 of of ADP ww72b853p7q 25 13 the the DET ww72b853p7q 25 14 immunobiology immunobiology NOUN ww72b853p7q 25 15 of of ADP ww72b853p7q 25 16 leishmania leishmania PROPN ww72b853p7q 25 17 infection infection NOUN ww72b853p7q 25 18 . . PUNCT ww72b853p7q 26 1 however however ADV ww72b853p7q 26 2 , , PUNCT ww72b853p7q 26 3 this this DET ww72b853p7q 26 4 work work NOUN ww72b853p7q 26 5 contributes contribute VERB ww72b853p7q 26 6 information information NOUN ww72b853p7q 26 7 about about ADP ww72b853p7q 26 8 potential potential ADJ ww72b853p7q 26 9 targets target NOUN ww72b853p7q 26 10 in in ADP ww72b853p7q 26 11 both both CCONJ ww72b853p7q 26 12 the the DET ww72b853p7q 26 13 host host NOUN ww72b853p7q 26 14 cell cell NOUN ww72b853p7q 26 15 and and CCONJ ww72b853p7q 26 16 pathogen pathogen NOUN ww72b853p7q 26 17 that that PRON ww72b853p7q 26 18 will will AUX ww72b853p7q 26 19 aid aid VERB ww72b853p7q 26 20 future future ADJ ww72b853p7q 26 21 investigations investigation NOUN ww72b853p7q 26 22 aimed aim VERB ww72b853p7q 26 23 towards towards ADP ww72b853p7q 26 24 development development NOUN ww72b853p7q 26 25 of of ADP ww72b853p7q 26 26 broadly broadly ADV ww72b853p7q 26 27 applicable applicable ADJ ww72b853p7q 26 28 drug drug NOUN ww72b853p7q 26 29 and and CCONJ ww72b853p7q 26 30 vaccine vaccine NOUN ww72b853p7q 26 31 regimes regime NOUN ww72b853p7q 26 32 for for ADP ww72b853p7q 26 33 leishmaniasis leishmaniasis NOUN ww72b853p7q 26 34 and and CCONJ ww72b853p7q 26 35 other other ADJ ww72b853p7q 26 36 related relate VERB ww72b853p7q 26 37 infectious infectious ADJ ww72b853p7q 26 38 diseases disease NOUN ww72b853p7q 26 39 . . PUNCT