id sid tid token lemma pos wd375t38f8j 1 1 in in ADP wd375t38f8j 1 2 recent recent ADJ wd375t38f8j 1 3 years year NOUN wd375t38f8j 1 4 , , PUNCT wd375t38f8j 1 5 extracellular extracellular ADJ wd375t38f8j 1 6 nucleic nucleic ADJ wd375t38f8j 1 7 acids acid NOUN wd375t38f8j 1 8 and and CCONJ wd375t38f8j 1 9 extracellular extracellular ADJ wd375t38f8j 1 10 rna rna PROPN wd375t38f8j 1 11 carriers carrier NOUN wd375t38f8j 1 12 have have AUX wd375t38f8j 1 13 been be AUX wd375t38f8j 1 14 demonstrated demonstrate VERB wd375t38f8j 1 15 as as ADP wd375t38f8j 1 16 promising promising ADJ wd375t38f8j 1 17 biomarkers biomarker NOUN wd375t38f8j 1 18 for for ADP wd375t38f8j 1 19 cancer cancer NOUN wd375t38f8j 1 20 diagnostics diagnostic NOUN wd375t38f8j 1 21 , , PUNCT wd375t38f8j 1 22 treatment treatment NOUN wd375t38f8j 1 23 , , PUNCT wd375t38f8j 1 24 and and CCONJ wd375t38f8j 1 25 prognostics prognostic NOUN wd375t38f8j 1 26 . . PUNCT wd375t38f8j 2 1 however however ADV wd375t38f8j 2 2 , , PUNCT wd375t38f8j 2 3 the the DET wd375t38f8j 2 4 lack lack NOUN wd375t38f8j 2 5 of of ADP wd375t38f8j 2 6 proper proper ADJ wd375t38f8j 2 7 isolation isolation NOUN wd375t38f8j 2 8 and and CCONJ wd375t38f8j 2 9 quantification quantification NOUN wd375t38f8j 2 10 tools tool NOUN wd375t38f8j 2 11 still still ADV wd375t38f8j 2 12 hinders hinder VERB wd375t38f8j 2 13 the the DET wd375t38f8j 2 14 advances advance NOUN wd375t38f8j 2 15 of of ADP wd375t38f8j 2 16 related relate VERB wd375t38f8j 2 17 liquid liquid ADJ wd375t38f8j 2 18 biopsy biopsy ADJ wd375t38f8j 2 19 technologies technology NOUN wd375t38f8j 2 20 based base VERB wd375t38f8j 2 21 on on ADP wd375t38f8j 2 22 these these DET wd375t38f8j 2 23 biomarkers biomarker NOUN wd375t38f8j 2 24 . . PUNCT wd375t38f8j 3 1 high high ADJ wd375t38f8j 3 2 - - PUNCT wd375t38f8j 3 3 efficiency efficiency NOUN wd375t38f8j 3 4 rna rna NOUN wd375t38f8j 3 5 carrier carrier NOUN wd375t38f8j 3 6 isolation isolation NOUN wd375t38f8j 3 7 techniques technique NOUN wd375t38f8j 3 8 must must AUX wd375t38f8j 3 9 be be AUX wd375t38f8j 3 10 accessible accessible ADJ wd375t38f8j 3 11 to to ADP wd375t38f8j 3 12 researchers researcher NOUN wd375t38f8j 3 13 and and CCONJ wd375t38f8j 3 14 doctors doctor NOUN wd375t38f8j 3 15 to to PART wd375t38f8j 3 16 truly truly ADV wd375t38f8j 3 17 understand understand VERB wd375t38f8j 3 18 and and CCONJ wd375t38f8j 3 19 utilize utilize VERB wd375t38f8j 3 20 them they PRON wd375t38f8j 3 21 for for ADP wd375t38f8j 3 22 clinical clinical ADJ wd375t38f8j 3 23 applications application NOUN wd375t38f8j 3 24 . . PUNCT wd375t38f8j 4 1 the the DET wd375t38f8j 4 2 sensitivity sensitivity NOUN wd375t38f8j 4 3 and and CCONJ wd375t38f8j 4 4 specificity specificity NOUN wd375t38f8j 4 5 of of ADP wd375t38f8j 4 6 nucleic nucleic ADJ wd375t38f8j 4 7 acid acid ADJ wd375t38f8j 4 8 quantification quantification NOUN wd375t38f8j 4 9 also also ADV wd375t38f8j 4 10 can can AUX wd375t38f8j 4 11 be be AUX wd375t38f8j 4 12 improved improve VERB wd375t38f8j 4 13 through through ADP wd375t38f8j 4 14 the the DET wd375t38f8j 4 15 development development NOUN wd375t38f8j 4 16 of of ADP wd375t38f8j 4 17 extraction extraction NOUN wd375t38f8j 4 18 methods method NOUN wd375t38f8j 4 19 with with ADP wd375t38f8j 4 20 better well ADJ wd375t38f8j 4 21 yield yield NOUN wd375t38f8j 4 22 and and CCONJ wd375t38f8j 4 23 purity purity NOUN wd375t38f8j 4 24 . . PUNCT wd375t38f8j 5 1 a a DET wd375t38f8j 5 2 fully fully ADV wd375t38f8j 5 3 - - PUNCT wd375t38f8j 5 4 automated automate VERB wd375t38f8j 5 5 point point NOUN wd375t38f8j 5 6 - - PUNCT wd375t38f8j 5 7 of of ADP wd375t38f8j 5 8 - - PUNCT wd375t38f8j 5 9 care care NOUN wd375t38f8j 5 10 system system NOUN wd375t38f8j 5 11 can can AUX wd375t38f8j 5 12 be be AUX wd375t38f8j 5 13 envisioned envision VERB wd375t38f8j 5 14 by by ADP wd375t38f8j 5 15 integrating integrate VERB wd375t38f8j 5 16 all all DET wd375t38f8j 5 17 these these DET wd375t38f8j 5 18 steps step NOUN wd375t38f8j 5 19 sequentially sequentially ADV wd375t38f8j 5 20 into into ADP wd375t38f8j 5 21 a a DET wd375t38f8j 5 22 turn turn NOUN wd375t38f8j 5 23 - - PUNCT wd375t38f8j 5 24 key key ADJ wd375t38f8j 5 25 microfluidic microfluidic ADJ wd375t38f8j 5 26 system system NOUN wd375t38f8j 5 27 . . PUNCT wd375t38f8j 6 1 we we PRON wd375t38f8j 6 2 address address VERB wd375t38f8j 6 3 these these DET wd375t38f8j 6 4 challenges challenge NOUN wd375t38f8j 6 5 through through ADP wd375t38f8j 6 6 the the DET wd375t38f8j 6 7 development development NOUN wd375t38f8j 6 8 and and CCONJ wd375t38f8j 6 9 integration integration NOUN wd375t38f8j 6 10 of of ADP wd375t38f8j 6 11 multiple multiple ADJ wd375t38f8j 6 12 micro micro ADJ wd375t38f8j 6 13 / / ADJ wd375t38f8j 6 14 nanofluidic nanofluidic ADJ wd375t38f8j 6 15 devices device NOUN wd375t38f8j 6 16 for for ADP wd375t38f8j 6 17 isolation isolation NOUN wd375t38f8j 6 18 of of ADP wd375t38f8j 6 19 carriers carrier NOUN wd375t38f8j 6 20 and and CCONJ wd375t38f8j 6 21 nucleic nucleic ADJ wd375t38f8j 6 22 acids acid NOUN wd375t38f8j 6 23 , , PUNCT wd375t38f8j 6 24 downstream downstream ADJ wd375t38f8j 6 25 lysis lysis NOUN wd375t38f8j 6 26 and and CCONJ wd375t38f8j 6 27 quantification quantification NOUN wd375t38f8j 6 28 . . PUNCT wd375t38f8j 7 1 sensitivity sensitivity NOUN wd375t38f8j 7 2 , , PUNCT wd375t38f8j 7 3 selectivity selectivity NOUN wd375t38f8j 7 4 , , PUNCT wd375t38f8j 7 5 and and CCONJ wd375t38f8j 7 6 throughput throughput NOUN wd375t38f8j 7 7 of of ADP wd375t38f8j 7 8 isolation isolation NOUN wd375t38f8j 7 9 and and CCONJ wd375t38f8j 7 10 diagnostic diagnostic ADJ wd375t38f8j 7 11 technologies technology NOUN wd375t38f8j 7 12 are be AUX wd375t38f8j 7 13 enhanced enhance VERB wd375t38f8j 7 14 with with ADP wd375t38f8j 7 15 optimized optimize VERB wd375t38f8j 7 16 non[1]equilibrium non[1]equilibrium NOUN wd375t38f8j 7 17 mechanisms mechanism NOUN wd375t38f8j 7 18 and and CCONJ wd375t38f8j 7 19 non non ADJ wd375t38f8j 7 20 - - ADJ wd375t38f8j 7 21 uniform uniform ADJ wd375t38f8j 7 22 structures structure NOUN wd375t38f8j 7 23 . . PUNCT wd375t38f8j 8 1 in in ADP wd375t38f8j 8 2 chapter chapter NOUN wd375t38f8j 8 3 1 1 NUM wd375t38f8j 8 4 , , PUNCT wd375t38f8j 8 5 i i PRON wd375t38f8j 8 6 review review VERB wd375t38f8j 8 7 current current ADJ wd375t38f8j 8 8 extracellular extracellular ADJ wd375t38f8j 8 9 rna rna PROPN wd375t38f8j 8 10 carrier carrier NOUN wd375t38f8j 8 11 isolation isolation NOUN wd375t38f8j 8 12 and and CCONJ wd375t38f8j 8 13 nucleic nucleic ADJ wd375t38f8j 8 14 acids acid NOUN wd375t38f8j 8 15 purification purification NOUN wd375t38f8j 8 16 / / SYM wd375t38f8j 8 17 quantification quantification NOUN wd375t38f8j 8 18 technologies technology NOUN wd375t38f8j 8 19 . . PUNCT wd375t38f8j 9 1 in in ADP wd375t38f8j 9 2 chapter chapter NOUN wd375t38f8j 9 3 2 2 NUM wd375t38f8j 9 4 , , PUNCT wd375t38f8j 9 5 i i PRON wd375t38f8j 9 6 demonstrate demonstrate VERB wd375t38f8j 9 7 our our PRON wd375t38f8j 9 8 solution solution NOUN wd375t38f8j 9 9 to to PART wd375t38f8j 9 10 overcome overcome VERB wd375t38f8j 9 11 the the DET wd375t38f8j 9 12 current current ADJ wd375t38f8j 9 13 inefficient inefficient ADJ wd375t38f8j 9 14 size size NOUN wd375t38f8j 9 15 - - PUNCT wd375t38f8j 9 16 based base VERB wd375t38f8j 9 17 ev ev ADJ wd375t38f8j 9 18 isolation isolation NOUN wd375t38f8j 9 19 by by ADP wd375t38f8j 9 20 asymmetric asymmetric ADJ wd375t38f8j 9 21 nanoporous nanoporous ADJ wd375t38f8j 9 22 membrane membrane NOUN wd375t38f8j 9 23 ( ( PUNCT wd375t38f8j 9 24 anm anm PROPN wd375t38f8j 9 25 ) ) PUNCT wd375t38f8j 9 26 ultrafiltration ultrafiltration NOUN wd375t38f8j 9 27 and and CCONJ wd375t38f8j 9 28 explain explain VERB wd375t38f8j 9 29 how how SCONJ wd375t38f8j 9 30 the the DET wd375t38f8j 9 31 symmetry symmetry NOUN wd375t38f8j 9 32 - - PUNCT wd375t38f8j 9 33 breaking break VERB wd375t38f8j 9 34 geometry geometry NOUN wd375t38f8j 9 35 of of ADP wd375t38f8j 9 36 the the DET wd375t38f8j 9 37 nanopore nanopore NOUN wd375t38f8j 9 38 combining combine VERB wd375t38f8j 9 39 with with ADP wd375t38f8j 9 40 shear shear ADJ wd375t38f8j 9 41 force force NOUN wd375t38f8j 9 42 increase increase VERB wd375t38f8j 9 43 the the DET wd375t38f8j 9 44 yield yield NOUN wd375t38f8j 9 45 and and CCONJ wd375t38f8j 9 46 throughput throughput NOUN wd375t38f8j 9 47 . . PUNCT wd375t38f8j 10 1 in in ADP wd375t38f8j 10 2 chapter chapter NOUN wd375t38f8j 10 3 3 3 NUM wd375t38f8j 10 4 , , PUNCT wd375t38f8j 10 5 i i PRON wd375t38f8j 10 6 will will AUX wd375t38f8j 10 7 further far ADV wd375t38f8j 10 8 utilize utilize VERB wd375t38f8j 10 9 the the DET wd375t38f8j 10 10 asymmetric asymmetric ADJ wd375t38f8j 10 11 nanoporous nanoporous ADJ wd375t38f8j 10 12 membrane membrane NOUN wd375t38f8j 10 13 ( ( PUNCT wd375t38f8j 10 14 anm anm PROPN wd375t38f8j 10 15 ) ) PUNCT wd375t38f8j 10 16 for for ADP wd375t38f8j 10 17 purification purification NOUN wd375t38f8j 10 18 of of ADP wd375t38f8j 10 19 both both DET wd375t38f8j 10 20 retrovirus retrovirus NOUN wd375t38f8j 10 21 and and CCONJ wd375t38f8j 10 22 sars sar NOUN wd375t38f8j 10 23 - - PUNCT wd375t38f8j 10 24 cov-2 cov-2 NOUN wd375t38f8j 10 25 . . PUNCT wd375t38f8j 11 1 i i PRON wd375t38f8j 11 2 demonstrate demonstrate VERB wd375t38f8j 11 3 our our PRON wd375t38f8j 11 4 technology technology NOUN wd375t38f8j 11 5 , , PUNCT wd375t38f8j 11 6 along along ADP wd375t38f8j 11 7 with with ADP wd375t38f8j 11 8 qrt qrt ADJ wd375t38f8j 11 9 - - PUNCT wd375t38f8j 11 10 pcr pcr NOUN wd375t38f8j 11 11 improves improve VERB wd375t38f8j 11 12 the the DET wd375t38f8j 11 13 virus virus NOUN wd375t38f8j 11 14 detection detection NOUN wd375t38f8j 11 15 sensitivity sensitivity NOUN wd375t38f8j 11 16 by by ADP wd375t38f8j 11 17 more more ADJ wd375t38f8j 11 18 than than ADP wd375t38f8j 11 19 30 30 NUM wd375t38f8j 11 20 - - ADJ wd375t38f8j 11 21 fold fold NOUN wd375t38f8j 11 22 compared compare VERB wd375t38f8j 11 23 to to ADP wd375t38f8j 11 24 the the DET wd375t38f8j 11 25 conventional conventional ADJ wd375t38f8j 11 26 rna rna PROPN wd375t38f8j 11 27 extraction extraction NOUN wd375t38f8j 11 28 - - PUNCT wd375t38f8j 11 29 based base VERB wd375t38f8j 11 30 method method NOUN wd375t38f8j 11 31 . . PUNCT wd375t38f8j 12 1 in in ADP wd375t38f8j 12 2 chapter chapter NOUN wd375t38f8j 12 3 4 4 NUM wd375t38f8j 12 4 , , PUNCT wd375t38f8j 12 5 a a DET wd375t38f8j 12 6 novel novel NOUN wd375t38f8j 12 7 electroplated electroplate VERB wd375t38f8j 12 8 magnetic magnetic ADJ wd375t38f8j 12 9 nanoporous nanoporous ADJ wd375t38f8j 12 10 membrane membrane NOUN wd375t38f8j 12 11 ( ( PUNCT wd375t38f8j 12 12 mnm mnm PROPN wd375t38f8j 12 13 ) ) PUNCT wd375t38f8j 12 14 with with ADP wd375t38f8j 12 15 heterogeneous heterogeneous ADJ wd375t38f8j 12 16 superparamagnetic superparamagnetic ADJ wd375t38f8j 12 17 nano nano NOUN wd375t38f8j 12 18 - - PUNCT wd375t38f8j 12 19 junction junction NOUN wd375t38f8j 12 20 is be AUX wd375t38f8j 12 21 fabricated fabricate VERB wd375t38f8j 12 22 to to PART wd375t38f8j 12 23 improve improve VERB wd375t38f8j 12 24 the the DET wd375t38f8j 12 25 throughput throughput NOUN wd375t38f8j 12 26 and and CCONJ wd375t38f8j 12 27 yield yield NOUN wd375t38f8j 12 28 of of ADP wd375t38f8j 12 29 immunocapture immunocapture NOUN wd375t38f8j 12 30 . . PUNCT wd375t38f8j 13 1 in in ADP wd375t38f8j 13 2 chapter chapter NOUN wd375t38f8j 13 3 5 5 NUM wd375t38f8j 13 4 , , PUNCT wd375t38f8j 13 5 an an DET wd375t38f8j 13 6 ionic ionic ADJ wd375t38f8j 13 7 transistor transistor NOUN wd375t38f8j 13 8 is be AUX wd375t38f8j 13 9 designed design VERB wd375t38f8j 13 10 to to PART wd375t38f8j 13 11 control control VERB wd375t38f8j 13 12 the the DET wd375t38f8j 13 13 non non ADJ wd375t38f8j 13 14 - - ADJ wd375t38f8j 13 15 equilibrium equilibrium ADJ wd375t38f8j 13 16 depletion depletion NOUN wd375t38f8j 13 17 front front NOUN wd375t38f8j 13 18 for for ADP wd375t38f8j 13 19 extraction extraction NOUN wd375t38f8j 13 20 of of ADP wd375t38f8j 13 21 highly highly ADV wd375t38f8j 13 22 - - PUNCT wd375t38f8j 13 23 charged charge VERB wd375t38f8j 13 24 biomolecules biomolecule NOUN wd375t38f8j 13 25 like like ADP wd375t38f8j 13 26 nucleic nucleic ADJ wd375t38f8j 13 27 acids acid NOUN wd375t38f8j 13 28 . . PUNCT wd375t38f8j 14 1 both both PRON wd375t38f8j 14 2 extracellular extracellular PROPN wd375t38f8j 14 3 dnas dnas PROPN wd375t38f8j 14 4 and and CCONJ wd375t38f8j 14 5 rnas rna NOUN wd375t38f8j 14 6 can can AUX wd375t38f8j 14 7 be be AUX wd375t38f8j 14 8 isolated isolate VERB wd375t38f8j 14 9 effectively effectively ADV wd375t38f8j 14 10 without without ADP wd375t38f8j 14 11 bias bias NOUN wd375t38f8j 14 12 in in ADP wd375t38f8j 14 13 length length NOUN wd375t38f8j 14 14 and and CCONJ wd375t38f8j 14 15 concentration concentration NOUN wd375t38f8j 14 16 . . PUNCT wd375t38f8j 15 1 in in ADP wd375t38f8j 15 2 chapter chapter NOUN wd375t38f8j 15 3 6 6 NUM wd375t38f8j 15 4 , , PUNCT wd375t38f8j 15 5 i i PRON wd375t38f8j 15 6 integrate integrate VERB wd375t38f8j 15 7 surface surface NOUN wd375t38f8j 15 8 acoustic acoustic ADJ wd375t38f8j 15 9 wave wave NOUN wd375t38f8j 15 10 lysis lysis NOUN wd375t38f8j 15 11 , , PUNCT wd375t38f8j 15 12 depletion depletion NOUN wd375t38f8j 15 13 - - PUNCT wd375t38f8j 15 14 induced induce VERB wd375t38f8j 15 15 concentration concentration NOUN wd375t38f8j 15 16 , , PUNCT wd375t38f8j 15 17 and and CCONJ wd375t38f8j 15 18 ion ion NOUN wd375t38f8j 15 19 - - PUNCT wd375t38f8j 15 20 exchange exchange NOUN wd375t38f8j 15 21 membrane membrane NOUN wd375t38f8j 15 22 sensors sensor NOUN wd375t38f8j 15 23 into into ADP wd375t38f8j 15 24 a a DET wd375t38f8j 15 25 microfluidic microfluidic ADJ wd375t38f8j 15 26 platform platform NOUN wd375t38f8j 15 27 for for ADP wd375t38f8j 15 28 plasma plasma NOUN wd375t38f8j 15 29 ev ev NOUN wd375t38f8j 15 30 - - PUNCT wd375t38f8j 15 31 mirna mirna ADJ wd375t38f8j 15 32 sensing sensing NOUN wd375t38f8j 15 33 . . PUNCT wd375t38f8j 16 1 the the DET wd375t38f8j 16 2 various various PROPN wd375t38f8j 16 3 micro micro PROPN wd375t38f8j 16 4 / / ADJ wd375t38f8j 16 5 nanofluidic nanofluidic ADJ wd375t38f8j 16 6 modules module NOUN wd375t38f8j 16 7 developed develop VERB wd375t38f8j 16 8 in in ADP wd375t38f8j 16 9 my my PRON wd375t38f8j 16 10 thesis thesis NOUN wd375t38f8j 16 11 , , PUNCT wd375t38f8j 16 12 plus plus CCONJ wd375t38f8j 16 13 their their PRON wd375t38f8j 16 14 parallel parallel ADJ wd375t38f8j 16 15 electronic electronic ADJ wd375t38f8j 16 16 modules module NOUN wd375t38f8j 16 17 , , PUNCT wd375t38f8j 16 18 enable enable VERB wd375t38f8j 16 19 a a DET wd375t38f8j 16 20 new new ADJ wd375t38f8j 16 21 turn turn NOUN wd375t38f8j 16 22 - - PUNCT wd375t38f8j 16 23 key key NOUN wd375t38f8j 16 24 integrated integrated ADJ wd375t38f8j 16 25 platform platform NOUN wd375t38f8j 16 26 for for ADP wd375t38f8j 16 27 isolating isolate VERB wd375t38f8j 16 28 and and CCONJ wd375t38f8j 16 29 quantifying quantify VERB wd375t38f8j 16 30 extracellular extracellular ADJ wd375t38f8j 16 31 nanocarriers nanocarrier NOUN wd375t38f8j 16 32 and and CCONJ wd375t38f8j 16 33 their their PRON wd375t38f8j 16 34 disease disease NOUN wd375t38f8j 16 35 biomarker biomarker NOUN wd375t38f8j 16 36 ( ( PUNCT wd375t38f8j 16 37 rna rna PROPN wd375t38f8j 16 38 and and CCONJ wd375t38f8j 16 39 protein protein NOUN wd375t38f8j 16 40 ) ) PUNCT wd375t38f8j 16 41 cargoes cargo NOUN wd375t38f8j 16 42 . . PUNCT wd375t38f8j 17 1 in in ADP wd375t38f8j 17 2 the the DET wd375t38f8j 17 3 last last ADJ wd375t38f8j 17 4 chapter chapter NOUN wd375t38f8j 17 5 , , PUNCT wd375t38f8j 17 6 i i PRON wd375t38f8j 17 7 summarize summarize VERB wd375t38f8j 17 8 their their PRON wd375t38f8j 17 9 functionalities functionality NOUN wd375t38f8j 17 10 , , PUNCT wd375t38f8j 17 11 how how SCONJ wd375t38f8j 17 12 they they PRON wd375t38f8j 17 13 can can AUX wd375t38f8j 17 14 be be AUX wd375t38f8j 17 15 further far ADV wd375t38f8j 17 16 improved improve VERB wd375t38f8j 17 17 and and CCONJ wd375t38f8j 17 18 the the DET wd375t38f8j 17 19 appropriate appropriate ADJ wd375t38f8j 17 20 integration integration NOUN wd375t38f8j 17 21 strategies strategy NOUN wd375t38f8j 17 22 for for ADP wd375t38f8j 17 23 different different ADJ wd375t38f8j 17 24 applications application NOUN wd375t38f8j 17 25 . . PUNCT