id sid tid token lemma pos wp988g8754c 1 1 since since SCONJ wp988g8754c 1 2 the the DET wp988g8754c 1 3 use use NOUN wp988g8754c 1 4 of of ADP wp988g8754c 1 5 penicillin penicillin NOUN wp988g8754c 1 6 during during ADP wp988g8754c 1 7 world world PROPN wp988g8754c 1 8 war war PROPN wp988g8754c 1 9 ii ii PROPN wp988g8754c 1 10 , , PUNCT wp988g8754c 1 11 the the DET wp988g8754c 1 12 cell cell NOUN wp988g8754c 1 13 wall wall PROPN wp988g8754c 1 14 biosynthesis biosynthesis NOUN wp988g8754c 1 15 pathway pathway NOUN wp988g8754c 1 16 has have AUX wp988g8754c 1 17 been be AUX wp988g8754c 1 18 a a DET wp988g8754c 1 19 target target NOUN wp988g8754c 1 20 for for ADP wp988g8754c 1 21 antibiotic antibiotic ADJ wp988g8754c 1 22 treatment treatment NOUN wp988g8754c 1 23 . . PUNCT wp988g8754c 2 1 although although SCONJ wp988g8754c 2 2 hundreds hundred NOUN wp988g8754c 2 3 of of ADP wp988g8754c 2 4 ìä ìä PROPN wp988g8754c 2 5 ü ü PROPN wp988g8754c 2 6 - - NOUN wp988g8754c 2 7 lactam lactam NOUN wp988g8754c 2 8 antibiotics antibiotic NOUN wp988g8754c 2 9 have have AUX wp988g8754c 2 10 been be AUX wp988g8754c 2 11 developed develop VERB wp988g8754c 2 12 and and CCONJ wp988g8754c 2 13 studied study VERB wp988g8754c 2 14 at at ADP wp988g8754c 2 15 great great ADJ wp988g8754c 2 16 length length ADJ wp988g8754c 2 17 , , PUNCT wp988g8754c 2 18 bacterial bacterial ADJ wp988g8754c 2 19 resistance resistance NOUN wp988g8754c 2 20 continually continually ADV wp988g8754c 2 21 threatens threaten VERB wp988g8754c 2 22 the the DET wp988g8754c 2 23 efficacy efficacy NOUN wp988g8754c 2 24 with with ADP wp988g8754c 2 25 which which PRON wp988g8754c 2 26 bacterial bacterial ADJ wp988g8754c 2 27 infections infection NOUN wp988g8754c 2 28 may may AUX wp988g8754c 2 29 be be AUX wp988g8754c 2 30 treated treat VERB wp988g8754c 2 31 . . PUNCT wp988g8754c 3 1 this this DET wp988g8754c 3 2 work work NOUN wp988g8754c 3 3 investigates investigate VERB wp988g8754c 3 4 small small ADJ wp988g8754c 3 5 molecule molecule NOUN wp988g8754c 3 6 scaffolds scaffold NOUN wp988g8754c 3 7 as as ADP wp988g8754c 3 8 potential potential ADJ wp988g8754c 3 9 inhibitors inhibitor NOUN wp988g8754c 3 10 of of ADP wp988g8754c 3 11 the the DET wp988g8754c 3 12 cell cell NOUN wp988g8754c 3 13 wall wall PROPN wp988g8754c 3 14 biosynthesis biosynthesis NOUN wp988g8754c 3 15 pathway pathway NOUN wp988g8754c 3 16 . . PUNCT wp988g8754c 4 1 the the DET wp988g8754c 4 2 molecules molecule NOUN wp988g8754c 4 3 are be AUX wp988g8754c 4 4 based base VERB wp988g8754c 4 5 on on ADP wp988g8754c 4 6 a a DET wp988g8754c 4 7 dipeptide dipeptide NOUN wp988g8754c 4 8 core core NOUN wp988g8754c 4 9 or or CCONJ wp988g8754c 4 10 were be AUX wp988g8754c 4 11 discovered discover VERB wp988g8754c 4 12 via via ADP wp988g8754c 4 13 computational computational ADJ wp988g8754c 4 14 screening screening NOUN wp988g8754c 4 15 of of ADP wp988g8754c 4 16 a a DET wp988g8754c 4 17 small small ADJ wp988g8754c 4 18 molecule molecule NOUN wp988g8754c 4 19 library library NOUN wp988g8754c 4 20 against against ADP wp988g8754c 4 21 the the DET wp988g8754c 4 22 active active ADJ wp988g8754c 4 23 site site NOUN wp988g8754c 4 24 of of ADP wp988g8754c 4 25 a a DET wp988g8754c 4 26 penicillin penicillin NOUN wp988g8754c 4 27 - - PUNCT wp988g8754c 4 28 binding bind VERB wp988g8754c 4 29 protein protein NOUN wp988g8754c 4 30 . . PUNCT wp988g8754c 5 1 the the DET wp988g8754c 5 2 small small ADJ wp988g8754c 5 3 molecules molecule NOUN wp988g8754c 5 4 were be AUX wp988g8754c 5 5 analyzed analyze VERB wp988g8754c 5 6 for for ADP wp988g8754c 5 7 in in ADP wp988g8754c 5 8 vivo vivo ADJ wp988g8754c 5 9 antibacterial antibacterial ADJ wp988g8754c 5 10 activity activity NOUN wp988g8754c 5 11 utilizing utilize VERB wp988g8754c 5 12 minimum minimum ADJ wp988g8754c 5 13 inhibitory inhibitory ADJ wp988g8754c 5 14 concentration concentration NOUN wp988g8754c 5 15 determination determination NOUN wp988g8754c 5 16 . . PUNCT wp988g8754c 6 1 in in ADP wp988g8754c 6 2 vitro vitro X wp988g8754c 6 3 activity activity NOUN wp988g8754c 6 4 was be AUX wp988g8754c 6 5 evaluated evaluate VERB wp988g8754c 6 6 using use VERB wp988g8754c 6 7 established establish VERB wp988g8754c 6 8 nitrocefin nitrocefin NOUN wp988g8754c 6 9 and and CCONJ wp988g8754c 6 10 bocillin bocillin PROPN wp988g8754c 6 11 - - PUNCT wp988g8754c 6 12 fl fl PROPN wp988g8754c 6 13 competition competition NOUN wp988g8754c 6 14 assays assay VERB wp988g8754c 6 15 for for ADP wp988g8754c 6 16 dd dd NOUN wp988g8754c 6 17 - - PUNCT wp988g8754c 6 18 transpeptidases transpeptidase NOUN wp988g8754c 6 19 . . PUNCT wp988g8754c 7 1 additionally additionally ADV wp988g8754c 7 2 , , PUNCT wp988g8754c 7 3 an an DET wp988g8754c 7 4 amplex amplex ADJ wp988g8754c 7 5 red red NOUN wp988g8754c 7 6 coupled couple VERB wp988g8754c 7 7 assay assay PROPN wp988g8754c 7 8 was be AUX wp988g8754c 7 9 employed employ VERB wp988g8754c 7 10 to to PART wp988g8754c 7 11 probe probe VERB wp988g8754c 7 12 dd dd PROPN wp988g8754c 7 13 - - PUNCT wp988g8754c 7 14 carboxypeptidase carboxypeptidase NOUN wp988g8754c 7 15 activity activity NOUN wp988g8754c 7 16 . . PUNCT wp988g8754c 8 1 the the DET wp988g8754c 8 2 design design NOUN wp988g8754c 8 3 , , PUNCT wp988g8754c 8 4 synthesis synthesis NOUN wp988g8754c 8 5 , , PUNCT wp988g8754c 8 6 and and CCONJ wp988g8754c 8 7 evaluation evaluation NOUN wp988g8754c 8 8 of of ADP wp988g8754c 8 9 these these DET wp988g8754c 8 10 small small ADJ wp988g8754c 8 11 molecules molecule NOUN wp988g8754c 8 12 are be AUX wp988g8754c 8 13 discussed discuss VERB wp988g8754c 8 14 herein herein ADV wp988g8754c 8 15 . . PUNCT