id sid tid token lemma pos wp988g87473 1 1 when when SCONJ wp988g87473 1 2 mammary mammary ADJ wp988g87473 1 3 epithelial epithelial ADJ wp988g87473 1 4 cells cell NOUN wp988g87473 1 5 become become VERB wp988g87473 1 6 detached detached ADJ wp988g87473 1 7 from from ADP wp988g87473 1 8 the the DET wp988g87473 1 9 extracellular extracellular ADJ wp988g87473 1 10 matrix matrix NOUN wp988g87473 1 11 ( ( PUNCT wp988g87473 1 12 ecm ecm NOUN wp988g87473 1 13 ) ) PUNCT wp988g87473 1 14 , , PUNCT wp988g87473 1 15 they they PRON wp988g87473 1 16 undergo undergo VERB wp988g87473 1 17 programmed programmed ADJ wp988g87473 1 18 cell cell NOUN wp988g87473 1 19 death death NOUN wp988g87473 1 20 . . PUNCT wp988g87473 2 1 over over ADP wp988g87473 2 2 the the DET wp988g87473 2 3 past past ADJ wp988g87473 2 4 twenty twenty NUM wp988g87473 2 5 years year NOUN wp988g87473 2 6 , , PUNCT wp988g87473 2 7 our our PRON wp988g87473 2 8 knowledge knowledge NOUN wp988g87473 2 9 regarding regard VERB wp988g87473 2 10 various various ADJ wp988g87473 2 11 mechanisms mechanism NOUN wp988g87473 2 12 utilized utilize VERB wp988g87473 2 13 by by ADP wp988g87473 2 14 cancerous cancerous ADJ wp988g87473 2 15 epithelial epithelial ADJ wp988g87473 2 16 cells cell NOUN wp988g87473 2 17 to to PART wp988g87473 2 18 overcome overcome VERB wp988g87473 2 19 ecm ecm NOUN wp988g87473 2 20 - - PUNCT wp988g87473 2 21 detachment detachment NOUN wp988g87473 2 22 - - PUNCT wp988g87473 2 23 induced induce VERB wp988g87473 2 24 death death NOUN wp988g87473 2 25 has have AUX wp988g87473 2 26 grown grow VERB wp988g87473 2 27 . . PUNCT wp988g87473 3 1 elucidating elucidate VERB wp988g87473 3 2 the the DET wp988g87473 3 3 ways way NOUN wp988g87473 3 4 in in ADP wp988g87473 3 5 which which PRON wp988g87473 3 6 cancer cancer NOUN wp988g87473 3 7 cells cell NOUN wp988g87473 3 8 overcome overcome VERB wp988g87473 3 9 ecm ecm NOUN wp988g87473 3 10 - - PUNCT wp988g87473 3 11 detachment detachment NOUN wp988g87473 3 12 - - PUNCT wp988g87473 3 13 induced induce VERB wp988g87473 3 14 cell cell NOUN wp988g87473 3 15 death death NOUN wp988g87473 3 16 is be AUX wp988g87473 3 17 important important ADJ wp988g87473 3 18 for for ADP wp988g87473 3 19 our our PRON wp988g87473 3 20 understanding understanding NOUN wp988g87473 3 21 of of ADP wp988g87473 3 22 the the DET wp988g87473 3 23 metastatic metastatic ADJ wp988g87473 3 24 progression progression NOUN wp988g87473 3 25 and and CCONJ wp988g87473 3 26 for for ADP wp988g87473 3 27 our our PRON wp988g87473 3 28 ability ability NOUN wp988g87473 3 29 to to PART wp988g87473 3 30 therapeutically therapeutically ADV wp988g87473 3 31 eliminate eliminate VERB wp988g87473 3 32 these these DET wp988g87473 3 33 cells cell NOUN wp988g87473 3 34 . . PUNCT wp988g87473 4 1 here here ADV wp988g87473 4 2 , , PUNCT wp988g87473 4 3 we we PRON wp988g87473 4 4 describe describe VERB wp988g87473 4 5 a a DET wp988g87473 4 6 novel novel ADJ wp988g87473 4 7 mechanism mechanism NOUN wp988g87473 4 8 utilized utilize VERB wp988g87473 4 9 by by ADP wp988g87473 4 10 inflammatory inflammatory ADJ wp988g87473 4 11 breast breast NOUN wp988g87473 4 12 cancer cancer NOUN wp988g87473 4 13 ( ( PUNCT wp988g87473 4 14 ibc ibc PROPN wp988g87473 4 15 ) ) PUNCT wp988g87473 4 16 cells cell NOUN wp988g87473 4 17 to to PART wp988g87473 4 18 overcome overcome VERB wp988g87473 4 19 ecm ecm NOUN wp988g87473 4 20 - - PUNCT wp988g87473 4 21 detachment detachment NOUN wp988g87473 4 22 - - PUNCT wp988g87473 4 23 induced induce VERB wp988g87473 4 24 apoptosis apoptosis NOUN wp988g87473 4 25 , , PUNCT wp988g87473 4 26 or or CCONJ wp988g87473 4 27 anoikis anoikis PROPN wp988g87473 4 28 . . PUNCT wp988g87473 5 1 ibc ibc PROPN wp988g87473 5 2 cells cell NOUN wp988g87473 5 3 were be AUX wp988g87473 5 4 shown show VERB wp988g87473 5 5 to to PART wp988g87473 5 6 survive survive VERB wp988g87473 5 7 in in ADP wp988g87473 5 8 ecm ecm PROPN wp988g87473 5 9 - - PUNCT wp988g87473 5 10 detached detach VERB wp988g87473 5 11 conditions condition NOUN wp988g87473 5 12 by by ADP wp988g87473 5 13 regulating regulate VERB wp988g87473 5 14 the the DET wp988g87473 5 15 intracellular intracellular ADJ wp988g87473 5 16 localization localization NOUN wp988g87473 5 17 of of ADP wp988g87473 5 18 the the DET wp988g87473 5 19 proapoptotic proapoptotic ADJ wp988g87473 5 20 protein protein NOUN wp988g87473 5 21 , , PUNCT wp988g87473 5 22 bim bim PROPN wp988g87473 5 23 - - PUNCT wp988g87473 5 24 el el PROPN wp988g87473 5 25 via via ADP wp988g87473 5 26 protein protein NOUN wp988g87473 5 27 interactions interaction NOUN wp988g87473 5 28 with with ADP wp988g87473 5 29 beclin-1 beclin-1 PROPN wp988g87473 5 30 and and CCONJ wp988g87473 5 31 lc8 lc8 PROPN wp988g87473 5 32 . . PUNCT wp988g87473 6 1 these these DET wp988g87473 6 2 data datum NOUN wp988g87473 6 3 are be AUX wp988g87473 6 4 the the DET wp988g87473 6 5 first first ADJ wp988g87473 6 6 to to PART wp988g87473 6 7 describe describe VERB wp988g87473 6 8 how how SCONJ wp988g87473 6 9 ibc ibc PROPN wp988g87473 6 10 cells cell NOUN wp988g87473 6 11 can can AUX wp988g87473 6 12 survive survive VERB wp988g87473 6 13 in in ADP wp988g87473 6 14 an an DET wp988g87473 6 15 ecm ecm NOUN wp988g87473 6 16 - - PUNCT wp988g87473 6 17 detached detach VERB wp988g87473 6 18 state state NOUN wp988g87473 6 19 . . PUNCT wp988g87473 7 1 interestingly interestingly ADV wp988g87473 7 2 , , PUNCT wp988g87473 7 3 inhibition inhibition NOUN wp988g87473 7 4 of of ADP wp988g87473 7 5 anoikis anoiki NOUN wp988g87473 7 6 alone alone ADV wp988g87473 7 7 is be AUX wp988g87473 7 8 not not PART wp988g87473 7 9 enough enough ADJ wp988g87473 7 10 to to PART wp988g87473 7 11 overcome overcome VERB wp988g87473 7 12 ecm ecm NOUN wp988g87473 7 13 - - PUNCT wp988g87473 7 14 detachment detachment NOUN wp988g87473 7 15 - - PUNCT wp988g87473 7 16 induced induce VERB wp988g87473 7 17 cell cell NOUN wp988g87473 7 18 death death NOUN wp988g87473 7 19 in in ADP wp988g87473 7 20 nontumorigenic nontumorigenic ADJ wp988g87473 7 21 mammary mammary ADJ wp988g87473 7 22 epithelial epithelial ADJ wp988g87473 7 23 cells cell NOUN wp988g87473 7 24 . . PUNCT wp988g87473 8 1 we we PRON wp988g87473 8 2 have have AUX wp988g87473 8 3 identified identify VERB wp988g87473 8 4 rip1 rip1 PROPN wp988g87473 8 5 as as ADP wp988g87473 8 6 a a DET wp988g87473 8 7 critical critical ADJ wp988g87473 8 8 mediator mediator NOUN wp988g87473 8 9 of of ADP wp988g87473 8 10 non non ADJ wp988g87473 8 11 - - ADJ wp988g87473 8 12 apoptotic apoptotic ADJ wp988g87473 8 13 ecm ecm NOUN wp988g87473 8 14 - - PUNCT wp988g87473 8 15 detachment detachment NOUN wp988g87473 8 16 - - PUNCT wp988g87473 8 17 induced induce VERB wp988g87473 8 18 cell cell NOUN wp988g87473 8 19 death death NOUN wp988g87473 8 20 , , PUNCT wp988g87473 8 21 which which PRON wp988g87473 8 22 we we PRON wp988g87473 8 23 believe believe VERB wp988g87473 8 24 to to PART wp988g87473 8 25 be be AUX wp988g87473 8 26 programmed program VERB wp988g87473 8 27 necrosis necrosis NOUN wp988g87473 8 28 . . PUNCT wp988g87473 9 1 rip1 rip1 PROPN wp988g87473 9 2 was be AUX wp988g87473 9 3 found find VERB wp988g87473 9 4 to to PART wp988g87473 9 5 be be AUX wp988g87473 9 6 highly highly ADV wp988g87473 9 7 expressed express VERB wp988g87473 9 8 in in ADP wp988g87473 9 9 ecm ecm PROPN wp988g87473 9 10 - - PUNCT wp988g87473 9 11 detached detach VERB wp988g87473 9 12 epithelial epithelial ADJ wp988g87473 9 13 cells cell NOUN wp988g87473 9 14 via via ADP wp988g87473 9 15 upregulation upregulation NOUN wp988g87473 9 16 of of ADP wp988g87473 9 17 the the DET wp988g87473 9 18 deubiquitinase deubiquitinase NOUN wp988g87473 9 19 , , PUNCT wp988g87473 9 20 cyld cyld NOUN wp988g87473 9 21 . . PUNCT wp988g87473 10 1 surprisingly surprisingly ADV wp988g87473 10 2 , , PUNCT wp988g87473 10 3 rip3 rip3 NOUN wp988g87473 10 4 and and CCONJ wp988g87473 10 5 mlkl mlkl PROPN wp988g87473 10 6 were be AUX wp988g87473 10 7 found find VERB wp988g87473 10 8 to to PART wp988g87473 10 9 be be AUX wp988g87473 10 10 dispensable dispensable ADJ wp988g87473 10 11 downstream downstream ADV wp988g87473 10 12 of of ADP wp988g87473 10 13 rip1 rip1 PROPN wp988g87473 10 14 for for ADP wp988g87473 10 15 ecm ecm NOUN wp988g87473 10 16 - - PUNCT wp988g87473 10 17 detachment detachment NOUN wp988g87473 10 18 - - PUNCT wp988g87473 10 19 induced induce VERB wp988g87473 10 20 programmed programmed ADJ wp988g87473 10 21 necrosis necrosis NOUN wp988g87473 10 22 . . PUNCT wp988g87473 11 1 furthermore furthermore ADV wp988g87473 11 2 , , PUNCT wp988g87473 11 3 tnfα tnfα ADP wp988g87473 11 4 ; ; PUNCT wp988g87473 11 5 does do AUX wp988g87473 11 6 not not PART wp988g87473 11 7 appear appear VERB wp988g87473 11 8 to to PART wp988g87473 11 9 represent represent VERB wp988g87473 11 10 the the DET wp988g87473 11 11 stimulation stimulation NOUN wp988g87473 11 12 factor factor NOUN wp988g87473 11 13 for for ADP wp988g87473 11 14 ecm ecm NOUN wp988g87473 11 15 - - PUNCT wp988g87473 11 16 detachment detachment NOUN wp988g87473 11 17 - - PUNCT wp988g87473 11 18 induced induce VERB wp988g87473 11 19 death death NOUN wp988g87473 11 20 . . PUNCT wp988g87473 12 1 together together ADV wp988g87473 12 2 these these DET wp988g87473 12 3 data datum NOUN wp988g87473 12 4 suggest suggest VERB wp988g87473 12 5 a a DET wp988g87473 12 6 novel novel ADJ wp988g87473 12 7 rip1 rip1 PROPN wp988g87473 12 8 - - PUNCT wp988g87473 12 9 mediated mediate VERB wp988g87473 12 10 , , PUNCT wp988g87473 12 11 rip3 rip3 PROPN wp988g87473 12 12 / / SYM wp988g87473 12 13 mlkl mlkl PROPN wp988g87473 12 14 - - PUNCT wp988g87473 12 15 independent independent ADJ wp988g87473 12 16 signaling signal VERB wp988g87473 12 17 cascade cascade NOUN wp988g87473 12 18 for for ADP wp988g87473 12 19 ecm ecm NOUN wp988g87473 12 20 - - PUNCT wp988g87473 12 21 detachment detachment NOUN wp988g87473 12 22 - - PUNCT wp988g87473 12 23 induced induce VERB wp988g87473 12 24 necrosis necrosis NOUN wp988g87473 12 25 . . PUNCT