id sid tid token lemma pos wh246q20m35 1 1 in in ADP wh246q20m35 1 2 gram gram ADJ wh246q20m35 1 3 - - PUNCT wh246q20m35 1 4 negative negative ADJ wh246q20m35 1 5 bacteria bacteria NOUN wh246q20m35 1 6 , , PUNCT wh246q20m35 1 7 a a DET wh246q20m35 1 8 wide wide ADJ wh246q20m35 1 9 range range NOUN wh246q20m35 1 10 of of ADP wh246q20m35 1 11 virulence virulence NOUN wh246q20m35 1 12 proteins protein NOUN wh246q20m35 1 13 are be AUX wh246q20m35 1 14 secreted secrete VERB wh246q20m35 1 15 via via ADP wh246q20m35 1 16 the the DET wh246q20m35 1 17 autotransporter autotransporter NOUN wh246q20m35 1 18 ( ( PUNCT wh246q20m35 1 19 at at ADP wh246q20m35 1 20 ) ) PUNCT wh246q20m35 1 21 pathway pathway NOUN wh246q20m35 1 22 . . PUNCT wh246q20m35 2 1 at at ADP wh246q20m35 2 2 pre pre ADJ wh246q20m35 2 3 - - NOUN wh246q20m35 2 4 proteins protein NOUN wh246q20m35 2 5 are be AUX wh246q20m35 2 6 synthesized synthesize VERB wh246q20m35 2 7 with with ADP wh246q20m35 2 8 an an DET wh246q20m35 2 9 n n ADJ wh246q20m35 2 10 - - PUNCT wh246q20m35 2 11 terminal terminal ADJ wh246q20m35 2 12 signal signal NOUN wh246q20m35 2 13 sequence sequence NOUN wh246q20m35 2 14 that that PRON wh246q20m35 2 15 facilitates facilitate VERB wh246q20m35 2 16 transport transport NOUN wh246q20m35 2 17 across across ADP wh246q20m35 2 18 the the DET wh246q20m35 2 19 inner inner ADJ wh246q20m35 2 20 membrane membrane NOUN wh246q20m35 2 21 , , PUNCT wh246q20m35 2 22 and and CCONJ wh246q20m35 2 23 a a DET wh246q20m35 2 24 c c NOUN wh246q20m35 2 25 - - PUNCT wh246q20m35 2 26 terminal terminal NOUN wh246q20m35 2 27 & & CCONJ wh246q20m35 2 28 # # SYM wh246q20m35 2 29 946;-barrel 946;-barrel NUM wh246q20m35 2 30 domain domain NOUN wh246q20m35 2 31 that that PRON wh246q20m35 2 32 is be AUX wh246q20m35 2 33 required require VERB wh246q20m35 2 34 for for ADP wh246q20m35 2 35 the the DET wh246q20m35 2 36 mature mature ADJ wh246q20m35 2 37 virulence virulence NOUN wh246q20m35 2 38 factor factor NOUN wh246q20m35 2 39 to to PART wh246q20m35 2 40 cross cross VERB wh246q20m35 2 41 the the DET wh246q20m35 2 42 outer outer ADJ wh246q20m35 2 43 membrane membrane NOUN wh246q20m35 2 44 ( ( PUNCT wh246q20m35 2 45 om om PROPN wh246q20m35 2 46 ) ) PUNCT wh246q20m35 2 47 , , PUNCT wh246q20m35 2 48 flanking flank VERB wh246q20m35 2 49 the the DET wh246q20m35 2 50 central central ADJ wh246q20m35 2 51 passenger passenger NOUN wh246q20m35 2 52 domain domain NOUN wh246q20m35 2 53 that that PRON wh246q20m35 2 54 forms form VERB wh246q20m35 2 55 the the DET wh246q20m35 2 56 mature mature ADJ wh246q20m35 2 57 , , PUNCT wh246q20m35 2 58 secreted secrete VERB wh246q20m35 2 59 virulence virulence NOUN wh246q20m35 2 60 factor factor NOUN wh246q20m35 2 61 . . PUNCT wh246q20m35 3 1 intriguingly intriguingly ADJ wh246q20m35 3 2 , , PUNCT wh246q20m35 3 3 there there PRON wh246q20m35 3 4 is be VERB wh246q20m35 3 5 no no DET wh246q20m35 3 6 significant significant ADJ wh246q20m35 3 7 concentration concentration NOUN wh246q20m35 3 8 of of ADP wh246q20m35 3 9 atp atp NOUN wh246q20m35 3 10 in in ADP wh246q20m35 3 11 the the DET wh246q20m35 3 12 periplasm periplasm NOUN wh246q20m35 3 13 , , PUNCT wh246q20m35 3 14 nor nor CCONJ wh246q20m35 3 15 a a DET wh246q20m35 3 16 proton proton NOUN wh246q20m35 3 17 gradient gradient NOUN wh246q20m35 3 18 across across ADP wh246q20m35 3 19 the the DET wh246q20m35 3 20 om om NOUN wh246q20m35 3 21 , , PUNCT wh246q20m35 3 22 and and CCONJ wh246q20m35 3 23 hence hence ADV wh246q20m35 3 24 the the DET wh246q20m35 3 25 energetic energetic ADJ wh246q20m35 3 26 origin origin NOUN wh246q20m35 3 27 of of ADP wh246q20m35 3 28 efficient efficient ADJ wh246q20m35 3 29 om om PROPN wh246q20m35 3 30 secretion secretion NOUN wh246q20m35 3 31 of of ADP wh246q20m35 3 32 at at ADP wh246q20m35 3 33 proteins protein NOUN wh246q20m35 3 34 is be AUX wh246q20m35 3 35 unknown unknown ADJ wh246q20m35 3 36 . . PUNCT wh246q20m35 4 1 yet yet ADV wh246q20m35 4 2 more more ADJ wh246q20m35 4 3 than than ADP wh246q20m35 4 4 97 97 NUM wh246q20m35 4 5 % % NOUN wh246q20m35 4 6 of of ADP wh246q20m35 4 7 at at ADP wh246q20m35 4 8 proteins protein NOUN wh246q20m35 4 9 are be AUX wh246q20m35 4 10 predicted predict VERB wh246q20m35 4 11 to to PART wh246q20m35 4 12 contain contain VERB wh246q20m35 4 13 right right ADJ wh246q20m35 4 14 - - PUNCT wh246q20m35 4 15 handed handed ADJ wh246q20m35 4 16 parallel parallel NOUN wh246q20m35 4 17 & & CCONJ wh246q20m35 4 18 # # SYM wh246q20m35 4 19 946;-helical 946;-helical ADJ wh246q20m35 4 20 structure structure NOUN wh246q20m35 4 21 , , PUNCT wh246q20m35 4 22 and and CCONJ wh246q20m35 4 23 the the DET wh246q20m35 4 24 four four NUM wh246q20m35 4 25 of of ADP wh246q20m35 4 26 the the DET wh246q20m35 4 27 five five NUM wh246q20m35 4 28 crystal crystal NOUN wh246q20m35 4 29 structures structure NOUN wh246q20m35 4 30 available available ADJ wh246q20m35 4 31 for for ADP wh246q20m35 4 32 at at ADP wh246q20m35 4 33 passenger passenger NOUN wh246q20m35 4 34 domains domain NOUN wh246q20m35 4 35 each each PRON wh246q20m35 4 36 contain contain VERB wh246q20m35 4 37 a a DET wh246q20m35 4 38 long long ADJ wh246q20m35 4 39 right right ADV wh246q20m35 4 40 - - PUNCT wh246q20m35 4 41 handed handed ADJ wh246q20m35 4 42 parallel parallel NOUN wh246q20m35 4 43 & & CCONJ wh246q20m35 4 44 # # SYM wh246q20m35 4 45 946;-helix 946;-helix NUM wh246q20m35 4 46 . . PUNCT wh246q20m35 5 1 in in ADP wh246q20m35 5 2 vitro vitro X wh246q20m35 5 3 folding fold VERB wh246q20m35 5 4 studies study NOUN wh246q20m35 5 5 of of ADP wh246q20m35 5 6 the the DET wh246q20m35 5 7 pertactin pertactin ADJ wh246q20m35 5 8 passenger passenger NOUN wh246q20m35 5 9 domain domain NOUN wh246q20m35 5 10 show show VERB wh246q20m35 5 11 that that SCONJ wh246q20m35 5 12 pertactin pertactin PROPN wh246q20m35 5 13 exhibits exhibit VERB wh246q20m35 5 14 three three NUM wh246q20m35 5 15 state state NOUN wh246q20m35 5 16 folding folding NOUN wh246q20m35 5 17 and and CCONJ wh246q20m35 5 18 has have VERB wh246q20m35 5 19 a a DET wh246q20m35 5 20 c c ADJ wh246q20m35 5 21 - - PUNCT wh246q20m35 5 22 terminal terminal ADJ wh246q20m35 5 23 stable stable ADJ wh246q20m35 5 24 core core NOUN wh246q20m35 5 25 structure structure NOUN wh246q20m35 5 26 . . PUNCT wh246q20m35 6 1 here here ADV wh246q20m35 6 2 we we PRON wh246q20m35 6 3 show show VERB wh246q20m35 6 4 that that SCONJ wh246q20m35 6 5 an an DET wh246q20m35 6 6 unrelated unrelated ADJ wh246q20m35 6 7 at at ADP wh246q20m35 6 8 passenger passenger NOUN wh246q20m35 6 9 domain domain NOUN wh246q20m35 6 10 pet pet NOUN wh246q20m35 6 11 , , PUNCT wh246q20m35 6 12 also also ADV wh246q20m35 6 13 exhibits exhibit VERB wh246q20m35 6 14 three three NUM wh246q20m35 6 15 state state NOUN wh246q20m35 6 16 unfolding unfolding NOUN wh246q20m35 6 17 and and CCONJ wh246q20m35 6 18 has have VERB wh246q20m35 6 19 a a DET wh246q20m35 6 20 c c ADJ wh246q20m35 6 21 - - PUNCT wh246q20m35 6 22 terminal terminal ADJ wh246q20m35 6 23 stable stable ADJ wh246q20m35 6 24 core core NOUN wh246q20m35 6 25 structure structure NOUN wh246q20m35 6 26 . . PUNCT wh246q20m35 7 1 stable stable ADJ wh246q20m35 7 2 core core NOUN wh246q20m35 7 3 structure structure NOUN wh246q20m35 7 4 in in ADP wh246q20m35 7 5 the the DET wh246q20m35 7 6 & & CCONJ wh246q20m35 7 7 # # SYM wh246q20m35 7 8 946;-helix 946;-helix NUM wh246q20m35 7 9 of of ADP wh246q20m35 7 10 at at ADP wh246q20m35 7 11 passenger passenger NOUN wh246q20m35 7 12 domains domain NOUN wh246q20m35 7 13 could could AUX wh246q20m35 7 14 be be AUX wh246q20m35 7 15 important important ADJ wh246q20m35 7 16 for for ADP wh246q20m35 7 17 efficient efficient ADJ wh246q20m35 7 18 om om PROPN wh246q20m35 7 19 secretion secretion NOUN wh246q20m35 7 20 of of ADP wh246q20m35 7 21 the the DET wh246q20m35 7 22 passenger passenger NOUN wh246q20m35 7 23 domain domain NOUN wh246q20m35 7 24 . . PUNCT wh246q20m35 8 1 to to PART wh246q20m35 8 2 test test VERB wh246q20m35 8 3 the the DET wh246q20m35 8 4 requirement requirement NOUN wh246q20m35 8 5 of of ADP wh246q20m35 8 6 different different ADJ wh246q20m35 8 7 domains domain NOUN wh246q20m35 8 8 of of ADP wh246q20m35 8 9 the the DET wh246q20m35 8 10 pet pet ADJ wh246q20m35 8 11 passenger passenger NOUN wh246q20m35 8 12 domain domain NOUN wh246q20m35 8 13 a a DET wh246q20m35 8 14 series series NOUN wh246q20m35 8 15 of of ADP wh246q20m35 8 16 passenger passenger NOUN wh246q20m35 8 17 domain domain NOUN wh246q20m35 8 18 deletion deletion NOUN wh246q20m35 8 19 mutants mutant NOUN wh246q20m35 8 20 were be AUX wh246q20m35 8 21 constructed construct VERB wh246q20m35 8 22 . . PUNCT wh246q20m35 9 1 these these DET wh246q20m35 9 2 studies study NOUN wh246q20m35 9 3 revealed reveal VERB wh246q20m35 9 4 that that SCONJ wh246q20m35 9 5 while while SCONJ wh246q20m35 9 6 a a DET wh246q20m35 9 7 passenger passenger NOUN wh246q20m35 9 8 domain domain NOUN wh246q20m35 9 9 consisting consist VERB wh246q20m35 9 10 of of ADP wh246q20m35 9 11 only only ADV wh246q20m35 9 12 the the DET wh246q20m35 9 13 c c NOUN wh246q20m35 9 14 - - PUNCT wh246q20m35 9 15 terminal terminal ADJ wh246q20m35 9 16 stable stable ADJ wh246q20m35 9 17 core core NOUN wh246q20m35 9 18 is be AUX wh246q20m35 9 19 secreted secrete VERB wh246q20m35 9 20 efficiently efficiently ADV wh246q20m35 9 21 , , PUNCT wh246q20m35 9 22 deletion deletion NOUN wh246q20m35 9 23 of of ADP wh246q20m35 9 24 the the DET wh246q20m35 9 25 stable stable ADJ wh246q20m35 9 26 core core NOUN wh246q20m35 9 27 results result NOUN wh246q20m35 9 28 in in ADP wh246q20m35 9 29 lower low ADJ wh246q20m35 9 30 levels level NOUN wh246q20m35 9 31 of of ADP wh246q20m35 9 32 secreted secrete VERB wh246q20m35 9 33 passenger passenger NOUN wh246q20m35 9 34 domain domain NOUN wh246q20m35 9 35 , , PUNCT wh246q20m35 9 36 which which PRON wh246q20m35 9 37 is be AUX wh246q20m35 9 38 not not PART wh246q20m35 9 39 correctly correctly ADV wh246q20m35 9 40 folded fold VERB wh246q20m35 9 41 , , PUNCT wh246q20m35 9 42 suggesting suggest VERB wh246q20m35 9 43 the the DET wh246q20m35 9 44 stable stable ADJ wh246q20m35 9 45 core core NOUN wh246q20m35 9 46 plays play VERB wh246q20m35 9 47 a a DET wh246q20m35 9 48 role role NOUN wh246q20m35 9 49 in in ADP wh246q20m35 9 50 both both CCONJ wh246q20m35 9 51 the the DET wh246q20m35 9 52 secretion secretion NOUN wh246q20m35 9 53 efficiency efficiency NOUN wh246q20m35 9 54 and and CCONJ wh246q20m35 9 55 folding folding NOUN wh246q20m35 9 56 of of ADP wh246q20m35 9 57 the the DET wh246q20m35 9 58 mature mature ADJ wh246q20m35 9 59 passenger passenger NOUN wh246q20m35 9 60 domain domain NOUN wh246q20m35 9 61 . . PUNCT wh246q20m35 10 1 the the DET wh246q20m35 10 2 pet pet ADJ wh246q20m35 10 3 passenger passenger NOUN wh246q20m35 10 4 domain domain NOUN wh246q20m35 10 5 consists consist VERB wh246q20m35 10 6 of of ADP wh246q20m35 10 7 an an DET wh246q20m35 10 8 nterminal nterminal ADJ wh246q20m35 10 9 protease protease NOUN wh246q20m35 10 10 domain domain NOUN wh246q20m35 10 11 in in ADP wh246q20m35 10 12 addition addition NOUN wh246q20m35 10 13 to to ADP wh246q20m35 10 14 the the DET wh246q20m35 10 15 & & CCONJ wh246q20m35 10 16 # # SYM wh246q20m35 10 17 946;-helix 946;-helix NUM wh246q20m35 10 18 domain domain NOUN wh246q20m35 10 19 . . PUNCT wh246q20m35 11 1 to to PART wh246q20m35 11 2 investigate investigate VERB wh246q20m35 11 3 the the DET wh246q20m35 11 4 role role NOUN wh246q20m35 11 5 of of ADP wh246q20m35 11 6 the the DET wh246q20m35 11 7 n n ADJ wh246q20m35 11 8 - - PUNCT wh246q20m35 11 9 terminal terminal ADJ wh246q20m35 11 10 globular globular ADJ wh246q20m35 11 11 domain domain NOUN wh246q20m35 11 12 of of ADP wh246q20m35 11 13 the the DET wh246q20m35 11 14 pet pet ADJ wh246q20m35 11 15 passenger passenger NOUN wh246q20m35 11 16 , , PUNCT wh246q20m35 11 17 we we PRON wh246q20m35 11 18 replaced replace VERB wh246q20m35 11 19 the the DET wh246q20m35 11 20 pet pet ADJ wh246q20m35 11 21 protease protease NOUN wh246q20m35 11 22 domain domain NOUN wh246q20m35 11 23 with with ADP wh246q20m35 11 24 dihydrofolate dihydrofolate NOUN wh246q20m35 11 25 reductase reductase NOUN wh246q20m35 11 26 ( ( PUNCT wh246q20m35 11 27 dhfr dhfr NOUN wh246q20m35 11 28 ) ) PUNCT wh246q20m35 11 29 , , PUNCT wh246q20m35 11 30 a a DET wh246q20m35 11 31 protein protein NOUN wh246q20m35 11 32 whose whose DET wh246q20m35 11 33 folding folding NOUN wh246q20m35 11 34 and and CCONJ wh246q20m35 11 35 stability stability NOUN wh246q20m35 11 36 are be AUX wh246q20m35 11 37 well well ADV wh246q20m35 11 38 characterized characterize VERB wh246q20m35 11 39 . . PUNCT wh246q20m35 12 1 the the DET wh246q20m35 12 2 chimeric chimeric ADJ wh246q20m35 12 3 dhfr dhfr ADJ wh246q20m35 12 4 - - PUNCT wh246q20m35 12 5 pet pet NOUN wh246q20m35 12 6 & & CCONJ wh246q20m35 12 7 # # SYM wh246q20m35 12 8 946;-helix 946;-helix NUM wh246q20m35 12 9 passenger passenger NOUN wh246q20m35 12 10 domain domain NOUN wh246q20m35 12 11 is be AUX wh246q20m35 12 12 secreted secrete VERB wh246q20m35 12 13 across across ADP wh246q20m35 12 14 the the DET wh246q20m35 12 15 om om PROPN wh246q20m35 12 16 and and CCONJ wh246q20m35 12 17 stabilization stabilization NOUN wh246q20m35 12 18 of of ADP wh246q20m35 12 19 dfhr dfhr NOUN wh246q20m35 12 20 by by ADP wh246q20m35 12 21 methotrexate methotrexate NOUN wh246q20m35 12 22 reduces reduce VERB wh246q20m35 12 23 the the DET wh246q20m35 12 24 level level NOUN wh246q20m35 12 25 of of ADP wh246q20m35 12 26 secreted secrete VERB wh246q20m35 12 27 chimera chimera NOUN wh246q20m35 12 28 . . PUNCT wh246q20m35 13 1 moreover moreover ADV wh246q20m35 13 2 , , PUNCT wh246q20m35 13 3 we we PRON wh246q20m35 13 4 altered alter VERB wh246q20m35 13 5 the the DET wh246q20m35 13 6 stability stability NOUN wh246q20m35 13 7 of of ADP wh246q20m35 13 8 the the DET wh246q20m35 13 9 dhfr dhfr NOUN wh246q20m35 13 10 domain domain NOUN wh246q20m35 13 11 by by ADP wh246q20m35 13 12 constructing construct VERB wh246q20m35 13 13 a a DET wh246q20m35 13 14 series series NOUN wh246q20m35 13 15 of of ADP wh246q20m35 13 16 point point NOUN wh246q20m35 13 17 mutations mutation NOUN wh246q20m35 13 18 , , PUNCT wh246q20m35 13 19 and and CCONJ wh246q20m35 13 20 observed observe VERB wh246q20m35 13 21 a a DET wh246q20m35 13 22 linear linear ADJ wh246q20m35 13 23 correlation correlation NOUN wh246q20m35 13 24 between between ADP wh246q20m35 13 25 dhfr dhfr NOUN wh246q20m35 13 26 stability stability NOUN wh246q20m35 13 27 and and CCONJ wh246q20m35 13 28 om om PROPN wh246q20m35 13 29 secretion secretion NOUN wh246q20m35 13 30 efficiency efficiency NOUN wh246q20m35 13 31 . . PUNCT wh246q20m35 14 1 in in ADP wh246q20m35 14 2 contrast contrast NOUN wh246q20m35 14 3 , , PUNCT wh246q20m35 14 4 mutations mutation NOUN wh246q20m35 14 5 that that PRON wh246q20m35 14 6 destabilize destabilize VERB wh246q20m35 14 7 the the DET wh246q20m35 14 8 pertactin pertactin ADJ wh246q20m35 14 9 stable stable ADJ wh246q20m35 14 10 core core NOUN wh246q20m35 14 11 result result NOUN wh246q20m35 14 12 in in ADP wh246q20m35 14 13 lower low ADJ wh246q20m35 14 14 levels level NOUN wh246q20m35 14 15 of of ADP wh246q20m35 14 16 om om PROPN wh246q20m35 14 17 secretion secretion NOUN wh246q20m35 14 18 , , PUNCT wh246q20m35 14 19 while while SCONJ wh246q20m35 14 20 a a DET wh246q20m35 14 21 mutation mutation NOUN wh246q20m35 14 22 that that PRON wh246q20m35 14 23 lowers lower VERB wh246q20m35 14 24 stability stability NOUN wh246q20m35 14 25 of of ADP wh246q20m35 14 26 only only ADV wh246q20m35 14 27 the the DET wh246q20m35 14 28 n n NOUN wh246q20m35 14 29 - - NOUN wh246q20m35 14 30 terminus terminus NOUN wh246q20m35 14 31 of of ADP wh246q20m35 14 32 the the DET wh246q20m35 14 33 pertactin pertactin ADJ wh246q20m35 14 34 ì_å_-helix ì_å_-helix PROPN wh246q20m35 14 35 has have VERB wh246q20m35 14 36 no no DET wh246q20m35 14 37 effect effect NOUN wh246q20m35 14 38 on on ADP wh246q20m35 14 39 om om PROPN wh246q20m35 14 40 secretion secretion NOUN wh246q20m35 14 41 . . PUNCT wh246q20m35 15 1 these these DET wh246q20m35 15 2 results result NOUN wh246q20m35 15 3 suggests suggest VERB wh246q20m35 15 4 that that SCONJ wh246q20m35 15 5 while while SCONJ wh246q20m35 15 6 the the DET wh246q20m35 15 7 stability stability NOUN wh246q20m35 15 8 of of ADP wh246q20m35 15 9 the the DET wh246q20m35 15 10 c c NOUN wh246q20m35 15 11 - - PUNCT wh246q20m35 15 12 terminal terminal ADJ wh246q20m35 15 13 stable stable ADJ wh246q20m35 15 14 core core NOUN wh246q20m35 15 15 provides provide VERB wh246q20m35 15 16 a a DET wh246q20m35 15 17 positive positive ADJ wh246q20m35 15 18 contribution contribution NOUN wh246q20m35 15 19 to to ADP wh246q20m35 15 20 om om PROPN wh246q20m35 15 21 secretion secretion NOUN wh246q20m35 15 22 , , PUNCT wh246q20m35 15 23 stabilizing stabilize VERB wh246q20m35 15 24 more more ADJ wh246q20m35 15 25 n n ADJ wh246q20m35 15 26 - - PUNCT wh246q20m35 15 27 terminal terminal ADJ wh246q20m35 15 28 portions portion NOUN wh246q20m35 15 29 of of ADP wh246q20m35 15 30 the the PRON wh246q20m35 15 31 at at ADP wh246q20m35 15 32 passenger passenger NOUN wh246q20m35 15 33 domain domain NOUN wh246q20m35 15 34 can can AUX wh246q20m35 15 35 be be AUX wh246q20m35 15 36 detrimental detrimental ADJ wh246q20m35 15 37 to to ADP wh246q20m35 15 38 efficient efficient ADJ wh246q20m35 15 39 om om PROPN wh246q20m35 15 40 secretion secretion NOUN wh246q20m35 15 41 . . PUNCT wh246q20m35 16 1 these these DET wh246q20m35 16 2 results result NOUN wh246q20m35 16 3 demonstrate demonstrate VERB wh246q20m35 16 4 for for ADP wh246q20m35 16 5 the the DET wh246q20m35 16 6 first first ADJ wh246q20m35 16 7 time time NOUN wh246q20m35 16 8 that that SCONJ wh246q20m35 16 9 passenger passenger NOUN wh246q20m35 16 10 domain domain NOUN wh246q20m35 16 11 stability stability NOUN wh246q20m35 16 12 plays play VERB wh246q20m35 16 13 a a DET wh246q20m35 16 14 direct direct ADJ wh246q20m35 16 15 role role NOUN wh246q20m35 16 16 in in ADP wh246q20m35 16 17 at at ADP wh246q20m35 16 18 om om PROPN wh246q20m35 16 19 secretion secretion NOUN wh246q20m35 16 20 efficiency efficiency NOUN wh246q20m35 16 21 . . PUNCT