id sid tid token lemma pos wp988g8869p 1 1 the the DET wp988g8869p 1 2 majority majority NOUN wp988g8869p 1 3 of of ADP wp988g8869p 1 4 cancer cancer NOUN wp988g8869p 1 5 - - PUNCT wp988g8869p 1 6 associated associate VERB wp988g8869p 1 7 deaths death NOUN wp988g8869p 1 8 are be AUX wp988g8869p 1 9 due due ADJ wp988g8869p 1 10 to to ADP wp988g8869p 1 11 metastasis metastasis NOUN wp988g8869p 1 12 , , PUNCT wp988g8869p 1 13 and and CCONJ wp988g8869p 1 14 understanding understand VERB wp988g8869p 1 15 mechanisms mechanism NOUN wp988g8869p 1 16 that that PRON wp988g8869p 1 17 initiate initiate VERB wp988g8869p 1 18 this this DET wp988g8869p 1 19 process process NOUN wp988g8869p 1 20 is be AUX wp988g8869p 1 21 essential essential ADJ wp988g8869p 1 22 for for ADP wp988g8869p 1 23 targeting target VERB wp988g8869p 1 24 aggressive aggressive ADJ wp988g8869p 1 25 tumors tumor NOUN wp988g8869p 1 26 . . PUNCT wp988g8869p 2 1 the the DET wp988g8869p 2 2 process process NOUN wp988g8869p 2 3 of of ADP wp988g8869p 2 4 invasion invasion NOUN wp988g8869p 2 5 is be AUX wp988g8869p 2 6 a a DET wp988g8869p 2 7 crucial crucial ADJ wp988g8869p 2 8 primary primary ADJ wp988g8869p 2 9 step step NOUN wp988g8869p 2 10 for for ADP wp988g8869p 2 11 cancer cancer NOUN wp988g8869p 2 12 metastasis metastasis NOUN wp988g8869p 2 13 , , PUNCT wp988g8869p 2 14 and and CCONJ wp988g8869p 2 15 the the DET wp988g8869p 2 16 mechanisms mechanism NOUN wp988g8869p 2 17 involved involve VERB wp988g8869p 2 18 are be AUX wp988g8869p 2 19 not not PART wp988g8869p 2 20 fully fully ADV wp988g8869p 2 21 understood understand VERB wp988g8869p 2 22 . . PUNCT wp988g8869p 3 1 in in ADP wp988g8869p 3 2 this this DET wp988g8869p 3 3 research research NOUN wp988g8869p 3 4 dissertation dissertation NOUN wp988g8869p 3 5 , , PUNCT wp988g8869p 3 6 the the DET wp988g8869p 3 7 role role NOUN wp988g8869p 3 8 for for ADP wp988g8869p 3 9 mixed mixed ADJ wp988g8869p 3 10 lineage lineage NOUN wp988g8869p 3 11 kinase kinase NOUN wp988g8869p 3 12 3 3 NUM wp988g8869p 3 13 ( ( PUNCT wp988g8869p 3 14 mlk3 mlk3 ADV wp988g8869p 3 15 ) ) PUNCT wp988g8869p 3 16 in in ADP wp988g8869p 3 17 the the DET wp988g8869p 3 18 regulation regulation NOUN wp988g8869p 3 19 of of ADP wp988g8869p 3 20 invasion invasion NOUN wp988g8869p 3 21 in in ADP wp988g8869p 3 22 melanoma melanoma PROPN wp988g8869p 3 23 is be AUX wp988g8869p 3 24 demonstrated demonstrate VERB wp988g8869p 3 25 . . PUNCT wp988g8869p 4 1 mlk3 mlk3 NOUN wp988g8869p 4 2 is be AUX wp988g8869p 4 3 a a DET wp988g8869p 4 4 mitogen mitogen NOUN wp988g8869p 4 5 - - PUNCT wp988g8869p 4 6 activated activate VERB wp988g8869p 4 7 protein protein NOUN wp988g8869p 4 8 kinase kinase NOUN wp988g8869p 4 9 kinase kinase NOUN wp988g8869p 4 10 kinase kinase NOUN wp988g8869p 4 11 ( ( PUNCT wp988g8869p 4 12 map3k map3k PROPN wp988g8869p 4 13 ) ) PUNCT wp988g8869p 4 14 that that PRON wp988g8869p 4 15 more more ADV wp988g8869p 4 16 recently recently ADV wp988g8869p 4 17 has have AUX wp988g8869p 4 18 been be AUX wp988g8869p 4 19 recognized recognize VERB wp988g8869p 4 20 as as ADP wp988g8869p 4 21 an an DET wp988g8869p 4 22 important important ADJ wp988g8869p 4 23 regulator regulator NOUN wp988g8869p 4 24 of of ADP wp988g8869p 4 25 tumor tumor NOUN wp988g8869p 4 26 invasion invasion NOUN wp988g8869p 4 27 and and CCONJ wp988g8869p 4 28 metastasis metastasis NOUN wp988g8869p 4 29 . . PUNCT wp988g8869p 5 1 using use VERB wp988g8869p 5 2 cellular cellular ADJ wp988g8869p 5 3 , , PUNCT wp988g8869p 5 4 molecular molecular ADJ wp988g8869p 5 5 and and CCONJ wp988g8869p 5 6 biochemical biochemical ADJ wp988g8869p 5 7 approaches approach NOUN wp988g8869p 5 8 , , PUNCT wp988g8869p 5 9 we we PRON wp988g8869p 5 10 have have AUX wp988g8869p 5 11 investigated investigate VERB wp988g8869p 5 12 the the DET wp988g8869p 5 13 effects effect NOUN wp988g8869p 5 14 of of ADP wp988g8869p 5 15 depleting deplete VERB wp988g8869p 5 16 mlk3 mlk3 NOUN wp988g8869p 5 17 in in ADP wp988g8869p 5 18 cutaneous cutaneous ADJ wp988g8869p 5 19 melanoma melanoma NOUN wp988g8869p 5 20 . . PUNCT wp988g8869p 6 1 we we PRON wp988g8869p 6 2 outline outline VERB wp988g8869p 6 3 a a DET wp988g8869p 6 4 pathway pathway NOUN wp988g8869p 6 5 involving involve VERB wp988g8869p 6 6 brafv600e brafv600e VERB wp988g8869p 6 7 hsp90 hsp90 NOUN wp988g8869p 6 8 and and CCONJ wp988g8869p 6 9 cdc37 cdc37 VERB wp988g8869p 6 10 that that PRON wp988g8869p 6 11 impacts impact VERB wp988g8869p 6 12 erk erk NOUN wp988g8869p 6 13 activation activation NOUN wp988g8869p 6 14 , , PUNCT wp988g8869p 6 15 wnt wnt PROPN wp988g8869p 6 16 signaling signaling NOUN wp988g8869p 6 17 and and CCONJ wp988g8869p 6 18 regulators regulator NOUN wp988g8869p 6 19 of of ADP wp988g8869p 6 20 extracellular extracellular ADJ wp988g8869p 6 21 matrix matrix NOUN wp988g8869p 6 22 invasion invasion NOUN wp988g8869p 6 23 including include VERB wp988g8869p 6 24 the the DET wp988g8869p 6 25 levels level NOUN wp988g8869p 6 26 and and CCONJ wp988g8869p 6 27 spatial spatial ADJ wp988g8869p 6 28 distribution distribution NOUN wp988g8869p 6 29 of of ADP wp988g8869p 6 30 matrix matrix NOUN wp988g8869p 6 31 metalloproteinases metalloproteinase NOUN wp988g8869p 6 32 . . PUNCT wp988g8869p 7 1 we we PRON wp988g8869p 7 2 also also ADV wp988g8869p 7 3 investigate investigate VERB wp988g8869p 7 4 mlk3 mlk3 NOUN wp988g8869p 7 5 signaling signal VERB wp988g8869p 7 6 on on ADP wp988g8869p 7 7 uveal uveal VERB wp988g8869p 7 8 melanoma melanoma NOUN wp988g8869p 7 9 invasion invasion NOUN wp988g8869p 7 10 . . PUNCT wp988g8869p 8 1 we we PRON wp988g8869p 8 2 demonstrate demonstrate VERB wp988g8869p 8 3 similarities similarity NOUN wp988g8869p 8 4 and and CCONJ wp988g8869p 8 5 differences difference NOUN wp988g8869p 8 6 in in ADP wp988g8869p 8 7 the the DET wp988g8869p 8 8 regulation regulation NOUN wp988g8869p 8 9 of of ADP wp988g8869p 8 10 cutaneous cutaneous ADJ wp988g8869p 8 11 and and CCONJ wp988g8869p 8 12 uveal uveal VERB wp988g8869p 8 13 melanoma melanoma ADJ wp988g8869p 8 14 invasion invasion NOUN wp988g8869p 8 15 . . PUNCT wp988g8869p 9 1 these these DET wp988g8869p 9 2 studies study NOUN wp988g8869p 9 3 provide provide VERB wp988g8869p 9 4 critical critical ADJ wp988g8869p 9 5 insights insight NOUN wp988g8869p 9 6 into into ADP wp988g8869p 9 7 the the DET wp988g8869p 9 8 role role NOUN wp988g8869p 9 9 of of ADP wp988g8869p 9 10 mlk3 mlk3 NOUN wp988g8869p 9 11 in in ADP wp988g8869p 9 12 cutaneous cutaneous ADJ wp988g8869p 9 13 and and CCONJ wp988g8869p 9 14 uveal uveal VERB wp988g8869p 9 15 melanoma melanoma NOUN wp988g8869p 9 16 cell cell NOUN wp988g8869p 9 17 invasion invasion NOUN wp988g8869p 9 18 . . PUNCT