id	sid	tid	token	lemma	pos
w0892805b86	1	1	chemoresistance	chemoresistance	NOUN
w0892805b86	1	2	is	be	AUX
w0892805b86	1	3	a	a	DET
w0892805b86	1	4	leading	lead	VERB
w0892805b86	1	5	cause	cause	NOUN
w0892805b86	1	6	of	of	ADP
w0892805b86	1	7	breast	breast	NOUN
w0892805b86	1	8	cancer	cancer	NOUN
w0892805b86	1	9	related	relate	VERB
w0892805b86	1	10	deaths	death	NOUN
w0892805b86	1	11	.	.	PUNCT
w0892805b86	2	1	therefore	therefore	ADV
w0892805b86	2	2	,	,	PUNCT
w0892805b86	2	3	understanding	understand	VERB
w0892805b86	2	4	the	the	DET
w0892805b86	2	5	molecular	molecular	ADJ
w0892805b86	2	6	basis	basis	NOUN
w0892805b86	2	7	for	for	ADP
w0892805b86	2	8	chemoresistance	chemoresistance	NOUN
w0892805b86	2	9	is	be	AUX
w0892805b86	2	10	essential	essential	ADJ
w0892805b86	2	11	for	for	ADP
w0892805b86	2	12	novel	novel	ADJ
w0892805b86	2	13	therapeutic	therapeutic	ADJ
w0892805b86	2	14	advancement	advancement	NOUN
w0892805b86	2	15	and	and	CCONJ
w0892805b86	2	16	improving	improve	VERB
w0892805b86	2	17	patient	patient	ADJ
w0892805b86	2	18	outcome	outcome	NOUN
w0892805b86	2	19	.	.	PUNCT
w0892805b86	3	1	the	the	DET
w0892805b86	3	2	adenomatous	adenomatous	ADJ
w0892805b86	3	3	polyposis	polyposis	NOUN
w0892805b86	3	4	coli	coli	NOUN
w0892805b86	3	5	(	(	PUNCT
w0892805b86	3	6	apc	apc	X
w0892805b86	3	7	)	)	PUNCT
w0892805b86	3	8	tumor	tumor	NOUN
w0892805b86	3	9	suppressor	suppressor	NOUN
w0892805b86	3	10	is	be	AUX
w0892805b86	3	11	lost	lose	VERB
w0892805b86	3	12	in	in	ADP
w0892805b86	3	13	up	up	ADP
w0892805b86	3	14	to	to	PART
w0892805b86	3	15	70	70	NUM
w0892805b86	3	16	%	%	NOUN
w0892805b86	3	17	of	of	ADP
w0892805b86	3	18	sporadic	sporadic	ADJ
w0892805b86	3	19	breast	breast	NOUN
w0892805b86	3	20	cancer	cancer	NOUN
w0892805b86	3	21	;	;	PUNCT
w0892805b86	3	22	however	however	ADV
w0892805b86	3	23	,	,	PUNCT
w0892805b86	3	24	little	little	ADJ
w0892805b86	3	25	is	be	AUX
w0892805b86	3	26	known	know	VERB
w0892805b86	3	27	about	about	ADP
w0892805b86	3	28	how	how	SCONJ
w0892805b86	3	29	apc	apc	PUNCT
w0892805b86	3	30	loss	loss	NOUN
w0892805b86	3	31	contributes	contribute	VERB
w0892805b86	3	32	to	to	ADP
w0892805b86	3	33	chemoresistance	chemoresistance	NOUN
w0892805b86	3	34	.	.	PUNCT
w0892805b86	4	1	using	use	VERB
w0892805b86	4	2	mammary	mammary	ADJ
w0892805b86	4	3	tumor	tumor	NOUN
w0892805b86	4	4	cells	cell	NOUN
w0892805b86	4	5	isolated	isolate	VERB
w0892805b86	4	6	from	from	ADP
w0892805b86	4	7	the	the	DET
w0892805b86	4	8	apcmin/+	apcmin/+	PROPN
w0892805b86	4	9	mouse	mouse	NOUN
w0892805b86	4	10	crossed	cross	VERB
w0892805b86	4	11	to	to	ADP
w0892805b86	4	12	the	the	DET
w0892805b86	4	13	polyoma	polyoma	ADJ
w0892805b86	4	14	middle	middle	PROPN
w0892805b86	4	15	t	t	PROPN
w0892805b86	4	16	antigen	antigen	NOUN
w0892805b86	4	17	(	(	PUNCT
w0892805b86	4	18	pymt	pymt	PROPN
w0892805b86	4	19	)	)	PUNCT
w0892805b86	4	20	transgenic	transgenic	NOUN
w0892805b86	4	21	model	model	NOUN
w0892805b86	4	22	,	,	PUNCT
w0892805b86	4	23	we	we	PRON
w0892805b86	4	24	made	make	VERB
w0892805b86	4	25	the	the	DET
w0892805b86	4	26	novel	novel	ADJ
w0892805b86	4	27	observation	observation	NOUN
w0892805b86	4	28	that	that	SCONJ
w0892805b86	4	29	apc	apc	NOUN
w0892805b86	4	30	loss	loss	NOUN
w0892805b86	4	31	decreased	decrease	VERB
w0892805b86	4	32	doxorubicin	doxorubicin	NOUN
w0892805b86	4	33	(	(	PUNCT
w0892805b86	4	34	dox)-induced	dox)-induce	VERB
w0892805b86	4	35	apoptosis	apoptosis	NOUN
w0892805b86	4	36	.	.	PUNCT
w0892805b86	5	1	we	we	PRON
w0892805b86	5	2	hypothesized	hypothesize	VERB
w0892805b86	5	3	that	that	SCONJ
w0892805b86	5	4	apc	apc	NOUN
w0892805b86	5	5	loss	loss	NOUN
w0892805b86	5	6	prevents	prevent	VERB
w0892805b86	5	7	dox	dox	PROPN
w0892805b86	5	8	-	-	PUNCT
w0892805b86	5	9	mediated	mediate	VERB
w0892805b86	5	10	apoptosis	apoptosis	NOUN
w0892805b86	5	11	through	through	ADP
w0892805b86	5	12	:	:	PUNCT
w0892805b86	5	13	1	1	X
w0892805b86	5	14	)	)	PUNCT
w0892805b86	5	15	reduced	reduce	VERB
w0892805b86	5	16	intracellular	intracellular	ADJ
w0892805b86	5	17	dox	dox	NOUN
w0892805b86	5	18	and	and	CCONJ
w0892805b86	5	19	2	2	X
w0892805b86	5	20	)	)	PUNCT
w0892805b86	5	21	alterations	alteration	NOUN
w0892805b86	5	22	in	in	ADP
w0892805b86	5	23	dna	dna	NOUN
w0892805b86	5	24	damage	damage	NOUN
w0892805b86	5	25	and	and	CCONJ
w0892805b86	5	26	repair	repair	NOUN
w0892805b86	5	27	with	with	ADP
w0892805b86	5	28	the	the	DET
w0892805b86	5	29	goal	goal	NOUN
w0892805b86	5	30	to	to	PART
w0892805b86	5	31	discover	discover	VERB
w0892805b86	5	32	new	new	ADJ
w0892805b86	5	33	combination	combination	NOUN
w0892805b86	5	34	therapies	therapy	NOUN
w0892805b86	5	35	for	for	ADP
w0892805b86	5	36	apc	apc	NOUN
w0892805b86	5	37	-	-	PUNCT
w0892805b86	5	38	deficient	deficient	ADJ
w0892805b86	5	39	cancer.to	cancer.to	NUM
w0892805b86	5	40	investigate	investigate	VERB
w0892805b86	5	41	the	the	DET
w0892805b86	5	42	intracellular	intracellular	ADJ
w0892805b86	5	43	dox	dox	NOUN
w0892805b86	5	44	accumulation	accumulation	NOUN
w0892805b86	5	45	,	,	PUNCT
w0892805b86	5	46	we	we	PRON
w0892805b86	5	47	measured	measure	VERB
w0892805b86	5	48	the	the	DET
w0892805b86	5	49	amount	amount	NOUN
w0892805b86	5	50	of	of	ADP
w0892805b86	5	51	dox	dox	PROPN
w0892805b86	5	52	intracellular	intracellular	ADJ
w0892805b86	5	53	fluorescence	fluorescence	NOUN
w0892805b86	5	54	and	and	CCONJ
w0892805b86	5	55	found	find	VERB
w0892805b86	5	56	decreased	decrease	VERB
w0892805b86	5	57	intracellular	intracellular	ADJ
w0892805b86	5	58	dox	dox	NOUN
w0892805b86	5	59	retention	retention	NOUN
w0892805b86	5	60	with	with	ADP
w0892805b86	5	61	apc	apc	NOUN
w0892805b86	5	62	loss	loss	NOUN
w0892805b86	5	63	.	.	PUNCT
w0892805b86	6	1	the	the	DET
w0892805b86	6	2	atp	atp	ADV
w0892805b86	6	3	-	-	PUNCT
w0892805b86	6	4	binding	bind	VERB
w0892805b86	6	5	cassette	cassette	NOUN
w0892805b86	6	6	(	(	PUNCT
w0892805b86	6	7	abc	abc	PROPN
w0892805b86	6	8	)	)	PUNCT
w0892805b86	6	9	transporters	transporter	NOUN
w0892805b86	6	10	,	,	PUNCT
w0892805b86	6	11	multidrug	multidrug	NOUN
w0892805b86	6	12	resistance	resistance	NOUN
w0892805b86	6	13	1	1	NUM
w0892805b86	6	14	(	(	PUNCT
w0892805b86	6	15	mdr1	mdr1	PROPN
w0892805b86	6	16	)	)	PUNCT
w0892805b86	6	17	and	and	CCONJ
w0892805b86	6	18	multidrug	multidrug	VERB
w0892805b86	6	19	resistance	resistance	NOUN
w0892805b86	6	20	protein	protein	NOUN
w0892805b86	6	21	1	1	NUM
w0892805b86	6	22	(	(	PUNCT
w0892805b86	6	23	mrp1	mrp1	PROPN
w0892805b86	6	24	)	)	PUNCT
w0892805b86	6	25	,	,	PUNCT
w0892805b86	6	26	are	be	AUX
w0892805b86	6	27	well	well	ADV
w0892805b86	6	28	established	establish	VERB
w0892805b86	6	29	to	to	PART
w0892805b86	6	30	contribute	contribute	VERB
w0892805b86	6	31	to	to	ADP
w0892805b86	6	32	drug	drug	NOUN
w0892805b86	6	33	resistance	resistance	NOUN
w0892805b86	6	34	through	through	ADP
w0892805b86	6	35	drug	drug	NOUN
w0892805b86	6	36	efflux	efflux	NOUN
w0892805b86	6	37	and	and	CCONJ
w0892805b86	6	38	are	be	AUX
w0892805b86	6	39	overexpressed	overexpresse	VERB
w0892805b86	6	40	in	in	ADP
w0892805b86	6	41	tumor	tumor	NOUN
w0892805b86	6	42	initiating	initiate	VERB
w0892805b86	6	43	cells	cell	NOUN
w0892805b86	6	44	(	(	PUNCT
w0892805b86	6	45	tics	tic	NOUN
w0892805b86	6	46	)	)	PUNCT
w0892805b86	6	47	.	.	PUNCT
w0892805b86	7	1	we	we	PRON
w0892805b86	7	2	showed	show	VERB
w0892805b86	7	3	that	that	SCONJ
w0892805b86	7	4	mmtv	mmtv	PROPN
w0892805b86	7	5	-	-	PUNCT
w0892805b86	7	6	pymt;apcmin/+	pymt;apcmin/+	PROPN
w0892805b86	7	7	cells	cell	NOUN
w0892805b86	7	8	have	have	VERB
w0892805b86	7	9	an	an	DET
w0892805b86	7	10	increased	increase	VERB
w0892805b86	7	11	tic	tic	ADJ
w0892805b86	7	12	population	population	NOUN
w0892805b86	7	13	.	.	PUNCT
w0892805b86	8	1	to	to	PART
w0892805b86	8	2	investigate	investigate	VERB
w0892805b86	8	3	this	this	DET
w0892805b86	8	4	decreased	decrease	VERB
w0892805b86	8	5	intracellular	intracellular	ADJ
w0892805b86	8	6	dox	dox	NOUN
w0892805b86	8	7	accumulation	accumulation	NOUN
w0892805b86	8	8	,	,	PUNCT
w0892805b86	8	9	we	we	PRON
w0892805b86	8	10	found	find	VERB
w0892805b86	8	11	increased	increase	VERB
w0892805b86	8	12	expression	expression	NOUN
w0892805b86	8	13	of	of	ADP
w0892805b86	8	14	mdr1	mdr1	PROPN
w0892805b86	8	15	and	and	CCONJ
w0892805b86	8	16	mrp1	mrp1	PROPN
w0892805b86	8	17	.	.	PUNCT
w0892805b86	9	1	mdr1	mdr1	PROPN
w0892805b86	9	2	inhibition	inhibition	NOUN
w0892805b86	9	3	and	and	CCONJ
w0892805b86	9	4	mrp1	mrp1	NOUN
w0892805b86	9	5	silencing	silencing	NOUN
w0892805b86	9	6	restored	restore	VERB
w0892805b86	9	7	dox	dox	PROPN
w0892805b86	9	8	intracellular	intracellular	ADJ
w0892805b86	9	9	retention	retention	NOUN
w0892805b86	9	10	,	,	PUNCT
w0892805b86	9	11	decreased	decrease	VERB
w0892805b86	9	12	the	the	DET
w0892805b86	9	13	tic	tic	ADJ
w0892805b86	9	14	population	population	NOUN
w0892805b86	9	15	,	,	PUNCT
w0892805b86	9	16	and	and	CCONJ
w0892805b86	9	17	increased	increase	VERB
w0892805b86	9	18	dox	dox	NOUN
w0892805b86	9	19	-	-	PUNCT
w0892805b86	9	20	induced	induce	VERB
w0892805b86	9	21	cleaved	cleaved	ADJ
w0892805b86	9	22	caspase	caspase	NOUN
w0892805b86	9	23	3	3	NUM
w0892805b86	9	24	expression	expression	NOUN
w0892805b86	9	25	in	in	ADP
w0892805b86	9	26	apc	apc	ADJ
w0892805b86	9	27	-	-	PUNCT
w0892805b86	9	28	deficient	deficient	ADJ
w0892805b86	9	29	cells	cell	NOUN
w0892805b86	9	30	.	.	PUNCT
w0892805b86	10	1	dual	dual	PROPN
w0892805b86	10	2	mdr1	mdr1	PROPN
w0892805b86	10	3	/	/	SYM
w0892805b86	10	4	mrp1	mrp1	NOUN
w0892805b86	10	5	inhibition	inhibition	NOUN
w0892805b86	10	6	did	do	AUX
w0892805b86	10	7	not	not	PART
w0892805b86	10	8	have	have	VERB
w0892805b86	10	9	an	an	DET
w0892805b86	10	10	additive	additive	ADJ
w0892805b86	10	11	effect	effect	NOUN
w0892805b86	10	12	.	.	PUNCT
w0892805b86	11	1	increased	increase	VERB
w0892805b86	11	2	mdr1	mdr1	PROPN
w0892805b86	11	3	activity	activity	NOUN
w0892805b86	11	4	was	be	AUX
w0892805b86	11	5	specific	specific	ADJ
w0892805b86	11	6	to	to	ADP
w0892805b86	11	7	apc	apc	NOUN
w0892805b86	11	8	loss	loss	NOUN
w0892805b86	11	9	,	,	PUNCT
w0892805b86	11	10	which	which	PRON
w0892805b86	11	11	was	be	AUX
w0892805b86	11	12	shown	show	VERB
w0892805b86	11	13	to	to	PART
w0892805b86	11	14	be	be	AUX
w0892805b86	11	15	mediated	mediate	VERB
w0892805b86	11	16	through	through	ADP
w0892805b86	11	17	signal	signal	ADJ
w0892805b86	11	18	transducer	transducer	NOUN
w0892805b86	11	19	and	and	CCONJ
w0892805b86	11	20	activator	activator	NOUN
w0892805b86	11	21	of	of	ADP
w0892805b86	11	22	transcription	transcription	NOUN
w0892805b86	11	23	3	3	NUM
w0892805b86	11	24	(	(	PUNCT
w0892805b86	11	25	stat3	stat3	NOUN
w0892805b86	11	26	)	)	PUNCT
w0892805b86	11	27	.	.	PUNCT
w0892805b86	12	1	to	to	PART
w0892805b86	12	2	investigate	investigate	VERB
w0892805b86	12	3	the	the	DET
w0892805b86	12	4	effect	effect	NOUN
w0892805b86	12	5	of	of	ADP
w0892805b86	12	6	apc	apc	ADJ
w0892805b86	12	7	loss	loss	NOUN
w0892805b86	12	8	on	on	ADP
w0892805b86	12	9	dna	dna	PROPN
w0892805b86	12	10	damage	damage	NOUN
w0892805b86	12	11	repair	repair	NOUN
w0892805b86	12	12	pathways	pathway	NOUN
w0892805b86	12	13	,	,	PUNCT
w0892805b86	12	14	we	we	PRON
w0892805b86	12	15	measured	measure	VERB
w0892805b86	12	16	the	the	DET
w0892805b86	12	17	amount	amount	NOUN
w0892805b86	12	18	of	of	ADP
w0892805b86	12	19	dox	dox	NOUN
w0892805b86	12	20	-	-	PUNCT
w0892805b86	12	21	induced	induce	VERB
w0892805b86	12	22	dna	dna	NOUN
w0892805b86	12	23	damage	damage	NOUN
w0892805b86	12	24	in	in	ADP
w0892805b86	12	25	apc	apc	ADJ
w0892805b86	12	26	-	-	PUNCT
w0892805b86	12	27	deficient	deficient	ADJ
w0892805b86	12	28	cells	cell	NOUN
w0892805b86	12	29	.	.	PUNCT
w0892805b86	13	1	there	there	PRON
w0892805b86	13	2	was	be	VERB
w0892805b86	13	3	decreased	decrease	VERB
w0892805b86	13	4	dox	dox	NOUN
w0892805b86	13	5	-	-	PUNCT
w0892805b86	13	6	induced	induce	VERB
w0892805b86	13	7	dna	dna	NOUN
w0892805b86	13	8	damage	damage	NOUN
w0892805b86	13	9	and	and	CCONJ
w0892805b86	13	10	damage	damage	NOUN
w0892805b86	13	11	signaling	signal	VERB
w0892805b86	13	12	mediated	mediate	VERB
w0892805b86	13	13	through	through	ADP
w0892805b86	13	14	ataxia	ataxia	NOUN
w0892805b86	13	15	-	-	PUNCT
w0892805b86	13	16	telangiectasia	telangiectasia	PROPN
w0892805b86	13	17	mutated	mutate	VERB
w0892805b86	13	18	(	(	PUNCT
w0892805b86	13	19	atm	atm	NOUN
w0892805b86	13	20	)	)	PUNCT
w0892805b86	13	21	activation	activation	NOUN
w0892805b86	13	22	with	with	ADP
w0892805b86	13	23	apc	apc	NOUN
w0892805b86	13	24	loss	loss	NOUN
w0892805b86	13	25	.	.	PUNCT
w0892805b86	14	1	inhibiting	inhibit	VERB
w0892805b86	14	2	atm	atm	NOUN
w0892805b86	14	3	or	or	CCONJ
w0892805b86	14	4	dna	dna	PROPN
w0892805b86	14	5	-	-	PUNCT
w0892805b86	14	6	pk	pk	PROPN
w0892805b86	14	7	increased	increase	VERB
w0892805b86	14	8	dox	dox	NOUN
w0892805b86	14	9	-	-	PUNCT
w0892805b86	14	10	induced	induce	VERB
w0892805b86	14	11	apoptosis	apoptosis	NOUN
w0892805b86	14	12	.	.	PUNCT
w0892805b86	15	1	in	in	ADP
w0892805b86	15	2	addition	addition	NOUN
w0892805b86	15	3	,	,	PUNCT
w0892805b86	15	4	we	we	PRON
w0892805b86	15	5	found	find	VERB
w0892805b86	15	6	that	that	SCONJ
w0892805b86	15	7	apc	apc	NOUN
w0892805b86	15	8	loss	loss	NOUN
w0892805b86	15	9	affects	affect	VERB
w0892805b86	15	10	topo	topo	NOUN
w0892805b86	15	11	iiα	iiα	NOUN
w0892805b86	15	12	activity	activity	NOUN
w0892805b86	15	13	decreasing	decrease	VERB
w0892805b86	15	14	topo	topo	NOUN
w0892805b86	15	15	iiα	iiα	NOUN
w0892805b86	15	16	/	/	SYM
w0892805b86	15	17	dna	dna	PROPN
w0892805b86	15	18	complexes	complex	NOUN
w0892805b86	15	19	.	.	PUNCT
w0892805b86	16	1	taken	take	VERB
w0892805b86	16	2	together	together	ADV
w0892805b86	16	3	,	,	PUNCT
w0892805b86	16	4	apc	apc	PROPN
w0892805b86	16	5	loss	loss	NOUN
w0892805b86	16	6	decreased	decrease	VERB
w0892805b86	16	7	intracellular	intracellular	ADJ
w0892805b86	16	8	dox	dox	NOUN
w0892805b86	16	9	accumulation	accumulation	NOUN
w0892805b86	16	10	through	through	ADP
w0892805b86	16	11	increased	increase	VERB
w0892805b86	16	12	efflux	efflux	NOUN
w0892805b86	16	13	and	and	CCONJ
w0892805b86	16	14	decreased	decrease	VERB
w0892805b86	16	15	dox	dox	NOUN
w0892805b86	16	16	-	-	PUNCT
w0892805b86	16	17	induced	induce	VERB
w0892805b86	16	18	dna	dna	NOUN
w0892805b86	16	19	damage	damage	NOUN
w0892805b86	16	20	.	.	PUNCT
w0892805b86	17	1	mdr1	mdr1	PROPN
w0892805b86	17	2	and	and	CCONJ
w0892805b86	17	3	atm	atm	NOUN
w0892805b86	17	4	inhibition	inhibition	NOUN
w0892805b86	17	5	restore	restore	VERB
w0892805b86	17	6	dox	dox	NOUN
w0892805b86	17	7	sensitivity	sensitivity	NOUN
w0892805b86	17	8	specifically	specifically	ADV
w0892805b86	17	9	with	with	ADP
w0892805b86	17	10	apc	apc	NOUN
w0892805b86	17	11	loss	loss	NOUN
w0892805b86	17	12	demonstrating	demonstrate	VERB
w0892805b86	17	13	the	the	DET
w0892805b86	17	14	potential	potential	ADJ
w0892805b86	17	15	use	use	NOUN
w0892805b86	17	16	of	of	ADP
w0892805b86	17	17	combination	combination	NOUN
w0892805b86	17	18	therapy	therapy	NOUN
w0892805b86	17	19	to	to	PART
w0892805b86	17	20	overcome	overcome	VERB
w0892805b86	17	21	chemoresistance	chemoresistance	NOUN
w0892805b86	17	22	.	.	PUNCT